Introduction. The authors are dealing with the questions often asked by their patients: how weath... more Introduction. The authors are dealing with the questions often asked by their patients: how weather changes, oscillations in humidity, air pressure and other climate factors affect functioning of the human body. Meteorology and Biometeorology. Definitions of meteorology and biometeorology are given, describing some of the most important characteristics, such as the types of disorders and the reasons for their occurrence, frequency, gender and age factors, etc. with particular reference to disorders related to the mental and nervous functions. Discussion. The possibilities of prevention, the importance of monitoring biometeorology forecasts and the questionable need for drug use during the seasonal shifts, which cause fatigue, irritability, poor concentration and apathy, hypersensitivity to pain, headache, dizziness, anxiety, head buzzing, etc. are discussed.
Multicentric, multinational and scientific research WHO MONICA Project, apart from having large s... more Multicentric, multinational and scientific research WHO MONICA Project, apart from having large scope and large statistical background, also have a scientific influence measured by citations of published works. In this paper is given an overview of total citation counts according to WоS (Wеb оf Science) citation database for works with collaborative significance. Citation analysis was performed in the Reference Centre of the Matica Srpska Library in Novi Sad for the period until July 2009. In this paper are presented the most cited works and total citation counts. Special attention was payed to works where YUG-NOS MONICA centre, with names of researchers from Novi Sad, was listed within Sites and key personnel of contributing MONICA centres.
This paper documented research revealed unfavorable trends the prevalence of stroke in the region... more This paper documented research revealed unfavorable trends the prevalence of stroke in the region which is linked to the general hospital in Doboj. In a research study conducted in 2010 included all patients who were hospitalized with a diagnosis of acute stroke. Registered epidemiological data were analyzed from the point of incidence between the sexes and age groups, the type and the corresponding vascular territory, and compared with the results of recent and significant scientific research and epidemiological studies of stroke, local, regional and global significance. It also discusses the positive effects of prophylactic measures undertaken in developed communities. The statistical processing and analysis commented registered epidemiological data conducted research studies. Confirmed the hypothesis of a significant incidence of stroke in the territory studied: stroke incidence 198.35/100,000 (ischemic stroke 148.57 and hemorrhagic stroke 34.50). Stroke is more common in men (52...
This study was aimed at investigating the vascular risk factors in stroke patients. It highlighte... more This study was aimed at investigating the vascular risk factors in stroke patients. It highlighted unfavorable trends in stroke mortality in the region gravitating towards the general hospital in Doboj. The study included all patients hospitalized with the diagnosis of first stroke and their main vascular risk factors were explored, both in terms of their importance in the occurrence of stroke, and in terms of gender and age lines. The research results were statistically processed, analyzed and commented on. The most common risk factor for the first stroke included hypertension (70%), smoking (35%), heart diseases (28%), diabetes mellitus (28%), hyperlipoproteinemia (26%), atrial fibrillation (18.5%) and immoderate consumption of alcohol (17%). The presence of vascular risk factors in the majority of patients is important, and at least one of them was present in 80% of patients. Alcohol consumption, smoking and hyperlipoproteinemia were significantly more freqeunt in men, and atrial...
Purpose: Defining of the basic characteristics of peak systolic frequencies (PSF) in CCA, ICA in ... more Purpose: Defining of the basic characteristics of peak systolic frequencies (PSF) in CCA, ICA in proximal part and distal part ECA and in six levels of stenosis percentage: a) normal finding, b) minimal lesion (1-15%), c) mild stenosis (16-49%), d) moderate stenosis (50-75%), e) severe stenosis (76-99%), f) total occlusion, and two control groups. Methods: A group of 53 patients who passed duplex scanner prior angiography, average age of 55.9 in acute phase of ischemic stroke in anterior circulation were examined. Central and dispersion parameters were analyzed for six levels of stenosis percentage and two controls (43 subjects average age of 36.9 /1st control group and 33 of 55.7/2nd control group). Results: On ANOVA basis it was found out that there existed the significant difference for detection points compared to stenosis level of ICA (p less than 0.05). Difference carrier is ICA proximal part (discriminative coefficient 1.72) and ICA distal part (1.08). By application of Hotel...
