Background The human immunodeficiency virus (HIV) is a neurotropic virus and one of its known eff... more Background The human immunodeficiency virus (HIV) is a neurotropic virus and one of its known effects on the nervous system is HIV Associated Neurocognitive Disorder (HAND). Method This was a cross-sectional prospective study carried out in a tertiary hospital in Southeastern Nigeria using a neuropsychological test battery drawn from the World Health Organization/University of California, Los Angeles test battery (WHO/UCLA). The performance of ninety-two HIV positive patients, divided into thirty-eight combined antiretroviral therapy (cART) experienced and fifty-four cART naïve patients, was compared with those of ninety-two HIV negative subjects. Sociodemographic data was collected from both arms and neuropsychological testing administered. The HIV positive patients also had blood samples collected for parked cell volume (PCV), CD4 count and HIV RNA viral load. The raw scores of the HIV positive patients were converted to standardized Z scores using the mean and standard deviation ...
Background The human immunodeficiency virus (HIV) is a neurotropic virus and one of its known eff... more Background The human immunodeficiency virus (HIV) is a neurotropic virus and one of its known effects on the nervous system is HIV Associated Neurocognitive Disorder (HAND). Method This was a cross-sectional prospective study carried out in a tertiary hospital in Southeastern Nigeria using a neuropsychological test battery drawn from the World Health Organization/University of California, Los Angeles test battery (WHO/UCLA). The performance of ninety-two HIV positive patients, divided into thirty-eight combined antiretroviral therapy (cART) experienced and fifty-four cART naïve patients, was compared with those of ninety-two HIV negative subjects. Sociodemographic data was collected from both arms and neuropsychological testing administered. The HIV positive patients also had blood samples collected for parked cell volume (PCV), CD4 count and HIV RNA viral load. The raw scores of the HIV positive patients were converted to standardized Z scores using the mean and standard deviation ...
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