diff --git a/Android/android.py b/Android/android.py
index 75f73cd30993da..e6090aa1d80db0 100755
--- a/Android/android.py
+++ b/Android/android.py
@@ -187,7 +187,7 @@ def unpack_deps(host, prefix_dir):
     os.chdir(prefix_dir)
     deps_url = "https://github.com/beeware/cpython-android-source-deps/releases/download"
     for name_ver in ["bzip2-1.0.8-3", "libffi-3.4.4-3", "openssl-3.0.15-4",
-                     "sqlite-3.49.1-0", "xz-5.4.6-1", "zstd-1.5.7-1"]:
+                     "sqlite-3.50.4-0", "xz-5.4.6-1", "zstd-1.5.7-1"]:
         filename = f"{name_ver}-{host}.tar.gz"
         download(f"{deps_url}/{name_ver}/{filename}")
         shutil.unpack_archive(filename)
diff --git a/Mac/BuildScript/build-installer.py b/Mac/BuildScript/build-installer.py
index b31cb766a468f4..8ae2cff93d2082 100755
--- a/Mac/BuildScript/build-installer.py
+++ b/Mac/BuildScript/build-installer.py
@@ -359,9 +359,9 @@ def library_recipes():
                   ),
           ),
           dict(
-              name="SQLite 3.49.1",
-              url="https://sqlite.org/2025/sqlite-autoconf-3490100.tar.gz",
-              checksum="106642d8ccb36c5f7323b64e4152e9b719f7c0215acf5bfeac3d5e7f97b59254",
+              name="SQLite 3.50.4",
+              url="https://www.sqlite.org/2025/sqlite-autoconf-3500400.tar.gz",
+              checksum="a3db587a1b92ee5ddac2f66b3edb41b26f9c867275782d46c3a088977d6a5b18",
               extra_cflags=('-Os '
                             '-DSQLITE_ENABLE_FTS5 '
                             '-DSQLITE_ENABLE_FTS4 '
diff --git a/Misc/NEWS.d/next/Windows/2025-07-27-02-16-53.gh-issue-137134.W0WpDF.rst b/Misc/NEWS.d/next/Windows/2025-07-27-02-16-53.gh-issue-137134.W0WpDF.rst
new file mode 100644
index 00000000000000..ddccf95b7d039a
--- /dev/null
+++ b/Misc/NEWS.d/next/Windows/2025-07-27-02-16-53.gh-issue-137134.W0WpDF.rst
@@ -0,0 +1 @@
+Update Windows installer to ship with SQLite 3.50.4.
diff --git a/Misc/NEWS.d/next/macOS/2025-07-27-02-17-40.gh-issue-137134.pjgITs.rst b/Misc/NEWS.d/next/macOS/2025-07-27-02-17-40.gh-issue-137134.pjgITs.rst
new file mode 100644
index 00000000000000..957270f5abae93
--- /dev/null
+++ b/Misc/NEWS.d/next/macOS/2025-07-27-02-17-40.gh-issue-137134.pjgITs.rst
@@ -0,0 +1 @@
+Update macOS installer to ship with SQLite version 3.50.4.
diff --git a/Misc/externals.spdx.json b/Misc/externals.spdx.json
index 69f3beec82ed34..a87af7f9173780 100644
--- a/Misc/externals.spdx.json
+++ b/Misc/externals.spdx.json
@@ -91,21 +91,21 @@
       "checksums": [
         {
           "algorithm": "SHA256",
-          "checksumValue": "e335aeb44fa36cde60ecbb6a9f8be6f5d449d645ce9b0199ee53a7e6728d19d2"
+          "checksumValue": "fb5ab81f27612b0a7b4861ba655906c76dc85ee969e7a4905d2075aff931e8d0"
         }
       ],
-      "downloadLocation": "https://github.com/python/cpython-source-deps/archive/refs/tags/sqlite-3.49.1.0.tar.gz",
+      "downloadLocation": "https://github.com/python/cpython-source-deps/archive/refs/tags/sqlite-3.50.4.0.tar.gz",
       "externalRefs": [
         {
           "referenceCategory": "SECURITY",
-          "referenceLocator": "cpe:2.3:a:sqlite:sqlite:3.49.1.0:*:*:*:*:*:*:*",
+          "referenceLocator": "cpe:2.3:a:sqlite:sqlite:3.50.4.0:*:*:*:*:*:*:*",
           "referenceType": "cpe23Type"
         }
       ],
       "licenseConcluded": "NOASSERTION",
       "name": "sqlite",
       "primaryPackagePurpose": "SOURCE",
-      "versionInfo": "3.49.1.0"
+      "versionInfo": "3.50.4.0"
     },
     {
       "SPDXID": "SPDXRef-PACKAGE-tcl-core",
diff --git a/PCbuild/get_externals.bat b/PCbuild/get_externals.bat
index e29054f5734d49..eff8d1ccd7f146 100644
--- a/PCbuild/get_externals.bat
+++ b/PCbuild/get_externals.bat
@@ -56,7 +56,7 @@ set libraries=%libraries%                                       bzip2-1.0.8
 if NOT "%IncludeLibffiSrc%"=="false" set libraries=%libraries%  libffi-3.4.4
 if NOT "%IncludeSSLSrc%"=="false" set libraries=%libraries%     openssl-3.0.16
 set libraries=%libraries%                                       mpdecimal-4.0.0
-set libraries=%libraries%                                       sqlite-3.49.1.0
+set libraries=%libraries%                                       sqlite-3.50.4.0
 if NOT "%IncludeTkinterSrc%"=="false" set libraries=%libraries% tcl-core-8.6.15.0
 if NOT "%IncludeTkinterSrc%"=="false" set libraries=%libraries% tk-8.6.15.0
 set libraries=%libraries%                                       xz-5.2.5
diff --git a/PCbuild/python.props b/PCbuild/python.props
index ddc7696d2762fe..e1c2ff3fe3cc11 100644
--- a/PCbuild/python.props
+++ b/PCbuild/python.props
@@ -74,7 +74,7 @@
   <Import Project="$(ExternalProps)" Condition="$(ExternalProps) != '' and Exists('$(ExternalProps)')" />
 
   <PropertyGroup>
-    <sqlite3Dir Condition="$(sqlite3Dir) == ''">$(ExternalsDir)sqlite-3.49.1.0\</sqlite3Dir>
+    <sqlite3Dir Condition="$(sqlite3Dir) == ''">$(ExternalsDir)sqlite-3.50.4.0\</sqlite3Dir>
     <bz2Dir Condition="$(bz2Dir) == ''">$(ExternalsDir)bzip2-1.0.8\</bz2Dir>
     <lzmaDir Condition="$(lzmaDir) == ''">$(ExternalsDir)xz-5.2.5\</lzmaDir>
     <libffiDir Condition="$(libffiDir) == ''">$(ExternalsDir)libffi-3.4.4\</libffiDir>
diff --git a/PCbuild/readme.txt b/PCbuild/readme.txt
index 01e19aabdecdc7..abb345019bf6b9 100644
--- a/PCbuild/readme.txt
+++ b/PCbuild/readme.txt
@@ -230,7 +230,7 @@ _ssl
     again when building.
 
 _sqlite3
-    Wraps SQLite 3.49.1, which is itself built by sqlite3.vcxproj
+    Wraps SQLite 3.50.4, which is itself built by sqlite3.vcxproj
     Homepage:
         https://www.sqlite.org/
 _tkinter