In a female patient with unexplained anemia, ascorbic acid ingestion and apparent false-negative ... more In a female patient with unexplained anemia, ascorbic acid ingestion and apparent false-negative occult blood tests were related. When she stopped ascorbic acid, her stools became strongly reactive ("4+") by three tests for occult stool blood; this association was observed repeatedly. A test developed to measure stool occult blood in the presence of ascorbic acid remained reactive throughout this observation, and the observation was confirmed by in-vitro studies. Current tests for occult blood depend on the pseudoperoxidase activity of heme and are inhibited by low levels of ascorbic acid. Reducing substances chemically similar to ascorbic acid also inhibits occult blood tests; oxidized ascorbic acid and sulfhydryl reducing agents do not inhibit them at physiologic levels.
A range of foods and bioavailable supplements are now available that provide better outcomes and ... more A range of foods and bioavailable supplements are now available that provide better outcomes and clinically significant leverage in managing the pathophysiology of cardiovascular disease. Targeted supplementation, in combination with individualized diet therapy, are included as are mental and physical exercises aimed at evoking healing responses in proportion to documented risk reductions.
Fifty percent of the risk for rheumatoid arthritis (RA) is attributable to genetic factors, which... more Fifty percent of the risk for rheumatoid arthritis (RA) is attributable to genetic factors, which frequently also create a susceptibility to one or more other autoimmune (AI) conditions such as AI thyroid conditions, celiac disease, juvenile RA, psoriatic arthritis, systemic lupus, or type 1 diabetes. These conditions are all characterized by excessive immune activity and inflammation. In an integrative approach, clinical strategies include identification of antigen load caused by food and chemical allergens to reduce immune reactivity. In addition, individual requirements for essential nutrients are verified through predictive tests of core functions, and a hypoallergenic whole foods diet is personalized to the patient's needs.
This article (part 3) is an update of functional, predictive, sensitive, and specific lab tests. ... more This article (part 3) is an update of functional, predictive, sensitive, and specific lab tests. Integrative immune system defense and repair assessments and treatment guides are described. In previous articles in this series, we reviewed that when healthy, we are tolerant to and resilient in the world outside us. We are resistant to infection and recycle any foreign antigens to which we are exposed. Our immune defense and repair system has the dual responsibilities of protecting us from the outside world and repairing us from daily wear-and-tear. Capacity of the immune system is finite. Regular and substantial exposure to environmental and food digestive remnant antigens can overload the immune system to an extent that defense becomes the primary role of the immune system and repair gets deferred until the situation improves. Reliable and accurate detection of these antigens is key to understanding the causes of autoimmune, chronic, and degenerative illnesses as well as to assessing the functional status of our health. As Bruce McEwan, a colleague from Rockefeller University, summarizes the dual nature of stress response, "Stress protects under acute conditions, but when activated chronically, it can cause damage and accelerate disease." His text The End of Stress as We Know It is recommended to those who want a deeper understanding of stress responses and adaptation to them. This article extends our series by looking at how what we eat and drink, as well as what we think and do, impact our health. Emphasis is on understanding, assessing, and getting feedback from the immune system. This allows us to know if our immune defense and repair system is getting the essential nutrients and other factors needed to keep an alkaline reserve, protect from oxidative stress, and communicate homeostatic balance in the integrated control system known as the psycho-neuro-immuno-hormonal system. The gut and central nervous systems are regulated through this higher, integrative control system.
The phospholipid composition of platelets from dogs on various experimental diets was determined.... more The phospholipid composition of platelets from dogs on various experimental diets was determined. Thyroidectomized foxhounds were fed a control diet or the control diet supplemented with (1) beef tallow, (2) beef tallow and cholesterol, or (3) beef tallow, cholesterol, and safflower oil for 23 weeks prior to isolation of platelets. Platelets from animals fed the control diet contained 36.7% phosphatidylcholine (PC), 22.8% phosphatidylethanolamine (PE), 18.4% sphingomyelin (Sph), 11.8% phosphatidylserine (PS), 6.3% phosphatidylinositol (PI), and 2.2% lysophosphatidylcholine. The PE was 77.6% in the plasmalogen form. No highly significant changes in the phospholipid class composition resulted from the experimental diets. Cholesterol supplementation of the diets, however, caused consistent alterations in the fatty acid compositions of the platelet phospholipids including increases in the percentages of 18:1 omega 9 (oleic acid), 18:2 omega 6 (linoleic acid), and 20:3 omega 6 (homo-gamma linolenic acid) and a decrease in the percentage of 20:4 omega 6 (arachidonic acid). Addition of safflower oil to the tallow-cholesterol diet partially reversed these effects. These cholesterol-induced alterations in fatty acid composition could be due to exchange with plasma lipids, de novo synthesis, or altered platelet metabolism. The mechanism remains to be determined.
