in different parts of the world [2, 3]. including in developing countries where clean and safe su... more in different parts of the world [2, 3]. including in developing countries where clean and safe surface water is scarce [4-6]. It is estimated that 300 million people are exposed to groundwater contamination by iAs and iF through drinking water [7]. The individual toxic effects of iAs and iF exposure have been widely studied and are relatively well known. The biological effects and possible interactions when the exposure is simultaneous are not a clear-cut understanding of their combined toxicity, and the results are controversial since independent, antagonistic, and synergistic effects have been reported [3]. iAs toxicity is closely related to its metabolism [8]. The conventional iAs methylation process includes reduction reactions where iAs(V) must first be reduced to iAs(III). This reduction process can be mediated by reduced glutathione (GSH), followed by a methylation process catalyzed by arsenic methyltransferase (AS3MT) with S-adenosylmethionine (SAM) as a methyl donor group where iAs is
Aquifers in the Región Lagunera in northern Mexico are heavily contaminated with arsenic. The ran... more Aquifers in the Región Lagunera in northern Mexico are heavily contaminated with arsenic. The range of total arsenic concentrations in 128 water samples analyzed was 0.008 to 0.624 mg litre(-1), and concentrations greater than 0.05 mg litre(-1) were found in 50% of them. Approximately 400 000 people living in rural areas were exposed to high As concentrations. Most of the As was in inorganic form and pentavalent arsenic [As(V)] was the predominant species in 93% of the samples. In 36% of the samples, however, variable percentages (20-50) of trivalent As [As(III)] were found. Organic arsenicals were present in very small amounts. Since As(III) is several times more toxic than As(V), we suggest that periodic studies be performed on the As(III)/As(V) ratio in wells whose total As concentrations are above 0.05 mg litre(-1), in combination with epidemiological studies to evaluate possible differences in health effects produced by different As species.
Background: Exposure to high concentrations of arsenic (As) in drinking water has been associated... more Background: Exposure to high concentrations of arsenic (As) in drinking water has been associated with increased risk of diabetes and cardiovascular disease (CVD. Less is known about possible adver...
Background: Exposure to inorganic arsenic (iAs) remains a public health issue. Typically, three m... more Background: Exposure to inorganic arsenic (iAs) remains a public health issue. Typically, three major forms of arsenic are measured in urine as biomarkers of iAs exposure, namely, iAs, and its meta...
The present cross-sectional study examined associations between inorganic arsenic (iAs) exposure ... more The present cross-sectional study examined associations between inorganic arsenic (iAs) exposure and cardiometabolic (CM) risk factors in a cohort of adult Chihuahua residents (n=933, ?18year old) ...
Background and Aims. Exposure to inorganic arsenic (iAs) is suspected of causing diabetes mellitu... more Background and Aims. Exposure to inorganic arsenic (iAs) is suspected of causing diabetes mellitus and other diseases. This study examined associations of diabetes with exposure to iAs in drinking ...
in different parts of the world [2, 3]. including in developing countries where clean and safe su... more in different parts of the world [2, 3]. including in developing countries where clean and safe surface water is scarce [4-6]. It is estimated that 300 million people are exposed to groundwater contamination by iAs and iF through drinking water [7]. The individual toxic effects of iAs and iF exposure have been widely studied and are relatively well known. The biological effects and possible interactions when the exposure is simultaneous are not a clear-cut understanding of their combined toxicity, and the results are controversial since independent, antagonistic, and synergistic effects have been reported [3]. iAs toxicity is closely related to its metabolism [8]. The conventional iAs methylation process includes reduction reactions where iAs(V) must first be reduced to iAs(III). This reduction process can be mediated by reduced glutathione (GSH), followed by a methylation process catalyzed by arsenic methyltransferase (AS3MT) with S-adenosylmethionine (SAM) as a methyl donor group where iAs is
Aquifers in the Región Lagunera in northern Mexico are heavily contaminated with arsenic. The ran... more Aquifers in the Región Lagunera in northern Mexico are heavily contaminated with arsenic. The range of total arsenic concentrations in 128 water samples analyzed was 0.008 to 0.624 mg litre(-1), and concentrations greater than 0.05 mg litre(-1) were found in 50% of them. Approximately 400 000 people living in rural areas were exposed to high As concentrations. Most of the As was in inorganic form and pentavalent arsenic [As(V)] was the predominant species in 93% of the samples. In 36% of the samples, however, variable percentages (20-50) of trivalent As [As(III)] were found. Organic arsenicals were present in very small amounts. Since As(III) is several times more toxic than As(V), we suggest that periodic studies be performed on the As(III)/As(V) ratio in wells whose total As concentrations are above 0.05 mg litre(-1), in combination with epidemiological studies to evaluate possible differences in health effects produced by different As species.
Background: Exposure to high concentrations of arsenic (As) in drinking water has been associated... more Background: Exposure to high concentrations of arsenic (As) in drinking water has been associated with increased risk of diabetes and cardiovascular disease (CVD. Less is known about possible adver...
Background: Exposure to inorganic arsenic (iAs) remains a public health issue. Typically, three m... more Background: Exposure to inorganic arsenic (iAs) remains a public health issue. Typically, three major forms of arsenic are measured in urine as biomarkers of iAs exposure, namely, iAs, and its meta...
The present cross-sectional study examined associations between inorganic arsenic (iAs) exposure ... more The present cross-sectional study examined associations between inorganic arsenic (iAs) exposure and cardiometabolic (CM) risk factors in a cohort of adult Chihuahua residents (n=933, ?18year old) ...
Background and Aims. Exposure to inorganic arsenic (iAs) is suspected of causing diabetes mellitu... more Background and Aims. Exposure to inorganic arsenic (iAs) is suspected of causing diabetes mellitus and other diseases. This study examined associations of diabetes with exposure to iAs in drinking ...
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