diff --git a/pyperformance/data-files/benchmarks/MANIFEST b/pyperformance/data-files/benchmarks/MANIFEST
index d472c2c1..01c87603 100644
--- a/pyperformance/data-files/benchmarks/MANIFEST
+++ b/pyperformance/data-files/benchmarks/MANIFEST
@@ -69,6 +69,7 @@ sympy	<local>
 telco	<local>
 tomli_loads	<local>
 tornado_http	<local>
+typing_runtime_protocols	<local>
 unpack_sequence	<local>
 unpickle	<local:pickle>
 unpickle_list	<local:pickle>
diff --git a/pyperformance/data-files/benchmarks/bm_typing_runtime_protocols/pyproject.toml b/pyperformance/data-files/benchmarks/bm_typing_runtime_protocols/pyproject.toml
new file mode 100644
index 00000000..a69cf598
--- /dev/null
+++ b/pyperformance/data-files/benchmarks/bm_typing_runtime_protocols/pyproject.toml
@@ -0,0 +1,9 @@
+[project]
+name = "pyperformance_bm_typing_runtime_protocols"
+requires-python = ">=3.8"
+dependencies = ["pyperf"]
+urls = {repository = "https://github.com/python/pyperformance"}
+dynamic = ["version"]
+
+[tool.pyperformance]
+name = "typing_runtime_protocols"
diff --git a/pyperformance/data-files/benchmarks/bm_typing_runtime_protocols/run_benchmark.py b/pyperformance/data-files/benchmarks/bm_typing_runtime_protocols/run_benchmark.py
new file mode 100644
index 00000000..dd8e7ef3
--- /dev/null
+++ b/pyperformance/data-files/benchmarks/bm_typing_runtime_protocols/run_benchmark.py
@@ -0,0 +1,180 @@
+"""
+Test the performance of isinstance() checks against runtime-checkable protocols.
+
+For programmes that make extensive use of this feature,
+these calls can easily become a bottleneck.
+See https://github.com/python/cpython/issues/74690
+
+The following situations all exercise different code paths
+in typing._ProtocolMeta.__instancecheck__,
+so each is tested in this benchmark:
+
+  (1) Comparing an instance of a class that directly inherits
+      from a protocol to that protocol.
+  (2) Comparing an instance of a class that fulfils the interface
+      of a protocol using instance attributes.
+  (3) Comparing an instance of a class that fulfils the interface
+      of a protocol using class attributes.
+  (4) Comparing an instance of a class that fulfils the interface
+      of a protocol using properties.
+
+Protocols with callable and non-callable members also
+exercise different code paths in _ProtocolMeta.__instancecheck__,
+so are also tested separately.
+"""
+
+import time
+from typing import Protocol, runtime_checkable
+
+import pyperf
+
+
+##################################################
+# Protocols to call isinstance() against
+##################################################
+
+
+@runtime_checkable
+class HasX(Protocol):
+    """A runtime-checkable protocol with a single non-callable member"""
+    x: int
+
+@runtime_checkable
+class HasManyAttributes(Protocol):
+    """A runtime-checkable protocol with many non-callable members"""
+    a: int
+    b: int
+    c: int
+    d: int
+    e: int
+
+@runtime_checkable
+class SupportsInt(Protocol):
+    """A runtime-checkable protocol with a single callable member"""
+    def __int__(self) -> int: ...
+
+@runtime_checkable
+class SupportsManyMethods(Protocol):
+    """A runtime-checkable protocol with many callable members"""
+    def one(self) -> int: ...
+    def two(self) -> str: ...
+    def three(self) -> bytes: ...
+    def four(self) -> memoryview: ...
+    def five(self) -> bytearray: ...
+
+@runtime_checkable
+class SupportsIntAndX(Protocol):
+    """A runtime-checkable protocol with a mix of callable and non-callable members"""
+    x: int
+    def __int__(self) -> int: ...
+
+
+##################################################
+# Classes for comparing against the protocols
+##################################################
+
+
+class Empty:
+    """Empty class with no attributes"""
+
+class PropertyX:
+    """Class with a property x"""
+    @property
+    def x(self) -> int: return 42
+
+class HasIntMethod:
+    """Class with an __int__ method"""
+    def __int__(self): return 42
+
+class HasManyMethods:
+    """Class with many methods"""
+    def one(self): return 42
+    def two(self): return "42"
+    def three(self): return b"42"
+    def four(self): return memoryview(b"42")
+    def five(self): return bytearray(b"42")
+
+class PropertyXWithInt:
+    """Class with a property x and an __int__ method"""
+    @property
+    def x(self) -> int: return 42
+    def __int__(self): return 42
+
+class ClassVarX:
+    """Class with a ClassVar x"""
+    x = 42
+
+class ClassVarXWithInt:
+    """Class with a ClassVar x and an __int__ method"""
+    x = 42
+    def __int__(self): return 42
+
+class InstanceVarX:
+    """Class with an instance var x"""
+    def __init__(self):
+        self.x = 42
+
+class ManyInstanceVars:
+    """Class with many instance vars"""
+    def __init__(self):
+        for attr in 'abcde':
+            setattr(self, attr, 42)
+
+class InstanceVarXWithInt:
+    """Class with an instance var x and an __int__ method"""
+    def __init__(self):
+        self.x = 42
+    def __int__(self):
+        return 42
+
+class NominalX(HasX):
+    """Class that explicitly subclasses HasX"""
+    def __init__(self):
+        self.x = 42
+
+class NominalSupportsInt(SupportsInt):
+    """Class that explicitly subclasses SupportsInt"""
+    def __int__(self):
+        return 42
+
+class NominalXWithInt(SupportsIntAndX):
+    """Class that explicitly subclasses NominalXWithInt"""
+    def __init__(self):
+        self.x = 42
+
+
+##################################################
+# Time to test the performance of isinstance()!
+##################################################
+
+
+def bench_protocols(loops: int) -> float:
+    protocols = [
+        HasX, HasManyAttributes, SupportsInt, SupportsManyMethods, SupportsIntAndX
+    ]
+    instances = [
+        cls()
+        for cls in (
+            Empty, PropertyX, HasIntMethod, HasManyMethods, PropertyXWithInt,
+            ClassVarX, ClassVarXWithInt, InstanceVarX, ManyInstanceVars,
+            InstanceVarXWithInt, NominalX, NominalSupportsInt, NominalXWithInt
+        )
+    ]
+
+    t0 = time.perf_counter()
+
+    for _ in range(loops):
+        for protocol in protocols:
+            for instance in instances:
+                isinstance(instance, protocol)
+
+    return time.perf_counter() - t0
+
+
+if __name__ == "__main__":
+    runner = pyperf.Runner()
+    runner.metadata["description"] = (
+        "Test the performance of isinstance() checks "
+        "against runtime-checkable protocols"
+    )
+    runner.bench_time_func("typing_runtime_protocols", bench_protocols)