Papers by Giuseppe Sileno
Supplemental material, Supplementary_material_version_4_1 for Smart Flow for the evaluation of th... more Supplemental material, Supplementary_material_version_4_1 for Smart Flow for the evaluation of the hemodialysis arteriovenous fistula by Marco Colucci, Massimo Torreggiani, Irene Bernardi, Simone Stangalino, Davide Catucci, Vittoria Esposito, Giuseppe Sileno and Ciro Esposito in The Journal of Vascular Access
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Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 2016
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Journal of Nephrology, 2021
A 61-year-old caucasian male patient undergoing peritoneal dialysis, contacted our Centre, fright... more A 61-year-old caucasian male patient undergoing peritoneal dialysis, contacted our Centre, frightened about the appearance of cloudy peritoneal effluent. His medical history was significant for chronic kidney disease secondary to AL systemic amyloidosis, ischemic heart disease, hypertension, dyslipidaemia. On admission the peritoneal fluid was markedly cloudy and yellowish (Fig. 1a). The patient reported no change in the peritoneal ultrafiltration. A stick of the effluent fluid was negative for leukocytes (Fig. 1b) and white cell count on peritoneal effluent showed 30 cells/ mmc. Peritoneal effluent and catheter exite site cultures and lab tests were performed. Even though the clinical suspicion of peritonitis was low, we eventually loaded the patient with a 2000 ml dwell cointaining glucose 1.36% heparin 2000 IU, gentamicin 16 mg and cefazolin 1000 mg. The results of the exams (Table 1) were all negative. During the medical examination the patient revealed that due to poor blood pr...
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Nephrology Dialysis Transplantation
Background and Aims Generalized edema, non responsive to oral diuretics, is one of the main cause... more Background and Aims Generalized edema, non responsive to oral diuretics, is one of the main causes of hospital admission for nephrotic syndrome patients. Although hospital length of stay (LOS) may vary widely, in 2017 the average LOS in acute-care hospitals was lower than 8 days in OECD countries. The aim of the present study was to determine the factors commonly associated with a longer LOS in patients admitted for edema due to nephrotic syndrome in the Nephrology Unit of ICS Maugeri, Pavia, Italy Method In this retrospective study we reviewed the medical records of all patients admitted for nephrotic syndrome between 2012-2020 in the Nephrology Unit of ICS Maugeri. Inclusion criteria were the following: age between 18-85 years of age; severe edema non responsive to oral, low dose diuretics; patients with heart failure, serum creatinine > 3.5 g/dl or on dialysis treatment were excluded from the study. Patients were divided into two groups according to the length of stay: ≤ 7 day...
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Kidney and Dialysis
The arteriovenous fistula (AVF) has long been considered the optimal vascular access. However, th... more The arteriovenous fistula (AVF) has long been considered the optimal vascular access. However, the evolving characteristics of the ageing dialysis population limit the creation of an AVF in all patients. Thus, more patients start hemodialysis (HD) with a central venous catheter (CVC) rather than an AVF, and the supremacy of the AVF has recently been questioned. The aim of this study was to analyze the incidence and rate of access complications in 100 patients between 2010 and 2015. A total of 63 patients started HD with an AVF, while 37 began HD with a CVC. We found no differences in patient survival according to the vascular access in use at the beginning of dialysis, but patients were more likely to die while undergoing dialysis by means of a CVC than an AVF. Patients started on dialysis with a CVC had more cardiovascular disease, while patients who began dialysis with an AVF presented more hypertension. Fistulas presented a longer survival time despite more hospital admissions, b...
