diff --git a/requirements.txt b/requirements.txt
index fc7e283..d29aa82 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -5,7 +5,7 @@ backcall==0.1.0
 biopython==1.73
 bleach==3.3.0
 bokeh==1.3.1
-certifi==2019.6.16
+certifi==2022.12.7
 chardet==3.0.4
 cycler==0.10.0
 DateTime==4.3
@@ -15,26 +15,26 @@ descartes==1.1.0
 entrypoints==0.3
 idna==2.8
 ipykernel==5.1.1
-ipython==7.7.0
+ipython==8.10.0
 ipython-genutils==0.2.0
 jedi==0.14.1
 Jinja2==2.11.3
-joblib==0.13.2
+joblib==1.2.0
 json5==0.8.5
 jsonschema==3.0.2
 jupyter-client==5.3.1
-jupyter-core==4.5.0
-jupyterlab==1.0.4
+jupyter-core==4.11.2
+jupyterlab==1.2.21
 jupyterlab-server==1.0.0
 kiwisolver==1.1.0
 MarkupSafe==1.1.1
 matplotlib==3.1.1
-mistune==0.8.4
+mistune==2.0.3
 mizani==0.5.4
-nbconvert==5.5.0
+nbconvert==6.5.1
 nbformat==4.4.0
-notebook==6.1.5
-numpy==1.16.4
+notebook==6.4.12
+numpy==1.22.0
 packaging==19.1
 palettable==3.2.0
 pandas==0.24.2
@@ -74,7 +74,7 @@ testpath==0.4.2
 toolz==0.10.0
 tornado==6.0.3
 traitlets==4.3.2
-urllib3==1.25.3
+urllib3==1.26.5
 vega-datasets==0.7.0
 wcwidth==0.1.7
 webencodings==0.5.1