Papers by Jeison Oliveira
Brazilian Journal of Development, 2021
O uso de plantas medicinais como alternativa terapêutica é tão antigo quanto a própria existência... more O uso de plantas medicinais como alternativa terapêutica é tão antigo quanto a própria existência humana. Desta maneira, a procura por famílias de plantas que apresentam atividades biológicas frente as patologias sendo uma alternativa para as pesquisas farmacológicas. Nesta gama de famílias de plantas podemos destacar o gênero Maytenus, que apresenta uma diversidade de aplicações biológicas com fins terapêuticos, inclusive propriedades antimicrobiana e antiparasitária. Assim, o objetivo desse trabalho foi realizar uma triagem nos depósitos de patentes sobre a ação antiparasitária até o momento. Para isso, a prospecção foi realizada no Escritório
Copyright © 2014 Jeison Saturnino-Oliveira et al. This is an open access article distributed unde... more Copyright © 2014 Jeison Saturnino-Oliveira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Snakebites are a public health problem, especially in tropical countries.However, treatmentwith antivenomhas limited effectiveness against venoms ’ local effects. Here, we investigated the ability of Abarema cochliacarpos hydroethanolic extract (EAc) to protect
O ofidismo e um problema de saude publica no mundo, especialmente nos paises tropicais. O objetiv... more O ofidismo e um problema de saude publica no mundo, especialmente nos paises tropicais. O objetivo deste trabalho foi investigar os mecanismos envolvidos no efeito do extrato hidroetanolico da entrecasca da Abarema cochliacarpos (EAc) na lesao muscular induzida pelo veneno de Bothrops leucurus . Foram utilizados camundongos Swiss machos (28-32 g; n=6 por grupo), que receberam injecao perimuscular do veneno Bothrops leucurus (BlV – 1 mg/Kg/pata – Volume 50 μl) no membro posterior direito e foram tratados por via oral (v.o.) com veiculo (solucao salina) ou EAc (100, 200 ou 400 mg/kg). Na hipernocicepcao mecânica, os animais foram avaliados nos tempos 2, 4 e 6 horas, utilizando o analgesimetro digital (Von Frey). Na atividade edematogenica, os animais foram avaliados nos tempos 15, 30, 60 e 90 minutos, utilizando o paquimetro digital. Ja atividade motora foi analisada pelo teste de rota-rod e os animais foram avaliados em 1, 3 e 7 dias. Na avaliacao histologica, o musculo Extensor digi...
A utilizacao de novas metodologias que fomentem o aprendizado deve ser parte integrante no proces... more A utilizacao de novas metodologias que fomentem o aprendizado deve ser parte integrante no processo de ensino-aprendizagem. Desta forma, a radiogra a e um importante recurso a ser utilizado no ensino da Anatomia Humana. Este projeto busca ampliar as ferramentas pedagogicas utilizadas no ensino das disciplinas de Anatomia Humana do Departamento de Morfologia CCBS/UFS. Coletamos as radiogra as provenientes do Hospital Universitario-UFS, que, depois de catalogadas e separadas por segmentos anatomicos, foram classificadas em patologicas ou normais. O acervo possui 1.080 lmes. Destes, 11,94% sao provenientes de criancas e/ou adolescentes e 79,91% de adultos. As radiogra as que apresentavam algum tipo de patologia representam 8,2% do total, sendo pe/tornozelo (37,5%), joelho e lombar (ambos 15,9%) os segmentos mais afetados. O projeto abrange cerca de 2.360 alunos/ano, cujas radiogra as poderao ser utilizadas por sete disciplinas da area de Anatomia Humana, demonstrando a relevância do de...