Transcranial Doppler was used on 159 p’s with carotid occlusive disease, cerebral angiography, as... more Transcranial Doppler was used on 159 p’s with carotid occlusive disease, cerebral angiography, as a criterion method, was used in 35, and a comparison of the results obtained by these methods are shown true positive 50, true negative in 444 findings, false positive were 5, and false negative in one of p’s. The sensitivity of ultrasound method was tested in terms of sensitivity, specificity, positive and negative predictive value. The sensitivity was assessed at 98%, specificity at 98.98%, positive predictive value (PPV) at 90.91%, and negative predictive value (NPV) at 99.77%. Our results point to high level of sensitivity of the ultrasound aid in the assessment of carotid occlusive disease, and seem to much the results in relation of the other researcher. Keywords: Carotid artery disease; TCD Reliability; sensitivity; specificity; predictive value;
In spite of being a common and important complication of stroke, post stroke depression is often ... more In spite of being a common and important complication of stroke, post stroke depression is often overlooked, so its impact on stroke outcome remains under recognized. The aim of the study was to determine the effect of depression on functional outcome and quality of life in stroke patients. The study included 60 patients treated for their first clinical stroke, 30 of them diagnosed with depression and 30 patients without depression. Testing was done in all patients two and six weeks after stroke. Depression was diagnosed according to the Mini International Neuropsychiatry Interview, DSM-IV diagnostic criteria, and depression severity was quantified by the Hamilton Depression Rating Scale; functional impairment was determined by the Barthel Index; and post stroke quality of life was assessed by the Short Form 36 (SF-36) questionnaires. The patients with depression had significantly more severe functional disability both at baseline and after rehabilitation treatment, although the pot...
Stroke is a rapidly developing clinical disturbance of focal or global cerebral function, lasting... more Stroke is a rapidly developing clinical disturbance of focal or global cerebral function, lasting for more than 1 hour. It is an acute form of symptoms of brain function disorder, with no apparent cause other than vascular origin. It is the final phase of arterial disease, the main cause of disability, and the second leading cause of death. Today, ischemic stroke can be treated successfully by acting on its cause using a very powerful weapon, thrombolytic therapy. The aim is to present a preliminary report of our experiences with thrombolytic therapy in patients with ischemic stroke. Results recorded in 20 patients who received thrombolytic therapy within three hours of stroke onset are presented. Nineteen patients survived and one patient died from therapy side effects, i.e. intracerebral hematoma. Seventeen of 19 patients were released from the hospital without any neurologic deficit, while two patients had Rankin score 2 (minimum disability) three months after stroke onset. Our e...
In this paper, we report our experience from a prospective study in 40 ischemic stroke patients a... more In this paper, we report our experience from a prospective study in 40 ischemic stroke patients admitted during the last two years at University Department of Neurology Stroke Unit, Banja Luka Clinical Center, in order to assess the safety and efficacy of thrombolytic therapy, the impact of age, sex and risk factors, and functional outcome at 6 months of intravenous tissue plasminogen activator treatment. According to the National Institutes of Health Stroke Scale, there were 5 mild, 22 moderate and 13 severe stroke cases in the study group. The outcome measures at 6 months of thrombolytic treatment were taken in 38 (100%) patients, yielding a Functional Independent Measure score > or=90 (good clinical outcome) in 21 (52.50%) and modified Rankin Score < or =2 (good clinical outcome) in 22 (55%) patients. The rate of symptomatic intracerebral hemorrhage in tissue plasminogen activator treated patients was 5%, with a mortality rate of 17.50%. The outcomes were comparable with th...
The aim of this prospective study was to evaluate therapeutic effects in a cohort of 32 patients ... more The aim of this prospective study was to evaluate therapeutic effects in a cohort of 32 patients with relapsing-remitting multiple sclerosis (RRMS) that were continuously treated with interferon beta-1b during a three-year period and to compare the results obtained with literature data available. Additionally, dropouts and side effects were assessed. The annual relapse rate at three years of treatment as the primary study end-point decreased by 60.5% compared with the relapse rate throughout the pretherapeutic course of disease (0.39 +/- 0.55 vs. 0.97 +/- 0.46; P<0.001) and by 71.3% compared with the relapse rate one year prior to treatment (0.39 +/- 0.55 vs. 1.34 +/- 0.65; P<0.001). The mean Extended Disability Status Scale (EDSS) increased significantly from 2.46 +/- 0.86 at baseline to 2.90 +/- 1.30 (P<0.01) at three years of treatment, whereas the mean progression index (EDSS/disease duration) decreased significantly from 0.76 +/- 0.50 prior to treatment to 0.43 +/- 0.2...