L-tryptophan was linked with an outbreak of eosinophilic myalgia syndrome (EMS) accounting for at... more L-tryptophan was linked with an outbreak of eosinophilic myalgia syndrome (EMS) accounting for at least 1580 clinical cases and 38 deaths [1]. This editorial examines the misguided linkage of L-tryptophan with EMS, presents the facts as they have emerged and recommends steps to avoid future health risks linked to contaminants introduced during manufacture of foods or dietary supplements.
The effect of diets high (15%) in saturated (beef tallow) or polyunsaturated (corn or cottonseed ... more The effect of diets high (15%) in saturated (beef tallow) or polyunsaturated (corn or cottonseed oil) fatty acids on the fatty acid composition of sphingomyelin from canine erythrocytes and platelets and sphingomyelin and neutral glycosphingolipids of swine erythrocytes was determined. Sphingolipids of platelets and erythrocytes from animals fed high levels of corn or cottonseed oil exhibited a dramatic alteration in their fatty acid composition, most notable of which was a 50% reduction in nervonic acid (24∶1ω9) as compared to levels observed in control or tallow fed animals. This decrease was compensated for by a quantitatively similar increase in a C24 dienoic acid. The long chain dienoic acid was isolated by silver nitrate thin layer chromatography and determined by analysis of its oxidation products to be Δ15, 18-tetracosadienoic acid (24∶2ω6). When the animals were fed the diets high in polyunsaturates, the 24∶2ω6 represented 13, 20, and 9% of the sphingomyelin fatty acids from canine erythrocytes, platelets, and swine erythrocytes, respectively, and 5% of the neutral glycosphingolipid fatty acids of swine erythrocytes. In contrast, the 24∶2ω6 represented less than 4% of the total cellular sphingolipid fatty acids in animals fed the control or high beef tallow diets. The 24∶1ω9 in the sphingolipids of the animals fed the polyunsaturated diet was roughly equal to that of 24∶2ω6, whereas in the sphingolipids of animals fed the control or saturated fat (beef tallow) diet, the 24∶1ω9 was twice these values. Since sphingomyelin is a membrane component, the increase in unsaturation (24∶2ω6) in its fatty acid moiety induced by dietary polyunsaturates may affect membrane fluidity and may alter membrane properties.
