diff --git a/Misc/NEWS.d/next/Build/2025-05-19-18-09-20.gh-issue-134273.ZAliyy.rst b/Misc/NEWS.d/next/Build/2025-05-19-18-09-20.gh-issue-134273.ZAliyy.rst
new file mode 100644
index 00000000000000..3eb13cefbe6dfc
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2025-05-19-18-09-20.gh-issue-134273.ZAliyy.rst
@@ -0,0 +1 @@
+Add support for configuring compiler flags for the JIT with ``CFLAGS_JIT``
diff --git a/Tools/jit/_targets.py b/Tools/jit/_targets.py
index d0a1c081ffecc2..b383e39da19456 100644
--- a/Tools/jit/_targets.py
+++ b/Tools/jit/_targets.py
@@ -10,6 +10,7 @@
 import sys
 import tempfile
 import typing
+import shlex
 
 import _llvm
 import _schema
@@ -46,6 +47,7 @@ class _Target(typing.Generic[_S, _R]):
     stable: bool = False
     debug: bool = False
     verbose: bool = False
+    cflags: str = ""
     known_symbols: dict[str, int] = dataclasses.field(default_factory=dict)
     pyconfig_dir: pathlib.Path = pathlib.Path.cwd().resolve()
 
@@ -62,6 +64,7 @@ def _compute_digest(self) -> str:
         hasher = hashlib.sha256()
         hasher.update(self.triple.encode())
         hasher.update(self.debug.to_bytes())
+        hasher.update(self.cflags.encode())
         # These dependencies are also reflected in _JITSources in regen.targets:
         hasher.update(PYTHON_EXECUTOR_CASES_C_H.read_bytes())
         hasher.update((self.pyconfig_dir / "pyconfig.h").read_bytes())
@@ -155,6 +158,8 @@ async def _compile(
             f"{o}",
             f"{c}",
             *self.args,
+            # Allow user-provided CFLAGS to override any defaults
+            *shlex.split(self.cflags),
         ]
         await _llvm.run("clang", args, echo=self.verbose)
         return await self._parse(o)
diff --git a/Tools/jit/build.py b/Tools/jit/build.py
index 1afd0c76bad1d2..a0733005929bf2 100644
--- a/Tools/jit/build.py
+++ b/Tools/jit/build.py
@@ -39,11 +39,15 @@
     parser.add_argument(
         "-v", "--verbose", action="store_true", help="echo commands as they are run"
     )
+    parser.add_argument(
+        "--cflags", help="additional flags to pass to the compiler", default=""
+    )
     args = parser.parse_args()
     for target in args.target:
         target.debug = args.debug
         target.force = args.force
         target.verbose = args.verbose
+        target.cflags = args.cflags
         target.pyconfig_dir = args.pyconfig_dir
         target.build(
             comment=comment,
diff --git a/configure b/configure
index c9ce9b4a73527d..68213817679534 100755
--- a/configure
+++ b/configure
@@ -906,6 +906,7 @@ DSYMUTIL_PATH
 DSYMUTIL
 JIT_STENCILS_H
 REGEN_JIT_COMMAND
+CFLAGS_JIT
 UNIVERSAL_ARCH_FLAGS
 WASM_STDLIB
 WASM_ASSETS_DIR
@@ -10832,6 +10833,7 @@ esac
 fi
 
 # Check for --enable-experimental-jit:
+
 { printf "%s\n" "$as_me:${as_lineno-$LINENO}: checking for --enable-experimental-jit" >&5
 printf %s "checking for --enable-experimental-jit... " >&6; }
 # Check whether --enable-experimental-jit was given.
@@ -10863,7 +10865,7 @@ then :
 
 else case e in #(
   e) as_fn_append CFLAGS_NODIST " $jit_flags"
-           REGEN_JIT_COMMAND="\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir ."
+           REGEN_JIT_COMMAND="\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir . --cflags=\"\$(CFLAGS_JIT)\""
            JIT_STENCILS_H="jit_stencils.h"
            if test "x$Py_DEBUG" = xtrue
 then :
diff --git a/configure.ac b/configure.ac
index eb52365d95be21..9ab4b370f1c050 100644
--- a/configure.ac
+++ b/configure.ac
@@ -2752,6 +2752,7 @@ AS_VAR_IF([ac_cv_gcc_compat], [yes], [
 ])
 
 # Check for --enable-experimental-jit:
+AC_SUBST([CFLAGS_JIT])
 AC_MSG_CHECKING([for --enable-experimental-jit])
 AC_ARG_ENABLE([experimental-jit],
               [AS_HELP_STRING([--enable-experimental-jit@<:@=no|yes|yes-off|interpreter@:>@],
@@ -2776,7 +2777,7 @@ AS_VAR_IF([jit_flags],
           [],
           [AS_VAR_APPEND([CFLAGS_NODIST], [" $jit_flags"])
            AS_VAR_SET([REGEN_JIT_COMMAND],
-                      ["\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir ."])
+                      ["\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir . --cflags=\"\$(CFLAGS_JIT)\""])
            AS_VAR_SET([JIT_STENCILS_H], ["jit_stencils.h"])
            AS_VAR_IF([Py_DEBUG],
                      [true],