Mounting evidence indicates climate change will adversely influence agricultural crop yields and ... more Mounting evidence indicates climate change will adversely influence agricultural crop yields and cause greater year-to-year variability. This paper considers how a rational, forward-looking and competitive commodity market would account for these anticipated changes and thereby influence time path of storage, prices, price volatility, and social welfare. We forecast 1600 hypothetical yield paths from 2000 to 2080 using estimates from a recent global statistical analysis of weather and crop yields combined with projections from 16 climate models. We then extend the dynamic competitive storage model to account for land response to price and anticipated yield shift. We simulate 1600 stochastic-equilibrium price paths under climate change relative to a baseline of stable prices using our hypothetical yield paths together with estimated demand and supply elasticities and storage cost from the literature. Our results indicate that, under the impact of climate change, world crop price leve...
Hypoparathyroidism is an endocrine disorder that occurs because of the inability to produce parat... more Hypoparathyroidism is an endocrine disorder that occurs because of the inability to produce parathyroid hormone (PTH) effectively. Previously, we reported the efficacy of tonsil-derived mesenchymal stem cells (TMSCs) differentiated into parathyroid-like cells for the treatment of hypoparathyroidism. Here, we investigated the feasibility of three-dimensional structural microbeads fabricated with TMSCs and alginate, a natural biodegradable polymer, to treat hypoparathyroidism. Alginate microbeads were fabricated by dropping a 2% (w/v) alginate solution containing TMSCs into a 5% CaCl2 solution and then differentiated into parathyroid-like cells using activin A and sonic hedgehog for 7 days. The protein expression of PTH, a specific marker of the parathyroid gland, was significantly higher in differentiated alginate microbeads with TMSCs (Al-dT) compared with in undifferentiated alginate microbeads with TMSCs. For in vivo experiments, we created the hypoparathyroidism animal model by p...
2022 IEEE/CVF Winter Conference on Applications of Computer Vision (WACV), 2022
Automatic detection of geoinformation from satellite images has been a fundamental yet challengin... more Automatic detection of geoinformation from satellite images has been a fundamental yet challenging problem, which aims to reduce the manual effort of human annotators in maintaining an up-to-date digital map. There are currently several high-resolution satellite imagery datasets that are publicly available. However, the associated ground-truth annotations are limited to road, building, and land use, while the annotations of other geographic objects or attributes are mostly not available. To bridge the gap, we present Grab-Pklot, the first high-resolution and context-enriched satellite imagery dataset for parking lot detection. Our dataset consists of 1344 satellite images with the ground-truth annotations of carparks in Singapore. Motivated by the observation that carparks are mostly co-appear with other geographic objects, we associate each satellite image in our dataset with the surrounding contextual information of road and building, given in the format of multi-channel images. As a side contribution, we present a fusion-based segmentation approach to demonstrate that the parking lot detection accuracy can be improved by modeling the correlations between parking lots and other geographic objects. Experiments on our dataset provide baseline results as well as new insights into the challenges and opportunities in parking lot detection from satellite images.
Females have lower blood pressure than males before menopause, blunted hypertensive response to A... more Females have lower blood pressure than males before menopause, blunted hypertensive response to AngII, and a leftward shift in pressure natriuresis. Estrogen decreases renal ACE and AT1R and increases NO and AT2R. At the renal transporter level, distal tubule Na+-Cl- cotransporter (NCC) is upregulated by estrogen and more abundant in females, while the loop of Henle (LH) Na+-K+-2Cl- cotransporter (NKCC2) is less abundant. This study aimed to compare female to male apical Na+ transporters’ abundance, distribution, phosphorylation and cleavage and to determine the functional consequences of the differences. Sprague Dawley rats were fasted overnight then fed a 0%KCl meal before termination. The figure displays relative abundance of total and modified (P -phosphorylated, CL-cleaved, FL-full length) transporters expressed along the nephron in females versus males (defined as 1.0), determined by quantitative immunoblotting. Lower abundance of NaPi2, villin, myosin VI, together with higher...
