diff --git a/src/Symfony/Component/Mailer/Bridge/Sendgrid/CHANGELOG.md b/src/Symfony/Component/Mailer/Bridge/Sendgrid/CHANGELOG.md
index 67c32a2d7ebd4..4a068489286f3 100644
--- a/src/Symfony/Component/Mailer/Bridge/Sendgrid/CHANGELOG.md
+++ b/src/Symfony/Component/Mailer/Bridge/Sendgrid/CHANGELOG.md
@@ -1,6 +1,11 @@
 CHANGELOG
 =========
 
+7.2
+---
+
+ * Add support for region in DSN
+
 6.4
 ---
 
diff --git a/src/Symfony/Component/Mailer/Bridge/Sendgrid/README.md b/src/Symfony/Component/Mailer/Bridge/Sendgrid/README.md
index a059eb4e90ed5..8f97d4ea08bd5 100644
--- a/src/Symfony/Component/Mailer/Bridge/Sendgrid/README.md
+++ b/src/Symfony/Component/Mailer/Bridge/Sendgrid/README.md
@@ -7,15 +7,15 @@ Configuration example:
 
 ```env
 # SMTP
-MAILER_DSN=sendgrid+smtp://KEY@default
+MAILER_DSN=sendgrid+smtp://KEY@default?region=REGION
 
 # API
-MAILER_DSN=sendgrid+api://KEY@default
+MAILER_DSN=sendgrid+api://KEY@default?region=REGION
 ```
 
 where:
  - `KEY` is your Sendgrid API Key
-
+ - `REGION` is Sendgrid selected region (default to global)
 
 Webhook
 -------
diff --git a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridApiTransportTest.php b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridApiTransportTest.php
index 4196d0897172f..37dd4598cbaeb 100644
--- a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridApiTransportTest.php
+++ b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridApiTransportTest.php
@@ -39,6 +39,10 @@ public static function getTransportData()
                 new SendgridApiTransport('KEY'),
                 'sendgrid+api://api.sendgrid.com',
             ],
+            [
+                new SendgridApiTransport('KEY', null, null, null, 'eu'),
+                'sendgrid+api://api.eu.sendgrid.com',
+            ],
             [
                 (new SendgridApiTransport('KEY'))->setHost('example.com'),
                 'sendgrid+api://example.com',
diff --git a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridTransportFactoryTest.php b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridTransportFactoryTest.php
index 433e905add6c5..b41d23941b380 100644
--- a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridTransportFactoryTest.php
+++ b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Tests/Transport/SendgridTransportFactoryTest.php
@@ -57,16 +57,22 @@ public static function supportsProvider(): iterable
 
     public static function createProvider(): iterable
     {
+        $client = new MockHttpClient();
         $logger = new NullLogger();
 
         yield [
             new Dsn('sendgrid+api', 'default', self::USER),
-            new SendgridApiTransport(self::USER, new MockHttpClient(), null, $logger),
+            new SendgridApiTransport(self::USER, $client, null, $logger),
+        ];
+
+        yield [
+            new Dsn('sendgrid+api', 'default', self::USER, '', null, ['region' => 'eu']),
+            new SendgridApiTransport(self::USER, $client, null, $logger, 'eu'),
         ];
 
         yield [
             new Dsn('sendgrid+api', 'example.com', self::USER, '', 8080),
-            (new SendgridApiTransport(self::USER, new MockHttpClient(), null, $logger))->setHost('example.com')->setPort(8080),
+            (new SendgridApiTransport(self::USER, $client, null, $logger))->setHost('example.com')->setPort(8080),
         ];
 
         yield [
diff --git a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridApiTransport.php b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridApiTransport.php
index 422b942cd217f..5e4214e8c5429 100644
--- a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridApiTransport.php
+++ b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridApiTransport.php
@@ -32,13 +32,14 @@
  */
 class SendgridApiTransport extends AbstractApiTransport
 {
-    private const HOST = 'api.sendgrid.com';
+    private const HOST = 'api.%region_dot%sendgrid.com';
 
     public function __construct(
         #[\SensitiveParameter] private string $key,
         ?HttpClientInterface $client = null,
         ?EventDispatcherInterface $dispatcher = null,
         ?LoggerInterface $logger = null,
+        private ?string $region = null
     ) {
         parent::__construct($client, $dispatcher, $logger);
     }
@@ -190,6 +191,11 @@ private function getAttachments(Email $email): array
 
     private function getEndpoint(): ?string
     {
-        return ($this->host ?: self::HOST).($this->port ? ':'.$this->port : '');
+        $host = $this->host ?: str_replace('%region_dot%', '', self::HOST);
+        if (null !== $this->region && null === $this->host) {
+            $host = str_replace('%region_dot%', $this->region.'.', self::HOST);
+        }
+
+        return $host.($this->port ? ':'.$this->port : '');
     }
 }
diff --git a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridSmtpTransport.php b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridSmtpTransport.php
index 647e202fa0073..d939359ff8bc0 100644
--- a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridSmtpTransport.php
+++ b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridSmtpTransport.php
@@ -20,9 +20,9 @@
  */
 class SendgridSmtpTransport extends EsmtpTransport
 {
-    public function __construct(#[\SensitiveParameter] string $key, ?EventDispatcherInterface $dispatcher = null, ?LoggerInterface $logger = null)
+    public function __construct(#[\SensitiveParameter] string $key, ?EventDispatcherInterface $dispatcher = null, ?LoggerInterface $logger = null, private ?string $region = null)
     {
-        parent::__construct('smtp.sendgrid.net', 465, true, $dispatcher, $logger);
+        parent::__construct('null' !== $region ? \sprintf('smtp.%s.sendgrid.net', $region) : 'smtp.sendgrid.net', 465, true, $dispatcher, $logger);
 
         $this->setUsername('apikey');
         $this->setPassword($key);
diff --git a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridTransportFactory.php b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridTransportFactory.php
index 22f56cbc857c6..1405538ab36ba 100644
--- a/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridTransportFactory.php
+++ b/src/Symfony/Component/Mailer/Bridge/Sendgrid/Transport/SendgridTransportFactory.php
@@ -25,16 +25,17 @@ public function create(Dsn $dsn): TransportInterface
     {
         $scheme = $dsn->getScheme();
         $key = $this->getUser($dsn);
+        $region = $dsn->getOption('region');
 
         if ('sendgrid+api' === $scheme) {
             $host = 'default' === $dsn->getHost() ? null : $dsn->getHost();
             $port = $dsn->getPort();
 
-            return (new SendgridApiTransport($key, $this->client, $this->dispatcher, $this->logger))->setHost($host)->setPort($port);
+            return (new SendgridApiTransport($key, $this->client, $this->dispatcher, $this->logger, $region))->setHost($host)->setPort($port);
         }
 
         if ('sendgrid+smtp' === $scheme || 'sendgrid+smtps' === $scheme || 'sendgrid' === $scheme) {
-            return new SendgridSmtpTransport($key, $this->dispatcher, $this->logger);
+            return new SendgridSmtpTransport($key, $this->dispatcher, $this->logger, $region);
         }
 
         throw new UnsupportedSchemeException($dsn, 'sendgrid', $this->getSupportedSchemes());