Papers by Bashar Haruna Gulumbe
Borneo Journal of Pharmacy
Carbapenems are regarded as unique among the �-lactam antibiotics due to their broad spectrum of ... more Carbapenems are regarded as unique among the �-lactam antibiotics due to their broad spectrum of activity and ability to resist �-lactamase hydrolysis. Carbapenems are the only �-lactam antibiotics with efficacy in severe infections caused by extended-spectrum beta-lactamase (ESBL) producing bacteria. However, recent reports of carbapenem resistance particularly among members of Enterobacteriaceae that are responsible for diseases such as gastrointestinal infections, septicemia, pneumonia, meningitis, peritonitis as well as urinary tract infections, call for concerns. In Africa, the problem of carbapenem-resistant Enterobacteriaceae (CRE) is aggravated by factors such as the high rate of infections, poor diagnostic tools, sub-optimal disease surveillance, and abuse of antibiotics. Besides, the problem of CRE in Africa is understudied. This review distills available literature on the spread of CRE in Africa, CRE genes in circulation, and the need to pay attention to this emerging thr...
Bashar Haruna GULUMBE and Abdullahi Adamu FAGGO, 2019
Multidrug-resistant organisms/bacteria (MDROs) have significant health implications that either h... more Multidrug-resistant organisms/bacteria (MDROs) have significant health implications that either have not been addressed or received only limited attention, especially in resource-constrained settings such as Africa, where access to newer, often costly antibiotics is limited. Acquisition of MDROs has been linked with poorer clinical outcomes and prolonged hospitalization. The evolution and spread of MDROs is influenced by factors such as selective pressure exerted by indiscriminate use of antimicrobials in both agriculture and medicine, lack of prescribing skills and training, lack of access to rapid and reliable diagnostics, suboptimal surveillance, as well as poor implementation and adherence to prevention measures. Reports indicate increased occurrence of MDROs in Africa, including members of Enterobacteriaceae which are often implicated in bloodstream, urinary tract, abdomen, skin and soft tissue infections. However, serious data limitation and underreporting are major hurdles th...
Medical Sciences
Schistosomiasis is a debilitating disease affecting over 200 million people, with the highest bur... more Schistosomiasis is a debilitating disease affecting over 200 million people, with the highest burden of morbidity and mortality in African countries. Despite its huge impact on the health and socioeconomic burden of the society, it remains a neglected tropical disease, with limited attention from governments and stakeholders in healthcare. One of the critical areas that is hugely underdeveloped is the development of accurate diagnostics for both intestinal and urogenital schistosomiasis. Diagnosis of schistosomiasis is important for the detection and treatment of disease in endemic and non-endemic settings. A conclusive detection method is also an indispensable part of treatment, both in the clinic and during mass drug administration (MDA), for the monitoring efficacy of treatment. Here, we review the available diagnostic methods and discuss the challenges encountered in diagnosis in resource limited settings. We also present the available diagnostics and cost implications for deployment in resource limited settings. Lastly, we emphasize the need for more funding directed towards the development of affordable diagnostic tools that is affordable for endemic countries as we work towards the elimination of the disease.
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Papers by Bashar Haruna Gulumbe