Additional file 1: Knockdown of hMYH and hTopBP1 affects to cell cycle progression. HEK293 cells ... more Additional file 1: Knockdown of hMYH and hTopBP1 affects to cell cycle progression. HEK293 cells were transfected with siGFP, siMYH, siTopBP1, or both siMYH and siTopBP1. Then untreated or treated 20 mM HU for 1 h. 3 mM Thymidine was treated for arresting cell cycle in S phase. After 18 h, cells were harvested or incubated in fresh media for 8 h to release thymidine. Knockdown of hMYH and hTopBP1 diminished the DNA damage recovery and cell cycle progress in contrast of control using siGFP. This result shown that knockdown of hMYH and hTopBP1 induced cell cycle arrest delay.
2013 18th OptoElectronics and Communications Conference held jointly with 2013 International Conference on Photonics in Switching, 2013
ABSTRACT This paper applies 4-ary ASK and nonlinear equalizer in WDM-PON to realize high-speed di... more ABSTRACT This paper applies 4-ary ASK and nonlinear equalizer in WDM-PON to realize high-speed dispersion-tolerant uplink. Error-free transmission of 40 Gb/s upstream signal over 30 km is experimentally demonstrated using a 20 GHz REAM.
2013 18th OptoElectronics and Communications Conference held jointly with 2013 International Conference on Photonics in Switching, 2013
ABSTRACT Implicit training for channel estimation in long-haul single-carrier polarization-multip... more ABSTRACT Implicit training for channel estimation in long-haul single-carrier polarization-multiplexed coherent optical systems has been experimentally demonstrated. Improved performance can be achieved by applying iterative channel estimation for up to 1900-km QPSK and 1000-km 16-QAM transmissions.
2013 18th OptoElectronics and Communications Conference held jointly with 2013 International Conference on Photonics in Switching, 2013
ABSTRACT We demonstrate a bidirectional 10 Gb/s WDM-PON with 100 km reach and REAM-based ONUs usi... more ABSTRACT We demonstrate a bidirectional 10 Gb/s WDM-PON with 100 km reach and REAM-based ONUs using heterodyne detection. The proposed network can support 640 customers at the rate of 1.25 Gb/s via TDM hybrid.
Optical Fiber Communication Conference/National Fiber Optic Engineers Conference 2013, 2013
ABSTRACT We propose the use of modified duobinary modulation in the downlink of a wavelength-reus... more ABSTRACT We propose the use of modified duobinary modulation in the downlink of a wavelength-reused WDM access network to combat the impacts of dispersion and reduce the crosstalk between 40-Gb/s downstream and 10-Gb/s upstream signals.
Introduction: Axicabtagene ciloleucel (Axi-Cel), an autologous anti-CD19 chimeric antigen recepto... more Introduction: Axicabtagene ciloleucel (Axi-Cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy demonstrated efficacy in patients with refractory large B cell lymphoma when conventional treatments failed. Cardiovascular side effects of CAR-T therapy that have been noticed so far include hypotension, left ventricular dysfunction, heart failure and cardiogenic shock in settings of CRS. We aimed to assess the cardiovascular side effects in a racially/ ethnically diverse patient population who underwent CAR-T cell therapy. Methods: This study included thirty-four consecutive adult patients who underwent treatment with CAR-T cell product Axi-Cel at an academic health system between 2018-2021. We performed detailed chart reviews and collected information related to the age, gender, hematological malignancy diagnosis, other medical comorbidities, therapeutic regimens, pretreatment cardiac risk factors, development of CRS with grading , pre and post treatment electro...
Histones package DNA and regulate epigenetic states. For the latter, probably the most im-portant... more Histones package DNA and regulate epigenetic states. For the latter, probably the most im-portant histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can accumulate in slowly dividing somatic cells, replacing canonical H3. Some replication-independent histones, through their ability to incorporate outside S-phase, are functionally important in the very slowly dividing mammalian germ line. Much remains to be learned of H3.3 functions in germ cell development. Histone H3.3 presents a unique genetic paradigm in that two conventional intron-containing genes encode the identical protein. Here, we present a comprehensive analysis of the developmental effects of null mutations in each of these genes. H3f3amutants were viable to adulthood. Females were fertile, while males were subfertile with dysmorphic sper-matozoa. H3f3bmutants were growth-deficient, dying at birth. H3f3b heterozygotes were also...