Introduction. The authors are dealing with the questions often asked by their patients: how weath... more Introduction. The authors are dealing with the questions often asked by their patients: how weather changes, oscillations in humidity, air pressure and other climate factors affect functioning of the human body. Meteorology and Biometeorology. Definitions of meteorology and biometeorology are given, describing some of the most important characteristics, such as the types of disorders and the reasons for their occurrence, frequency, gender and age factors, etc. with particular reference to disorders related to the mental and nervous functions. Discussion. The possibilities of prevention, the importance of monitoring biometeorology forecasts and the questionable need for drug use during the seasonal shifts, which cause fatigue, irritability, poor concentration and apathy, hypersensitivity to pain, headache, dizziness, anxiety, head buzzing, etc. are discussed.
Multicentric, multinational and scientific research WHO MONICA Project, apart from having large s... more Multicentric, multinational and scientific research WHO MONICA Project, apart from having large scope and large statistical background, also have a scientific influence measured by citations of published works. In this paper is given an overview of total citation counts according to WоS (Wеb оf Science) citation database for works with collaborative significance. Citation analysis was performed in the Reference Centre of the Matica Srpska Library in Novi Sad for the period until July 2009. In this paper are presented the most cited works and total citation counts. Special attention was payed to works where YUG-NOS MONICA centre, with names of researchers from Novi Sad, was listed within Sites and key personnel of contributing MONICA centres.
This paper documented research revealed unfavorable trends the prevalence of stroke in the region... more This paper documented research revealed unfavorable trends the prevalence of stroke in the region which is linked to the general hospital in Doboj. In a research study conducted in 2010 included all patients who were hospitalized with a diagnosis of acute stroke. Registered epidemiological data were analyzed from the point of incidence between the sexes and age groups, the type and the corresponding vascular territory, and compared with the results of recent and significant scientific research and epidemiological studies of stroke, local, regional and global significance. It also discusses the positive effects of prophylactic measures undertaken in developed communities. The statistical processing and analysis commented registered epidemiological data conducted research studies. Confirmed the hypothesis of a significant incidence of stroke in the territory studied: stroke incidence 198.35/100,000 (ischemic stroke 148.57 and hemorrhagic stroke 34.50). Stroke is more common in men (52...
This study was aimed at investigating the vascular risk factors in stroke patients. It highlighte... more This study was aimed at investigating the vascular risk factors in stroke patients. It highlighted unfavorable trends in stroke mortality in the region gravitating towards the general hospital in Doboj. The study included all patients hospitalized with the diagnosis of first stroke and their main vascular risk factors were explored, both in terms of their importance in the occurrence of stroke, and in terms of gender and age lines. The research results were statistically processed, analyzed and commented on. The most common risk factor for the first stroke included hypertension (70%), smoking (35%), heart diseases (28%), diabetes mellitus (28%), hyperlipoproteinemia (26%), atrial fibrillation (18.5%) and immoderate consumption of alcohol (17%). The presence of vascular risk factors in the majority of patients is important, and at least one of them was present in 80% of patients. Alcohol consumption, smoking and hyperlipoproteinemia were significantly more freqeunt in men, and atrial...
Purpose: Defining of the basic characteristics of peak systolic frequencies (PSF) in CCA, ICA in ... more Purpose: Defining of the basic characteristics of peak systolic frequencies (PSF) in CCA, ICA in proximal part and distal part ECA and in six levels of stenosis percentage: a) normal finding, b) minimal lesion (1-15%), c) mild stenosis (16-49%), d) moderate stenosis (50-75%), e) severe stenosis (76-99%), f) total occlusion, and two control groups. Methods: A group of 53 patients who passed duplex scanner prior angiography, average age of 55.9 in acute phase of ischemic stroke in anterior circulation were examined. Central and dispersion parameters were analyzed for six levels of stenosis percentage and two controls (43 subjects average age of 36.9 /1st control group and 33 of 55.7/2nd control group). Results: On ANOVA basis it was found out that there existed the significant difference for detection points compared to stenosis level of ICA (p less than 0.05). Difference carrier is ICA proximal part (discriminative coefficient 1.72) and ICA distal part (1.08). By application of Hotel...
