Papers by MANUEL CERVANTES ORTA
Revista Pistas Educativas, 2013
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Toxicology Letters, 2010
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Nucleic Acids Research, 2014
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2008
The fundamental nuclear enzyme DNA topoisomerase I (topo I), cleaves the double-stranded DNA mole... more The fundamental nuclear enzyme DNA topoisomerase I (topo I), cleaves the double-stranded DNA molecule at preferred sequences within its recognition/binding sites. We have recently reported that when cells incorporate halogenated nucleosides analogues of thymidine into DNA, it interferes with normal chromosome segregation, as shown by an extraordinarily high yield of endoreduplication, and results in a protection against DNA breakage induced by the topo II poison m-AMSA [F. Cortés, N. Pastor, S. Mateos, I. Domínguez, The nature of DNA plays a role in chromosome segregation: endoreduplication in halogen-substituted chromosomes, DNA Repair 2 (2003) 719-726; G. Cantero, S. Mateos, N. Pastor; F. Cortés, Halogen substitution of DNA protects from poisoning of topoisomerase II that results in DNA double-strand breaks (DSBs), DNA Repair 5 (2006) 667-674]. In the present investigation, we have assessed whether the presence of halogenated nucleosides in DNA diminishes the frequency of interaction of topo I with DNA and thus the frequency with which the stabilisation of cleavage complexes by the topo I poison camptothecin (CPT) takes place, in such a way that it protects from chromosome breakage and sister-chromatid exchange. This protective effect is shown to parallel a loss in halogen-substituted cells of the otherwise CPT-increased catalytic activity bound to DNA.
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BioMed Research International, 2014
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that shar... more Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid-like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na+/K+-ATPase. Cardiac glycosides have been used for many years in the treatment of cardiac congestion and some types of cardiac arrhythmias. Recent data suggest that cardiac glycosides may also be useful in the treatment of cancer. These compounds typically inhibit cancer cell proliferation at nanomolar concentrations, and recent high-throughput screenings of drug libraries have therefore identified cardiac glycosides as potent inhibitors of cancer cell growth. Cardiac glycosides can also block tumor growth in rodent models, which further supports the idea that they have potential for cancer therapy. Evidence also suggests, however, that cardiac glycosides may not inhibit cancer cell proliferation selectively and the potent inhibition of tum...
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Toxicology Letters, 2013
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RESUMEN El Gobierno Federal ha estado impulsando en la formación de profesores, su capacitación y... more RESUMEN El Gobierno Federal ha estado impulsando en la formación de profesores, su capacitación y su práctica, el uso de las TIC en las instituciones de educación superior, bajo una imagen de modernidad que conlleva progreso que, en el caso de la educación, ...
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Planta Medica, 2013
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Pharmacological Reports, 2012
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Nucleic Acids Research, 2013
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Mutagenesis, 2009
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Molecular Cell, 2010
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Journal of Agricultural and Food Chemistry, 2013
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Journal of Agricultural and Food Chemistry, 2012
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Revista Eletrônica de Ciências Administrativas, 2004
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Papers by MANUEL CERVANTES ORTA