T his article addresses aspects of the human healing re- sponse in the context of what the eviden... more T his article addresses aspects of the human healing re- sponse in the context of what the evidence supports in the use of functional assays to improve diagnostic precision, patient-specific comprehensive case management, and outcomes monitoring. Essential and innate to human life is our immune system, with a principal action in defense and repair. Both defense in response to foreign invaders and repair in response to daily wear and tear are the immune systems primary and required roles for maintenance of human life. The fundamental approach to first line care articulated herein is based on patient-specific, comprehensive, functional, ex vivo tests and treatment plans. The roles of immune system dysfunction in good health and chronic ill health are explored. Advanced assays that provide comprehensive determination of an individual's delayed type hypersensitivity (DTH)/delayed allergy reactions are used as examples of how to get to the cause of many chronic "treatment-resistant" issues. While largely previously overlooked, functional immune responses provide examples of novel, "leap frog " technologies that improve diagnostic precision, enhance patient sat-isfaction, and lower total cost of care, particularly for high cost, high morbidity and mortality conditions ranging from obesity and diabetes to autism and neural tube defects. Getting to the causes is more likely to be sensitive, specific, predictive, and reliable than the current generation of largely static or physical chemical measurements now routinely performed in medical practices. Healthy resilience and disease resistance are reviewed. The causes of ill health, rather than their symptomatic consequences, are explored. Emphasis is on validated, successful approaches to sustainable remissions. Focus includes health maintenance, enhancement or restoration, based on clinically proven approaches. Clinically validated in randomized controlled trials (RCT), this approach to rehabilitate immune responses and, thereby, restore healthy tolerance and achieve sustainable remissions based on correctly cumulative repair deficits in chronic illnesses are described herein. Let us start with an understanding of the nature of health. When healthy, we are tolerant to the world around us. [4] This means we digest our food fully to molecular building blocks, enzyme activating vitamins, and minerals as well as efficiently assimilated and utilized energy sources. 5,6 A healthy "transit time" from food consumption through digestion, assimilation, and waste elimination is an efficient 12-to 18-hour interval. We can thus use transit time measurements as an overall, noninvasive, cost-effective, clinical assessment of digestive health. When healthy, any foreign immunoreactants (foreign antigen invaders) that gain entry are promptly identified, engulfed, and recycled by our ample supply of dendritic (phagocytic) surveillance cells. [4] The types of foreign antigens that the immune system is responsible for neutralizing (when we are healthy) or defending against (when our immune defenses are burdened) include: 1. Infectious agents (from prions and viruses to mycoplasma and nanobacter bacteria) 2. Inhaled pollen or aeroallergens (either in lungs or swallowed and in the gut) Russell Jaffe is Senior Fellow of the Health Studies Collegium research foundation. He is developer of various functional methods from occult blood detection in early colon cancer screening to platelet dose-response aggregation studies in coagulation to the LRA by ELISA/ACT tests and plans, the D-penicillamine nutritional and toxic mineral assessment protocol, the ascorbate calibration protocol, magnesium uptake protocol, glutamine recycling protocol, among others. He serves as director of ELISA/ACT Biotechnologies, LLC, and PERQUE, LLC, nutritive supplements. He is recipient of the International Scientist of the Year 2003 awarded by the International Biographical Commission of Cambridge, England to recognize his lifetime contributions to Biochemistry, Clinical Medicine, and Immunomics. He was recently elected as a Fellow of the National Academy of Clinical Biochemistry. He also maintains Fellow status in the
Immune tolerance or learned reactivity to the non-self ‘external’ world is largely epigenetic; ac... more Immune tolerance or learned reactivity to the non-self ‘external’ world is largely epigenetic; acquired immune-memory carried by a group of specialized white blood cells known as lymphocytes. Activ...
The clinical perception of diabetes has expanded far beyond simply blood sugar issues. Given the ... more The clinical perception of diabetes has expanded far beyond simply blood sugar issues. Given the full physiologic impact of these conditions, it is important to assess a number of other metabolic markers – to determine the full extent of disturbed insulin and glucose metabolism. Associated secondary pathologies include impaired energy metabolism, immune dysregulation, leaky gut syndrome, maldigestion, and related biochemical effects. These issues are so widespread that they merit our full clinical attention.
Studies now link metabolic acidosis as an underlying cause in such diverse conditions as insulin ... more Studies now link metabolic acidosis as an underlying cause in such diverse conditions as insulin resistance, syndrome X, cardiometabolic risk, coronary artery disease, osteoporosis, and cancer. An alkaline contributing, whole foods diet is provided in tandem with management of glycemic load and immunocompatible food choices. Delayed food and chemical allergies can be identified through functional lymphocyte response assays. Antigen levels can be reduced through substitution for reactive foods and environmental stimulants, a nutrient-rich diet, and mental and physical exercises as appropriate to each case. This approach both reduces metabolic stress from dietary habits and supports innate regulatory systems in recovery.
This article describes the history of an outbreak of eosinophilia myalgia syndrome (EMS) in 1989,... more This article describes the history of an outbreak of eosinophilia myalgia syndrome (EMS) in 1989, which was rapidly linked by researchers to the amino acid L-tryptophan (tryptophan), which is widely taken as a supplement. An alternative hypothesis was proposed for the cause of EMS, based on the safety associated with the use of tryptophan over decades and the possibility of contamination of the tryptophan during manufacture. The process by which this hypothesis has been substantiated and the contaminant identified is described here.
