Papers by Md. Hasan Mahmud
Farming Information Management System of Bangladesh" is a web-based system that is developed to g... more Farming Information Management System of Bangladesh" is a web-based system that is developed to giving the information about building a (small or big) farm to World Wide Web so that anyone can get information from any place rather than going to a farm. The major goal of this system is to reduce time that people waste while going to a farm to collect the information needed, especially, when we live in the village it becomes difficult to get information. User can buy and sell their farms products by using this system. They also can read recent news, make posts to interact with other users. Users also get notification about news updates, offers, successful buy and sell confirmation etc. The proposed system delivers a great user experience because it is both secure and easy to use, it saves a lot of time, money and hassle. It is also easy to use and very effective, allows the government to deliver farming information around the country easily. It is also very cost effective and time saving when compared to traditional system.
Gastroenterologia Japonica, 1991
Cancer research, Jan 5, 2018
High expression of vascular endothelial growth factor C (VEGFC) predicts adverse prognosis in acu... more High expression of vascular endothelial growth factor C (VEGFC) predicts adverse prognosis in acute myeloid leukemia (AML). We therefore explored VEGFC targeting efficacy as an AML therapy using a VEGFC monoclonal antibody. VEGFC antibody therapy enforced myelocytic differentiation of clonal CD34+ AML blasts. Treatment of CD34+ AML blasts with the antibody reduced expansion potential by 30-50% and enhanced differentiation via FOXO3A suppression and inhibition of MAPK/ERK proliferative signals. VEGFC antibody therapy also accelerated leukemia cell differentiation in a systemic humanized AML mouse model. Collectively, these results define a regulatory function of VEGFC in CD34+ AML cell fate decisions via FOXO3A and serve as a new potential differentiation therapy for AML patients.
BMC genetics, Jan 10, 2018
Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, ... more Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon exposure to oxidative stress induced by certain foods such as fava beans, drugs or infections. Although hemizygous males and homozygous females are easily detected by conventional G6PD enzyme assay method, the heterozygous state could be missed by the conventional methods as the mosaic population of both normal and deficient RBCs circulates in the blood. Thus the present study aimed to apply high resolution melting (HRM) curve analysis approach to see whether HRM could be used as a supplemental approach to increase the chance of detection of G6PD heterozygosity. Sixty-three clinically suspected females were evaluated for G6PD status using both enzyme assay and HRM analysis. Four out of sixty-three participants came out as G6PD deficient by the enzyme assay method, whereas HRM approa...
Molecular cancer research : MCR, Jan 18, 2018
Heterogeneity in the genetic landscape of pediatric acute myeloid leukemia (AML) makes personaliz... more Heterogeneity in the genetic landscape of pediatric acute myeloid leukemia (AML) makes personalized medicine challenging. As genetic events are mediated by the expression and function of proteins, recognition of recurrent protein patterns could enable classification of pediatric AML patients and could reveal crucial protein dependencies. This could help to rationally select combinations of therapeutic targets. To determine if protein expression levels could be clustered into functionally relevant groups, custom Reverse Phase Protein Arrays (RPPA) were performed on pediatric AML (n=95) and CD34+ normal bone marrow (n=10) clinical specimens using 194 validated antibodies. To analyze proteins in the context of other proteins, all proteins were assembled into 31 Protein Functional Groups (PFG). For each PFG an optimal number of protein clusters was defined that represented distinct transition states. Block clustering analysis revealed strong correlations between various protein clusters...
Oncotarget, Jan 27, 2017
The t(8;21) (q22;q22) chromosomal translocation is one of the most frequent genetic alterations i... more The t(8;21) (q22;q22) chromosomal translocation is one of the most frequent genetic alterations in acute myeloid leukemia (AML) which has a need for improved therapeutic strategies. We found PLC-γ1 as one of the highest phosphorylated peptides in t(8;21) AML samples compared to NBM or CN-AML in our previous peptide microarray. PLC-γ1 is known to play a role in cancer progression, however, the impact of PLC-γ1 in AML is currently unknown. Therefore, we aimed to study the functional role of PLC-γ1 by investigating the cellular growth, survival and its underlying mechanism in t(8;21) AML.In this study, PLC-γ1 expression was significantly higher in t(8;21) AML compared to other karyotypes. The PLC-γ1 protein expression was suppressed in AML1-ETO knock down cells indicating that it might induce kasumi-1 cell death. ShRNA-mediated PLC-γ1 knockdown in kasumi-1 cells significantly blocked cell growth, induced apoptosis and cell cycle arrest which was explained by the increased activation of...
