The Green Deal aims at transforming the European economy for safer and more sustainable chemicals... more The Green Deal aims at transforming the European economy for safer and more sustainable chemicals, materials, processes and products. The goal is to encourage technological progress, while maximizing health and environmental protection as part of an ambitious approach to tackle pollution from all sources and move towards a toxic-free environment. To be able to fulfil these policy ambitions, the Chemicals Strategy for Sustainability and the Zero Pollution Action Plan describe the need for a paradigm shift towards prevention-based risk governance via a transition towards safe-and-sustainable-by-design (SSbD). The SSbD approach pro-actively ensures that safety, functionality and sustainability are embedded in the early design stages of new chemicals, materials and products. This is opposed to the current regulatory paradigm that retroactively imposes measures to mitigate risks/impacts once the products are already on the market. The complexity of advanced materials, their enabling nature, as well as the roles of the different stakeholders involved in the risk governance process result in significant difficulties to define any trade-offs among safety, functionality and sustainability when it comes to developing and regulating new materials and products. Defining metrics of these fundamental aspects and integrating them for decision making cannot be a technocratic taskit should be a co-creative process that involves key actors along entire supply chains of production and downstream use and balances the perspectives of stakeholders from industry, regulation and policy. The establishment of such an ecosystem of actors and the application of approaches from decision science as well as digital tools can provide a significant contribution towards the practical operationalization of SSbD and can support the ongoing policy transition towards preventionbased risk governance of chemicals and advanced materials. Sustainability spotlight The new generations of chemicals and advanced materials present unprecedented opportunities but also pose complex environmental, health and safety risks as well as challenges to ensure environmental, social and economic sustainability. The adequate management of these risks/challenges requires a paradigm shi towards Safe and Sustainable by Design (SSbD) systems approach that integrates technical data on safety, functionality, and sustainability with decision makers' trade-offs already in the early R&D stages of innovation. Dening metrics of these fundamental aspects and integrating them into a multi-criteria decision analysis model is one way to support the development of safer and more sustainable technologies in line with the United Nations sustainable development goals (
Climate scenarios produce climate change-related information and data at a geographical scale gen... more Climate scenarios produce climate change-related information and data at a geographical scale generally not useful for coastal planners to study impacts locally. To provide a suitable characterization of climate-related hazards in the North Adriatic Sea coast, a model chain, with progressively higher resolution was developed and implemented. It includes Global and Regional Circulation Models representing atmospheric and oceanic dynamics for the global and sub-continental domains, and hydrodynamic/wave models useful to analyze physical impacts of sea-level rise and coastal erosion at a sub-national/local scale. The model chain, integrating multiple types of numerical models running at different spatial scales, provides information about spatial and temporal patterns of relevant hazard metrics (e.g., sea temperature, atmospheric pressure, wave height), usable to represent climate-induced events causing potential environmental or socio-economic damages. Furthermore, it allows the discu...
The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices... more The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic procedures to address a wide range of diseases. However, the successful translation of these technologies from their inception (proof-of-concept) to clinical practice has been challenged by substantial gaps in the scientific and technical capacity of R&D companies, especially SMEs, to keep up with the ever-evolving regulatory expectations in the emerging area of nanomedicine. To address these challenges, the EU Horizon 2020 project REFINE has developed a Decision Support System (DSS) to support developers of nanotechnology-enabled health products in bringing their products to the clinic. The REFINE DSS has been developed to support experts, innovators and regulators in the implementation of Intelligent Testing Strategies (ITS) for efficient preclinical assessment of...
Parole chiave: gas serra, cambiamento climatico, fattori di emissione, inventari delle emissioni,... more Parole chiave: gas serra, cambiamento climatico, fattori di emissione, inventari delle emissioni, università.
This manuscript describes an innovative approach to socio-economic assessment of (advanced) engin... more This manuscript describes an innovative approach to socio-economic assessment of (advanced) engineered nanomaterials and nano-enabled products (NEPs) to support safe-and-sustainable-by-design (SSbD) decision making by industries in the early stages of product development. This semi-quantitative methodology is based on a sound conceptual framework grounded in the combination of social life cycle analysis and multi-criteria decision analysis methods and supports decision making based upon socio-economic impacts assessed over the full life cycle of a product. To facilitate its application by industries, the methodology was implemented as an Excel-based self-assessment tool. This easy-to-use, cost- and time-efficient tool can guide users through their SSbD decision making regarding newly developed nanomaterials and NEPs and can also be applied to re-evaluate existing materials and NEPs in order to improve their sustainability from a socio-economic perspective. The relatively low require...
