diff --git a/.ci/docker/requirements-ci.txt b/.ci/docker/requirements-ci.txt
index d4bdd9b2a9cb..aeb2807c74e5 100644
--- a/.ci/docker/requirements-ci.txt
+++ b/.ci/docker/requirements-ci.txt
@@ -363,10 +363,11 @@ pwlf==2.2.1
 #Pinned versions: 2.2.1
 #test that import: test_sac_estimator.py
 
-# To build PyTorch itself
+# To build PyTorch itself (see also pyproject.toml)
+packaging>=24.2
 pyyaml
 pyzstd
-setuptools>=70.1.0
+setuptools>=77.0.0
 six
 
 scons==4.5.2 ; platform_machine == "aarch64"
diff --git a/.ci/pytorch/build.sh b/.ci/pytorch/build.sh
index 65f97389324a..8099eeeb902c 100755
--- a/.ci/pytorch/build.sh
+++ b/.ci/pytorch/build.sh
@@ -243,6 +243,10 @@ if [[ "$BUILD_ENVIRONMENT" == *-bazel-* ]]; then
     tools/bazel build --config=no-tty "${BAZEL_MEM_LIMIT}" "${BAZEL_CPU_LIMIT}" //...
   fi
 else
+  # Install build-system requirements before running setup.py commands
+  # We need manage the build environment manually because we are not using build isolation
+  python -m pip install -r requirements-build.txt
+
   # check that setup.py would fail with bad arguments
   echo "The next three invocations are expected to fail with invalid command error messages."
   ( ! get_exit_code python setup.py bad_argument )
diff --git a/.ci/pytorch/macos-build.sh b/.ci/pytorch/macos-build.sh
index d7447e7d4858..f8d8a6f23b80 100755
--- a/.ci/pytorch/macos-build.sh
+++ b/.ci/pytorch/macos-build.sh
@@ -33,6 +33,10 @@ if which sccache > /dev/null; then
   export PATH="${tmp_dir}:$PATH"
 fi
 
+# Install build-system requirements before running setup.py commands
+# We need manage the build environment manually because we are not using build isolation
+python -m pip install -r requirements-build.txt
+
 print_cmake_info
 if [[ ${BUILD_ENVIRONMENT} == *"distributed"* ]]; then
   # Needed for inductor benchmarks, as lots of HF networks make `torch.distribtued` calls
diff --git a/.ci/pytorch/macos-test.sh b/.ci/pytorch/macos-test.sh
index c9d926a5df37..dcd557a70616 100755
--- a/.ci/pytorch/macos-test.sh
+++ b/.ci/pytorch/macos-test.sh
@@ -16,17 +16,31 @@ popd
 # enable debug asserts in serialization
 export TORCH_SERIALIZATION_DEBUG=1
 
+export __TEST_PYTHON_HAS_SETUP=''
+
 setup_test_python() {
+  if [[ -n "${__TEST_PYTHON_HAS_SETUP}" ]]; then
+    return
+  fi
+
   # The CircleCI worker hostname doesn't resolve to an address.
   # This environment variable makes ProcessGroupGloo default to
   # using the address associated with the loopback interface.
   export GLOO_SOCKET_IFNAME=lo0
-  echo "Ninja version: $(ninja --version)"
   echo "Python version: $(which python) ($(python --version))"
+  python -m pip install -qr requirements-build.txt
+
+  echo "CMake version: $(cmake --version)"
+  echo "Ninja version: $(ninja --version)"
+
+  echo "Python packages:"
+  python -m pip freeze
 
   # Set the limit on open file handles to 16384
   # might help with intermittent compiler test failures
   ulimit -n 16384
+
+  export __TEST_PYTHON_HAS_SETUP=1
 }
 
 test_python_all() {
@@ -184,6 +198,8 @@ checkout_install_torchbench() {
 }
 
 torchbench_setup_macos() {
+  setup_test_python
+
   git clone --recursive https://github.com/pytorch/vision torchvision
   git clone --recursive https://github.com/pytorch/audio torchaudio
   brew install jpeg-turbo libpng
diff --git a/.ci/pytorch/win-test-helpers/build_pytorch.bat b/.ci/pytorch/win-test-helpers/build_pytorch.bat
index 7ceb425ce2d1..2e0c798d042a 100644
--- a/.ci/pytorch/win-test-helpers/build_pytorch.bat
+++ b/.ci/pytorch/win-test-helpers/build_pytorch.bat
@@ -126,6 +126,12 @@ if "%USE_CUDA%"=="1" (
   set CMAKE_CUDA_COMPILER_LAUNCHER=%TMP_DIR%/bin/randomtemp.exe;%TMP_DIR%\bin\sccache.exe
 )
 
