Papers by Samineh Barmaki
Journal of Material Sciences & Engineering, Jan 3, 2015
Small joints of wrist can be affected by hand arthritis leading to pain and deformity of the join... more Small joints of wrist can be affected by hand arthritis leading to pain and deformity of the joints. Prosthetic development must take in to consideration range of motion, stability, ease of implantation and soft tissue reconstruction. This research is focused on the arthritis of the basal joint of the thumb which most often affects middle-aged women. Several surgical techniques have been described for management of degenerative basal joint changes. These include excision of the trapezium alone, ligament reconstruction with or without tendon interposition (LRTI) and trapezium resection, arthrodesis and multiple arthroplasty options using biologic and synthetic implants, including silastic prostheses, metal prostheses and allograft interpositions. Researchers found out, successful and durable results with ligament reconstruction with or without tendon interposition. However pinch strength was not satisfactory due to shortening of the thumb by trapeziectomy. Joint arthroplasty can aid maintenance of the length of the thumb and provide greater pinch strength. Several studies about silicone implants reported implant wear, synovitis and osteolysis. Metallic implants resulted in implant loosening and instability. Researchers found out a porous poly-L/D-lactide copolymer implant with an L: D monomer ratio of 96:4 (P (L/D) LA 96/4) resulted significant strength and can be replaced with fibrous tissue in 2-3 years. Silicone implant is better at palmar stability compared to PLDLA (poly-L/D-lactide copolymer) implant, whereas lack of silicone synovitis and osteolysis are the advantages of the PLDLA implant. For achieving definite results, longer follow-ups are needed for synthetic allograft and PLDLA implants.
Powered by TCPDF (www.tcpdf.org) This material is protected by copyright and other intellectual p... more Powered by TCPDF (www.tcpdf.org) This material is protected by copyright and other intellectual property rights, and duplication or sale of all or part of any of the repository collections is not permitted, except that material may be duplicated by you for your research use or educational purposes in electronic or print form. You must obtain permission for any other use. Electronic or print copies may not be offered, whether for sale or otherwise to anyone who is not an authorised user. Barmaki, Samineh; Jokinen, Ville; Obermaier, Daniela; Blokhina, Daria; Korhonen, Matti; Ras, Robin H.A.; Vuola, Jyrki; Franssila, Sami; Kankuri, Esko A microfluidic oxygen sink to create a targeted cellular hypoxic microenvironment under ambient atmospheric conditions
Biomaterials and Biosystems
Micromachines
A hypoxic (low oxygen level) microenvironment and nitric oxide paracrine signaling play important... more A hypoxic (low oxygen level) microenvironment and nitric oxide paracrine signaling play important roles in the control of both biological and pathological cell responses. In this study, we present a microfluidic chip architecture for nitric oxide delivery under a hypoxic microenvironment in human embryonic kidney cells (HEK-293). The chip utilizes two separate, but interdigitated microfluidic channels. The hypoxic microenvironment was created by sodium sulfite as the oxygen scavenger in one of the channels. The nitric oxide microenvironment was created by sodium nitroprusside as the light-activated nitric oxide donor in the other channel. The solutions are separated from the cell culture by a 30 µm thick gas-permeable, but liquid-impermeable polydimethylsiloxane membrane. We show that the architecture is preliminarily feasible to define the gaseous microenvironment of a cell culture in the 100 µm and 1 mm length scales.
Acta Biomaterialia
Physiological oxygen levels within the tissue microenvironment are usually lower than 14%, in ste... more Physiological oxygen levels within the tissue microenvironment are usually lower than 14%, in stem cell niches these levels can be as low as 0-1%. In cell cultures, such low oxygen levels are usually mimicked by altering the global culture environment either by O 2 removal (vacuum or oxygen absorption) or by N 2 supplementation for O 2 replacement. To generate a targeted cellular hypoxic microenvironment under ambient atmospheric conditions, we characterised the ability of the dissolved oxygen-depleting sodium sulfite to generate an in-liquid oxygen sink. We utilised a microfluidic design to place the cultured cells in the vertical oxygen gradient and to physically separate the cells from the liquid.
Acta Biomaterialia
Physiological oxygen levels within the tissue microenvironment are usually lower than 14%, in ste... more Physiological oxygen levels within the tissue microenvironment are usually lower than 14%, in stem cell niches these levels can be as low as 0-1%. In cell cultures, such low oxygen levels are usually mimicked by altering the global culture environment either by O 2 removal (vacuum or oxygen absorption) or by N 2 supplementation for O 2 replacement. To generate a targeted cellular hypoxic microenvironment under ambient atmospheric conditions, we characterised the ability of the dissolved oxygen-depleting sodium sulfite to generate an in-liquid oxygen sink. We utilised a microfluidic design to place the cultured cells in the vertical oxygen gradient and to physically separate the cells from the liquid.