Journal of hematology & oncology, Aug 3, 2016
The epidermal growth factor receptor (EGFR) inhibitor erlotinib has been shown to induce complete... more The epidermal growth factor receptor (EGFR) inhibitor erlotinib has been shown to induce complete remission of acute myeloid leukemia (AML) in two patients with concurrent lung cancer and raised attention for a role of EGFR in AML whereas a recent phase II clinical study with gefitinib in AML demonstrated a negative result on the outcome. However, from several studies, EGFR expression in AML is poorly defined and the role of EGFR in AML remains unclear. Herein, we report the results of EGFR expression in AML of large cohorts of adult and pediatric AML patients with the data of total protein and phosphorylation levels of EGFR. Our data conclude that there is the expression of EGFR at the protein level in a subset of AML, which was identified to be functionally active in ~15 % of AML patients. This suggests that future studies need to be conducted with a subset of AML patients characterized by high EGFR expression.
Journal of the American College of Cardiology, 2016
Vitamin D deficiency is one of the most common nutritional deficiencies worldwide. Maternal vitam... more Vitamin D deficiency is one of the most common nutritional deficiencies worldwide. Maternal vitamin D deficiency is associated with increased susceptibility to hypertension in offspring, but the reasons for this remain unknown. The aim of this study was to determine if parental vitamin D deficiency leads to altered DNA methylation in offspring that may relate to hypertension. Male and female Sprague-Dawley rats were fed a standard or vitamin D-depleted diet. After 10 wk, nonsibling rats were mated. The conceived pups received standard chow. We observed an increased systolic and diastolic blood pressure in the offspring from depleted parents (F1-depl). Genome-wide methylation analyses in offspring identified hypermethylation of the promoter region of the Pannexin-1 (Panx1) gene in F1-depl rats. Panx1 encodes a hemichannel known to be involved in endothelial-dependent relaxation, and we demonstrated that in F1-depl rats the increase in blood pressure was associated with impaired endothelial relaxation of the large vessels, suggesting an underlying biological mechanism of increased blood pressure in children from parents with vitamin deficiency. Parental vitamin D deficiency is associated with epigenetic changes and increased blood pressure levels in offspring. Listen to this article's corresponding podcast at http://ajpheart. podbean.com/e/parental-vitamin-d-deficiency-increases-bp-in-offspring/. blood pressure; epigenetics; vitamin D; endothelial dysfunction; Pannexin-1 NEW & NOTEWORTHY Parental vitamin D deficiency is associated with increased blood pressure in the offspring and with epigenetic changes of Panx1, a gene encoding for a hemichannel involved in endo-thelial-dependent relaxation. Offspring from vitamin D-depleted parents have impaired endothelial relaxation of the large vessels, suggesting an underlying biological mechanism.
International Journal of Computer Applications, Mar 15, 2013
Different types of sensors are often fused to acquire information which cannot be acquired by a s... more Different types of sensors are often fused to acquire information which cannot be acquired by a single sensor. Sensor fusion is particularly applicable for mobile robots for object detection and navigation. The techniques that have been developed so far for detecting an obstacle are costly. Hence, a new technique is proposed which can detect an obstacle, judge its distance and measure the size of the obstacle using one camera and one ultrasonic sensor. The technique is cheap in terms of sensor cost and in terms of computational cost.
