Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O... more Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O)CHC(O)C6F13]2], can be achieved with fluorous solid-phase extraction, after the Lewis acid catalysed synthesis of enaminodiones in conventional organic solvents.
Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O... more Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O)CHC(O)C6F13]2], can be achieved with fluorous solid-phase extraction, after the Lewis acid catalysed synthesis of enaminodiones in conventional organic solvents.
One of the most challenging topics in organofluorine chemistry is the asymmetric introduction of ... more One of the most challenging topics in organofluorine chemistry is the asymmetric introduction of fluorine atoms, difluoromethylene and trifluoromethyl groups. Outstanding progress has been made in recent years, but further developments are necessary for chiral fluorinated molecules to be increasingly used in medicinal, agricultural and material chemistry. The enantioselective addition of the fluorinated Reformatsky reagent to aromatic aldehydes in the presence of chiral aminoalcohols to give α,α-difluoro-β-hydroxy esters in good enantiomeric excess is well established. However, the two step protocol is inconvenient because of the need for zinc activation, as well as the relatively high temperatures required for the generation of the fluorinated Reformatsky reagent. Consequently, a one-pot asymmetric Reformatsky reaction of ethyl bromodifluoroacetate with benzaldehyde promoted by diethylzinc under mild reaction conditions (0 o C) has been developed. A very good yield (66 %) and enant...
Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O... more Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O)CHC(O)C6F13]2], can be achieved with fluorous solid-phase extraction, after the Lewis acid catalysed synthesis of enaminodiones in conventional organic solvents.
Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O... more Highly efficient separation, recovery and recycling of the fluorous-tagged catalyst, [Ni[F13C6C(O)CHC(O)C6F13]2], can be achieved with fluorous solid-phase extraction, after the Lewis acid catalysed synthesis of enaminodiones in conventional organic solvents.
One of the most challenging topics in organofluorine chemistry is the asymmetric introduction of ... more One of the most challenging topics in organofluorine chemistry is the asymmetric introduction of fluorine atoms, difluoromethylene and trifluoromethyl groups. Outstanding progress has been made in recent years, but further developments are necessary for chiral fluorinated molecules to be increasingly used in medicinal, agricultural and material chemistry. The enantioselective addition of the fluorinated Reformatsky reagent to aromatic aldehydes in the presence of chiral aminoalcohols to give α,α-difluoro-β-hydroxy esters in good enantiomeric excess is well established. However, the two step protocol is inconvenient because of the need for zinc activation, as well as the relatively high temperatures required for the generation of the fluorinated Reformatsky reagent. Consequently, a one-pot asymmetric Reformatsky reaction of ethyl bromodifluoroacetate with benzaldehyde promoted by diethylzinc under mild reaction conditions (0 o C) has been developed. A very good yield (66 %) and enant...
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