Papers by ANTONIO LO CASTO
International Journal of Gynecological Pathology, 2006
We report a case of primary transitional cell carcinoma of the endometrium and review the literat... more We report a case of primary transitional cell carcinoma of the endometrium and review the literature which reveals only 12 cases described to date. The patient presented with postmenopausal bleeding, and there were no distinctive clinical features. An endometrial sample taken at hysteroscopy was reported as a poorly differentiated, papillary, nonserous carcinoma with probable squamous metaplasia. The tumor removed at hysterectomy and bilateral salpingo-oophorectomy was almost all transitional cell with small areas of endometrioid, glandular differentiation. Immunohistochemistry demonstrated a similar immunoprofile to endometrioid carcinoma of the endometrium and different from reported cases of transitional cell carcinoma of the ovary and of the urinary tract.
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Bone, Mar 1, 2008
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Clinical neuroradiology, Nov 20, 2015
In recent years many papers about diagnostic applications of diffusion tensor imaging (DTI) have ... more In recent years many papers about diagnostic applications of diffusion tensor imaging (DTI) have been published. This is because DTI allows to evaluate in vivo and in a non-invasive way the process of diffusion of water molecules in biological tissues. However, the simplified description of the diffusion process assumed in DTI does not permit to completely map the complex underlying cellular components and structures, which hinder and restrict the diffusion of water molecules. These limitations can be partially overcome by means of diffusion kurtosis imaging (DKI). The aim of this paper is the description of the theory of DKI, a new topic of growing interest in radiology. DKI is a higher order diffusion model that is a straightforward extension of the DTI model. Here, we analyze the physics underlying this method, we report our MRI acquisition protocol with the preprocessing pipeline used and the DKI parametric maps obtained on a 1.5 T scanner, and we review the most relevant clinical applications of this technique in various neurological diseases.
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Journal of radiological review, Mar 1, 2020
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DOAJ (DOAJ: Directory of Open Access Journals), Mar 1, 2022
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Poster: "ECR 2018 / C-0327 / CT findings of hepatic vascular disease: what the radiologist n... more Poster: "ECR 2018 / C-0327 / CT findings of hepatic vascular disease: what the radiologist needs to know" by: "S. Pellegrino1, D. Giambelluca1, G. Caruana1, M. Dimarco1, M. R. VACCARO NOTTE2, D. Picone1, G. Salvaggio1, A. Lo Casto3, R. Lagalla1; 1Palermo/IT, 2PALERMO, ITALIA/IT, 3Palermo /IT"
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Acta Medica Mediterranea, 2014
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Electronic Commerce Research, Mar 6, 2014
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PubMed, Apr 1, 1996
The extensive use of magnetic resonance imaging in medical diagnosis needs experimental confirmat... more The extensive use of magnetic resonance imaging in medical diagnosis needs experimental confirmation of the real biological harmlessness of magnetic fields and radiofrequencies in the imaging process. To date, no unquestionable conclusions have been drawn and experimental results differ in various literature reports. We investigated the effects of radiofrequencies and magnetic fields on the amino acid content of plasma samples from 10 healthy volunteers aged 25 to 30 years; the samples were exposed for 60 minutes to MR fields at 0.5 T with the sequences commonly used in clinical practice. After exposure to magnetic fields, the samples were analyzed with chromatography and the results compared with those of plasma samples not exposed to MR fields. Thirty-four different amino acids were investigated and no significant changes were observed in the total concentration of any of them. Our results show that, at least in a cell-free system, exposure to a magnetic field at 0.5 T causes no significant quantitative changes in amino acid composition, at least no changes demonstrable at chromatography. On the other hand, our preliminary observation does not exclude that exposure to nonionizing radiation may modify in vivo enzyme kinetics with transient qualitative, but not quantitative, changes.