Evaluating the spatial and temporal model performance of distributed hydrological models is neces... more Evaluating the spatial and temporal model performance of distributed hydrological models is necessary to ensure that the simulated spatial and temporal patterns are meaningful. In recent years, spatial and temporal remote sensing data have been increasingly used for model performance evaluation. Previous studies, however, have focused on either the temporal or spatial model performance evaluation. In addition, temporal (or spatial) model performance evaluation is often done in a spatially (or temporally) lumped approach. Here, we evaluated (1) the temporal model performance evaluation in a spatially distributed approach (spatiotemporal) and (2) the spatial model performance in a temporally distributed approach (temporospatial) model performance evaluation. This study demonstrated that both spatiotemporal and temporospatial model performance evaluations are necessary since they provide different aspects of the model performance. For example, spatiotemporal model performance evaluatio...
ABSTRACT We report a two-stage frequency domain equalization method for non-data-aided coherent p... more ABSTRACT We report a two-stage frequency domain equalization method for non-data-aided coherent polarizationmultiplexed 16-QAM system. Robust performance against polarization-mode-dispersion and long-haul transmission is experimentally demonstrated using cascaded blind CD compensation and dual-mode adaptive equalization.
Background: Australian rates of obesity are increasing. General practice has a definite role to p... more Background: Australian rates of obesity are increasing. General practice has a definite role to play in addressing obesity and preventing further chronic disease but relatively few encounters focus primarily on weight management. The HeLP GP trial assisted overweight and obese patients to make positive lifestyle changes to diet and physical activity and increase the capacity of practice nurses to deliver comprehensive weight management. The nurse led intervention comprised a health check and access to a lifestyle app and/or telephone coaching. Within this paper we describe the experience of implementing this intervention through the lens of organisational readiness with specific emphasis on the role of the practice nurse. Methods: Routinely collected research data, quantitative practice surveys, and qualitative field notes from research officers and facilitators were mapped against a recognised organisational readiness framework. Motivation to implement, general capacity and interve...
ESTA INVENCION SE REFIERE A UNOS PROCEDIMIENTOS DE MEJORA DE LA PURIFICACION Y CUANTIFICACION DE ... more ESTA INVENCION SE REFIERE A UNOS PROCEDIMIENTOS DE MEJORA DE LA PURIFICACION Y CUANTIFICACION DE LAS PROTEINAS DEL FACTOR DE CRECIMIENTO DERIVADO DE LAS PLAQUETAS (PDGF) QUE TIENEN UNA HETEROGENEIDAD ESTRUCTURAL. LA PREPARACION DE ISOFORMAS PRACTICAMENTE PURAS DE ESTAS PROTEINAS SE LLEVA A CABO MEDIANTE CROMATOGRAFIA DE INTERCAMBIO CATIONICO DE TSK SULFOPROPILO Y CROMATOGRAFIA LIQUIDA EN FASE INVERTIDA DE ALTO RENDIMIENTO. UN PROCEDIMIENTO DE ELECTROFORESIS DE ZONA SOBRE UNA COLUMNA CAPILAR CON CARGA INVERSA PERMITE LA CUANTIFICACION DE ISOFORMAS PRACTICAMENTE PURAS DE ESTAS PROTEINAS POR MODIFICACIONES POST TRANSLACIONALES ENDOPROTEOLITICAS. DICHAS COMPOSICIONES SON ISOFORMAS PRACTICAMENTE PURAS DE PROTEINAS PDGF SECRETADAS QUE TIENEN UNA HETEROGENEIDAD ESTRUCTURAL, MAS ESPECIALMENTE ISOFORMAS CON CORTE SIMPLE O DOBLE, INTACTAS, PURIFICADAS, DE PROTEINAS PDGF - BB DE RECOMBINACION. ESTA INVENCION SE REFIERE TAMBIEN A UNAS COMPOSICIONES FARMACEUTICAS QUE TIENEN, POR LO MENOS, UNA DE...
