diff --git a/Makefile.pre.in b/Makefile.pre.in
index 925e0a243c9e96..dc1db80d88d7bd 100644
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -166,7 +166,7 @@ WHEEL_PKG_DIR=	@WHEEL_PKG_DIR@
 
 # Detailed destination directories
 BINLIBDEST=	@BINLIBDEST@
-LIBDEST=	$(SCRIPTDIR)/python$(VERSION)$(ABI_THREAD)
+LIBDEST=	@LIBDEST@
 INCLUDEPY=	$(INCLUDEDIR)/python$(LDVERSION)
 CONFINCLUDEPY=	$(CONFINCLUDEDIR)/python$(LDVERSION)
 
diff --git a/Misc/NEWS.d/next/Build/2025-04-29-18-25-34.gh-issue-108819.qMUTRB.rst b/Misc/NEWS.d/next/Build/2025-04-29-18-25-34.gh-issue-108819.qMUTRB.rst
new file mode 100644
index 00000000000000..e374a86f0bc9a2
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2025-04-29-18-25-34.gh-issue-108819.qMUTRB.rst
@@ -0,0 +1,3 @@
+Honor :option:`--with-platlibdir` in the pure-Python standard library
+installation path, if ``PLATLIBDIR`` doesn't match the value used in
+``LIBDIR``.
diff --git a/configure b/configure
index 205f196a25af2d..0de4b0aed51d70 100755
--- a/configure
+++ b/configure
@@ -837,8 +837,9 @@ LIBREADLINE_CFLAGS
 WHEEL_PKG_DIR
 LIBPL
 PY_ENABLE_SHARED
-PLATLIBDIR
 BINLIBDEST
+LIBDEST
+PLATLIBDIR
 LIBPYTHON
 MODULE_DEPS_SHARED
 EXT_SUFFIX
@@ -26212,15 +26213,10 @@ if test "$ac_sys_system" = "iOS"; then
   MODULE_DEPS_SHARED="$MODULE_DEPS_SHARED \$(PYTHONFRAMEWORKDIR)/\$(PYTHONFRAMEWORK)"
 fi
 
-
-
-BINLIBDEST='$(LIBDIR)/python$(VERSION)$(ABI_THREAD)'
-
-
 # Check for --with-platlibdir
 # /usr/$PLATLIBDIR/python$(VERSION)$(ABI_THREAD)
 
-PLATLIBDIR="lib"
+PLATLIBDIR="lib"  # XXX: We should probably calculate the defauly from libdir, if defined.
 { printf "%s\n" "$as_me:${as_lineno-$LINENO}: checking for --with-platlibdir" >&5
 printf %s "checking for --with-platlibdir... " >&6; }
 
@@ -26237,7 +26233,6 @@ then
   { printf "%s\n" "$as_me:${as_lineno-$LINENO}: result: yes" >&5
 printf "%s\n" "yes" >&6; }
   PLATLIBDIR="$withval"
-  BINLIBDEST='${exec_prefix}/${PLATLIBDIR}/python$(VERSION)$(ABI_THREAD)'
 else
   { printf "%s\n" "$as_me:${as_lineno-$LINENO}: result: no" >&5
 printf "%s\n" "no" >&6; }
@@ -26251,10 +26246,14 @@ fi
 
 
 
+LIBDEST='${prefix}/${PLATLIBDIR}/python$(VERSION)$(ABI_THREAD)'
+BINLIBDEST='${exec_prefix}/${PLATLIBDIR}/python$(VERSION)$(ABI_THREAD)'
+
+
 if test x$PLATFORM_TRIPLET = x; then
-  LIBPL='$(prefix)'"/${PLATLIBDIR}/python${VERSION}${ABI_THREAD}/config-${LDVERSION}"
+  LIBPL='$(LIBDEST)'"/config-${LDVERSION}"
 else
-  LIBPL='$(prefix)'"/${PLATLIBDIR}/python${VERSION}${ABI_THREAD}/config-${LDVERSION}-${PLATFORM_TRIPLET}"
+  LIBPL='$(LIBDEST)'"/config-${LDVERSION}-${PLATFORM_TRIPLET}"
 fi
 
 
diff --git a/configure.ac b/configure.ac
index f0ae7fbec1cbfe..f53be1bd944b0f 100644
--- a/configure.ac
+++ b/configure.ac
@@ -6248,15 +6248,10 @@ if test "$ac_sys_system" = "iOS"; then
   MODULE_DEPS_SHARED="$MODULE_DEPS_SHARED \$(PYTHONFRAMEWORKDIR)/\$(PYTHONFRAMEWORK)"
 fi
 
-
-AC_SUBST([BINLIBDEST])
-BINLIBDEST='$(LIBDIR)/python$(VERSION)$(ABI_THREAD)'
-
-
 # Check for --with-platlibdir
 # /usr/$PLATLIBDIR/python$(VERSION)$(ABI_THREAD)
 AC_SUBST([PLATLIBDIR])
-PLATLIBDIR="lib"
+PLATLIBDIR="lib"  # XXX: We should probably calculate the defauly from libdir, if defined.
 AC_MSG_CHECKING([for --with-platlibdir])
 AC_ARG_WITH(
   [platlibdir],
@@ -6273,19 +6268,22 @@ if test -n "$withval" -a "$withval" != yes -a "$withval" != no
 then
   AC_MSG_RESULT([yes])
   PLATLIBDIR="$withval"
-  BINLIBDEST='${exec_prefix}/${PLATLIBDIR}/python$(VERSION)$(ABI_THREAD)'
 else
   AC_MSG_RESULT([no])
 fi],
 [AC_MSG_RESULT([no])])
 
+AC_SUBST([LIBDEST])
+AC_SUBST([BINLIBDEST])
+LIBDEST='${prefix}/${PLATLIBDIR}/python$(VERSION)$(ABI_THREAD)'
+BINLIBDEST='${exec_prefix}/${PLATLIBDIR}/python$(VERSION)$(ABI_THREAD)'
 
 dnl define LIBPL after ABIFLAGS and LDVERSION is defined.
 AC_SUBST([PY_ENABLE_SHARED])
 if test x$PLATFORM_TRIPLET = x; then
-  LIBPL='$(prefix)'"/${PLATLIBDIR}/python${VERSION}${ABI_THREAD}/config-${LDVERSION}"
+  LIBPL='$(LIBDEST)'"/config-${LDVERSION}"
 else
-  LIBPL='$(prefix)'"/${PLATLIBDIR}/python${VERSION}${ABI_THREAD}/config-${LDVERSION}-${PLATFORM_TRIPLET}"
+  LIBPL='$(LIBDEST)'"/config-${LDVERSION}-${PLATFORM_TRIPLET}"
 fi
 AC_SUBST([LIBPL])