2015 IEEE 21st International Symposium on High Performance Computer Architecture (HPCA), 2015
Power-hungry data centers face an urgent pressure on reducing the energy cost. The existing effor... more Power-hungry data centers face an urgent pressure on reducing the energy cost. The existing efforts, despite being numerous, have primarily centered around owner-operated data centers (e.g., Google), leaving another critical data center segment-colocation data center (e.g., Equinix) which rents out physical space to multiple tenants for housing their own servers-much less explored. Colocations have a major barrier to achieve cost efficiency: server power management by individual tenants is uncoordinated. This paper proposes RECO (REward for COst reduction), which shifts tenants' power management from uncoordinated to coordinated, using financial reward as a lever. RECO pays (voluntarily participating) tenants for energy reduction such that the colocation operator's overall cost is minimized. RECO incorporates the time-varying operation environment (e.g., cooling efficiency, intermittent renewables), addresses the peak power demand charge, and also proactively learns tenants' unknown responses to the offered reward. RECO includes a new feedback-based online algorithm to optimize the reward without far future offline information. We evaluate RECO using both scaled-down prototype experiments and simulations. Our results show that RECO is "win-win" and can successfully reduce the colocation operator's overall cost, by up to 27% compared to the no-incentive baseline case. Further, tenants receive financial rewards (up to 15% of their colocation costs) for "free" without violating Service Level Agreements. Data Center Power Utility Demand Energy Demand Charge Location (Rate Schedule) Charge Charge (% of total) Phoneix, AZ APS (E-35
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009
Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage and cell membra... more Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Eryptosis is triggered by increase in cytosolic Ca(2+) concentration upon energy depletion. The present study explored the involvement of leukotrienes. Western blotting was employed to detect the cysteinyl-leukotriene receptor cysLT1, competitive immune assay to determine leukotriene release from erythrocytes, Fluo3 fluorescence to estimate cytosolic Ca(2+) concentration, forward scatter to analyse cell volume and annexin V-binding to disclose phosphatidylserine exposure. As a result, erythrocytes expressed the leukotriene receptor CysLT1. Glucose depletion (24 hours) significantly increased the formation of the cysteinyl-leukotrienes C(4)/D(4)/E(4). Leukotriene C(4) (10 nM) increased Ca(2+) entry, decreased forward scatter, activated caspases 3 and 8, and stimulated annexin V-binding. Glucose depletion similarly ...
IEEE Transactions on Services Computing, 2016
The growing environmental and sustainability concerns have made energy efficiency a pressing issu... more The growing environmental and sustainability concerns have made energy efficiency a pressing issue for data center operation. Governments, as well as various organizations, are urging data centers to cap the increasing energy consumption. Naturally, achieving long term energy capping involves deciding energy usage over a long timescale (without accurately foreseeing the far future) and hence, we call this process "energy budgeting". In this paper, we introduce an online resource management solution, called eBud (energy Budgeting), for a virtualized data center. eBud determines the number of servers, resource allocation to virtual machines and corresponding workload distribution to minimize data center operational cost while satisfying a long term energy cap. We prove that eBud achieves a close-to-minimum cost compared to the optimal offline algorithm with future information, while bounding the potential violation of energy budget constraint, in an almost arbitrarily random environment. We also perform a trace-based simulation study to complement the performance analysis. The simulation results show that eBud reduces the cost by more than 16 percent (compared to state-of-the-art prediction-based algorithm) while resulting in a zero energy budget deficit. We also perform an experimental study based on RUBiS, demonstrating that in a real life scenario, eBud can achieve energy capping with a negligible increase in operational cost.