Mounting evidence indicates climate change will adversely influence agricultural crop yields and ... more Mounting evidence indicates climate change will adversely influence agricultural crop yields and cause greater year-to-year variability. This paper considers how a rational, forward-looking and competitive commodity market would account for these anticipated changes and thereby influence time path of storage, prices, price volatility, and social welfare. We forecast 1600 hypothetical yield paths from 2000 to 2080 using estimates from a recent global statistical analysis of weather and crop yields combined with projections from 16 climate models. We then extend the dynamic competitive storage model to account for land response to price and anticipated yield shift. We simulate 1600 stochastic-equilibrium price paths under climate change relative to a baseline of stable prices using our hypothetical yield paths together with estimated demand and supply elasticities and storage cost from the literature. Our results indicate that, under the impact of climate change, world crop price leve...
Hypoparathyroidism is an endocrine disorder that occurs because of the inability to produce parat... more Hypoparathyroidism is an endocrine disorder that occurs because of the inability to produce parathyroid hormone (PTH) effectively. Previously, we reported the efficacy of tonsil-derived mesenchymal stem cells (TMSCs) differentiated into parathyroid-like cells for the treatment of hypoparathyroidism. Here, we investigated the feasibility of three-dimensional structural microbeads fabricated with TMSCs and alginate, a natural biodegradable polymer, to treat hypoparathyroidism. Alginate microbeads were fabricated by dropping a 2% (w/v) alginate solution containing TMSCs into a 5% CaCl2 solution and then differentiated into parathyroid-like cells using activin A and sonic hedgehog for 7 days. The protein expression of PTH, a specific marker of the parathyroid gland, was significantly higher in differentiated alginate microbeads with TMSCs (Al-dT) compared with in undifferentiated alginate microbeads with TMSCs. For in vivo experiments, we created the hypoparathyroidism animal model by p...
2022 IEEE/CVF Winter Conference on Applications of Computer Vision (WACV), 2022
Automatic detection of geoinformation from satellite images has been a fundamental yet challengin... more Automatic detection of geoinformation from satellite images has been a fundamental yet challenging problem, which aims to reduce the manual effort of human annotators in maintaining an up-to-date digital map. There are currently several high-resolution satellite imagery datasets that are publicly available. However, the associated ground-truth annotations are limited to road, building, and land use, while the annotations of other geographic objects or attributes are mostly not available. To bridge the gap, we present Grab-Pklot, the first high-resolution and context-enriched satellite imagery dataset for parking lot detection. Our dataset consists of 1344 satellite images with the ground-truth annotations of carparks in Singapore. Motivated by the observation that carparks are mostly co-appear with other geographic objects, we associate each satellite image in our dataset with the surrounding contextual information of road and building, given in the format of multi-channel images. As a side contribution, we present a fusion-based segmentation approach to demonstrate that the parking lot detection accuracy can be improved by modeling the correlations between parking lots and other geographic objects. Experiments on our dataset provide baseline results as well as new insights into the challenges and opportunities in parking lot detection from satellite images.
Females have lower blood pressure than males before menopause, blunted hypertensive response to A... more Females have lower blood pressure than males before menopause, blunted hypertensive response to AngII, and a leftward shift in pressure natriuresis. Estrogen decreases renal ACE and AT1R and increases NO and AT2R. At the renal transporter level, distal tubule Na+-Cl- cotransporter (NCC) is upregulated by estrogen and more abundant in females, while the loop of Henle (LH) Na+-K+-2Cl- cotransporter (NKCC2) is less abundant. This study aimed to compare female to male apical Na+ transporters’ abundance, distribution, phosphorylation and cleavage and to determine the functional consequences of the differences. Sprague Dawley rats were fasted overnight then fed a 0%KCl meal before termination. The figure displays relative abundance of total and modified (P -phosphorylated, CL-cleaved, FL-full length) transporters expressed along the nephron in females versus males (defined as 1.0), determined by quantitative immunoblotting. Lower abundance of NaPi2, villin, myosin VI, together with higher...
