diff --git a/Misc/ACKS b/Misc/ACKS
index 20ea85c4addece..15d4470e2842cf 100644
--- a/Misc/ACKS
+++ b/Misc/ACKS
@@ -516,6 +516,7 @@ Michael Ernst
 Ben Escoto
 Andy Eskilsson
 André Espaze
+Lucas Esposito
 Stefan Esser
 Nicolas Estibals
 Jonathan Eunice
diff --git a/Misc/NEWS.d/next/Windows/2024-07-19-21-50-54.gh-issue-100256.GDrKba.rst b/Misc/NEWS.d/next/Windows/2024-07-19-21-50-54.gh-issue-100256.GDrKba.rst
new file mode 100644
index 00000000000000..f0156ddd4772ed
--- /dev/null
+++ b/Misc/NEWS.d/next/Windows/2024-07-19-21-50-54.gh-issue-100256.GDrKba.rst
@@ -0,0 +1 @@
+:mod:`mimetypes` no longer fails when it encounters an inaccessible registry key.
diff --git a/Modules/_winapi.c b/Modules/_winapi.c
index edb1181809c53b..76f18c71a0713d 100644
--- a/Modules/_winapi.c
+++ b/Modules/_winapi.c
@@ -2268,7 +2268,7 @@ _winapi__mimetypes_read_windows_registry_impl(PyObject *module,
         }
 
         err = RegOpenKeyExW(hkcr, ext, 0, KEY_READ, &subkey);
-        if (err == ERROR_FILE_NOT_FOUND) {
+        if (err == ERROR_FILE_NOT_FOUND || err == ERROR_ACCESS_DENIED) {
             err = ERROR_SUCCESS;
             continue;
         } else if (err != ERROR_SUCCESS) {