Objective: The purpose of our study was to evaluate the cognitive decline in patients with primit... more Objective: The purpose of our study was to evaluate the cognitive decline in patients with primitive brain tumors. Material and methods: We enrolled in our study 188 patients diagnosed with brain tumors, hospitalized in the Clinic of Neurology Craiova between January 2006 and December 2010. Depending on the origin of the brain tumors the group was divided as follows: • Group A, composed of 45 patients with tumors of the meninges • Group B, composed of 105 patients with neuroepithelial tumors Each patient was evaluated by neurological and neuroimaging exam (computed tomography and/or nuclear magnetic resonance). For the evaluation of global disability we used Karnofsky Performance Status Scale. Cognitive function was assessed using: Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The results were analyzed by Student’s T test, considering statistically significant p<0,05. Results: Statistical analysis, in terms of the average age and average years of ...
Objective. The aim of our study was to evaluate the cognitive impairment in patients diagnosed wi... more Objective. The aim of our study was to evaluate the cognitive impairment in patients diagnosed with malignant brain tumors. Material and methods. We enrolled in our study 105 patients diagnosed with astrocytomas, hospitalized in the Clinic of Neurology between January 2006 and December 2010. Depending on the histology of the tumor, the study-group was composed of 19 cases diagnosed with diffuse astrocytomas, 13 cases with anaplastic astrocytomas and 73 cases with glioblastomas. Each patient was evaluated by neurological and neuro-imagistic exam (computed tomography and/or nuclear magnetic resonance). Each patient was evaluated in the term of disability using Karnofsky Performance Status, which is a scale commonly used in patients with cancer to quantify functional status. Presurgical cognitive functions of the patients were assessed using Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), The results were analyzed using Student’s T test and Chi-Squared te...
Romanian Journal of Morphology and Embryology, Sep 9, 2022
This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
Evaluation of mild cognitive impairment is important for early management in order to prevent sev... more Evaluation of mild cognitive impairment is important for early management in order to prevent severe dementia. The goal of our study was to assess the cognitive state in patients with ischemic vascular events (first ever stroke or transient ischemic attack).We studied 86 patients who were hospitalized in The Clinic of Neurology from Craiova during the year 2007, for first ever stroke (56 patients) or transient ischemic attack (TIA-32 patients) and also a group composed of 92 control subjects without signs of cerebrovascular disease but with vascular risk factors present. We used for the assessment two scales: Mini Mental State Examination (MMSE) and Cambridge Cognitive Examination (CAMCOG). We made assessment at baseline, after 3 months respectively 6 months. We performed computed tomography in both groups, for a correct diagnosis. At baseline the patient group had a mean MMSE score 27,3 and a mean CAMCOG score 93,9. The control subjects had a mean MMSE score 28,5 and a mean CAMCOG ...
Objective: The aim of the study was to evaluate anxiety in patients with Parkinson's disease.... more Objective: The aim of the study was to evaluate anxiety in patients with Parkinson's disease. Patients and method: We studied a group of 37 non-demented patients with Parkinson's disease, 17 women and 20 men, aged between 50 and 70 years. Sixteen patients were in stage I and 21 patients in stage II of the disease on Hoehn-Yahr Scale. The patients were treated either with dopaminergic agonists or with levo-dopa associated with dopaminergic agonists. To assess the symptoms of anxiety we performed to each patient The Zung Self-Rating Anxiety Scale and The Hamilton Anxiety Rating Scale. For the depressive disorders we also performed The Hamilton Depression Rating Scale. The results were analyzed by Student's Test and Chi-Square Test. Results: Twelve patients (32,4%) had anxiety disorders: generalized anxiety (5 patients), panic attack (2 patients), social fobia (one patient) and unspecified anxiety disorder (4 patients). The association between anxiety and depression was fou...