Additional file 1: Knockdown of hMYH and hTopBP1 affects to cell cycle progression. HEK293 cells ... more Additional file 1: Knockdown of hMYH and hTopBP1 affects to cell cycle progression. HEK293 cells were transfected with siGFP, siMYH, siTopBP1, or both siMYH and siTopBP1. Then untreated or treated 20 mM HU for 1 h. 3 mM Thymidine was treated for arresting cell cycle in S phase. After 18 h, cells were harvested or incubated in fresh media for 8 h to release thymidine. Knockdown of hMYH and hTopBP1 diminished the DNA damage recovery and cell cycle progress in contrast of control using siGFP. This result shown that knockdown of hMYH and hTopBP1 induced cell cycle arrest delay.
2013 18th OptoElectronics and Communications Conference held jointly with 2013 International Conference on Photonics in Switching, 2013
ABSTRACT This paper applies 4-ary ASK and nonlinear equalizer in WDM-PON to realize high-speed di... more ABSTRACT This paper applies 4-ary ASK and nonlinear equalizer in WDM-PON to realize high-speed dispersion-tolerant uplink. Error-free transmission of 40 Gb/s upstream signal over 30 km is experimentally demonstrated using a 20 GHz REAM.
2013 18th OptoElectronics and Communications Conference held jointly with 2013 International Conference on Photonics in Switching, 2013
ABSTRACT Implicit training for channel estimation in long-haul single-carrier polarization-multip... more ABSTRACT Implicit training for channel estimation in long-haul single-carrier polarization-multiplexed coherent optical systems has been experimentally demonstrated. Improved performance can be achieved by applying iterative channel estimation for up to 1900-km QPSK and 1000-km 16-QAM transmissions.
2013 18th OptoElectronics and Communications Conference held jointly with 2013 International Conference on Photonics in Switching, 2013
ABSTRACT We demonstrate a bidirectional 10 Gb/s WDM-PON with 100 km reach and REAM-based ONUs usi... more ABSTRACT We demonstrate a bidirectional 10 Gb/s WDM-PON with 100 km reach and REAM-based ONUs using heterodyne detection. The proposed network can support 640 customers at the rate of 1.25 Gb/s via TDM hybrid.
Optical Fiber Communication Conference/National Fiber Optic Engineers Conference 2013, 2013
ABSTRACT We propose the use of modified duobinary modulation in the downlink of a wavelength-reus... more ABSTRACT We propose the use of modified duobinary modulation in the downlink of a wavelength-reused WDM access network to combat the impacts of dispersion and reduce the crosstalk between 40-Gb/s downstream and 10-Gb/s upstream signals.
Introduction: Axicabtagene ciloleucel (Axi-Cel), an autologous anti-CD19 chimeric antigen recepto... more Introduction: Axicabtagene ciloleucel (Axi-Cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy demonstrated efficacy in patients with refractory large B cell lymphoma when conventional treatments failed. Cardiovascular side effects of CAR-T therapy that have been noticed so far include hypotension, left ventricular dysfunction, heart failure and cardiogenic shock in settings of CRS. We aimed to assess the cardiovascular side effects in a racially/ ethnically diverse patient population who underwent CAR-T cell therapy. Methods: This study included thirty-four consecutive adult patients who underwent treatment with CAR-T cell product Axi-Cel at an academic health system between 2018-2021. We performed detailed chart reviews and collected information related to the age, gender, hematological malignancy diagnosis, other medical comorbidities, therapeutic regimens, pretreatment cardiac risk factors, development of CRS with grading , pre and post treatment electro...
Histones package DNA and regulate epigenetic states. For the latter, probably the most im-portant... more Histones package DNA and regulate epigenetic states. For the latter, probably the most im-portant histone is H3. Mammals have three near-identical H3 isoforms: canonical H3.1 and H3.2, and the replication-independent variant H3.3. This variant can accumulate in slowly dividing somatic cells, replacing canonical H3. Some replication-independent histones, through their ability to incorporate outside S-phase, are functionally important in the very slowly dividing mammalian germ line. Much remains to be learned of H3.3 functions in germ cell development. Histone H3.3 presents a unique genetic paradigm in that two conventional intron-containing genes encode the identical protein. Here, we present a comprehensive analysis of the developmental effects of null mutations in each of these genes. H3f3amutants were viable to adulthood. Females were fertile, while males were subfertile with dysmorphic sper-matozoa. H3f3bmutants were growth-deficient, dying at birth. H3f3b heterozygotes were also...