O Estudo de Anatomia Simples e Dinâmico 3, Sep 25, 2019
O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilida... more O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Conselho Editorial Ciências Humanas e Sociais Aplicadas O Estudo de Anatomia Simples e Dinâmico 3 Capítulo 1
O ofidismo e um problema de saude publica em todo o mundo, especialmente nos paises tropicais. O ... more O ofidismo e um problema de saude publica em todo o mundo, especialmente nos paises tropicais. O objetivo deste trabalho foi de investigar os mecanismos envolvidos no efeito do extrato hidroetanolico da entrecasca da Abarema cochliacarpos (EAc) (popularmente conhecida como gbarbatimao h) na lesao muscular induzida pelo veneno de Bothrops leucurus (BlV). Foram utilizados camundongos Swiss machos (28-32 g; n=6 por grupo), que receberam injecao perimuscular do veneno Bothrops leucurus (BlV . 1 mg/Kg/pata . Volume 50 El) no membro posterior direito, tratados por via oral (v.o.), com veiculo (solucao salina) ou EAc (100, 200 ou 400 mg/kg). Na hipernocicepcao mecanica os animais foram avaliados nos tempos 2, 4 e 6 horas, utilizando o analgesimetro digital (Von Frey). Na atividade edematogenica os animais foram avaliados nos tempos 15, 30, 60 e 90 minutos, utilizando o paquimetro digital. Ja atividade motora foi avaliada pelo teste de rota-rod e os animais foram avaliados em 1, 3 e 7 dias....
Brazilian Journal of Development
Revista De Educacao Continuada Em Medicina Veterinaria E Zootecnia, 2014
Revista Brasileira de Farmacognosia, 2015
Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species i... more Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly used plant species in Sergipe to treat oral and gastrointestinal pain and inflammation. The aim of the present study was to analyze the relation between periodontitis and changes in the corporal mass and alveolar bone structure after induction of experimental periodontal disease in rat treated or not treated with H. pectinata gel at 5% (GS5%) and 10% (GS10%), comparing their effects with doxycycline gel at 10% (D10%, positive control), vehicle gel (negative control) and a group with experimental periodontal disease, but non-treated. The gels were locally applied in the gingival region immediately after the experimental periodontal disease induction by ligature (3×/day, 11 days). Bone destruction was determined through clinical exam, histopathological analysis and cone beam computed tomography of the experimental animals (n = 36). After 11 days of periodontitis induction, all groups that received ligature presented a decrease in the corporal mass, except to the naïve group (without experimental periodontal disease) (p < 0.05). Computed tomography results have shown healthy bone structure in the group I and bone resorption for the test groups. Histopathological analysis confirmed the healthy bone structure for naïve group animals, while the test groups exhibited bone loss in several degrees. In particular, the non-treated group animals had an intense inflammatory process. When the periodontium of the animals treated with GS10% was histopathologically analyzed, insertion periodontium was preserved. The results for these groups were significantly different of the vehicle group (p < 0.05). According to the results, the gel based in the aqueous extract of H. pectinata at 10% can prevent bone loss in experimental periodontal disease similarly to doxycycline 10%.
Revista Gestão, Inovação e Tecnologias, 2014
The snakebite is a public health problem worldwide, especially in tropical countries. The snake b... more The snakebite is a public health problem worldwide, especially in tropical countries. The snake bite mainly causes tissue damage, with edema, hemorrhage and necrosis that may progress to complete degeneration of the affected muscle. His only treatment recognized by the World Health Organization (WHO) is the antivenom and is not always satisfactory, and can generate systemic side effects. Characterized by a concern for global public health, several studies have been conducted in the search for new treatment alternatives, among which are medicinal plants. Thus, the objective was to survey the research has developed and patented results, evaluating the uses of medicinal plants in the treatment of snakebite. The survey was conducted in the European Patent Office, the World Intellectual Property Organization, the Derwent World Patents Index and Database of the National Institute of Industrial Property of Brazil. The international classification A61K and this prospect was among the depositors are the World Intellectual Property Organization and China. We observed a reduced number of patents for snake bite treatment in the period 2003-2013, presenting an opportunity to be exploited in the area of technological innovation.
