diff --git a/PCbuild/pyproject.props b/PCbuild/pyproject.props
index ce51e342241686..cf35e705f355a7 100644
--- a/PCbuild/pyproject.props
+++ b/PCbuild/pyproject.props
@@ -100,8 +100,8 @@
       <AdditionalDependencies>advapi32.lib;shell32.lib;ole32.lib;oleaut32.lib;%(AdditionalDependencies)</AdditionalDependencies>
       <AdditionalOptions Condition="$(Configuration) != 'Debug'">/OPT:REF,NOICF %(AdditionalOptions)</AdditionalOptions>
       <AdditionalOptions Condition="$(MSVCHasBrokenARM64Clamping) == 'true' and $(Platform) == 'ARM64'">-d2:-pattern-opt-disable:-932189325 %(AdditionalOptions)</AdditionalOptions>
-      <AdditionalOptions Condition="$(SupportPGO) and $(Configuration) == 'PGInstrument'">/GENPROFILE %(AdditionalOptions)</AdditionalOptions>
-      <AdditionalOptions Condition="$(SupportPGO) and $(Configuration) == 'PGUpdate'">/USEPROFILE %(AdditionalOptions)</AdditionalOptions>
+      <AdditionalOptions Condition="$(SupportPGO) and $(Configuration) == 'PGInstrument' and $(PlatformToolset) != 'ClangCL'">/GENPROFILE %(AdditionalOptions)</AdditionalOptions>
+      <AdditionalOptions Condition="$(SupportPGO) and $(Configuration) == 'PGUpdate' and $(PlatformToolset) != 'ClangCL'">/USEPROFILE %(AdditionalOptions)</AdditionalOptions>
     </Link>
     <Lib>
       <LinkTimeCodeGeneration>false</LinkTimeCodeGeneration>