Papers by Muhammad Furqon Ali
Laporan akhir praktikum pemetaan geologi
Phytochemistry, 1999
A new monoterpene-glycoside (2-exo-b-D-glucopyranosyl-1,8-cineol) named bucharioside from the met... more A new monoterpene-glycoside (2-exo-b-D-glucopyranosyl-1,8-cineol) named bucharioside from the methanol-soluble part and a new sesquiterpenoid (4,10-epoxy-6a±hydroxyguaiane) named buchariol from the hexane-soluble part of Salvia bucharica were obtained. Their structures were elucidated with the help of NMR spectroscopy including 1D and 2D experiments. #
THE EFFECT OF GLUCOSE ON GROWTH OF MESENCHYMAL STEM CELLS DERIVED FROM UMBILICAL CORDS OF NORMAL ... more THE EFFECT OF GLUCOSE ON GROWTH OF MESENCHYMAL STEM CELLS DERIVED FROM UMBILICAL CORDS OF NORMAL AND GESTATIONAL DIABETIC MOTHERS. Abstract Objective: To explore the effects of glucose concentration on growth of Wharton’s jelly mesenchymal stem cells from umbilical cords of gestational diabetic mothers (DWJMSCs) and normal mothers (NWJMSCs). Methods: NWJMSCs and DWJMSCs were treated at passage 3 with low (5.5mM) or high glucose. Cells’ growth was evaluated by methyl thiazolyl tetrazolium uptake and cytotoxicity by LDH release. Status of oxidative stress was estimated by release of stress enzymes i.e. glutathione s transferase (GSH) and catalase. Results: The results of cells’ growth assays indicated a significant increase of proliferation in DWJMSCs when treated with high glucose as compared to low glucose while opposite was found in NWJMSCs. Conversely cytotoxicity was lower in DWJMSCs treated with 25mM glucose while it was increased in NWJMSCs at same concentration and vice-versa....
European Journal of Inorganic Chemistry
Keywords: Nonlinear optics / Polyoxometalates / Organic–inorganic hybrid composites / Charge tran... more Keywords: Nonlinear optics / Polyoxometalates / Organic–inorganic hybrid composites / Charge transfer / Density functional calculations DFT calculations were carried out in order to study the sec-ond-order nonlinear optical (NLO) response of a series of proposed 2D polyoxometalate-based terpyridine-substituted compounds. These compounds can be formulated as [Mo 6 O 17 {N 4 C 25 H 16 (X) 2 }{N 4 C 25 H 16 (X) 2 }] 2– (X = H, F, Cl, Br, I, CF 3 , or CN), which has a wedge Λ-shaped acceptor––π-con-jugated bridge––donor––π-conjugated bridge––acceptor (A-π-D-π-A) configuration. The calculations showed that these compounds possess significantly large molecular second-order polarizabilities that range from approximately 1000 10 –30 to 4300 10 –30 esu. The combination of tri-fluoromethyl (CF 3) and cyanide (CN) groups at the end of the terpyridine ligand strengthens the bridge conjugation, which is useful for the enhancement of the NLO response.
DNA damage repairing take place by mainly three methods involving different enzymes. Majority of ... more DNA damage repairing take place by mainly three methods involving different enzymes. Majority of the DNA damage affects the primary structure. Templates stand and new strand are different but mechanism to distinguish the template strand and new strand is still unclear. DNA damage occurs very often and basic problem for life. DNA damage leads to mutations that result in the form of cancer. An abnormal growth of the cells that may spread in an uncontrolled manner.
Density functional theory (DFT) was used to determine the ground state geometries of indigo and n... more Density functional theory (DFT) was used to determine the ground state geometries of indigo and new design dyes (IM-Dye-1 IM-Dye-2 and IM-Dye-3). The time dependant density functional theory (TDDFT) was used to calculate the excitation energies. All the calculations were performed in both gas and solvent phase. The LUMO energies of all the dyes were above the conduction band of TiO2, while the HOMOs were below the redox couple (except IM-Dye-3). The HOMO-LUMO energy gaps of new design dyes were smaller as compared to indigo. All new design dyes were strongly red shifted as compared to indigo. The improved light harvesting efficiency (LHE) and free energy change of electron injection ΔG inject of new designed sensitizers revealed that these materials would be excellent sensitizers. The broken coplanarity between the benzene near anchoring group having LUMO and the last benzene attached to TPA unit in all new design dyes consequently would hamper the recombination reaction. This theoretical designing will the pave way for experimentalists to synthesize the efficient sensitizers for solar cells.