The goal of our study was to assess the cognitive state in patients with Parkinson's disease ... more The goal of our study was to assess the cognitive state in patients with Parkinson's disease (PD). We studied 58 patients ( 23 men and 35 women, mean age 70,1± 4,5 years and mean educational level 11,9 ±1 years). They were admitted to the Clinic of Neurology from Craiova between March 2007- March 2008 for Parkinson Disease. All the patients met the diagnostic criteria for Parkinson's Disease. In this study we included only patients in stage I and II on Hoehn and Yahr scale. Thirty-two patients were in stage I and 26 patients in stage II. The patients were treated with levo-dopa monotherapy, dopaminergic agonists monotherapy, or levodopa associated with dopaminergic agonists. We have also included in our study a control group composed of 62 control subjects with the same range of educational level and age. To assess the cognitive state we tested the patients using Mini Mental State Examination (MMSE) and the revised version of the Addenbrooke's Cognitive Examination (ACE-...
The purpose of this study is to appreciate if there is an immune response in malignant brain tumo... more The purpose of this study is to appreciate if there is an immune response in malignant brain tumors. Material and methods: Eleven astrocytomas of varying histological features were immunohistologically studied, using a panel of monoclonal antibody against CD20cy to highlight T-lymphocytes, CD3 for B-lymphocytes and CD68 as marker of the macrophages. Ki67 antibody was used as marker of proliferation. We evaluated the presence of these markers in peritumoral stroma and intratumoral tissue. Results: In our study, none of the astrocytic tumors studied showed B-lymphocytes. The presence of T lymphocytes was evidenced in all 11 selected cases. While low-grade astrocytomas showed positive CD3 immunostaining only in tumoral cells, anaplastic astrocytomas and glioblastomas revealed positive immunostaining also in perivascular space. As it was expected, mean values for proliferative marker Ki-67 revealed that there was a significant difference between the indices of low(grade II) and high-gra...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2018
Meningitis and encephalitis are inflammatory diseases in which acute and chronic inflammatory cel... more Meningitis and encephalitis are inflammatory diseases in which acute and chronic inflammatory cells infiltrate leptomeninges, especially the arachnoid, and migrate through the subarachnoid space and by diapedesis, in order to extend around blood vessels and into the brain parenchyma. To what extent migrated/resident inflammatory cells participate to these interactions, or what are exactly the initial steps by which these cells reach the brain interstitium, it is not yet completely known. Recent years have brought new insights into the description of water flow circuits in the brain, suggesting that the cerebrospinal fluid enters the brain within the perivascular spaces of arteries, while interstitial fluid drains along perivascular venous sector. Moreover, it has been showed that vascular basement membranes have a complex multi-layered architecture that originates with epithelial, endothelial, smooth muscle cells and glial cells, and that the virtual space between these layers might...
The aim of this study was to assess the cognitive decline in patients with Parkinson's disease an... more The aim of this study was to assess the cognitive decline in patients with Parkinson's disease and to study its correlation with their depression. We studied 64 consecutive patients (30 men and 34 women), mean education level 11.2±1 years and mean age 72.3±3.5 years. These patients were admitted to Clinic of Neuropsychiatry Craiova between January 2016 and October 2016. They underwent a neurological and neuropsychological examination at baseline, after 6 months and 12 months later. For the cognitive assessment we used the revised version of the Addenbrooke′s Cognitive Examination (ACE-R) and Montreal Cognitive Assessment (MoCA) and for the evaluation of depression we used Hamilton Depression Rating Scale (HDRS). We have also included in our study a control group composed of 76 control subjects with the same range of educational level and age. All the patients met the diagnostic criteria for Parkinson′s Disease. In this study we included patients in stage I and II on Hoehn and Yahr scale. Twenty-six patients were in stage I and 38 patients in stage II. The patients were treated with levo-dopa monotherapy, dopaminergic agonists monotherapy, or levodopa associated with dopaminergic agonists. At baseline the patients in stage I showed a mean MoCA score 26.8 and a mean ACE-R score 89.6. The patients in stage II had a mean MoCA score 26.5 and a mean ACE-R score 89.4 at baseline. The control subjects showed a mean MoCA score 27.06 and a mean ACE-R score 90.3. One year later the patients group I showed a mean MoCA score 19.8 and 84.7 mean ACE-R score. The groups of patients in stage II had a mean MoCA score 18.3 and ACE-R score 84.2. The control group the mean MoCA values was 22.56 and ACE-R 87.1. Regarding asssessment of depression, we obtained the next scores: at baseline, patients in stage I showed a mean HDRS score of 14.6; the patients in stage II a mean HDRS score 14.8 and the control group a HDRS mean score of 8. One year later group I showed a mean HDRS score of 18.8; the group II 19.9 and the control group 9.7. For the statistical analyse, we used Student test (p<0.05 statistically considerable). The patients with PD showed a greater cognitive impairment and depression than the control subjects. We observed that the patients in stage II Hoehn and Yahr had a greater cognitive decline and depression than patients in stage I. Depression was diagnosed in 40 patients at 6 months and in 56 of the patients at 12 months. The cognitive impairment was higher at 12 months than at 6 months. The depressive patients had more severe cognitive decline than the nondepressive patients.
