diff --git a/Lib/test/test_capi/test_opt.py b/Lib/test/test_capi/test_opt.py
index 8a3819dabe44ce..bf22ef2a5922e7 100644
--- a/Lib/test/test_capi/test_opt.py
+++ b/Lib/test/test_capi/test_opt.py
@@ -2275,6 +2275,21 @@ def f(n):
         self.assertIn("_UNPACK_SEQUENCE_TWO_TUPLE", uops)
         self.assertNotIn("_GUARD_TOS_TUPLE", uops)
 
+    def test_unary_invert_long_type(self):
+        def testfunc(n):
+            for _ in range(n):
+                a = 9397
+                x = ~a + ~a
+
+        testfunc(TIER2_THRESHOLD)
+
+        ex = get_first_executor(testfunc)
+        self.assertIsNotNone(ex)
+        uops = get_opnames(ex)
+
+        self.assertNotIn("_GUARD_TOS_INT", uops)
+        self.assertNotIn("_GUARD_NOS_INT", uops)
+
 
 def global_identity(x):
     return x
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2025-06-06-01-09-44.gh-issue-131798.1SuxO9.rst b/Misc/NEWS.d/next/Core_and_Builtins/2025-06-06-01-09-44.gh-issue-131798.1SuxO9.rst
new file mode 100644
index 00000000000000..a377526230659f
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2025-06-06-01-09-44.gh-issue-131798.1SuxO9.rst
@@ -0,0 +1 @@
+Optimize ``_UNARY_INVERT`` in JIT-compiled code.
diff --git a/Python/optimizer_bytecodes.c b/Python/optimizer_bytecodes.c
index fbf4dfd3db629c..a9d5e92ca02a59 100644
--- a/Python/optimizer_bytecodes.c
+++ b/Python/optimizer_bytecodes.c
@@ -467,6 +467,15 @@ dummy_func(void) {
         res = sym_new_truthiness(ctx, value, false);
     }
 
+    op(_UNARY_INVERT, (value -- res)) {
+        if (sym_matches_type(value, &PyLong_Type)) {
+            res = sym_new_type(ctx, &PyLong_Type);
+        }
+        else {
+            res = sym_new_not_null(ctx);
+        }
+    }
+
     op(_COMPARE_OP, (left, right -- res)) {
         if (oparg & 16) {
             res = sym_new_type(ctx, &PyBool_Type);
diff --git a/Python/optimizer_cases.c.h b/Python/optimizer_cases.c.h
index b42f47c75eaf50..4780e492f61d74 100644
--- a/Python/optimizer_cases.c.h
+++ b/Python/optimizer_cases.c.h
@@ -285,8 +285,15 @@
         }
 
         case _UNARY_INVERT: {
+            JitOptSymbol *value;
             JitOptSymbol *res;
-            res = sym_new_not_null(ctx);
+            value = stack_pointer[-1];
+            if (sym_matches_type(value, &PyLong_Type)) {
+                res = sym_new_type(ctx, &PyLong_Type);
+            }
+            else {
+                res = sym_new_not_null(ctx);
+            }
             stack_pointer[-1] = res;
             break;
         }