Pakistan journal of pharmaceutical sciences, 2012
The aim of this study was to optimize the extraction conditions for the extraction of phenolic co... more The aim of this study was to optimize the extraction conditions for the extraction of phenolic compounds from Moringa oleifera leaves using response surface methodology (RSM). A user-defined design was applied to determine the effects of extraction time (min), extraction temperature ((o)C) and ethanol concentration (%), on total phenolic content (TPC) from Moringa oleifera leaves dried by three methods (oven, sunlight and ambient air). The RSM was used to optimize the extraction conditions for the extraction of TPC of Moringa oleifera leaves. The optimum conditions that maximize the extraction of TPC were extraction time, 60 min; extraction temperature, 90(o)C and % of methanol, 50 % (v/v). TPC extracted under these conditions were 12.28, 12.65 and 13.14 mg GAE/g DW for samples dried by different methods. Significant difference between drying methods was found (p<0.001). Pair wise significant difference was found only between oven and ambient air drying methods…
Pakistan journal of pharmaceutical sciences, 2015
Mesothelioma is a rare form of cancer affecting the mesothelium lining. It is usually caused by a... more Mesothelioma is a rare form of cancer affecting the mesothelium lining. It is usually caused by asbestos exposure or exposure to nanofibers. Median survival is less than one year in the mesothelioma patients. Due to its severity, there is a dire necessity to find out new diagnostic and therapeutic strategies. Some recent strategies could help us in fighting against mesothelioma. Diagnostic tools include a range of biomarkers or biotechnological procedure. Therapeutic tools include chemotherapeutic strategies along with immunotherapy, gene therapy and alternative therapy.
International Conference on Computer Networks and Information Technology, 2011
The next generation of wireless networks will integrate the current co-existing wireless networks... more The next generation of wireless networks will integrate the current co-existing wireless networks to allow the users to connect to the network that best suits their needs. The users will be enabled to roam among diff erent networks by a process known as vertical handover. Vertical handover can be imperative or alternative depending upon the reason of handover initiation. In this paper, we have proposed algorithms to perform imperative and alternative handovers.
Pakistan journal of pharmaceutical sciences, 2015
Epigenetics means the study of alterations in the genetic material that affect the phenotype but ... more Epigenetics means the study of alterations in the genetic material that affect the phenotype but does not affect the genotype. Epigenetics cause alterations in cell properties, which are inherited; but it does not cause alterations in DNA sequence. Epigenetic mediated silencing of gene is of four types, which are DNA methylation, histone deacetylation, RNA associated silencing and Genomic imprinting. Other factors (environmental and xenobiotics) can also cause gene silencing but DNA methytlation and changes in histones of chromatin are two important changes, which are responsible for malignant diseases. Two groups of drugs are under development, which corrects the epigenetic alterations. These are histone deacetylation (HDAC) inhibitors and DNA methytransferase (DNMT) inhibitors. These drugs may be used in cancer because in cancer, hypermethylation of cancer suppressor gene causes gene silencing. Epigenetic therapy scope is likely to increase in future.
2011 Eighth International Conference on Information Technology: New Generations, 2011
Abstract At present, none of the wireless access or mobile cellular network technologies provides... more Abstract At present, none of the wireless access or mobile cellular network technologies provides ubiquitous coverage and the complete set of services required by the users. Therefore, the next generation of wireless networks ie 4th Generation (4G) network aims at the integration of ...