+:: Install build-system requirements before running setup.py commands
+:: We need manage the build environment manually because we are not using build isolation
+python -m pip install -r requirements-build.txt
+if errorlevel 1 goto fail
+if not errorlevel 0 goto fail
+
 :: Print all existing environment variable for debugging
 set
 
diff --git a/.ci/pytorch/windows/setup_build.bat b/.ci/pytorch/windows/setup_build.bat
index 9b492eef664d..bdab16f0e594 100644
--- a/.ci/pytorch/windows/setup_build.bat
+++ b/.ci/pytorch/windows/setup_build.bat
@@ -7,6 +7,7 @@ call "internal\install_python.bat"
 
 %PYTHON_EXEC% --version
 set "PATH=%CD%\Python\Lib\site-packages\cmake\data\bin;%CD%\Python\Scripts;%CD%\Python;%PATH%"
+
 if "%DESIRED_PYTHON%" == "3.13t" %PYTHON_EXEC% -m pip install numpy==2.2.1 cmake
 if "%DESIRED_PYTHON%" == "3.13" %PYTHON_EXEC% -m pip install numpy==2.1.2 cmake
 if "%DESIRED_PYTHON%" == "3.12" %PYTHON_EXEC% -m pip install numpy==2.0.2 cmake
@@ -16,7 +17,7 @@ if "%DESIRED_PYTHON%" == "3.9" %PYTHON_EXEC% -m pip install numpy==2.0.2 cmake
 
 %PYTHON_EXEC% -m pip install pyyaml
 %PYTHON_EXEC% -m pip install mkl-include mkl-static
-%PYTHON_EXEC% -m pip install boto3 ninja typing_extensions setuptools==72.1.0
+%PYTHON_EXEC% -m pip install boto3 ninja typing-extensions setuptools packaging
 
 where cmake.exe
 
diff --git a/.ci/wheel/build_wheel.sh b/.ci/wheel/build_wheel.sh
index b90e6f38e911..40b74d3e92b1 100755
--- a/.ci/wheel/build_wheel.sh
+++ b/.ci/wheel/build_wheel.sh
@@ -127,7 +127,7 @@ export INSTALL_TEST=0 # dont install test binaries into site-packages
 export MACOSX_DEPLOYMENT_TARGET=10.15
 export CMAKE_PREFIX_PATH=${CONDA_PREFIX:-"$(dirname $(which conda))/../"}
 