Levodopa (L-dopa), a precursor of dopamine, remained the gold standard among antiparkinsonian dru... more Levodopa (L-dopa), a precursor of dopamine, remained the gold standard among antiparkinsonian drugs and virtually, in different stages, all patients will require the more powerful symptomatic effect of L-dopa. In addition, continuous Levodopa/Carbidopa intestinal gel (LCIG) infusion therapy, via a percutaneous endoscopic gastrostomy (PEG) and a portable infusion pump, is well established for the treatment of advanced Parkinson�s disease (PD), substantially improving motor symptoms and quality of life in these patients. This study aimed to evaluate the necessity of LCGI depending the PD motor subtypes and age at onset of the disease. Seventy patients diagnosed with PD were included in our study. The Unified Parkinson�s Disease Rating Scale (UPDRS) was performed in on state. The patients were classified as tremor-dominant type (TDT), akinetic-rigid type (ART) and mixed type (MT). Depending on form of levodopa, thirty-six patients were on L-dopa orally and thirty-four patients were on ...
Cardiovascular risk management decisions are based on the full profile of cardiovascular risk fac... more Cardiovascular risk management decisions are based on the full profile of cardiovascular risk factors.It is important not only the number of cardiovascular risk factors accumulated by a patient but the magnitude of each factor, both being proportional to cardiovascular risk.
The aim of this study was to evaluate the correlation between motor and non-motor symptoms in pat... more The aim of this study was to evaluate the correlation between motor and non-motor symptoms in patients diagnosed with Parkinson. We included in our study 72 patients diagnosed with Parkinson disease:28 female and 44 males. Each patient was evaluated using Non-motor Symptoms Questionnaire for Parkinson Disease, for motor status we used Unified Parkinson Disease Rating Scale (UPDRS) part 3 (motor part). The results of our study indicated that there is a correlation between the non-motor state and the motor symptoms but not in all non-motor domains. The study indicates that the digestive symptoms, the, cardiovascular, sleep and miscellaneous correlate with the motor symptoms but urinary symptoms, memory, hallucination, depression and sexual dysfunction does not show an interdependence with the motor state.
Cardiac affectation is one of the leading causes of death in the world. Rhythmic disorders such a... more Cardiac affectation is one of the leading causes of death in the world. Rhythmic disorders such as ventricular extrasystoles, atrial extrasysoles, atrial fibrillation, atrial flutter represent a major risk factor with a gloomy progression and prognosis. Our goal was to analyze the existing arrhythmia risk in patients with chronic hepatic disease. Being known the alteration of the somatic status of the patient with liver cirrhosis or other chronic liver disease in the presence of comorbid cardiac symptoms, we consider vital to prevent arrhythmia risk in hepatic pathology.
Alcoholism use disorders are very frequent present all over the world. The use of alcohol is resp... more Alcoholism use disorders are very frequent present all over the world. The use of alcohol is responsable for many behavioral symptoms like impulsivity, violence, depressive mood and anxiety. The aim of our research was to find the clinical and the biochemical changes induced by alcohol at the patient with mental illness.
The aim of this study was to evaluate possible correlation between routes of administration of le... more The aim of this study was to evaluate possible correlation between routes of administration of levodopa in patients diagnosed with Parkinson�s disease and the presence of digestive symptoms. We included in this study 31 patients diagnosed with Parkinson�s disease:14 patients were on oral levodopa and 17 patients were on intrajejunal administration of levodopa/carbidopa. Each patient was assessed using Non-motor Symptoms Questionnaire for Parkinson�s Disease regarding the dysfunction of gastrointestinal tract. The results of our study indicated that there is a different distribution of the digestive dysfunction between the two groups of patients. The study indicate that the constipation was more frequent in those patients with oral medication.