The manuscript did undergo copyediting, typesetting, and review of the resulting proof before it ... more The manuscript did undergo copyediting, typesetting, and review of the resulting proof before it was published in its final form.
Sustainable remediation guidance, frameworks, and case studies have been published at an internat... more Sustainable remediation guidance, frameworks, and case studies have been published at an international level illustrating established sustainability assessment methodologies and successful implementation. Though the terminology and indicators evaluated may differ, one common theme among international organizations and regulatory bodies is more comprehensive and transparent methods are needed to evaluate the social sphere of sustainable remediation. Based on a literature review and stakeholder input, this paper focused on three main areas: (1) status quo of how the social element of sustainable remediation is assessed among various countries and organizations; (2) methodologies to quantitatively and qualitatively evaluate societal impacts; and (3) findings from this research, including challenges, obstacles, and a path forward. In conclusion, several existing social impact assessment techniques are readily available for use by the remediation community, including rating and scoring system evaluations, enhanced cost benefit analysis, surveys/interviews, social network analysis, and multicriteria decision analysis. In addition, a list of 10 main social indicator categories were developed: health and safety, economic stimulation, stakeholder collaboration, benefits community at large, alleviate undesirable community impacts, equality issues, value of ecosystem services and natural resources, risk-based land management and remedial solutions, regional and global societal impacts, and contributions to other policies. Evaluation of the social element of remedial activities is not without challenges and knowledge gaps. Identification of obstacles and gaps during the project planning process is essential to defining sustainability objectives and choosing the appropriate tool and methodology to conduct an assessment. Challenges identified include meaningful stakeholder engagement, risk perception of stakeholders, and trade-offs among the various triple bottom line dimensions. c⃝ 2015 Wiley Periodicals, Inc.
In the last decade, the regeneration of derelict or underused sites, fully or partly located in u... more In the last decade, the regeneration of derelict or underused sites, fully or partly located in urban areas (or so called "brownfields"), has become more common, since free developable land (or so called "greenfields") has more and more become a scare and, hence, more expensive resource, especially in densely populated areas. Although the regeneration of brownfield sites can offer development potentials, the complexity of these sites requires considerable efforts to successfully complete their revitalization projects and the proper selection of promising sites is a pre-requisite to efficiently allocate the limited financial resources. The identification and analysis of success factors for brownfield sites regeneration can support investors and decision makers in selecting those sites which are the most advantageous for successful regeneration. The objective of this paper is to present the Timbre Brownfield Prioritization Tool (TBPT), developed as a web-based solu...
The Timbre project entitled "An Integrated Framework of Methods, Technologies, Tools and Pol... more The Timbre project entitled "An Integrated Framework of Methods, Technologies, Tools and Policies for Improvement of Brownfield Regeneration in Europe" takes as its point of departure the observation that current success in brownfield regeneration is less than satisfying. Although many technologies for site clean-up as well as tools to support decision makin g processes are available within the European Union, they are only rarely applied using their full potential. In order to address this predicament, the project aims to overcome existing barriers to brownfield regeneration by developing and providing customised problem- and target-oriented packages of approaches, technologies and tools. The solution provided by Timbre is, thus, to provide a customisable toolbox specifically addressing the diverse processes that have to be dealt with during the course of a regeneration project. In this way, end-users will be enabled to find the best practice-based solutions according to ...
This TIMBRE project deliverable report (full title: “Results of demonstration studies, outreach m... more This TIMBRE project deliverable report (full title: “Results of demonstration studies, outreach material (brochure, extended documentation, online presentation, cartographic outputs); Targeted dissemination of the outcomes and public relations (PR) by providing applicable brochures, documentations, websites and cartographic outputs for the end users”) describes the process of testing and tailoring the web-based prioritization tool for the user-friendly assessment and classification of brownfield sites, which is available at the following internet address http://www.timbre-project.eu/prioritization-tool.html This report, which is based on efforts both by WP3 partners and by many other different stakeholders outside the research consortium, is divided into the following chapters: - Methods of testing and tailoring the web-based prioritization tool – this chapter briefly describes the methods used for testing and tailoring the pilot version of the web-based prioritization tool - Result...