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Kidney and Blood Pressure Research
Introduction: Living donor kidney transplant (LDKT) is one of the best therapeutic options for en... more Introduction: Living donor kidney transplant (LDKT) is one of the best therapeutic options for end-stage kidney disease (ESKD). Guidelines identify different estimated glomerular filtration rate (eGFR) thresholds to determine the eligibility of donors. The aim of our study was to evaluate whether pretransplant donor eGFR was associated with kidney function in the recipient. Methods: We retrospectively studied LDKT recipients who received a kidney graft between September 1, 2005, and June 30, 2016 in the same transplant center in France and that had eGFR data available at 3, 12, 24, and 36 months posttransplant. Results: We studied 90 donor-recipient pairs. The average age at time of transplant was 51.47 ± 10.95 for donors and 43.04 ± 13.52 years for recipients. Donors’ average eGFR was 91.99 ± 15.37 mL/min/1.73 m2. Donor’s age and eGFR were significantly correlated (p < 0.0001, r2 0.023). Donor’s age and eGFR significantly correlated with recipient’s eGFR at 3, 12, and 24 months ...
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Kidney International Reports
Introduction Patients on dialysis (HDP) are a category at high risk from COVID-19 and thus a high... more Introduction Patients on dialysis (HDP) are a category at high risk from COVID-19 and thus a high-priority group for vaccination. COVID-19 vaccine hesitancy has been a concern since the availability of the first vaccine. The objective of this study was to determine hesitancy rates and factors associated with hesitancy towards COVID-19 vaccination in HDP. Methods HDP were surveyed with an ad hoc questionnaire in four large dialysis facilities in Europe: Le Mans and Paris, in France, Cagliari and Pavia, in Italy. The questionnaire explored different domains associated with vaccine hesitancy, such as perception of disease severity, sources of information about the vaccine and the disease, and confidence in the healthcare system. Results 417 patients (average age 69, 60% men) agreed to answer the questionnaire. Hesitancy was associated with younger age (p 0.003), lower perception of disease severity (<0.001) and vaccine efficacy (p<0.001), lower trust in vaccination (p<0.001) and in the healthcare system and scientists (p<0.001) in the univariate analysis. In the multivariate models, concerns about side effects (p 0.004) and vaccine efficacy (<0.001) and living in France (p 0.04) remained associated with higher vaccine hesitancy, while having received an influenza vaccine (p 0.032) and trusting scientists (p 0.032) were associated with a more positive attitude towards vaccination. Conclusions HDP have a good understanding of the risks associated with COVID-19. Vaccine hesitancy was not associated with educational level, age or gender but rather with lack of confidence in vaccine efficacy and concerns about safety. HDP were quite skeptical about the healthcare system but generally trusted scientists.
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Giornale di Clinica Nefrologica e Dialisi
L'iperbilirubinemia severa si associa spesso al danno renale acuto (AKI), soprattutto in pazi... more L'iperbilirubinemia severa si associa spesso al danno renale acuto (AKI), soprattutto in pazienti con livelli di bilirubinemia pari a 20–25 mg/dL. Considerando la potenziale tossicità renale della bilirubina, è possibile che la rimozione di tale sostanza dal plasma rappresenti un modo per migliorare la funzione renale nei pazienti con AKI associato a iperbilirubinemia. Qui presentiamo il caso di un uomo di 47 anni, ricoverato per ittero ingravescente e ascite. All'anamnesi il paziente presentava una mielofibrosi idiopatica, associata a epatopatia con valori di bilirubina stabili intorno ai 4 mg/dL. Al momento del ricovero, la bilirubinemia era pari a 45 mg/dL, con valori di creatininemia di 2.1 mg (valore precedente 0.7 mg/dL). La biopsia epatica mostrava un quadro di severa colangite linfogranulocitaria. Per il peggioramento del quadro ematochimico (bilirubinemia 59.7 mg/dL e creatininemia 4 mg/dL), una volta escluse cause funzionali di insufficienza renale e la sindrome ep...
