Maria del Carmen Chacon Castro

Follower

Following

Public Views

Noel B. Salazar

KU Leuven

Jana Javornik

University of East London

Armando Marques-Guedes

UNL - New University of Lisbon

Gwen Robbins Schug

University of North Carolina at Greensboro

Kevin Arbuckle

Swansea University

Jesper Hoffmeyer

University of Copenhagen

Simon Springer

The University of Newcastle

Richard Cloutier

Université du Québec à Rimouski

Timothy Morton

Rice University

Nicola Lupo

LUISS Guido Carli

InterestsView All (6)

Uploads

Papers by Maria del Carmen Chacon Castro

Abstract 2386: Investigating cyclopamine tartrate as a potential suppressor of lung adenocarcinoma and squamous cell carcinoma

Cancer Research

Lung cancer is the leading cause of death by cancer, and non-small cell lung cancer comprises of ... more Lung cancer is the leading cause of death by cancer, and non-small cell lung cancer comprises of 85-90% of lung cancer cases. Previous studies have demonstrated the importance of heme in mitochondrial metabolism and OXPHOS. Heme is an essential molecule in the oxidative phosphorylation pathway especially since Complex II-IV all contain heme. During lung tumorigenesis there is a marked increase in heme synthesis and uptake; other protein and enzymes relating to heme were also upregulated. Heme-sequestration proteins (HeSPs) have shown high effectiveness in suppressing the development and progression of lung adenocarcinoma and squamous cell carcinoma, therefore targeting heme using CycT should yield similar results. Previous studies have indicated that cyclopamine tartrate (CycT) can effectively arrest lung tumor growth and progression. CycT does this by inhibiting the levels of proteins and enzymes involved in heme uptake, synthesis, as well as reducing heme synthesis and degradation...

CACERES: TITIRAS VECTORAS DE LA "UTA'

Especies de Lutzomyia (Diptera: Psychodidae, Phlebotominae) vectores de la "uta" en el Perú. Abra... more Especies de Lutzomyia (Diptera: Psychodidae, Phlebotominae) vectores de la "uta" en el Perú. Abraham G. Cáceres 1 RESUMEN CACERES A. ¡995. Especies ele Lutzomyia (Díptera: Psychodidae, Phlebolominae) vectores de la "uta" en el Perú. Rev. per. Ent. 38.-Se hace especial referencia a dos especies de insectos comprobadas como vectores de la leishmaniasis cutánea andina o "uta" (Lutzomyia ayacuchensis y Lu. peruensis) y a tres consideradas como vectores potenciales (Lu. lejadai, Lu. verrucarum y Lu. pesceí). Palabras clave: iMlzomyia, leishmaniasis cutánea andina, "uta", titiras, flebótomos. SUMMARY CACERES A. 1995. Species of Lutzomyia (Díptera: Psychodidae, Phlebolominae) vectors of "uta" in Perú. Rev. per. Ent. 38.-The autor makes special reference to two species of inseets probed to be vectors of Andean cutaneous leishmaniasis or "uta" (Lutzomyia ayacuchensis and Lu. peruensis) and to other three species considered as potencial vectors (Lu. lejeulai, Lu. verrucarum, and Lu. pesceí)

Download