The Green Deal aims at transforming the European economy for safer and more sustainable chemicals... more The Green Deal aims at transforming the European economy for safer and more sustainable chemicals, materials, processes and products. The goal is to encourage technological progress, while maximizing health and environmental protection as part of an ambitious approach to tackle pollution from all sources and move towards a toxic-free environment. To be able to fulfil these policy ambitions, the Chemicals Strategy for Sustainability and the Zero Pollution Action Plan describe the need for a paradigm shift towards prevention-based risk governance via a transition towards safe-and-sustainable-by-design (SSbD). The SSbD approach pro-actively ensures that safety, functionality and sustainability are embedded in the early design stages of new chemicals, materials and products. This is opposed to the current regulatory paradigm that retroactively imposes measures to mitigate risks/impacts once the products are already on the market. The complexity of advanced materials, their enabling nature, as well as the roles of the different stakeholders involved in the risk governance process result in significant difficulties to define any trade-offs among safety, functionality and sustainability when it comes to developing and regulating new materials and products. Defining metrics of these fundamental aspects and integrating them for decision making cannot be a technocratic taskit should be a co-creative process that involves key actors along entire supply chains of production and downstream use and balances the perspectives of stakeholders from industry, regulation and policy. The establishment of such an ecosystem of actors and the application of approaches from decision science as well as digital tools can provide a significant contribution towards the practical operationalization of SSbD and can support the ongoing policy transition towards preventionbased risk governance of chemicals and advanced materials. Sustainability spotlight The new generations of chemicals and advanced materials present unprecedented opportunities but also pose complex environmental, health and safety risks as well as challenges to ensure environmental, social and economic sustainability. The adequate management of these risks/challenges requires a paradigm shi towards Safe and Sustainable by Design (SSbD) systems approach that integrates technical data on safety, functionality, and sustainability with decision makers' trade-offs already in the early R&D stages of innovation. Dening metrics of these fundamental aspects and integrating them into a multi-criteria decision analysis model is one way to support the development of safer and more sustainable technologies in line with the United Nations sustainable development goals (
Climate scenarios produce climate change-related information and data at a geographical scale gen... more Climate scenarios produce climate change-related information and data at a geographical scale generally not useful for coastal planners to study impacts locally. To provide a suitable characterization of climate-related hazards in the North Adriatic Sea coast, a model chain, with progressively higher resolution was developed and implemented. It includes Global and Regional Circulation Models representing atmospheric and oceanic dynamics for the global and sub-continental domains, and hydrodynamic/wave models useful to analyze physical impacts of sea-level rise and coastal erosion at a sub-national/local scale. The model chain, integrating multiple types of numerical models running at different spatial scales, provides information about spatial and temporal patterns of relevant hazard metrics (e.g., sea temperature, atmospheric pressure, wave height), usable to represent climate-induced events causing potential environmental or socio-economic damages. Furthermore, it allows the discu...
The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices... more The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic procedures to address a wide range of diseases. However, the successful translation of these technologies from their inception (proof-of-concept) to clinical practice has been challenged by substantial gaps in the scientific and technical capacity of R&D companies, especially SMEs, to keep up with the ever-evolving regulatory expectations in the emerging area of nanomedicine. To address these challenges, the EU Horizon 2020 project REFINE has developed a Decision Support System (DSS) to support developers of nanotechnology-enabled health products in bringing their products to the clinic. The REFINE DSS has been developed to support experts, innovators and regulators in the implementation of Intelligent Testing Strategies (ITS) for efficient preclinical assessment of...
Parole chiave: gas serra, cambiamento climatico, fattori di emissione, inventari delle emissioni,... more Parole chiave: gas serra, cambiamento climatico, fattori di emissione, inventari delle emissioni, università.
This manuscript describes an innovative approach to socio-economic assessment of (advanced) engin... more This manuscript describes an innovative approach to socio-economic assessment of (advanced) engineered nanomaterials and nano-enabled products (NEPs) to support safe-and-sustainable-by-design (SSbD) decision making by industries in the early stages of product development. This semi-quantitative methodology is based on a sound conceptual framework grounded in the combination of social life cycle analysis and multi-criteria decision analysis methods and supports decision making based upon socio-economic impacts assessed over the full life cycle of a product. To facilitate its application by industries, the methodology was implemented as an Excel-based self-assessment tool. This easy-to-use, cost- and time-efficient tool can guide users through their SSbD decision making regarding newly developed nanomaterials and NEPs and can also be applied to re-evaluate existing materials and NEPs in order to improve their sustainability from a socio-economic perspective. The relatively low require...
