diff --git a/Python/ceval.c b/Python/ceval.c
index 9b7c42cbe4b114..487e09bc664173 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -5032,7 +5032,7 @@ _PyEval_EvalFrameDefault(PyThreadState *tstate, _PyInterpreterFrame *frame, int
             STAT_INC(PRECALL, hit);
             // PRECALL + CALL + POP_TOP
             JUMPBY(INLINE_CACHE_ENTRIES_PRECALL + 1 + INLINE_CACHE_ENTRIES_CALL + 1);
-            assert(next_instr[-1] == POP_TOP);
+            assert(_Py_OPCODE(next_instr[-1]) == POP_TOP);
             PyObject *arg = POP();
             if (_PyList_AppendTakeRef((PyListObject *)list, arg) < 0) {
                 goto error;