diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index 9f137b720937..ba33ad760859 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -62,15 +62,21 @@ jobs:
             python-version: 3.9
             extra-requirements: '-r requirements/testing/extra.txt'
             CFLAGS: "-fno-lto"  # Ensure that disabling LTO works.
+            # https://github.com/matplotlib/matplotlib/pull/26052#issuecomment-1574595954
+            pyqt6-ver: '!=6.5.1'
             # https://bugreports.qt.io/projects/PYSIDE/issues/PYSIDE-2346
             pyside6-ver: '!=6.5.1'
           - os: ubuntu-20.04
             python-version: '3.10'
             extra-requirements: '-r requirements/testing/extra.txt'
+            # https://github.com/matplotlib/matplotlib/pull/26052#issuecomment-1574595954
+            pyqt6-ver: '!=6.5.1'
             # https://bugreports.qt.io/projects/PYSIDE/issues/PYSIDE-2346
             pyside6-ver: '!=6.5.1'
           - os: ubuntu-20.04
             python-version: '3.11'
+            # https://github.com/matplotlib/matplotlib/pull/26052#issuecomment-1574595954
+            pyqt6-ver: '!=6.5.1'
             # https://bugreports.qt.io/projects/PYSIDE/issues/PYSIDE-2346
             pyside6-ver: '!=6.5.1'
           - os: macos-latest
diff --git a/lib/matplotlib/backends/backend_qt.py b/lib/matplotlib/backends/backend_qt.py
index faeb0d6bb700..f4b281bdd05c 100644
--- a/lib/matplotlib/backends/backend_qt.py
+++ b/lib/matplotlib/backends/backend_qt.py
@@ -106,8 +106,10 @@ def _create_qApp():
         # of Qt is not instantiated in the process
         if QT_API in {'PyQt6', 'PySide6'}:
             other_bindings = ('PyQt5', 'PySide2')
+            qt_version = 6
         elif QT_API in {'PyQt5', 'PySide2'}:
             other_bindings = ('PyQt6', 'PySide6')
+            qt_version = 5
         else:
             raise RuntimeError("Should never be here")
 
@@ -123,11 +125,11 @@ def _create_qApp():
                     'versions may not work as expected.'
                 )
                 break
-        try:
-            QtWidgets.QApplication.setAttribute(
-                QtCore.Qt.AA_EnableHighDpiScaling)
-        except AttributeError:  # Only for Qt>=5.6, <6.
-            pass
+        if qt_version == 5:
+            try:
+                QtWidgets.QApplication.setAttribute(QtCore.Qt.AA_EnableHighDpiScaling)
+            except AttributeError:  # Only for Qt>=5.6, <6.
+                pass
         try:
             QtWidgets.QApplication.setHighDpiScaleFactorRoundingPolicy(
                 QtCore.Qt.HighDpiScaleFactorRoundingPolicy.PassThrough)
@@ -141,10 +143,8 @@ def _create_qApp():
         app.lastWindowClosed.connect(app.quit)
         cbook._setup_new_guiapp()
 
-    try:
-        app.setAttribute(QtCore.Qt.AA_UseHighDpiPixmaps)  # Only for Qt<6.
-    except AttributeError:
-        pass
+        if qt_version == 5:
+            app.setAttribute(QtCore.Qt.AA_UseHighDpiPixmaps)
 
     return app
 
@@ -522,9 +522,6 @@ class FigureManagerQT(FigureManagerBase):
     def __init__(self, canvas, num):
         self.window = MainWindow()
         super().__init__(canvas, num)
-        self.window.closing.connect(
-            # The lambda prevents the event from being immediately gc'd.
-            lambda: CloseEvent("close_event", self.canvas)._process())
         self.window.closing.connect(self._widgetclosed)
 
         if sys.platform != "darwin":
@@ -569,6 +566,7 @@ def full_screen_toggle(self):
             self.window.showFullScreen()
 
     def _widgetclosed(self):
+        CloseEvent("close_event", self.canvas)._process()
         if self.window._destroying:
             return
         self.window._destroying = True