Papers by Margarita Moreno
In 2006 the Document Supply Service at the National Library of Australia began its automation pro... more In 2006 the Document Supply Service at the National Library of Australia began its automation project. There were two main objectives: firstly to improve the services to customers measured by turnaround time; secondly to streamline interlibrary loan and document delivery (ILL/DD) workflows. Eighteen months later, what efficiencies have been gained? This paper will explore the changes introduced as a result
Interlending & Document Supply, 2010
Purpose – This paper aims to describe the role of the National Library of Australia in the Austra... more Purpose – This paper aims to describe the role of the National Library of Australia in the Australian interlibrary loan environment, not just in terms of providing access to National Library collections through the document supply service, but also in providing infrastructure to support interlibrary loans across Australia. Design/methodology/approach – The paper describes the various roles the National Library plays
Interlending & Document Supply, 2007
Purpose – This paper aims to describe the national interlibrary loan and document delivery (ILL/D... more Purpose – This paper aims to describe the national interlibrary loan and document delivery (ILL/DD) benchmarking study undertaken by Australian libraries in 2001 and evaluates its impact. It outlines the nature and scope of ILL/DD in Australia, including research into the significance of this library activity to researchers. Design/methodology/approach – The evaluation was undertaken through a survey including detailed statistical information from libraries in all sectors. Additional analysis is done using statistics from university libraries and the national interlibrary lending system. Findings – The paper finds that the benchmarking study and activities undertaken to implement the findings of the study have improved the turnaround time and the operation of ILL/DD in Australia both for libraries and users. All sectors reduced delivery time by up to 50 per cent, creating much more effective access for users to the Australian distributed collection. Originality/value – This is the first formal evaluation of a national benchmarking project and demonstrates that by working on the performance of libraries from a national approach significant improvements can be made in effectiveness and efficiency. It provides a model that could be used to evaluate other benchmarking studies. As it is the first formal evaluation of a national benchmarking study it has high originality.
Interlending & Document Supply, 2005
... These groups were established by the National Library to support the development of a nationa... more ... These groups were established by the National Library to support the development of a nationalresource sharing infrastructure following a series of national meetings and discussions. ... Participation. Resource sharing is a critical issue for all library sectors. ...
European Psychiatry, 2002
Behavioural Pharmacology, 2005
The present work studied the long-term effects of chronic perinatal manipulation of cannabinoid C... more The present work studied the long-term effects of chronic perinatal manipulation of cannabinoid CB1 receptors in male and female rats. Perinatal activation of cannabinoid CB1 receptors by chronic administration of delta9-tetrahydrocannabinol at different doses (0.1, 0.5, 2 mg/kg, p.o.) induced sexually dimorphic behavioural changes in adulthood, altering habituation of locomotion, immobility and exploratory activity. These behavioural effects were also accompanied by alterations in corticosterone levels in the adult period. Prenatal blockade of CB1 receptors by chronic administration of 3 mg/kg (s.c.) of SR141716A decreased immobility behaviour in male and female animals, without any significant changes in corticosterone plasma levels. Cannabinoid CB1 receptors appear to play an important role in the ontogeny of psychomotor behaviours, and activation or blockade of these receptors during stages of plasticity, such as the prenatal or perinatal periods, can induce long-term effects, as shown by sexually dimorphic changes in behavioural patterns in adulthood.
Behavioural Pharmacology, 2005
The present study investigated spontaneous and quinpirole-induced motor responses of in rats, fol... more The present study investigated spontaneous and quinpirole-induced motor responses of in rats, following withdrawal from chronic treatment with the potent cannabinoid agonist HU-210. Withdrawal from chronic HU-210 (20 microg/kg daily, 14 days) produced a decrease in spontaneous activity at 1 and 2 days and enhanced the hyperactivity induced by acute administration of the dopamine D2 agonist quinpirole (0.5 mg/kg) at 4 days after the end of HU-210 treatment. Administration of quinpirole on day 4 of withdrawal from chronic HU-210 enhanced stereotyped responses and induced jumping behaviour. These results suggest that withdrawal from chronic exposure to cannabinoid agonists could induce a time-dependent alteration in dopamine D2 psychomotor function, leading to a behavioural disorganization, comparable to acute psychotic episodes after continuous cannabinoids.
Pharmacology Biochemistry and Behavior, 2003
Marijuana abuse is very prominent among pregnant women. Although marijuana cannabinoids have been... more Marijuana abuse is very prominent among pregnant women. Although marijuana cannabinoids have been shown to exert immunosuppression in adults, virtually nothing is known about the effects of marijuana use during pregnancy on the developing immune system of the fetus and during postnatal life. We noted that murine fetal thymus expressed high levels of the cannabinoid receptors CB1 and CB2. Moreover, perinatal exposure to ⌬ 9 -tetrahydrocannabinol (THC) had a profound effect on the fetus as evidenced by a decrease in thymic cellularity on gestational days 16, 17, and 18 and postgestational day 1 and marked alterations in T cell subpopulations. These outcomes were reversed by CB1/CB2 antagonists, suggesting that THCmediated these effects through cannabinoid receptors. Thymic atrophy induced in the fetus correlated with caspase-depen-dent apoptosis in thymocytes. Thymic atrophy was the result of direct action of THC and not based on maternal factors inasmuch as THC was able to induce T cell apoptosis in vitro in fetal thymic organ cultures. It is noteworthy that perinatal exposure to THC also had a profound effect on the immune response during postnatal life. Peripheral T cells from such mice showed decreased proliferative response to T cell mitogen as well as both T cell and antibody response to HIV-1 p17/p24/gp120 antigens. Together, our data demonstrate for the first time that perinatal exposure to THC triggers profound T cell dysfunction, thereby suggesting that the offspring of marijuana abusers who have been exposed to THC in utero may be at a higher risk of exhibiting immune dysfunction and contracting infectious diseases including HIV.
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Papers by Margarita Moreno