-SETUPTOOLS_PINNED_VERSION="==70.1.0"
+SETUPTOOLS_PINNED_VERSION="==77.0.0"
 PYYAML_PINNED_VERSION="=5.3"
 EXTRA_CONDA_INSTALL_FLAGS=""
 CONDA_ENV_CREATE_FLAGS=""
@@ -135,7 +135,7 @@ RENAME_WHEEL=true
 case $desired_python in
     3.13t)
         echo "Using 3.13 deps"
-        SETUPTOOLS_PINNED_VERSION=">=70.1.0"
+        SETUPTOOLS_PINNED_VERSION=">=77.0.0"
         PYYAML_PINNED_VERSION=">=6.0.1"
         NUMPY_PINNED_VERSION="=2.1.0"
         CONDA_ENV_CREATE_FLAGS="python-freethreading"
@@ -145,31 +145,31 @@ case $desired_python in
         ;;
     3.13)
         echo "Using 3.13 deps"
-        SETUPTOOLS_PINNED_VERSION=">=70.1.0"
+        SETUPTOOLS_PINNED_VERSION=">=77.0.0"
         PYYAML_PINNED_VERSION=">=6.0.1"
         NUMPY_PINNED_VERSION="=2.1.0"
         ;;
     3.12)
         echo "Using 3.12 deps"
-        SETUPTOOLS_PINNED_VERSION=">=70.1.0"
+        SETUPTOOLS_PINNED_VERSION=">=77.0.0"
         PYYAML_PINNED_VERSION=">=6.0.1"
         NUMPY_PINNED_VERSION="=2.0.2"
         ;;
     3.11)
         echo "Using 3.11 deps"
-        SETUPTOOLS_PINNED_VERSION=">=70.1.0"
+        SETUPTOOLS_PINNED_VERSION=">=77.0.0"
         PYYAML_PINNED_VERSION=">=5.3"
         NUMPY_PINNED_VERSION="=2.0.2"
         ;;
     3.10)
         echo "Using 3.10 deps"
-        SETUPTOOLS_PINNED_VERSION=">=70.1.0"
+        SETUPTOOLS_PINNED_VERSION=">=77.0.0"
         PYYAML_PINNED_VERSION=">=5.3"
         NUMPY_PINNED_VERSION="=2.0.2"
         ;;
     3.9)
         echo "Using 3.9 deps"
-        SETUPTOOLS_PINNED_VERSION=">=70.1.0"
+        SETUPTOOLS_PINNED_VERSION=">=77.0.0"
         PYYAML_PINNED_VERSION=">=5.3"
         NUMPY_PINNED_VERSION="=2.0.2"
         ;;
diff --git a/.github/requirements/pip-requirements-macOS.txt b/.github/requirements/pip-requirements-macOS.txt
index 224835188d87..dda7e37a7680 100644
--- a/.github/requirements/pip-requirements-macOS.txt
+++ b/.github/requirements/pip-requirements-macOS.txt
@@ -12,7 +12,7 @@ numba==0.59.0
 numpy==1.26.4
 opt-einsum>=3.3
 optree==0.13.0
-packaging==23.1
+packaging==25.0
 parameterized==0.8.1
 pillow==10.3.0
 protobuf==5.29.4
@@ -26,7 +26,7 @@ pytest-xdist==3.3.1
 pytest==7.3.2
 pyyaml==6.0.2
 scipy==1.12.0
-setuptools==72.1.0
+setuptools==80.9.0
 sympy==1.13.3
 tlparse==0.3.30
 tensorboard==2.13.0
diff --git a/pyproject.toml b/pyproject.toml
index a911a2a723b1..f84a73d1c86a 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -2,13 +2,13 @@
 
 [build-system]
 requires = [
-    # 70.1.0: min version for integrated bdist_wheel command from wheel package
     # 77.0.0: min version for SPDX expression support for project.license
-    "setuptools>=70.1.0,<80.0",
+    "setuptools>=77.0.0,<80.0",
     "cmake>=3.27",
     "ninja",
     "numpy",
-    "packaging",
+    # 24.2: min version required by setuptools for SPDX expression support
+    "packaging>=24.2",
     "pyyaml",
     "requests",
     "six",  # dependency chain: NNPACK -> PeachPy -> six
@@ -21,11 +21,7 @@ name = "torch"
 description = "Tensors and Dynamic neural networks in Python with strong GPU acceleration"
 readme = "README.md"
 requires-python = ">=3.9"
-# TODO: change to `license = "BSD-3-Clause"` and enable PEP 639 after pinning setuptools>=77
-# FIXME: As of 2025.06.20, it is hard to ensure the minimum version of setuptools in our CI environment.
-# TOML-table-based license deprecated in setuptools>=77, and the deprecation warning will be changed
-# to an error on 2026.02.18. See also: https://github.com/pypa/setuptools/issues/4903
-license = { text = "BSD-3-Clause" }
+license = "BSD-3-Clause"
 authors = [{ name = "PyTorch Team", email = "packages@pytorch.org" }]
 keywords = ["pytorch", "machine learning"]
 classifiers = [
diff --git a/requirements-build.txt b/requirements-build.txt
index be19d987f73d..90b79e402404 100644
--- a/requirements-build.txt
+++ b/requirements-build.txt
@@ -1,9 +1,9 @@
-# Build System requirements
-setuptools>=70.1.0,<80.0  # setuptools develop deprecated on 80.0
+# Build System requirements (see also: pyproject.toml)
+setuptools>=77.0.0,<80.0  # setuptools develop deprecated on 80.0
 cmake>=3.27
 ninja
 numpy
-packaging
+packaging>=24.2
 pyyaml
 requests
 six  # dependency chain: NNPACK -> PeachPy -> six