The manuscript did undergo copyediting, typesetting, and review of the resulting proof before it ... more The manuscript did undergo copyediting, typesetting, and review of the resulting proof before it was published in its final form.
Sustainable remediation guidance, frameworks, and case studies have been published at an internat... more Sustainable remediation guidance, frameworks, and case studies have been published at an international level illustrating established sustainability assessment methodologies and successful implementation. Though the terminology and indicators evaluated may differ, one common theme among international organizations and regulatory bodies is more comprehensive and transparent methods are needed to evaluate the social sphere of sustainable remediation. Based on a literature review and stakeholder input, this paper focused on three main areas: (1) status quo of how the social element of sustainable remediation is assessed among various countries and organizations; (2) methodologies to quantitatively and qualitatively evaluate societal impacts; and (3) findings from this research, including challenges, obstacles, and a path forward. In conclusion, several existing social impact assessment techniques are readily available for use by the remediation community, including rating and scoring system evaluations, enhanced cost benefit analysis, surveys/interviews, social network analysis, and multicriteria decision analysis. In addition, a list of 10 main social indicator categories were developed: health and safety, economic stimulation, stakeholder collaboration, benefits community at large, alleviate undesirable community impacts, equality issues, value of ecosystem services and natural resources, risk-based land management and remedial solutions, regional and global societal impacts, and contributions to other policies. Evaluation of the social element of remedial activities is not without challenges and knowledge gaps. Identification of obstacles and gaps during the project planning process is essential to defining sustainability objectives and choosing the appropriate tool and methodology to conduct an assessment. Challenges identified include meaningful stakeholder engagement, risk perception of stakeholders, and trade-offs among the various triple bottom line dimensions. c⃝ 2015 Wiley Periodicals, Inc.
In the last decade, the regeneration of derelict or underused sites, fully or partly located in u... more In the last decade, the regeneration of derelict or underused sites, fully or partly located in urban areas (or so called "brownfields"), has become more common, since free developable land (or so called "greenfields") has more and more become a scare and, hence, more expensive resource, especially in densely populated areas. Although the regeneration of brownfield sites can offer development potentials, the complexity of these sites requires considerable efforts to successfully complete their revitalization projects and the proper selection of promising sites is a pre-requisite to efficiently allocate the limited financial resources. The identification and analysis of success factors for brownfield sites regeneration can support investors and decision makers in selecting those sites which are the most advantageous for successful regeneration. The objective of this paper is to present the Timbre Brownfield Prioritization Tool (TBPT), developed as a web-based solu...
The Timbre project entitled "An Integrated Framework of Methods, Technologies, Tools and Pol... more The Timbre project entitled "An Integrated Framework of Methods, Technologies, Tools and Policies for Improvement of Brownfield Regeneration in Europe" takes as its point of departure the observation that current success in brownfield regeneration is less than satisfying. Although many technologies for site clean-up as well as tools to support decision makin g processes are available within the European Union, they are only rarely applied using their full potential. In order to address this predicament, the project aims to overcome existing barriers to brownfield regeneration by developing and providing customised problem- and target-oriented packages of approaches, technologies and tools. The solution provided by Timbre is, thus, to provide a customisable toolbox specifically addressing the diverse processes that have to be dealt with during the course of a regeneration project. In this way, end-users will be enabled to find the best practice-based solutions according to ...
This TIMBRE project deliverable report (full title: “Results of demonstration studies, outreach m... more This TIMBRE project deliverable report (full title: “Results of demonstration studies, outreach material (brochure, extended documentation, online presentation, cartographic outputs); Targeted dissemination of the outcomes and public relations (PR) by providing applicable brochures, documentations, websites and cartographic outputs for the end users”) describes the process of testing and tailoring the web-based prioritization tool for the user-friendly assessment and classification of brownfield sites, which is available at the following internet address http://www.timbre-project.eu/prioritization-tool.html This report, which is based on efforts both by WP3 partners and by many other different stakeholders outside the research consortium, is divided into the following chapters: - Methods of testing and tailoring the web-based prioritization tool – this chapter briefly describes the methods used for testing and tailoring the pilot version of the web-based prioritization tool - Result...
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Papers by Lisa Pizzol