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Radiologia Medica, Feb 17, 2018
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Tumori Journal, Nov 10, 2022
Introduction: This monocentric, single-arm, retrospective study investigated the role of stereota... more Introduction: This monocentric, single-arm, retrospective study investigated the role of stereotactic body radiotherapy in patients with metastatic castration resistant prostate cancer who experienced oligoprogression during androgen receptor targeted agents. Methods: We retrospectively enrolled metastatic castration resistant prostate cancer patients treated with androgen receptor targeted agents between December 2016 and January 2022. All patients experienced an oligoprogression (defined as the appearance and/or the progression of ⩽5 bone or nodal or soft tissue metastases) during treatment with androgen receptor targeted agents and received stereotactic body radiotherapy upon oligoprogressive sites, preserving the androgen receptor targeted agents. Further stereotactic body radiotherapy upon new metastatic sites was permitted. Patients showing visceral metastases or receiving palliative radiotherapy were excluded. Progressive disease at >5 metastatic sites or the appearance of visceral metastases led to a change of the systemic treatment. Primary endpoints were 36-month survival rate and 36-month rate of patients receiving treatment with androgen receptor targeted agents. Secondary endpoints were local disease control, biochemical response and safety. Results: We analyzed data from 30 patients. The 36-month survival rate was 90% (27 patients); 36-month rate of patients who were still on treatment with androgen receptor targeted agents was 50%. 20 of 30 patients had performed imaging control after a single course of stereotactic body radiotherapy: overall response rate was 50%, while clinical benefit was 93%. No ⩾G2 adverse events related to stereotactic body radiotherapy were recorded. Conclusions: Stereotactic body radiotherapy in oligoprogressive metastatic sites during androgen receptor targeted agent treatment resulted in a feasible and effective treatment to delay the start of next-line systemic treatment and prolong overall survival in metastatic castration resistant prostate cancer. Longer follow-up and further prospective studies are necessary to confirm our preliminary results.
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Poster: "ECR 2018 / C-0544 / Prenatal and postnatal imaging evaluation of Congenital Pulmona... more Poster: "ECR 2018 / C-0544 / Prenatal and postnatal imaging evaluation of Congenital Pulmonary Airway Malformation (CPAM) and Pulmonary Sequestration: what the radiologist needs to know" by: "D. Giambelluca1, M. Dimarco1, M. R. VACCARO NOTTE2, S. Pellegrino1, G. Caruana1, C. Tudisca1, D. Picone1, A. Lo Casto3, R. Lagalla1; 1Palermo/IT, 2PALERMO, ITALIA/IT, 3Palermo /IT"
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Pharmacologyonline, 2017
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Annals of Oncology, Jun 1, 2007
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PubMed, Mar 1, 1999
Purpose: We investigated possible alterations in the enzyme activity of catalase and isozyme MB-c... more Purpose: We investigated possible alterations in the enzyme activity of catalase and isozyme MB-creatine kinase induced by prolonged exposure of laboratory rodents to a static magnetic field generated by a .5 T Magnetic Resonance unit. Material and methods: Thirty Wistar albino mice were divided into two groups of 15 mice, one to be exposed to the static magnetic field for 12 hours and the other to be kept in the same environmental conditions as a control group. Immediately after the exposure a peripheral venous blood sample was collected, the cardiac muscle was removed from the mice and the enzyme activity of catalase and MB-creatine kinase were assayed using the spectrophotometric analysis. Results: No statistically significant variation was detected between the enzyme activity of catalase and MB-creatine kinase in the serum and cardiac muscle of the exposed versus the control mice. In the mice exposed to the static magnetic field the enzyme activity of serum and cardiac muscle catalase were respectively .2154 U/L and .0707 U/L after 10 minutes; they were; .2699 U/L and .0946 U/L after 160 minutes. In the control mice the enzyme activity of serum and cardiac muscle catalase were respectively .1941 U/L and .0707 U/L after 10 minutes; they were .2061 U/L and .1068 U/L after 160 minutes. The enzyme activity of MB-creatine kinase in mice was measured in the exposed (80.8 U/L) versus the control (79.6 U/L) group: the difference does not exceed standard deviation. Discussion and conclusion: Our results seem to exclude any alteration in the activity of catalase and MB-CK after 12 hours' exposure to the static magnetic field. However some homeostatic mechanisms peculiar to pluricellular organisms might act in vivo to adapt to the effects of the static magnetic field during exposure.
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British Journal of Radiology, 2013
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Papers by ANTONIO LO CASTO