We studied the effect of pulsed ultrasound therapy (UST) and antibothropic polyvalent antivenom (... more We studied the effect of pulsed ultrasound therapy (UST) and antibothropic polyvalent antivenom (PAV) on the regeneration of mouse extensor digitorum longus muscle following damage by Bothrops jararacussu venom. Animals (Swiss male and female mice weighing 25.0 ± 5.0 g; 5 animals per group) received a perimuscular injection of venom (1 mg/kg) and treatment with UST was started 1 h later (1 min/day, 3 MHz, 0.3 W/cm 2 , pulsed mode). Three and 28 days after injection, muscles were dissected and processed for light microscopy. The venom caused complete degeneration of muscle fibers. UST alone and combined with PAV (1.0 mL/kg) partially protected these fibers, whereas muscles receiving no treatment showed disorganized fascicules and fibers with reduced diameter. Treatment with UST and PAV decreased the effects of the venom on creatine kinase content and motor activity (approximately 75 and 48%, respectively). Sonication of the venom solution immediately before application decreased the in vivo and ex vivo myotoxic activities (approximately 60 and 50%, respectively). The present data show that UST counteracts some effects of B. jararacussu venom, causing structural and functional improvement of the regenerated muscle after venom injury.
BioMed Research International, 2014
Snakebites are a public health problem, especially in tropical countries. However, treatment with... more Snakebites are a public health problem, especially in tropical countries. However, treatment with antivenom has limited effectiveness against venoms’ local effects. Here, we investigated the ability ofAbarema cochliacarposhydroethanolic extract (EAc) to protect mice against injection ofBothrops leucurusvenom. Swiss mice received perimuscular venom injection and were subsequently treated orally with EAc in different doses. Treatment with EAc 100, 200, and 400 mg/kg reduced the edema induced byB. leucurusin 1%, 13%, and 39%, respectively. Although lower doses showed no antihypernociceptive effect in the Von Frey test, the higher dose significantly reduced hyperalgesia induced by the venom. Antimyotoxic activity of EAc was also observed by microscopy assessment, with treated muscles presenting preserved structures, decreased edema, and inflammatory infiltrate as compared to untreated ones. Finally, on the rotarod test, the treated mice showed better motor function, once muscle fibers w...
Toxicon, 2008
We investigated the myotoxicity of Bothrops jararacussu crude venom and other cytolytic agents on... more We investigated the myotoxicity of Bothrops jararacussu crude venom and other cytolytic agents on mouse isolated extensor digitorum longus (EDL) and soleus (SOL) muscles, which present distinct properties: EDL is a fast-twitch, white muscle with predominantly glycolytic fibers, while SOL is slow-twitch, red muscle with predominantly oxidative fibers. Muscles were exposed to B. jararacussu crude venom (25 mg/ml) and other crotaline venoms (Agkistrodon contortrix laticinctus; Crotalus viridis viridis; Crotalus durissus terrificus) at the same concentration. Basal creatine kinase (CK) release to bathing solution was 0.43 AE 0.06 for EDL and 0.29 AE 0.06 for SOL (U g À1 h À1 , n ¼ 36 for each muscle). Sixty minutes after exposure to B. jararacussu venom, EDL presented higher increase in the rate of CK release than SOL, respectively, 13.2 AE 1.5 and 2.9 AE 0.7 U g À1 h À1 , n ¼ 10-12. Muscle denervation, despite decreasing CK content, did not affect sensitivities to B. jararacussu venom. Ouabain and potassium channel blockers (TEA; clotrimazole; glibenclamide) increased the rate of CK release by B. jararacussu in EDL and SOL muscles, decreasing and almost abolishing the different sensitivity. When we exposed EDL or SOL muscles to Naja naja, Apis mellifera venoms (25 mg/ml), or Triton X-100 (0.01%), they showed similar rate of CK release. Our present data suggest that a mechanism involving intracellular calcium regulation or potassium channels may participate in the different sensitivity of EDL and SOL to B. jararacussu venom.
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Papers by Jeison Oliveira