Evaluating the spatial and temporal model performance of distributed hydrological models is neces... more Evaluating the spatial and temporal model performance of distributed hydrological models is necessary to ensure that the simulated spatial and temporal patterns are meaningful. In recent years, spatial and temporal remote sensing data have been increasingly used for model performance evaluation. Previous studies, however, have focused on either the temporal or spatial model performance evaluation. In addition, temporal (or spatial) model performance evaluation is often done in a spatially (or temporally) lumped approach. Here, we evaluated (1) the temporal model performance evaluation in a spatially distributed approach (spatiotemporal) and (2) the spatial model performance in a temporally distributed approach (temporospatial) model performance evaluation. This study demonstrated that both spatiotemporal and temporospatial model performance evaluations are necessary since they provide different aspects of the model performance. For example, spatiotemporal model performance evaluatio...
ABSTRACT We report a two-stage frequency domain equalization method for non-data-aided coherent p... more ABSTRACT We report a two-stage frequency domain equalization method for non-data-aided coherent polarizationmultiplexed 16-QAM system. Robust performance against polarization-mode-dispersion and long-haul transmission is experimentally demonstrated using cascaded blind CD compensation and dual-mode adaptive equalization.
Background: Australian rates of obesity are increasing. General practice has a definite role to p... more Background: Australian rates of obesity are increasing. General practice has a definite role to play in addressing obesity and preventing further chronic disease but relatively few encounters focus primarily on weight management. The HeLP GP trial assisted overweight and obese patients to make positive lifestyle changes to diet and physical activity and increase the capacity of practice nurses to deliver comprehensive weight management. The nurse led intervention comprised a health check and access to a lifestyle app and/or telephone coaching. Within this paper we describe the experience of implementing this intervention through the lens of organisational readiness with specific emphasis on the role of the practice nurse. Methods: Routinely collected research data, quantitative practice surveys, and qualitative field notes from research officers and facilitators were mapped against a recognised organisational readiness framework. Motivation to implement, general capacity and interve...
ESTA INVENCION SE REFIERE A UNOS PROCEDIMIENTOS DE MEJORA DE LA PURIFICACION Y CUANTIFICACION DE ... more ESTA INVENCION SE REFIERE A UNOS PROCEDIMIENTOS DE MEJORA DE LA PURIFICACION Y CUANTIFICACION DE LAS PROTEINAS DEL FACTOR DE CRECIMIENTO DERIVADO DE LAS PLAQUETAS (PDGF) QUE TIENEN UNA HETEROGENEIDAD ESTRUCTURAL. LA PREPARACION DE ISOFORMAS PRACTICAMENTE PURAS DE ESTAS PROTEINAS SE LLEVA A CABO MEDIANTE CROMATOGRAFIA DE INTERCAMBIO CATIONICO DE TSK SULFOPROPILO Y CROMATOGRAFIA LIQUIDA EN FASE INVERTIDA DE ALTO RENDIMIENTO. UN PROCEDIMIENTO DE ELECTROFORESIS DE ZONA SOBRE UNA COLUMNA CAPILAR CON CARGA INVERSA PERMITE LA CUANTIFICACION DE ISOFORMAS PRACTICAMENTE PURAS DE ESTAS PROTEINAS POR MODIFICACIONES POST TRANSLACIONALES ENDOPROTEOLITICAS. DICHAS COMPOSICIONES SON ISOFORMAS PRACTICAMENTE PURAS DE PROTEINAS PDGF SECRETADAS QUE TIENEN UNA HETEROGENEIDAD ESTRUCTURAL, MAS ESPECIALMENTE ISOFORMAS CON CORTE SIMPLE O DOBLE, INTACTAS, PURIFICADAS, DE PROTEINAS PDGF - BB DE RECOMBINACION. ESTA INVENCION SE REFIERE TAMBIEN A UNAS COMPOSICIONES FARMACEUTICAS QUE TIENEN, POR LO MENOS, UNA DE...
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