Due to the increased frequency of cardiovascular diseases in the evolution of chronic liver disea... more Due to the increased frequency of cardiovascular diseases in the evolution of chronic liver disease, we proposed to assess echocardiographic changes in patients with rhythm disorders associated with chronic liver disease. To analyze the degree of cardiac damage, each patient was subjected to a complete cardiovascular examination.
The prevalance of depression and anxiety is higher at the patients diagnosticated with viral live... more The prevalance of depression and anxiety is higher at the patients diagnosticated with viral liver disease. The corelation between stress and chronic liver disease is a natural, implicit one, but still insufficiently studied. The study has the objective of finding out the clinical and also biochemical correlations between stress and chronic viral diseases. Our research was realised on a group of 78 patients with chronic viral liver disease, who underwent an evaluation of the stress level, both from a subjective point of view and based on concrete methods like questionnaires. The patients were asked to espress their state more or less affected by stress, and, subsequently, they were subjected to a questionnaire that was analyzed, followed by establishing the necessary correlations. Our patients were also evaluated by cardiologicaly, psychologicaly and psyhiatricaly examinations. After the first evaluation we had these results :38 patients (49.19%) consider that they have an average s...
There are limited data regarding factors affecting outcomes among acute coronary syndrome (ACS) p... more There are limited data regarding factors affecting outcomes among acute coronary syndrome (ACS) patients presenting with varying degrees of left ventricle (LV) dysfunction. We aimed to identify factors associated with mortality according to LV ejection fraction (LVEF) at 1st admission in ACS patients. A total of 8983 ACS patients prospectively enrolled in the Acute Coronary Syndrome Israeli Survey (2000-2010) were categorized according to their LVEF at admission: severe LV dysfunction (LVEF < 30% [n = 845]), mild-moderate LV dysfunction (LVEF 30%-49% [n = 4470]); preserved LV function (LVEF ≥ 50% [n = 3659]). Multivariable Cox proportional hazards regression modeling was used to assess the risk factors for 1-year mortality according to LVEF on admission. Over the past decade there was a gradual decline in the proportion of patients admitted with low LVEF. Mortality rates were highest among patients with severe LV dysfunction (36%), intermediate among those with mild-moderate LV dysfunction (10%), and lowest among those with preserved LV function (4%, P < 0.001). We recognized different risk factors for mortality according to LVEF at admission. Admission clinical features (syncope, anterior myocardial infarction, and ST elevation myocardial infarction [STEMI]) predicted mortality risk in patients with severe LV dysfunction (all P < 0.05), whereas the presence of comorbidities (hypertension, diabetes mellitus, chronic renal failure, and peripheral arterial disease) predicted mortality risk in patients with more preserved LV function. Age and admission Killip class ≥II were consistent predictors in all LVEF subsets. LVEF at admission is a strong predictor of mortality in ACS, and prognostic factors differ according to LVEF during admission. In patients with severe LV dysfunction signs of clinical instability are related to 1-year mortality; in patients with a more preserved LV function the prognosis is related to the presence of co-morbidities.
A significant proportion of patients with epilepsy are at an increased risk of cognitive impairme... more A significant proportion of patients with epilepsy are at an increased risk of cognitive impairment. The goal of our study was to assess the cognitive state in elderly patients with idiopathic epilepsy. We studied 48 patients (20 men and 28 women, mean age 71,1± 4,5 years and mean educational level 10,8 ±1 years). They had a duration of the disease at least 6 years and a stable medication for 3 months prior the study. The types of seizures were as follows: 9 of the patients had tonic-clonic seizures, 5 patients had tonic seizures, 3 patients with clonic seizures, 18 patients with simple partial seizures and 13 patients with complex partial seizures. We have also included in our study a control group composed of 52 control subjects with the same range of educational level and age. The controls had no neurological or psychiatric illness, no family history of seizures, no history of medication. To assess the cognitive state we tested the patients using Mini Mental State Examination (MM...