Objective: Write an equation that discretely models human immune system function (from tolerance ... more Objective: Write an equation that discretely models human immune system function (from tolerance to sensitivity and hypersensitivity including all independent variables and cofactors of the triune neuroimmunoendocrine control system. Methods: Use meta analysis, statistical and mathematical modeling techniques to translate functions into equational elements that are mutually discrete and functionally measurable within defined variances. Molecular biology and immunopathology observations and data sets are fit into discrete elements of an equation that accurately models human immune defense and repair functionalities. Results: Modeling thus far has yielded the following insights: a. In health Qfi + sIgA, is sufficient to neutralize foreign invader activity. All other terms of the equation can be ignored; this is the state of homeostasis; of tolerance. b. In states of acute sensitivity, &-mediated activity is primary. an and sIgA, are essentially overwhelmed and all other terms can be ignored in uncomplicated acute allergic conditions. c. In states of chronis sensitivity, Ig,, I&, and CMI, are important to the contribution of each element specific for the autoimmune condition associated. Indeed @, and sIgA, may be functionally exhausted. This repair deficit/reactive state in the HIS is the domain of DTH,. Hashimoto's thyroiditis; Graves' disease; autoimmune diabetes; hypersensitivity orchitis; Sjiigrens rhinitis sicca syndromes; systemic lupus erythematosus (SLE) are among the AI conditions of the endocrine/hormonal system. Each differentiated organ system has its own AI syndromes. The model predicts three discrete states of HIS functionality which operate as tolerance, acute sensitivity and chronis sensitivity. Each state is autonomous rather than a continuous territory. Further studies are needed to determine the usefulness and implications of the model in predicting patient outcomes. For practice guidelines and cost-based comprehensive care, for informatics and molecular immunology, and for policy and regulator use, such modeling techniques advance our deep understanding of the mathematical elegance and power of true outcome-based emulations.
In a female patient with unexplained anemia, ascorbic acid ingestion and apparent false-negative ... more In a female patient with unexplained anemia, ascorbic acid ingestion and apparent false-negative occult blood tests were related. When she stopped ascorbic acid, her stools became strongly reactive ("4+") by three tests for occult stool blood; this association was observed repeatedly. A test developed to measure stool occult blood in the presence of ascorbic acid remained reactive throughout this observation, and the observation was confirmed by in-vitro studies. Current tests for occult blood depend on the pseudoperoxidase activity of heme and are inhibited by low levels of ascorbic acid. Reducing substances chemically similar to ascorbic acid also inhibits occult blood tests; oxidized ascorbic acid and sulfhydryl reducing agents do not inhibit them at physiologic levels.
A range of foods and bioavailable supplements are now available that provide better outcomes and ... more A range of foods and bioavailable supplements are now available that provide better outcomes and clinically significant leverage in managing the pathophysiology of cardiovascular disease. Targeted supplementation, in combination with individualized diet therapy, are included as are mental and physical exercises aimed at evoking healing responses in proportion to documented risk reductions.
Fifty percent of the risk for rheumatoid arthritis (RA) is attributable to genetic factors, which... more Fifty percent of the risk for rheumatoid arthritis (RA) is attributable to genetic factors, which frequently also create a susceptibility to one or more other autoimmune (AI) conditions such as AI thyroid conditions, celiac disease, juvenile RA, psoriatic arthritis, systemic lupus, or type 1 diabetes. These conditions are all characterized by excessive immune activity and inflammation. In an integrative approach, clinical strategies include identification of antigen load caused by food and chemical allergens to reduce immune reactivity. In addition, individual requirements for essential nutrients are verified through predictive tests of core functions, and a hypoallergenic whole foods diet is personalized to the patient's needs.
