Introduction: Kallistatin, serin proteinase inhibitor exhibits its properties in inhibiting infla... more Introduction: Kallistatin, serin proteinase inhibitor exhibits its properties in inhibiting inflammation, oxidative stress and apoptosis, angiogenesis. Severe pulmonary hypertension caused by left to right shunt congenital heart disease and Eisenmenger syndrome is progressive obliterative vasculopathy; the pathogenesis endothelial dysfunction and function of ion channels, calcium homeostasis, changes in platelet and endothelial function, intravascular thrombosis proliferation reactivity increased vascular inflammation and remodeling. In this study, we aimed to show the possible relationship between kalistatin levels, pro-inflammatory TNF-alfa and anti-inflammatory cytokine IL-10 levels in pulmonary arterial hypertension Material and Method: The study was performed in Erciyes University Medical Faculty Hospital. Patient group was formed from pulmonary hypertensive patients (Eisenmenger syndrome and primary Pulmonary Hypertension). We enrolled the patients with pulmonary arterial hypertension diagnosis that confirmed by the angiocardiography in our center. Pulmonary arterial hypertension is defined as mean pulmonary arterial pressure greater than 25mmHg. Serum kallistatin, TNF-alfa, IL-10, NtProBNP levels were studied in each patient. Results: The study included total 50 patients: 25 patients in pulmonary hypertension group (16with Eisenmenger syndrome, 9 with primary pulmonary arterial hypertension). Control group consisted 25 patients with innocent murmur.Median value of kallistatin in pulmonary hypertension group was 1.42(1.0-1.58), control group 2.27(1.57-3.38).Serum levels of kallistatin were significantly lower (p<0.05) in pulmonary hypertensive patients. Negative correlation was detected between mean pulmonary arterial pressure and serum kallistatin levels.However no correlation was found for proinflammatory cytokine TNF-alfa and anti-inflammatory cytokine IL10. Conclusion: Anti-inflammatory and anti-apoptotic features of Kallistatin were shown in various diseases like arthritis, pneumonia etc. Our study is the first one that shows the anti-inflammatory effect of kalistatin in pulmonary hypertension. Kallistatin levels were low in pulmonary hypertension because of increased lung inflammation. Since no correlation between IL10 and TNF-alfa was found, probably they used different pathways in the pathogenesis of inflammation.
Proceedings of the 8th WSEAS international …, 2009
Knowledge is the most valuable asset in today's dynamic business environment. In many organi... more Knowledge is the most valuable asset in today's dynamic business environment. In many organizations, decisions are made based on a combination of judgment and knowledge extracted from databases. Successful business organization to be able to react rapidly to the ...
Pulmonary hypertension is a progressive obliterative vasculopathy. Underlying mechanisms are very... more Pulmonary hypertension is a progressive obliterative vasculopathy. Underlying mechanisms are very complex; there is not a single but group of events. The one that takes the main role seems to be endothelial dysfunction. Other events are changes in function of platelet and ion channels, calcium homeostasis, inflammation, angiogenesis etc. 1 Pulmonary arterial hypertension (PAH) is a subgroup of pulmonary hypertension that has idiopathic, genetic, and comorbid etiologies (e.g., connective tissue disorders, HIV infection, schistosomiasis, etc.). 2 It is characterized by occlusion of pulmonary arterioles that results the increase in the pulmonary vascular resistance, right ventricular hypertrophy, and finally right sided heart failure. In recent years, there is an increased understanding of the pathophysiology of
Introduction: Kallistatin, serin proteinase inhibitor exhibits its properties in inhibiting infla... more Introduction: Kallistatin, serin proteinase inhibitor exhibits its properties in inhibiting inflammation, oxidative stress and apoptosis, angiogenesis. Severe pulmonary hypertension caused by left to right shunt congenital heart disease and Eisenmenger syndrome is progressive obliterative vasculopathy; the pathogenesis endothelial dysfunction and function of ion channels, calcium homeostasis, changes in platelet and endothelial function, intravascular thrombosis proliferation reactivity increased vascular inflammation and remodeling. In this study, we aimed to show the possible relationship between kalistatin levels, pro-inflammatory TNF-alfa and anti-inflammatory cytokine IL-10 levels in pulmonary arterial hypertension Material and Method: The study was performed in Erciyes University Medical Faculty Hospital. Patient group was formed from pulmonary hypertensive patients (Eisenmenger syndrome and primary Pulmonary Hypertension). We enrolled the patients with pulmonary arterial hypertension diagnosis that confirmed by the angiocardiography in our center. Pulmonary arterial hypertension is defined as mean pulmonary arterial pressure greater than 25mmHg. Serum kallistatin, TNF-alfa, IL-10, NtProBNP levels were studied in each patient. Results: The study included total 50 patients: 25 patients in pulmonary hypertension group (16with Eisenmenger syndrome, 9 with primary pulmonary arterial hypertension). Control group consisted 25 patients with innocent murmur.Median value of kallistatin in pulmonary hypertension group was 1.42(1.0-1.58), control group 2.27(1.57-3.38).Serum levels of kallistatin were significantly lower (p<0.05) in pulmonary hypertensive patients. Negative correlation was detected between mean pulmonary arterial pressure and serum kallistatin levels.However no correlation was found for proinflammatory cytokine TNF-alfa and anti-inflammatory cytokine IL10. Conclusion: Anti-inflammatory and anti-apoptotic features of Kallistatin were shown in various diseases like arthritis, pneumonia etc. Our study is the first one that shows the anti-inflammatory effect of kalistatin in pulmonary hypertension. Kallistatin levels were low in pulmonary hypertension because of increased lung inflammation. Since no correlation between IL10 and TNF-alfa was found, probably they used different pathways in the pathogenesis of inflammation.
Proceedings of the 8th WSEAS international …, 2009
Knowledge is the most valuable asset in today's dynamic business environment. In many organi... more Knowledge is the most valuable asset in today's dynamic business environment. In many organizations, decisions are made based on a combination of judgment and knowledge extracted from databases. Successful business organization to be able to react rapidly to the ...
Pulmonary hypertension is a progressive obliterative vasculopathy. Underlying mechanisms are very... more Pulmonary hypertension is a progressive obliterative vasculopathy. Underlying mechanisms are very complex; there is not a single but group of events. The one that takes the main role seems to be endothelial dysfunction. Other events are changes in function of platelet and ion channels, calcium homeostasis, inflammation, angiogenesis etc. 1 Pulmonary arterial hypertension (PAH) is a subgroup of pulmonary hypertension that has idiopathic, genetic, and comorbid etiologies (e.g., connective tissue disorders, HIV infection, schistosomiasis, etc.). 2 It is characterized by occlusion of pulmonary arterioles that results the increase in the pulmonary vascular resistance, right ventricular hypertrophy, and finally right sided heart failure. In recent years, there is an increased understanding of the pathophysiology of
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