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Journal of Nephrology
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Nephrology Dialysis Transplantation
Background and Aims The WHO has defined type II Diabetes Mellitus (DMII) as an epidemic disease. ... more Background and Aims The WHO has defined type II Diabetes Mellitus (DMII) as an epidemic disease. Indeed worldwide, diabetic patients are estimated to be 400 millions and this number is bound to grow in the next decades 1.Diabetic nephropathy (DN) develops in 20-40% of patients with DM 2.It is a condition generally characterized by presence of proteinuria and leads to a progressive reduction in kidney function and ultimately to End Stage Renal Disease (ESRD). Although DN represents a frequent complication in patients with DM it is well known that diabetic patients may develop kidney disease due to any other cause. Several studies have shown that about 30% of diabetic patients undergoing a kidney biopsy will be diagnosed with a non diabetic renal disease ( NDRD) 3.This suggests the importance of kidney biopsy in patients with DM.. Aim of our study was to evaluate the frequency of NDRD in our population, to identify pre-existing clinical or humoral parameters in patients with histologi...
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Nephrology Dialysis Transplantation
Background and Aims Potassium (K) is mostly an intracellular ion, with a complex homeostasis that... more Background and Aims Potassium (K) is mostly an intracellular ion, with a complex homeostasis that is deeply modified in ESRD patients undergoing hemodialysis (HD). Several factors (diet, insulin, acid-base balance, aldosterone, etc) may contribute to determine the level of serum extracellular K, but it is not clear which factor contributes the most. We aimed to evaluate the importance of several factors in inducing hyperkalemia in HD patients. Methods Chronic tri-weekly HD patients were evaluated. Patients on diuretics or on potassium binders were excluded. For every patient we recorded age, sex, Kt/V and we measured the post-HD kalemia on the day before the long interHD interval. On the day after the long interHD interval we evaluated: pre-HD K, glucose, creatinine, aldosterone, LDH, CPK, arterial blood gases, ECG, overhydration by bioelectrical impedance analysis, body weight increase after the long interHD interval and daily urinary output. K amount introduced by diet was calcula...
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The Journal of Vascular Access
Background: Smart Flow is an innovative tool available on the Carestream Touch Prime Ultrasound m... more Background: Smart Flow is an innovative tool available on the Carestream Touch Prime Ultrasound machines, which provides automated blood flow measurement and shows the vectors that form the blood flow in the vessel. We compared the use of Smart Flow with traditional Duplex Doppler Ultrasound to evaluate blood flow of arteriovenous fistulas in prevalent hemodialysis patients. Methods: A total of 31 chronic patients on hemodialysis were enrolled. Blood flow was measured on the brachial artery with Smart Flow and duplex Doppler ultrasound. In a subset of 26 patients, a video of the juxta-anastomotic efferent vein was recorded and analyzed to calculate an index of flow turbulence. Results: We enrolled 21 males and 10 females aged 68.52 ± 11.64 years at the time of evaluation with an average arteriovenous fistulas vintage of 50.23 ± 47.42 months and followed them up for 18.03 ± 5.18 months. Smart Flow and Duplex Doppler Ultrasound blood flow measurements positively correlated (p
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Nephrology Dialysis Transplantation
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Nephrology Dialysis Transplantation
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Nephrology Dialysis Transplantation
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Nephrology Dialysis Transplantation, 2013
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The Living Library …, 2005
... Bang, Erzsébet Bánki, Barbara Bártfai, Claudia Belchior, Diego Belford de Henriques, Mercedes... more ... Bang, Erzsébet Bánki, Barbara Bártfai, Claudia Belchior, Diego Belford de Henriques, Mercedes Berencz, Ågot Berger, Rok Bermez, Jean-Philippe Bozouls, Goran Buldioski, Manuel Comeron, Katalin Csörsz, Péter Csörsz, Réka Daróczy, Tamás Dujmov, Christoffer Saabye ...
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NDT …, 2011
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Nephrology Dialysis Transplantation, May 1, 2018
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Nephrology Dialysis Transplantation, 2015
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Papers by Giuseppe Sileno