Transcranial Doppler was used on 159 p’s with carotid occlusive disease, cerebral angiography, as... more Transcranial Doppler was used on 159 p’s with carotid occlusive disease, cerebral angiography, as a criterion method, was used in 35, and a comparison of the results obtained by these methods are shown true positive 50, true negative in 444 findings, false positive were 5, and false negative in one of p’s. The sensitivity of ultrasound method was tested in terms of sensitivity, specificity, positive and negative predictive value. The sensitivity was assessed at 98%, specificity at 98.98%, positive predictive value (PPV) at 90.91%, and negative predictive value (NPV) at 99.77%. Our results point to high level of sensitivity of the ultrasound aid in the assessment of carotid occlusive disease, and seem to much the results in relation of the other researcher. Keywords: Carotid artery disease; TCD Reliability; sensitivity; specificity; predictive value;
In spite of being a common and important complication of stroke, post stroke depression is often ... more In spite of being a common and important complication of stroke, post stroke depression is often overlooked, so its impact on stroke outcome remains under recognized. The aim of the study was to determine the effect of depression on functional outcome and quality of life in stroke patients. The study included 60 patients treated for their first clinical stroke, 30 of them diagnosed with depression and 30 patients without depression. Testing was done in all patients two and six weeks after stroke. Depression was diagnosed according to the Mini International Neuropsychiatry Interview, DSM-IV diagnostic criteria, and depression severity was quantified by the Hamilton Depression Rating Scale; functional impairment was determined by the Barthel Index; and post stroke quality of life was assessed by the Short Form 36 (SF-36) questionnaires. The patients with depression had significantly more severe functional disability both at baseline and after rehabilitation treatment, although the pot...
Stroke is a rapidly developing clinical disturbance of focal or global cerebral function, lasting... more Stroke is a rapidly developing clinical disturbance of focal or global cerebral function, lasting for more than 1 hour. It is an acute form of symptoms of brain function disorder, with no apparent cause other than vascular origin. It is the final phase of arterial disease, the main cause of disability, and the second leading cause of death. Today, ischemic stroke can be treated successfully by acting on its cause using a very powerful weapon, thrombolytic therapy. The aim is to present a preliminary report of our experiences with thrombolytic therapy in patients with ischemic stroke. Results recorded in 20 patients who received thrombolytic therapy within three hours of stroke onset are presented. Nineteen patients survived and one patient died from therapy side effects, i.e. intracerebral hematoma. Seventeen of 19 patients were released from the hospital without any neurologic deficit, while two patients had Rankin score 2 (minimum disability) three months after stroke onset. Our e...
In this paper, we report our experience from a prospective study in 40 ischemic stroke patients a... more In this paper, we report our experience from a prospective study in 40 ischemic stroke patients admitted during the last two years at University Department of Neurology Stroke Unit, Banja Luka Clinical Center, in order to assess the safety and efficacy of thrombolytic therapy, the impact of age, sex and risk factors, and functional outcome at 6 months of intravenous tissue plasminogen activator treatment. According to the National Institutes of Health Stroke Scale, there were 5 mild, 22 moderate and 13 severe stroke cases in the study group. The outcome measures at 6 months of thrombolytic treatment were taken in 38 (100%) patients, yielding a Functional Independent Measure score > or=90 (good clinical outcome) in 21 (52.50%) and modified Rankin Score < or =2 (good clinical outcome) in 22 (55%) patients. The rate of symptomatic intracerebral hemorrhage in tissue plasminogen activator treated patients was 5%, with a mortality rate of 17.50%. The outcomes were comparable with th...
The aim of this prospective study was to evaluate therapeutic effects in a cohort of 32 patients ... more The aim of this prospective study was to evaluate therapeutic effects in a cohort of 32 patients with relapsing-remitting multiple sclerosis (RRMS) that were continuously treated with interferon beta-1b during a three-year period and to compare the results obtained with literature data available. Additionally, dropouts and side effects were assessed. The annual relapse rate at three years of treatment as the primary study end-point decreased by 60.5% compared with the relapse rate throughout the pretherapeutic course of disease (0.39 +/- 0.55 vs. 0.97 +/- 0.46; P<0.001) and by 71.3% compared with the relapse rate one year prior to treatment (0.39 +/- 0.55 vs. 1.34 +/- 0.65; P<0.001). The mean Extended Disability Status Scale (EDSS) increased significantly from 2.46 +/- 0.86 at baseline to 2.90 +/- 1.30 (P<0.01) at three years of treatment, whereas the mean progression index (EDSS/disease duration) decreased significantly from 0.76 +/- 0.50 prior to treatment to 0.43 +/- 0.2...
Uploads
Papers by Milorad Z