Papers by Alessandra Lucchese
Dental Materials, 2014
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PubMed, Dec 1, 2016
Congenitally missing teeth are one of the most common tooth anomalies associated to therapeutic s... more Congenitally missing teeth are one of the most common tooth anomalies associated to therapeutic sets of problems. Orthodontists should consider these clinical cases because management often requires an integrated orthodontic and restorative approach. In the present study authors reported a therapy note referred to a 14-year-old male patient affected by missing maxillary lateral incisors, bilateral dental Class II and deep bite, treated in 2009 at the Department of Orthodontics of the University of Messina. An orthodontic treatment has been planned with the aim of distalize maxillary molar and the following opening of the spaces necessary for the prosthetic restoration of missing lateral incisor. For the distalization of maxillary molars has been decided to use a Distal Jet supported by miniscrew (Distal-Screw, American Orthodontics, Sheboygan, WI, USA). After seven months of treatment with distal screw, maxillary molar distalization was completed, obtaining a bilateral molar Class I. A multi-bracket orthodontic appliance was bonded in the upper and lower arch using Empower Brackets (American Orthodontics). Class II molar relationship has been over-corrected to Class I in about seven months. The orientation of the force vector resulted in a tipping and rotation of the first molars, without significant vertical changes. Distal Jet reinforced with screws seems to be effective in molar distalization without any type of side effects. The advantages of this device were the absence of patient compliance, relatively predictable outcomes, favorable esthetics, possibility of different activations in each side.
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Journal of Applied Biomaterials & Functional Materials, Sep 1, 2014
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PubMed, Feb 1, 2016
Background: Myeloablative and hematopoietic stem cells transplantation therapy (HSCT) often acts ... more Background: Myeloablative and hematopoietic stem cells transplantation therapy (HSCT) often acts as side-effect to oral mucositis (OM) with no effective treatment. This randomized-controlled trial analyzed the efficacy of palifermin, administered as a dose during HSCT therapy, as primary prophylaxis on pediatric patients with acute lymphoblastic leukemia (ALL). Methods: In this study forty-six patients (9-15 years) with B-cell acute lymphoblastic leukemia (B-ALL) were analyzed. The patients underwent allogenic HSCT conditioned by myeloablative regimen. Subsequently to randomization, patients in the palifermin group were assigned to receive palifermin, 60 mg/kg, intravenously as a single dose 3 days before and after transplant conditioning regimen cycle. The patients in the Control group received only a placebo treatment. Maximum severity of OM, incidence and duration of ulcerative OM, incidence and duration of severe OM limitations were evaluated. Results: A statistically significant reduction in the incidence of OM up to grade 3 in the palifermin group compared to the control group was discovered. There was also a reduction, confirmed at 60 days, in the degree of severity of mucositis in the palifermin group, with an average of 1.54 grade in the palifermin group, and of 2.16 in the Control group and in the use of opioid analgesics. Conclusions: This study indicates that a single dose of palifermin used as primary prophylaxis during HSTC therapy can prevent severe OM in pediatric patients with ALL and used as secondary prophylaxis can prevent the recurrence of severe OM in high-risk patients with previous mucosal injury and improves the quality of life in pediatric patients with ALL.
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Turkish Journal of Orthodontics, Mar 30, 2022
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Journal of Craniofacial Surgery, May 1, 2014
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Leukemia & Lymphoma, Nov 20, 2015
This randomized-controlled trial studied the efficacy of palifermin, administered as a dose durin... more This randomized-controlled trial studied the efficacy of palifermin, administered as a dose during HSCT therapy, as primary prophylaxis on paediatric patients with Acute lymphoblastic leukemia in order to reduce Oral Mucositis. Patients in the palifermin group were randomly assigned to receive Palifermin, 60 μg/kg, intravenously as a single dose 3 days before and 0, +1, and +2 post autologous HSCT infusion. The patients in the control group received only a placebo treatment. OM-related assessments were the WHO oral-toxicity scale and the patient-reported outcomes. There was a statistically significant reduction in the incidence of OM grade 3 and 4 in the palifermin group compared to the control group. There was also a reduction in the degree of severity of OM in the palifermin group (1.65 grade respect to 2.33 in the control group). Palifermin could prevent the recurrence of severe OM and improve the quality of life in patients with ALL.