The wrist joints are often involved early in rheumatoid arthritis (RA). Small joints of wrist can... more The wrist joints are often involved early in rheumatoid arthritis (RA). Small joints of wrist can be affected by hand arthritis leading to pain and deformity of the joints. Prosthetic development must take in to consideration range of motion, stability, fixation, ease of implantation, biocompatibility and soft tissue resconstruction. The metacarpophalangeal, interphalangeal and trapeziometacarpal joints each present different problems in the design of prostheses.This thesis focused on the arthritis of the basal joint of the thumb which most often affects middle-aged women. Basal joint is formed by carpometacarpal (CMC) joint and trapezium bone. Several surgical techniques have been described for management of degenarative basal joint changes. These include excision of the trapezium alone, ligament reconstruction with or with out tendon interposition (LRTI) and trapezium resection, arthrodesis and multiple arthroplasty options using biologic and synthetic implants, including silastic prostheses, metal prostheses and allograft interpositions.
Conference Presentations by Samineh Barmaki
A biomaterial can be defined as a material intended to interface with biological systems to
eval... more A biomaterial can be defined as a material intended to interface with biological systems to
evaluate, treat, augment or replace any tissue, organ or function of the body. Many different
biomaterials are used clinically as implants or devices for diagnosis or therapy. Biomaterials for
cardiovascular applications are usually prepared using polymers because these are available in a
wide variety of compositions with adequate physical and mechanical properties and can be easy
manufactured into products with the desired shape. Polyether urethane urea and Polysulfones are
the most common polymers which are used for artificial heart components and heart valve. A
blood-contacting diaphragm within the pump is made from a special type of polyurethane that is
also textured to provide blood cell adherence. Two tubular grafts are made from polyester (which
are used to attach the device to the aorta) and the valves are actual heart valves removed from a
pig. Other parts that make up the motor are made from titanium or other metals and ceramics.
A titanium-aluminum-vanadium alloy is used for the pump because it is biocompatible and has
suitable structural properties. In Japan, researchers are developing total artificial hearts based on
a silicone ball valve system and a centrifugal pump with a bearing system made from alumina
ceramic and polyethylene components. Recent studies reveal the progress in investigation of
novel techniques of biomaterials of the artificial heart in terms of longer follow-ups.
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Papers by Samineh Barmaki
Conference Presentations by Samineh Barmaki
evaluate, treat, augment or replace any tissue, organ or function of the body. Many different
biomaterials are used clinically as implants or devices for diagnosis or therapy. Biomaterials for
cardiovascular applications are usually prepared using polymers because these are available in a
wide variety of compositions with adequate physical and mechanical properties and can be easy
manufactured into products with the desired shape. Polyether urethane urea and Polysulfones are
the most common polymers which are used for artificial heart components and heart valve. A
blood-contacting diaphragm within the pump is made from a special type of polyurethane that is
also textured to provide blood cell adherence. Two tubular grafts are made from polyester (which
are used to attach the device to the aorta) and the valves are actual heart valves removed from a
pig. Other parts that make up the motor are made from titanium or other metals and ceramics.
A titanium-aluminum-vanadium alloy is used for the pump because it is biocompatible and has
suitable structural properties. In Japan, researchers are developing total artificial hearts based on
a silicone ball valve system and a centrifugal pump with a bearing system made from alumina
ceramic and polyethylene components. Recent studies reveal the progress in investigation of
novel techniques of biomaterials of the artificial heart in terms of longer follow-ups.
evaluate, treat, augment or replace any tissue, organ or function of the body. Many different
biomaterials are used clinically as implants or devices for diagnosis or therapy. Biomaterials for
cardiovascular applications are usually prepared using polymers because these are available in a
wide variety of compositions with adequate physical and mechanical properties and can be easy
manufactured into products with the desired shape. Polyether urethane urea and Polysulfones are
the most common polymers which are used for artificial heart components and heart valve. A
blood-contacting diaphragm within the pump is made from a special type of polyurethane that is
also textured to provide blood cell adherence. Two tubular grafts are made from polyester (which
are used to attach the device to the aorta) and the valves are actual heart valves removed from a
pig. Other parts that make up the motor are made from titanium or other metals and ceramics.
A titanium-aluminum-vanadium alloy is used for the pump because it is biocompatible and has
suitable structural properties. In Japan, researchers are developing total artificial hearts based on
a silicone ball valve system and a centrifugal pump with a bearing system made from alumina
ceramic and polyethylene components. Recent studies reveal the progress in investigation of
novel techniques of biomaterials of the artificial heart in terms of longer follow-ups.