diff --git a/Lib/test/test_asyncore.py b/Lib/test/test_asyncore.py
index 20eceb635059ed..dc2b626f1e73ed 100644
--- a/Lib/test/test_asyncore.py
+++ b/Lib/test/test_asyncore.py
@@ -606,6 +606,9 @@ def test_handle_expt(self):
         # Note: this might fail on some platforms as OOB data is
         # tenuously supported and rarely used.
 
+        if sys.platform == "darwin" and self.use_poll:
+            self.skipTest("poll may fail on macOS; see issue #28087")
+
         class TestClient(BaseClient):
             def handle_expt(self):
                 self.flag = True
diff --git a/Misc/NEWS b/Misc/NEWS
index 5a0335b118830a..acd20159bc93ae 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -137,6 +137,10 @@ Build
 Tests
 -----
 
+- bpo-28087: Skip test_asyncore and test_eintr poll failures on macOS.
+  Skip some tests of select.poll when running on macOS due to unresolved
+  issues with the underlying system poll function on some macOS versions.
+
 - bpo-15083: Convert ElementTree doctests to unittests.