Objective: The purpose of our study was to evaluate the cognitive decline in patients with primit... more Objective: The purpose of our study was to evaluate the cognitive decline in patients with primitive brain tumors. Material and methods: We enrolled in our study 188 patients diagnosed with brain tumors, hospitalized in the Clinic of Neurology Craiova between January 2006 and December 2010. Depending on the origin of the brain tumors the group was divided as follows: • Group A, composed of 45 patients with tumors of the meninges • Group B, composed of 105 patients with neuroepithelial tumors Each patient was evaluated by neurological and neuroimaging exam (computed tomography and/or nuclear magnetic resonance). For the evaluation of global disability we used Karnofsky Performance Status Scale. Cognitive function was assessed using: Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). The results were analyzed by Student’s T test, considering statistically significant p<0,05. Results: Statistical analysis, in terms of the average age and average years of ...
Objective. The aim of our study was to evaluate the cognitive impairment in patients diagnosed wi... more Objective. The aim of our study was to evaluate the cognitive impairment in patients diagnosed with malignant brain tumors. Material and methods. We enrolled in our study 105 patients diagnosed with astrocytomas, hospitalized in the Clinic of Neurology between January 2006 and December 2010. Depending on the histology of the tumor, the study-group was composed of 19 cases diagnosed with diffuse astrocytomas, 13 cases with anaplastic astrocytomas and 73 cases with glioblastomas. Each patient was evaluated by neurological and neuro-imagistic exam (computed tomography and/or nuclear magnetic resonance). Each patient was evaluated in the term of disability using Karnofsky Performance Status, which is a scale commonly used in patients with cancer to quantify functional status. Presurgical cognitive functions of the patients were assessed using Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), The results were analyzed using Student’s T test and Chi-Squared te...
Romanian Journal of Morphology and Embryology, Sep 9, 2022
This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
Evaluation of mild cognitive impairment is important for early management in order to prevent sev... more Evaluation of mild cognitive impairment is important for early management in order to prevent severe dementia. The goal of our study was to assess the cognitive state in patients with ischemic vascular events (first ever stroke or transient ischemic attack).We studied 86 patients who were hospitalized in The Clinic of Neurology from Craiova during the year 2007, for first ever stroke (56 patients) or transient ischemic attack (TIA-32 patients) and also a group composed of 92 control subjects without signs of cerebrovascular disease but with vascular risk factors present. We used for the assessment two scales: Mini Mental State Examination (MMSE) and Cambridge Cognitive Examination (CAMCOG). We made assessment at baseline, after 3 months respectively 6 months. We performed computed tomography in both groups, for a correct diagnosis. At baseline the patient group had a mean MMSE score 27,3 and a mean CAMCOG score 93,9. The control subjects had a mean MMSE score 28,5 and a mean CAMCOG ...
Objective: The aim of the study was to evaluate anxiety in patients with Parkinson's disease.... more Objective: The aim of the study was to evaluate anxiety in patients with Parkinson's disease. Patients and method: We studied a group of 37 non-demented patients with Parkinson's disease, 17 women and 20 men, aged between 50 and 70 years. Sixteen patients were in stage I and 21 patients in stage II of the disease on Hoehn-Yahr Scale. The patients were treated either with dopaminergic agonists or with levo-dopa associated with dopaminergic agonists. To assess the symptoms of anxiety we performed to each patient The Zung Self-Rating Anxiety Scale and The Hamilton Anxiety Rating Scale. For the depressive disorders we also performed The Hamilton Depression Rating Scale. The results were analyzed by Student's Test and Chi-Square Test. Results: Twelve patients (32,4%) had anxiety disorders: generalized anxiety (5 patients), panic attack (2 patients), social fobia (one patient) and unspecified anxiety disorder (4 patients). The association between anxiety and depression was fou...
