diff --git a/Lib/test/test_peepholer.py b/Lib/test/test_peepholer.py
index ef596630b930f7..a59f6b6accc2b5 100644
--- a/Lib/test/test_peepholer.py
+++ b/Lib/test/test_peepholer.py
@@ -292,6 +292,7 @@ def test_constant_folding_unaryop(self):
             ('---x', 'UNARY_NEGATIVE', None, False, None, None),
             ('~~~x', 'UNARY_INVERT', None, False, None, None),
             ('+++x', 'CALL_INTRINSIC_1', intrinsic_positive, False, None, None),
+            ('~True', 'UNARY_INVERT', None, False, None, None),
         ]
 
         for (
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2025-05-31-19-24-54.gh-issue-134280.NDVbzY.rst b/Misc/NEWS.d/next/Core_and_Builtins/2025-05-31-19-24-54.gh-issue-134280.NDVbzY.rst
new file mode 100644
index 00000000000000..f822721690975a
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2025-05-31-19-24-54.gh-issue-134280.NDVbzY.rst
@@ -0,0 +1,2 @@
+Disable constant folding for ``~`` with a boolean argument.
+This moves the deprecation warning from compile time to runtime.
diff --git a/Python/flowgraph.c b/Python/flowgraph.c
index 2adc8c84d83974..1cb6f03169e3b5 100644
--- a/Python/flowgraph.c
+++ b/Python/flowgraph.c
@@ -1892,6 +1892,10 @@ eval_const_unaryop(PyObject *operand, int opcode, int oparg)
             result = PyNumber_Negative(operand);
             break;
         case UNARY_INVERT:
+            // XXX: This should be removed once the ~bool depreciation expires.
+            if (PyBool_Check(operand)) {
+                return NULL;
+            }
             result = PyNumber_Invert(operand);
             break;
         case UNARY_NOT: {