diff --git a/src/runtime/runtime.cs b/src/runtime/runtime.cs
index 55c827b67..7acdc0f7e 100644
--- a/src/runtime/runtime.cs
+++ b/src/runtime/runtime.cs
@@ -846,12 +846,6 @@ internal static IntPtr Py_CompileStringFlags(string str, string file, int start,
         [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
         internal static extern IntPtr PyCFunction_Call(IntPtr func, IntPtr args, IntPtr kw);
 
-        [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
-        internal static extern IntPtr PyInstance_New(IntPtr cls, IntPtr args, IntPtr kw);
-
-        [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
-        internal static extern IntPtr PyInstance_NewRaw(IntPtr cls, IntPtr dict);
-
         [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
         internal static extern IntPtr PyMethod_New(IntPtr func, IntPtr self, IntPtr cls);
 
@@ -1018,9 +1012,6 @@ internal static long PyObject_Size(IntPtr pointer)
         // Python buffer API
         //====================================================================
 
-        [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
-        internal static extern int PyObject_CheckBuffer(IntPtr obj);
-
         [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
         internal static extern int PyObject_GetBuffer(IntPtr exporter, ref Py_buffer view, int flags);
 
@@ -1793,9 +1784,6 @@ internal static IntPtr PyType_GenericAlloc(IntPtr type, long n)
         [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
         internal static extern IntPtr _PyObject_GetDictPtr(IntPtr obj);
 
-        [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
-        internal static extern IntPtr PyObject_GC_New(IntPtr tp);
-
         [DllImport(_PythonDll, CallingConvention = CallingConvention.Cdecl)]
         internal static extern void PyObject_GC_Del(IntPtr tp);