diff --git a/Misc/NEWS.d/next/Windows/2025-05-07-11-25-29.gh-issue-133568.oYV0d8.rst b/Misc/NEWS.d/next/Windows/2025-05-07-11-25-29.gh-issue-133568.oYV0d8.rst
new file mode 100644
index 00000000000000..1e2a5b582cbe7f
--- /dev/null
+++ b/Misc/NEWS.d/next/Windows/2025-05-07-11-25-29.gh-issue-133568.oYV0d8.rst
@@ -0,0 +1 @@
+Fix compile error when using a WinAPI partition that doesn't support the RPC runtime library.
diff --git a/Modules/socketmodule.h b/Modules/socketmodule.h
index 63624d511c35a0..200b2b8c7d8310 100644
--- a/Modules/socketmodule.h
+++ b/Modules/socketmodule.h
@@ -259,7 +259,7 @@ typedef int SOCKET_T;
 #endif
 
 // AF_HYPERV is only supported on Windows
-#if defined(AF_HYPERV) && defined(MS_WINDOWS)
+#if defined(AF_HYPERV) && (defined(MS_WINDOWS_APP) || defined(MS_WINDOWS_SYSTEM))
 #  define HAVE_AF_HYPERV
 #endif