This article (part 3) is an update of functional, predictive, sensitive, and specific lab tests. ... more This article (part 3) is an update of functional, predictive, sensitive, and specific lab tests. Integrative immune system defense and repair assessments and treatment guides are described. In previous articles in this series, we reviewed that when healthy, we are tolerant to and resilient in the world outside us. We are resistant to infection and recycle any foreign antigens to which we are exposed. Our immune defense and repair system has the dual responsibilities of protecting us from the outside world and repairing us from daily wear-and-tear. Capacity of the immune system is finite. Regular and substantial exposure to environmental and food digestive remnant antigens can overload the immune system to an extent that defense becomes the primary role of the immune system and repair gets deferred until the situation improves. Reliable and accurate detection of these antigens is key to understanding the causes of autoimmune, chronic, and degenerative illnesses as well as to assessing the functional status of our health. As Bruce McEwan, a colleague from Rockefeller University, summarizes the dual nature of stress response, "Stress protects under acute conditions, but when activated chronically, it can cause damage and accelerate disease." His text The End of Stress as We Know It is recommended to those who want a deeper understanding of stress responses and adaptation to them. This article extends our series by looking at how what we eat and drink, as well as what we think and do, impact our health. Emphasis is on understanding, assessing, and getting feedback from the immune system. This allows us to know if our immune defense and repair system is getting the essential nutrients and other factors needed to keep an alkaline reserve, protect from oxidative stress, and communicate homeostatic balance in the integrated control system known as the psycho-neuro-immuno-hormonal system. The gut and central nervous systems are regulated through this higher, integrative control system.
The phospholipid composition of platelets from dogs on various experimental diets was determined.... more The phospholipid composition of platelets from dogs on various experimental diets was determined. Thyroidectomized foxhounds were fed a control diet or the control diet supplemented with (1) beef tallow, (2) beef tallow and cholesterol, or (3) beef tallow, cholesterol, and safflower oil for 23 weeks prior to isolation of platelets. Platelets from animals fed the control diet contained 36.7% phosphatidylcholine (PC), 22.8% phosphatidylethanolamine (PE), 18.4% sphingomyelin (Sph), 11.8% phosphatidylserine (PS), 6.3% phosphatidylinositol (PI), and 2.2% lysophosphatidylcholine. The PE was 77.6% in the plasmalogen form. No highly significant changes in the phospholipid class composition resulted from the experimental diets. Cholesterol supplementation of the diets, however, caused consistent alterations in the fatty acid compositions of the platelet phospholipids including increases in the percentages of 18:1 omega 9 (oleic acid), 18:2 omega 6 (linoleic acid), and 20:3 omega 6 (homo-gamma linolenic acid) and a decrease in the percentage of 20:4 omega 6 (arachidonic acid). Addition of safflower oil to the tallow-cholesterol diet partially reversed these effects. These cholesterol-induced alterations in fatty acid composition could be due to exchange with plasma lipids, de novo synthesis, or altered platelet metabolism. The mechanism remains to be determined.
L-tryptophan was linked with an outbreak of eosinophilic myalgia syndrome (EMS) accounting for at... more L-tryptophan was linked with an outbreak of eosinophilic myalgia syndrome (EMS) accounting for at least 1580 clinical cases and 38 deaths [1]. This editorial examines the misguided linkage of L-tryptophan with EMS, presents the facts as they have emerged and recommends steps to avoid future health risks linked to contaminants introduced during manufacture of foods or dietary supplements.