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European Journal of Orthodontics, Oct 8, 2012
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The International Journal of Oral & Maxillofacial Implants, Oct 18, 2017
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Minerva stomatologica, Feb 1, 2016
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Dental Cadmos, Jun 1, 2016
Riassunto Obiettivi Lo scopo di questo studio e stato valutare le caratteristiche, le alterazioni... more Riassunto Obiettivi Lo scopo di questo studio e stato valutare le caratteristiche, le alterazioni morfostrutturali e le conseguenze disfunzionali dell’articolazione temporomandibolare (ATM) in pazienti affetti da artrite idiopatica giovanile (AIG). Materiali e metodi Lo studio e stato condotto su 45 soggetti di eta compresa tra 7 e 19 anni, affetti da AIG. Tutti i pazienti arruolati sono stati sottoposti a valutazione clinico-gnatologica (anamnesi, parametri di laboratorio, tipo di terapia) e strumentale mediante l’imaging a risonanza magnetica delle ATM. Risultati Dei 45 pazienti del campione, il 37,8% presentava interessamento dell’ATM. Tra questi pazienti (17 pazienti, 13 femmine e 4 maschi) si sono riscontrate: forma poliarticolare 41,2% (7 casi), forma oligoarticolare 35,3% (6 casi), artrite sistemica 11,8% (2 casi), artrite psoriasica 5,9% (1 caso), sindrome entesite- artrite (SEA) 5,9% (1 caso). I principali sintomi riportati erano: click temporomandibolare monolaterale e bilaterale, limitazione funzionale monolaterale e bilaterale associata a dolore, click bilaterale e monolaterale durante la masticazione e laterodeviazione mandibolare associata a sintomatologia delle ATM. Conclusioni I risultati ottenuti in questo studio suggeriscono l’utilita di un’attenta valutazione gnatologica all’esordio dell’AIG. Controlli periodici associati a una diagnosi precoce sono infatti in grado di ridurre e migliorare le problematiche funzionali ed estetiche in questi giovani pazienti.
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Dental Materials, 2014
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Korean Journal of Orthodontics, 2018
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Minerva stomatologica, 2013
Le Fort I osteotomy of the maxilla continues to be one of the most common techniques used in the ... more Le Fort I osteotomy of the maxilla continues to be one of the most common techniques used in the surgical correction of a variety of dento-midfacial deformities. Occasionaly, however, surgeons may encounter difficulties during three-pieces Le Fort I procedures because the surgical movements are also prone to adverse movement and subsequent relapse. This case report describes a 26 year old man, who presented with a skeletal Class III malocclusion and a transverse maxillary deficency. The malocclusion was corrected with a bilateral sagittal split osteotomy (BSSO) and a segmental Le Fort I and post-treatment stabilization was achieved with the STABLE (Surgical Tripartition Auxiliary Block Element), a new and innovative device usefull after three-part maxillary Le Fort I surgery.
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European Journal of Inflammation, 2014
This study compared the analgesic and anti-inflammatory efficacy of intra-alveolar administration... more This study compared the analgesic and anti-inflammatory efficacy of intra-alveolar administration of a thermosetting gel containing Doxycycline Hyclate 3% + Ketorolac Tromethamine 0.5% (Tg-DHKT) (Thermosetting gel, Monteresearch, Bollate, Italy) on patient discomfort after third molar surgery. This study was a single-blind, randomized clinical trial, including two study groups of 39 and 41 patients each, who required surgical removal of a single mandibular impacted third molar. After the extraction the test group received an intra-alveolar injection with Tg-DHKT and the second group a thermosetting gel containing only Doxycycline Hyclate 3% (Tg-DH). Each patient's symptoms (pain, swelling, reddening, bleeding and body temperature) was assessed with a follow-up questionnaire (PoSSe scale). Nimesulide 100 mg, a painkiller, every 8 hours was prescribed to the Control and Test groups if necessary (maximum 3 doses); if they needed to assume it they were asked to mark it on the questionnaire. Results showed that on the second day after surgery pain, oedema and reddening decreased faster in the Control group (Tg-DH). There was no difference between the two groups when postoperative bleeding was evaluated. In both groups bleeding decreased in the same way, probably due to the mechanical characteristics of the gel itself. 46% of patients of the Test group did not require to take any painkiller at home. Our data demonstrate that the use of Tg-DHKT is less effective in the prevention of postoperative symptoms after third molar extraction compared to Tg-DH. However, almost half of patients in the Test group did not need to take more pain medication at home, suggesting that a single postoperative local administration of Tg-DHKT is a safe and effective concept for controlling pain, oedema and inflammation after third molar extraction.
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Journal of clinical orthodontics : JCO, 2013
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The European Journal of Orthodontics, 2012
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European Journal of Inflammation, 2012
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Applied sciences, Mar 23, 2021
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Journal of Clinical Medicine, 2020
The aim of this in vitro study was to evaluate the effects of a single dose application of two da... more The aim of this in vitro study was to evaluate the effects of a single dose application of two daily toothpastes on enamel exposed to acid attack. The research was conducted on human molars enamel fragments (n = 72). The two different toothpastes active ingredients were sodium fluoride (NaF) and stannous fluoride (SnF2). They were compared in protecting the surface of the enamel exposed to three acids: citric acid, lactic acid and hydrochloric acid. A spectrophotometer was used to measure the calcium ions and phosphate released in the solutions by the enamel specimens. Afterward, ionic concentrations were analyzed through the t-Student test, in order to estimate the significance level (p < 0.05) of the solubility differences obtained between the treatment and control groups. Finally, sample surfaces were analyzed with scanning electron microscopy and X-ray energy dispersive spectroscopy (SEM/EDX). The two analyzed toothpastes did not reveal any statistically significant variation...
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Papers by Alessandra Lucchese