The goal of our study was to assess the cognitive state in patients with Parkinson's disease ... more The goal of our study was to assess the cognitive state in patients with Parkinson's disease (PD). We studied 58 patients ( 23 men and 35 women, mean age 70,1± 4,5 years and mean educational level 11,9 ±1 years). They were admitted to the Clinic of Neurology from Craiova between March 2007- March 2008 for Parkinson Disease. All the patients met the diagnostic criteria for Parkinson's Disease. In this study we included only patients in stage I and II on Hoehn and Yahr scale. Thirty-two patients were in stage I and 26 patients in stage II. The patients were treated with levo-dopa monotherapy, dopaminergic agonists monotherapy, or levodopa associated with dopaminergic agonists. We have also included in our study a control group composed of 62 control subjects with the same range of educational level and age. To assess the cognitive state we tested the patients using Mini Mental State Examination (MMSE) and the revised version of the Addenbrooke's Cognitive Examination (ACE-...
The purpose of this study is to appreciate if there is an immune response in malignant brain tumo... more The purpose of this study is to appreciate if there is an immune response in malignant brain tumors. Material and methods: Eleven astrocytomas of varying histological features were immunohistologically studied, using a panel of monoclonal antibody against CD20cy to highlight T-lymphocytes, CD3 for B-lymphocytes and CD68 as marker of the macrophages. Ki67 antibody was used as marker of proliferation. We evaluated the presence of these markers in peritumoral stroma and intratumoral tissue. Results: In our study, none of the astrocytic tumors studied showed B-lymphocytes. The presence of T lymphocytes was evidenced in all 11 selected cases. While low-grade astrocytomas showed positive CD3 immunostaining only in tumoral cells, anaplastic astrocytomas and glioblastomas revealed positive immunostaining also in perivascular space. As it was expected, mean values for proliferative marker Ki-67 revealed that there was a significant difference between the indices of low(grade II) and high-gra...
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2018
Meningitis and encephalitis are inflammatory diseases in which acute and chronic inflammatory cel... more Meningitis and encephalitis are inflammatory diseases in which acute and chronic inflammatory cells infiltrate leptomeninges, especially the arachnoid, and migrate through the subarachnoid space and by diapedesis, in order to extend around blood vessels and into the brain parenchyma. To what extent migrated/resident inflammatory cells participate to these interactions, or what are exactly the initial steps by which these cells reach the brain interstitium, it is not yet completely known. Recent years have brought new insights into the description of water flow circuits in the brain, suggesting that the cerebrospinal fluid enters the brain within the perivascular spaces of arteries, while interstitial fluid drains along perivascular venous sector. Moreover, it has been showed that vascular basement membranes have a complex multi-layered architecture that originates with epithelial, endothelial, smooth muscle cells and glial cells, and that the virtual space between these layers might...
The aim of this study was to assess the cognitive decline in patients with Parkinson's disease an... more The aim of this study was to assess the cognitive decline in patients with Parkinson's disease and to study its correlation with their depression. We studied 64 consecutive patients (30 men and 34 women), mean education level 11.2±1 years and mean age 72.3±3.5 years. These patients were admitted to Clinic of Neuropsychiatry Craiova between January 2016 and October 2016. They underwent a neurological and neuropsychological examination at baseline, after 6 months and 12 months later. For the cognitive assessment we used the revised version of the Addenbrooke′s Cognitive Examination (ACE-R) and Montreal Cognitive Assessment (MoCA) and for the evaluation of depression we used Hamilton Depression Rating Scale (HDRS). We have also included in our study a control group composed of 76 control subjects with the same range of educational level and age. All the patients met the diagnostic criteria for Parkinson′s Disease. In this study we included patients in stage I and II on Hoehn and Yahr scale. Twenty-six patients were in stage I and 38 patients in stage II. The patients were treated with levo-dopa monotherapy, dopaminergic agonists monotherapy, or levodopa associated with dopaminergic agonists. At baseline the patients in stage I showed a mean MoCA score 26.8 and a mean ACE-R score 89.6. The patients in stage II had a mean MoCA score 26.5 and a mean ACE-R score 89.4 at baseline. The control subjects showed a mean MoCA score 27.06 and a mean ACE-R score 90.3. One year later the patients group I showed a mean MoCA score 19.8 and 84.7 mean ACE-R score. The groups of patients in stage II had a mean MoCA score 18.3 and ACE-R score 84.2. The control group the mean MoCA values was 22.56 and ACE-R 87.1. Regarding asssessment of depression, we obtained the next scores: at baseline, patients in stage I showed a mean HDRS score of 14.6; the patients in stage II a mean HDRS score 14.8 and the control group a HDRS mean score of 8. One year later group I showed a mean HDRS score of 18.8; the group II 19.9 and the control group 9.7. For the statistical analyse, we used Student test (p<0.05 statistically considerable). The patients with PD showed a greater cognitive impairment and depression than the control subjects. We observed that the patients in stage II Hoehn and Yahr had a greater cognitive decline and depression than patients in stage I. Depression was diagnosed in 40 patients at 6 months and in 56 of the patients at 12 months. The cognitive impairment was higher at 12 months than at 6 months. The depressive patients had more severe cognitive decline than the nondepressive patients.
