diff --git a/Lib/ftplib.py b/Lib/ftplib.py
index 50771e8c17c250..2f2b0078a5577f 100644
--- a/Lib/ftplib.py
+++ b/Lib/ftplib.py
@@ -324,7 +324,11 @@ def makeport(self):
     def makepasv(self):
         """Internal: Does the PASV or EPSV handshake -> (address, port)"""
         if self.af == socket.AF_INET:
-            untrusted_host, port = parse227(self.sendcmd('PASV'))
+            pasv_response = self.sendcmd('PASV')
+            try:
+                untrusted_host, port = parse227(pasv_response)
+            except error_reply:
+                untrusted_host, port = parse229(pasv_response, self.sock.getpeername())
             if self.trust_server_pasv_ipv4_address:
                 host = untrusted_host
             else:
diff --git a/Misc/NEWS.d/next/Library/2024-12-01-16-43-38.gh-issue-127478.fHI_y9.rst b/Misc/NEWS.d/next/Library/2024-12-01-16-43-38.gh-issue-127478.fHI_y9.rst
new file mode 100644
index 00000000000000..0cc4fc1a92d6d2
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2024-12-01-16-43-38.gh-issue-127478.fHI_y9.rst
@@ -0,0 +1 @@
+Enhancement to support FTP connection with NAT scenario.