The effect of diets high (15%) in saturated (beef tallow) or polyunsaturated (corn or cottonseed ... more The effect of diets high (15%) in saturated (beef tallow) or polyunsaturated (corn or cottonseed oil) fatty acids on the fatty acid composition of sphingomyelin from canine erythrocytes and platelets and sphingomyelin and neutral glycosphingolipids of swine erythrocytes was determined. Sphingolipids of platelets and erythrocytes from animals fed high levels of corn or cottonseed oil exhibited a dramatic alteration in their fatty acid composition, most notable of which was a 50% reduction in nervonic acid (24∶1ω9) as compared to levels observed in control or tallow fed animals. This decrease was compensated for by a quantitatively similar increase in a C24 dienoic acid. The long chain dienoic acid was isolated by silver nitrate thin layer chromatography and determined by analysis of its oxidation products to be Δ15, 18-tetracosadienoic acid (24∶2ω6). When the animals were fed the diets high in polyunsaturates, the 24∶2ω6 represented 13, 20, and 9% of the sphingomyelin fatty acids from canine erythrocytes, platelets, and swine erythrocytes, respectively, and 5% of the neutral glycosphingolipid fatty acids of swine erythrocytes. In contrast, the 24∶2ω6 represented less than 4% of the total cellular sphingolipid fatty acids in animals fed the control or high beef tallow diets. The 24∶1ω9 in the sphingolipids of the animals fed the polyunsaturated diet was roughly equal to that of 24∶2ω6, whereas in the sphingolipids of animals fed the control or saturated fat (beef tallow) diet, the 24∶1ω9 was twice these values. Since sphingomyelin is a membrane component, the increase in unsaturation (24∶2ω6) in its fatty acid moiety induced by dietary polyunsaturates may affect membrane fluidity and may alter membrane properties.
T his article addresses aspects of the human healing re- sponse in the context of what the eviden... more T his article addresses aspects of the human healing re- sponse in the context of what the evidence supports in the use of functional assays to improve diagnostic precision, patient-specific comprehensive case management, and outcomes monitoring. Essential and innate to human life is our immune system, with a principal action in defense and repair. Both defense in response to foreign invaders and repair in response to daily wear and tear are the immune systems primary and required roles for maintenance of human life. The fundamental approach to first line care articulated herein is based on patient-specific, comprehensive, functional, ex vivo tests and treatment plans. The roles of immune system dysfunction in good health and chronic ill health are explored. Advanced assays that provide comprehensive determination of an individual's delayed type hypersensitivity (DTH)/delayed allergy reactions are used as examples of how to get to the cause of many chronic "treatment-resistant" issues. While largely previously overlooked, functional immune responses provide examples of novel, "leap frog " technologies that improve diagnostic precision, enhance patient sat-isfaction, and lower total cost of care, particularly for high cost, high morbidity and mortality conditions ranging from obesity and diabetes to autism and neural tube defects. Getting to the causes is more likely to be sensitive, specific, predictive, and reliable than the current generation of largely static or physical chemical measurements now routinely performed in medical practices. Healthy resilience and disease resistance are reviewed. The causes of ill health, rather than their symptomatic consequences, are explored. Emphasis is on validated, successful approaches to sustainable remissions. Focus includes health maintenance, enhancement or restoration, based on clinically proven approaches. Clinically validated in randomized controlled trials (RCT), this approach to rehabilitate immune responses and, thereby, restore healthy tolerance and achieve sustainable remissions based on correctly cumulative repair deficits in chronic illnesses are described herein. Let us start with an understanding of the nature of health. When healthy, we are tolerant to the world around us. [4] This means we digest our food fully to molecular building blocks, enzyme activating vitamins, and minerals as well as efficiently assimilated and utilized energy sources. 5,6 A healthy "transit time" from food consumption through digestion, assimilation, and waste elimination is an efficient 12-to 18-hour interval. We can thus use transit time measurements as an overall, noninvasive, cost-effective, clinical assessment of digestive health. When healthy, any foreign immunoreactants (foreign antigen invaders) that gain entry are promptly identified, engulfed, and recycled by our ample supply of dendritic (phagocytic) surveillance cells. [4] The types of foreign antigens that the immune system is responsible for neutralizing (when we are healthy) or defending against (when our immune defenses are burdened) include: 1. Infectious agents (from prions and viruses to mycoplasma and nanobacter bacteria) 2. Inhaled pollen or aeroallergens (either in lungs or swallowed and in the gut) Russell Jaffe is Senior Fellow of the Health Studies Collegium research foundation. He is developer of various functional methods from occult blood detection in early colon cancer screening to platelet dose-response aggregation studies in coagulation to the LRA by ELISA/ACT tests and plans, the D-penicillamine nutritional and toxic mineral assessment protocol, the ascorbate calibration protocol, magnesium uptake protocol, glutamine recycling protocol, among others. He serves as director of ELISA/ACT Biotechnologies, LLC, and PERQUE, LLC, nutritive supplements. He is recipient of the International Scientist of the Year 2003 awarded by the International Biographical Commission of Cambridge, England to recognize his lifetime contributions to Biochemistry, Clinical Medicine, and Immunomics. He was recently elected as a Fellow of the National Academy of Clinical Biochemistry. He also maintains Fellow status in the
Immune tolerance or learned reactivity to the non-self ‘external’ world is largely epigenetic; ac... more Immune tolerance or learned reactivity to the non-self ‘external’ world is largely epigenetic; acquired immune-memory carried by a group of specialized white blood cells known as lymphocytes. Activ...