Levodopa (L-dopa), a precursor of dopamine, remained the gold standard among antiparkinsonian dru... more Levodopa (L-dopa), a precursor of dopamine, remained the gold standard among antiparkinsonian drugs and virtually, in different stages, all patients will require the more powerful symptomatic effect of L-dopa. In addition, continuous Levodopa/Carbidopa intestinal gel (LCIG) infusion therapy, via a percutaneous endoscopic gastrostomy (PEG) and a portable infusion pump, is well established for the treatment of advanced Parkinson�s disease (PD), substantially improving motor symptoms and quality of life in these patients. This study aimed to evaluate the necessity of LCGI depending the PD motor subtypes and age at onset of the disease. Seventy patients diagnosed with PD were included in our study. The Unified Parkinson�s Disease Rating Scale (UPDRS) was performed in on state. The patients were classified as tremor-dominant type (TDT), akinetic-rigid type (ART) and mixed type (MT). Depending on form of levodopa, thirty-six patients were on L-dopa orally and thirty-four patients were on ...
Cardiovascular risk management decisions are based on the full profile of cardiovascular risk fac... more Cardiovascular risk management decisions are based on the full profile of cardiovascular risk factors.It is important not only the number of cardiovascular risk factors accumulated by a patient but the magnitude of each factor, both being proportional to cardiovascular risk.
The aim of this study was to evaluate the correlation between motor and non-motor symptoms in pat... more The aim of this study was to evaluate the correlation between motor and non-motor symptoms in patients diagnosed with Parkinson. We included in our study 72 patients diagnosed with Parkinson disease:28 female and 44 males. Each patient was evaluated using Non-motor Symptoms Questionnaire for Parkinson Disease, for motor status we used Unified Parkinson Disease Rating Scale (UPDRS) part 3 (motor part). The results of our study indicated that there is a correlation between the non-motor state and the motor symptoms but not in all non-motor domains. The study indicates that the digestive symptoms, the, cardiovascular, sleep and miscellaneous correlate with the motor symptoms but urinary symptoms, memory, hallucination, depression and sexual dysfunction does not show an interdependence with the motor state.
Cardiac affectation is one of the leading causes of death in the world. Rhythmic disorders such a... more Cardiac affectation is one of the leading causes of death in the world. Rhythmic disorders such as ventricular extrasystoles, atrial extrasysoles, atrial fibrillation, atrial flutter represent a major risk factor with a gloomy progression and prognosis. Our goal was to analyze the existing arrhythmia risk in patients with chronic hepatic disease. Being known the alteration of the somatic status of the patient with liver cirrhosis or other chronic liver disease in the presence of comorbid cardiac symptoms, we consider vital to prevent arrhythmia risk in hepatic pathology.
Alcoholism use disorders are very frequent present all over the world. The use of alcohol is resp... more Alcoholism use disorders are very frequent present all over the world. The use of alcohol is responsable for many behavioral symptoms like impulsivity, violence, depressive mood and anxiety. The aim of our research was to find the clinical and the biochemical changes induced by alcohol at the patient with mental illness.
The aim of this study was to evaluate possible correlation between routes of administration of le... more The aim of this study was to evaluate possible correlation between routes of administration of levodopa in patients diagnosed with Parkinson�s disease and the presence of digestive symptoms. We included in this study 31 patients diagnosed with Parkinson�s disease:14 patients were on oral levodopa and 17 patients were on intrajejunal administration of levodopa/carbidopa. Each patient was assessed using Non-motor Symptoms Questionnaire for Parkinson�s Disease regarding the dysfunction of gastrointestinal tract. The results of our study indicated that there is a different distribution of the digestive dysfunction between the two groups of patients. The study indicate that the constipation was more frequent in those patients with oral medication.
