Microbial production of hyaluronic acid (HA) is an area of research that has been gaining attenti... more Microbial production of hyaluronic acid (HA) is an area of research that has been gaining attention in recent years due to the increasing demand for this biopolymer for several industrial applications. Hyaluronic acid is a linear, non-sulfated glycosaminoglycan that is widely distributed in nature and is mainly composed of repeating units of N-acetylglucosamine and glucuronic acid. It has a wide and unique range of properties such as viscoelasticity, lubrication, and hydration, which makes it an attractive material for several industrial applications such as cosmetics, pharmaceuticals, and medical devices. This review presents and discusses the available fermentation strategies to produce hyaluronic acid.
Large-scale production of microalgae and their bioactive compounds has steadily increased in resp... more Large-scale production of microalgae and their bioactive compounds has steadily increased in response to global demand for natural compounds. Spirulina, in particular, has been used due to its high nutritional value, especially its high protein content. Promising biological functions have been associated with Spirulina extracts, mainly related to its high value added blue pigment, phycocyanin. Phycocyanin is used in several industries such as food, cosmetics, and pharmaceuticals, which increases its market value. Due to the worldwide interest and the need to replace synthetic compounds with natural ones, efforts have been made to optimize large-scale production processes and maintain phycocyanin stability, which is a highly unstable protein. The aim of this review is to update the scientific knowledge on phycocyanin applications and to describe the reported production, extraction, and purification methods, including the main physical and chemical parameters that may affect the purit...
Dissertação de Mestrado em Química Farmacêutica Industrial apresentada à Faculdade de FarmáciaThe... more Dissertação de Mestrado em Química Farmacêutica Industrial apresentada à Faculdade de FarmáciaThe fluorination of biologically active organic compounds has been explored and widely used in drug design and development. By modulating important physicochemical properties, the fluorine atom influences the pharmacokinetic and pharmacological properties of drugs, contributing to the increasing number of fluorinated drugs in the market. Due to the success of fluorinated drugs, medicinal chemists have explored various fluorination strategies (monofluorination, difluoromethylation and trifluoromethylation) in order to make fluorination reactions more selective, more effective and with milder conditions. Natural compounds represent interesting scaffolds for the design and development of new drugs, due to their structural diversity, complexity and new mechanisms of action, among other features. One strategy to improve the their potency, selectivity and pharmacokinetic profile of natural compou...
Microbial production of hyaluronic acid (HA) is an area of research that has been gaining attenti... more Microbial production of hyaluronic acid (HA) is an area of research that has been gaining attention in recent years due to the increasing demand for this biopolymer for several industrial applications. Hyaluronic acid is a linear, non-sulfated glycosaminoglycan that is widely distributed in nature and is mainly composed of repeating units of N-acetylglucosamine and glucuronic acid. It has a wide and unique range of properties such as viscoelasticity, lubrication, and hydration, which makes it an attractive material for several industrial applications such as cosmetics, pharmaceuticals, and medical devices. This review presents and discusses the available fermentation strategies to produce hyaluronic acid.
Large-scale production of microalgae and their bioactive compounds has steadily increased in resp... more Large-scale production of microalgae and their bioactive compounds has steadily increased in response to global demand for natural compounds. Spirulina, in particular, has been used due to its high nutritional value, especially its high protein content. Promising biological functions have been associated with Spirulina extracts, mainly related to its high value added blue pigment, phycocyanin. Phycocyanin is used in several industries such as food, cosmetics, and pharmaceuticals, which increases its market value. Due to the worldwide interest and the need to replace synthetic compounds with natural ones, efforts have been made to optimize large-scale production processes and maintain phycocyanin stability, which is a highly unstable protein. The aim of this review is to update the scientific knowledge on phycocyanin applications and to describe the reported production, extraction, and purification methods, including the main physical and chemical parameters that may affect the purit...
Dissertação de Mestrado em Química Farmacêutica Industrial apresentada à Faculdade de FarmáciaThe... more Dissertação de Mestrado em Química Farmacêutica Industrial apresentada à Faculdade de FarmáciaThe fluorination of biologically active organic compounds has been explored and widely used in drug design and development. By modulating important physicochemical properties, the fluorine atom influences the pharmacokinetic and pharmacological properties of drugs, contributing to the increasing number of fluorinated drugs in the market. Due to the success of fluorinated drugs, medicinal chemists have explored various fluorination strategies (monofluorination, difluoromethylation and trifluoromethylation) in order to make fluorination reactions more selective, more effective and with milder conditions. Natural compounds represent interesting scaffolds for the design and development of new drugs, due to their structural diversity, complexity and new mechanisms of action, among other features. One strategy to improve the their potency, selectivity and pharmacokinetic profile of natural compou...
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