The clinical perception of diabetes has expanded far beyond simply blood sugar issues. Given the ... more The clinical perception of diabetes has expanded far beyond simply blood sugar issues. Given the full physiologic impact of these conditions, it is important to assess a number of other metabolic markers – to determine the full extent of disturbed insulin and glucose metabolism. Associated secondary pathologies include impaired energy metabolism, immune dysregulation, leaky gut syndrome, maldigestion, and related biochemical effects. These issues are so widespread that they merit our full clinical attention.
Studies now link metabolic acidosis as an underlying cause in such diverse conditions as insulin ... more Studies now link metabolic acidosis as an underlying cause in such diverse conditions as insulin resistance, syndrome X, cardiometabolic risk, coronary artery disease, osteoporosis, and cancer. An alkaline contributing, whole foods diet is provided in tandem with management of glycemic load and immunocompatible food choices. Delayed food and chemical allergies can be identified through functional lymphocyte response assays. Antigen levels can be reduced through substitution for reactive foods and environmental stimulants, a nutrient-rich diet, and mental and physical exercises as appropriate to each case. This approach both reduces metabolic stress from dietary habits and supports innate regulatory systems in recovery.
This article describes the history of an outbreak of eosinophilia myalgia syndrome (EMS) in 1989,... more This article describes the history of an outbreak of eosinophilia myalgia syndrome (EMS) in 1989, which was rapidly linked by researchers to the amino acid L-tryptophan (tryptophan), which is widely taken as a supplement. An alternative hypothesis was proposed for the cause of EMS, based on the safety associated with the use of tryptophan over decades and the possibility of contamination of the tryptophan during manufacture. The process by which this hypothesis has been substantiated and the contaminant identified is described here.
Objective: Write an equation that discretely models human immune system function (from tolerance ... more Objective: Write an equation that discretely models human immune system function (from tolerance to sensitivity and hypersensitivity including all independent variables and cofactors of the triune neuroimmunoendocrine control system. Methods: Use meta analysis, statistical and mathematical modeling techniques to translate functions into equational elements that are mutually discrete and functionally measurable within defined variances. Molecular biology and immunopathology observations and data sets are fit into discrete elements of an equation that accurately models human immune defense and repair functionalities. Results: Modeling thus far has yielded the following insights: a. In health Qfi + sIgA, is sufficient to neutralize foreign invader activity. All other terms of the equation can be ignored; this is the state of homeostasis; of tolerance. b. In states of acute sensitivity, &-mediated activity is primary. an and sIgA, are essentially overwhelmed and all other terms can be ignored in uncomplicated acute allergic conditions. c. In states of chronis sensitivity, Ig,, I&, and CMI, are important to the contribution of each element specific for the autoimmune condition associated. Indeed @, and sIgA, may be functionally exhausted. This repair deficit/reactive state in the HIS is the domain of DTH,. Hashimoto's thyroiditis; Graves' disease; autoimmune diabetes; hypersensitivity orchitis; Sjiigrens rhinitis sicca syndromes; systemic lupus erythematosus (SLE) are among the AI conditions of the endocrine/hormonal system. Each differentiated organ system has its own AI syndromes. The model predicts three discrete states of HIS functionality which operate as tolerance, acute sensitivity and chronis sensitivity. Each state is autonomous rather than a continuous territory. Further studies are needed to determine the usefulness and implications of the model in predicting patient outcomes. For practice guidelines and cost-based comprehensive care, for informatics and molecular immunology, and for policy and regulator use, such modeling techniques advance our deep understanding of the mathematical elegance and power of true outcome-based emulations.
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