Due to the increased frequency of cardiovascular diseases in the evolution of chronic liver disea... more Due to the increased frequency of cardiovascular diseases in the evolution of chronic liver disease, we proposed to assess echocardiographic changes in patients with rhythm disorders associated with chronic liver disease. To analyze the degree of cardiac damage, each patient was subjected to a complete cardiovascular examination.
The prevalance of depression and anxiety is higher at the patients diagnosticated with viral live... more The prevalance of depression and anxiety is higher at the patients diagnosticated with viral liver disease. The corelation between stress and chronic liver disease is a natural, implicit one, but still insufficiently studied. The study has the objective of finding out the clinical and also biochemical correlations between stress and chronic viral diseases. Our research was realised on a group of 78 patients with chronic viral liver disease, who underwent an evaluation of the stress level, both from a subjective point of view and based on concrete methods like questionnaires. The patients were asked to espress their state more or less affected by stress, and, subsequently, they were subjected to a questionnaire that was analyzed, followed by establishing the necessary correlations. Our patients were also evaluated by cardiologicaly, psychologicaly and psyhiatricaly examinations. After the first evaluation we had these results :38 patients (49.19%) consider that they have an average s...
There are limited data regarding factors affecting outcomes among acute coronary syndrome (ACS) p... more There are limited data regarding factors affecting outcomes among acute coronary syndrome (ACS) patients presenting with varying degrees of left ventricle (LV) dysfunction. We aimed to identify factors associated with mortality according to LV ejection fraction (LVEF) at 1st admission in ACS patients. A total of 8983 ACS patients prospectively enrolled in the Acute Coronary Syndrome Israeli Survey (2000-2010) were categorized according to their LVEF at admission: severe LV dysfunction (LVEF < 30% [n = 845]), mild-moderate LV dysfunction (LVEF 30%-49% [n = 4470]); preserved LV function (LVEF ≥ 50% [n = 3659]). Multivariable Cox proportional hazards regression modeling was used to assess the risk factors for 1-year mortality according to LVEF on admission. Over the past decade there was a gradual decline in the proportion of patients admitted with low LVEF. Mortality rates were highest among patients with severe LV dysfunction (36%), intermediate among those with mild-moderate LV dysfunction (10%), and lowest among those with preserved LV function (4%, P < 0.001). We recognized different risk factors for mortality according to LVEF at admission. Admission clinical features (syncope, anterior myocardial infarction, and ST elevation myocardial infarction [STEMI]) predicted mortality risk in patients with severe LV dysfunction (all P < 0.05), whereas the presence of comorbidities (hypertension, diabetes mellitus, chronic renal failure, and peripheral arterial disease) predicted mortality risk in patients with more preserved LV function. Age and admission Killip class ≥II were consistent predictors in all LVEF subsets. LVEF at admission is a strong predictor of mortality in ACS, and prognostic factors differ according to LVEF during admission. In patients with severe LV dysfunction signs of clinical instability are related to 1-year mortality; in patients with a more preserved LV function the prognosis is related to the presence of co-morbidities.
A significant proportion of patients with epilepsy are at an increased risk of cognitive impairme... more A significant proportion of patients with epilepsy are at an increased risk of cognitive impairment. The goal of our study was to assess the cognitive state in elderly patients with idiopathic epilepsy. We studied 48 patients (20 men and 28 women, mean age 71,1± 4,5 years and mean educational level 10,8 ±1 years). They had a duration of the disease at least 6 years and a stable medication for 3 months prior the study. The types of seizures were as follows: 9 of the patients had tonic-clonic seizures, 5 patients had tonic seizures, 3 patients with clonic seizures, 18 patients with simple partial seizures and 13 patients with complex partial seizures. We have also included in our study a control group composed of 52 control subjects with the same range of educational level and age. The controls had no neurological or psychiatric illness, no family history of seizures, no history of medication. To assess the cognitive state we tested the patients using Mini Mental State Examination (MM...
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