The American Journal of Gastroenterology, 2001
The aim of this study was to investigate the prevalence of irritable bowel syndrome (IBS) and the... more The aim of this study was to investigate the prevalence of irritable bowel syndrome (IBS) and the pattern of symptoms and health care seeking behavior of IBS subjects in the rural population in Bangladesh. METHODS: This was an observational study to do a positive diagnosis of IBS. A total of 2426 persons Ն15 yr old were interviewed by a predesigned questionnaire based on the Rome criteria. Two villages of a northern district in Bangladesh were included. RESULTS: A response of 95.4% yielded 2426 questionnaires for analysis. Mean age of the surveyed sample was 32.3 Ϯ 14.2 yr. In total, 1113 (45.9%) were men, and 1313 (54.1%) were women. Farmers and housewives comprised 2058 (84.8%) persons. The apparent prevalence of IBS was 24.4% with a prevalence of 20.6% in men and 27.7% in women. With strict Rome criteria, the overall prevalence was 8.5% (10.7% in women and 5.8% in men). Age was not found to influence the prevalence in either sex. Other than abdominal pain, the most common IBS symptom was altered stool passage (81.1%). Others in order of frequency were passage of mucus with stool (56.8%), abdominal distension (46.2%), altered stool form (46%), and altered stool frequency (18.2%). Spastic colon pain was noted in 339 (57.2%). IBS subjects with more prevalence of colonic symptoms in the nonspastic group. Drinking milk was found to have a little impact on IBS. A total of 35% IBS subjects consulted doctors for symptoms. Age, sex, and number of symptoms did not influence health care seeking behavior. CONCLUSIONS: IBS is also a problem in rural people in Bangladesh with a prevalence almost identical to most other countries, and only a minority of them seeks health care. Positive diagnosis of IBS can be done by precisely enquiring colonic symptoms in apparently healthy people.
The American journal of clinical nutrition, 2004
Nonheme-iron absorption requires an acidic milieu. Reduced gastric acid output as a consequence o... more Nonheme-iron absorption requires an acidic milieu. Reduced gastric acid output as a consequence of Helicobacter pylori infection could be an important limiting factor for iron absorption. We measured gastric acid output and iron absorption from a non-water-soluble iron compound (ferrous fumarate) and a water-soluble iron compound (ferrous sulfate) in children with and without H. pylori infection. Gastric acid output was quantified before (basal acid output, or BAO) and after pentagastrin stimulation (stimulated acid output, or SAO) in 2-5-y-old children with iron deficiency anemia who were (n = 13) or were not (n = 12) infected with H. pylori. Iron absorption was measured by using a double-stable-isotope technique. H. pylori-infected children were studied before and after eradication therapy. BAO and SAO were significantly lower in the H. pylori-infected children (0.2 +/- 0.2 and 1.6 +/- 0.9 mmol/h, respectively) than in the uninfected children (0.9 +/- 0.7 and 3.1 +/- 0.9 mmol/h, r...
2013 International Green Computing Conference Proceedings, 2013
With the ever-increasing power density generating an excessive amount of heat that potentially in... more With the ever-increasing power density generating an excessive amount of heat that potentially induces server damage and outages, data center operation must be judiciously optimized to prevent server overheating. Moreover, data center is subject to various peak power constraints (such as peak server power) that have to be satisfied at all times for reliability concerns. In this paper, we propose a novel resource management algorithm, called DREAM (Distributed REsource mAnagement with teMperature constraint), to optimally control the server capacity provisioning (via power adjustment) and load distribution for minimizing the data center operational cost while satisfying the IT peak power and maximum server inlet temperature constraints. By using DREAM, each server can autonomously adjust its discrete processing speed (and hence, power consumption, too) and optimally decide the amount of workloads to process, in order to minimize the total cost that incorporates both power consumption and service delay. We rigorously prove that DREAM can yield the minimum cost with an arbitrarily high probability while satisfying the peak power and inlet temperature constraints. To complement the analysis, we perform a simulation study and show that DREAM can significantly reduce the cost compared to the optimal temperature-unaware algorithm (by up to 23%) and equal load distribution (by up to 69%).
Vaccine, 2007
Zinc deficiency is known to impair immunologic functions. However, the effect of zinc supplementa... more Zinc deficiency is known to impair immunologic functions. However, the effect of zinc supplementation on immune response to polysaccharide vaccines is not known. To determine the immunogenicity of the heptavalent Pneumococcal protein conjugate (PNC) vaccine in poor Bangladeshi infants and to assess the effect of zinc supplementation on immune response to the PNC vaccine. We immunized a sub-cohort of 241 infants who had previously received three doses of a Hib conjugate vaccine with three doses of the heptavalent PNC vaccine at 4 weeks intervals beginning at 18+/-1 weeks of age. The infants were supplemented with daily 5 mg zinc or placebo from 4 to 33 weeks of age. Response to each of the seven PNC serotypes were assessed at 4, 24 and 33 weeks of age. After three doses of PNC, at 29 weeks of age, geometric mean titres for the pneumococcal serotypes ranged from 3.68 to 13.34 microg/ml. Titres were significantly higher for infants who had received PNC compared to infants who had only received DTP-Hib. Zinc supplementation resulted in higher titres for serotype 9V (4.09 microg/ml; [95% CI: 3.27; 5.10] and 3.33 microg/ml; [95% CI: 2.79; 3.96] for zinc and placebo group, respectively; p<0.05) after three doses but had no effect on other serotypes. A heptavalent PNC vaccine proved to be safe and immunogenic in Bangladeshi infants. Zinc supplementation enhanced the immune response to only one of the serotypes (9V). However, there was no effect on other serotypes.
Tropical Medicine & International Health, 2013
objective To estimate the risk of early-onset neonatal sepsis among newborns of mothers with chor... more objective To estimate the risk of early-onset neonatal sepsis among newborns of mothers with chorioamnionitis and/or bacterial colonisation in Dhaka. methods We conducted a cohort study at a maternity centre following 600 mother-newborn pairs. Women with a positive bacterial vaginal culture or positive Group B streptococcus (GBS) rectal culture during labour were classified as colonised. Women with placental histopathology demonstrating signs of maternal or foetal inflammation were classified as having chorioamnionitis. Newborns were followed over the first 7 days of life. The primary outcome measure was physician or community health worker diagnosis of neonatal sepsis following modified World Health Organization Integrated Management of Childhood Illnesses criteria. Survival analysis was conducted with nonparametric, parametric and semiparametric models. results Of the 600 mother-newborn pairs, 12.8% of newborns were diagnosed with early-onset sepsis. Five hundred and forty-three women had both colonisation and chorioamnionitis data, 55.4% of mothers were non-exposed, 31.7% were only colonised and 12.9% had chorioamnionitis regardless of colonisation status. After adjusting for birthweight, sex, maternal characteristics and wealth, newborns of only colonised mothers developed sepsis 63% faster and had a 71% higher risk of developing sepsis than their nonexposed counterparts (RT = 0.37, 95% CI 0.14-1.03; RH = 1.71, 95% CI 1.00-2.94). Newborns of mothers with chorioamnionitis developed sepsis 74% faster and had a 111% higher risk of developing sepsis (RT = 0.26, 95% CI 0.07-0.94; RH = 2.11, 95% CI 1.06-4.21). conclusions Newborns born to mothers with colonisation or chorioamnionitis developed sepsis faster and were at higher risk of developing sepsis in Dhaka.
Toxicology, 2008
Cisplatin, a cytotoxic drug for the treatment of cancer, induces suicidal death or apoptosis of n... more Cisplatin, a cytotoxic drug for the treatment of cancer, induces suicidal death or apoptosis of nucleated cells. Side effects of cisplatin include anemia, which, at least in theory, could similarly result from suicidal cell death. Erythrocyte suicidal death or eryptosis is characterized by cell shrinkage and cell membrane scrambling, the latter leading to exposure of phosphatidylserine (PS) at the cell surface. PS-exposing cells are rapidly cleared from circulating blood. The present experiments explored whether cisplatin could trigger eryptosis. According to forward scatter in FACS analysis, a 48 h exposure to cisplatin (≥1 M) indeed decreased cell volume and, according to annexin V-binding, cisplatin (≥1 M, 48 h) indeed increased PS exposure at the cell surface. Cisplatin did not induce hemolysis. According to Fluo3 fluorescence, cisplatin increased cytosolic Ca 2+ activity, a known stimulator of eryptosis. In the absence of extracellular Ca 2+ , the effect of cisplatin on annexin V-binding was blunted. Cisplatin did not significantly modify the formation of ceramide, another stimulator of eryptosis. Cisplatin moderately decreased the cellular concentration of ATP, which is known to favour eryptosis. In conclusion, cisplatin triggers suicidal erythrocyte death at least partially by increasing cytosolic Ca 2+ activity. The effect contributes to or even accounts for the development of anemia during cisplatin treatment.
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Papers by Md. Hasan Mahmud