Process Biochemistry, 2015
Invertase (EC.3.2.1.26) belongs to glycoside hydrolases that catalyzes sucrose (table sugar) into... more Invertase (EC.3.2.1.26) belongs to glycoside hydrolases that catalyzes sucrose (table sugar) into two monosaccharides i.e. glucose and fructose. Invertases produced by a large number of microorganisms having molecular mass in the range of 47-430 kDa, K m value from 0.063 to 470 mM, K cat from 5.68 to 7.4 × 10 6 s −1 and half-life of 2.42-78.8 min (at 65 • C) worked optimally between temperature of 30-75 • C and pH of 2.9-6.2. They are extensively used in the preparation of jams, marshmallows, infant formulas, candies containing liquefied sugar centers, chocolate covered cherries, digestive aid tablets, artificial honey, beverages and bakery items. Invertases are also important for the prevention of diseases (ulcers, intestinal ailments, reduce colds etc.) in humans, in anti-aging process and physical rejuvenation. Their ability to convert glucose into hydrogen per oxide categorize them as powerful antimicrobial and antioxidant agents, hence, assist in defense reaction against bacterial infections and gut fermentation by oxidation. Microbial invertases have been extensively studied during last decades. However, their wider applications ranging from industry to human health demands a comprehensive review on production, purification, properties and their benefits.
2013 IEEE 11th Malaysia International Conference on Communications (MICC), 2013
ABSTRACT Frequent change in the topology of a disrupted social network is a barrier in using trad... more ABSTRACT Frequent change in the topology of a disrupted social network is a barrier in using traditional routing protocols. One way to deal with this problem is to collect mobility profiles of nodes and to utilize them for future routing decisions. The solution however lacks scalability since it is difficult for nodes to keep updated information of the whole network. The paper thus devises a scalable scheme that exploits the limited social circles of the mobile device owners; i.e. it breaks network into social communities and employs a fine-grained heuristic routing scheme for intra-community communication. Moreover the paper specifies a simple method for identification of bridging nodes to transfer message to destination lying outside the community. The idea paper is expected to bring a near to optimal routing solution for disrupted social networks.
African journal of pharmacy and pharmacology
observed in blood through angiogenesis, this leads to progression of cancer.
2011 Eighth International Conference on Information Technology: New Generations, 2011
Abstract Due to the disrupted nature of intermittently connected networks, traditional security i... more Abstract Due to the disrupted nature of intermittently connected networks, traditional security infrastructure ie, Public Key Infrastructure (PKI) suffers difficulty in security provision. Unlike PKI, Identity Based Cryptography (IBC) does not need end-to-end connectivity to trusted ...
Pakistan journal of pharmaceutical sciences
ABSTRACT Epigenetics means the study of alterations in the genetic material that affect the pheno... more ABSTRACT Epigenetics means the study of alterations in the genetic material that affect the phenotype but does not affect the genotype. Epigenetics cause alterations in cell properties, which are inherited; but it does not cause alterations in DNA sequence. Epigenetic mediated silencing of gene is of four types, which are DNA methylation, histone deacetylation, RNA associated silencing and Genomic imprinting. Other factors (environmental and xenobiotics) can also cause gene silencing but DNA methytlation and changes in histones of chromatin are two important changes, which are responsible for malignant diseases. Two groups of drugs are under development, which corrects the epigenetic alterations. These are histone deacetylation (HDAC) inhibitors and DNA methytransferase (DNMT) inhibitors. These drugs may be used in cancer because in cancer, hypermethylation of cancer suppressor gene causes gene silencing. Epigenetic therapy scope is likely to increase in future.
Journal of Molecular Graphics and Modelling, 2008
A Quantitative Structure-Property Relationships (QSPRs) study for the prediction of the environme... more A Quantitative Structure-Property Relationships (QSPRs) study for the prediction of the environmental persistence of a set of 250 heterogeneous organic compounds is here presented. Three a priori defined classes of environmental persistence were generated, by Hierarchical Cluster Analysis, from the combination of half-life data in air, water, soil and sediment available for all the studied compounds. QSPR classification models were successfully developed using different techniques (k-NN, CART and CP-ANN) and three interpretable theoretical molecular descriptors. Robust external validation was provided by statistical splitting and also on completely new data. The good performances of all these models were compared and their structural domains were analyzed. The analysis of the errors highlights a slight tendency of persistence overestimation, misclassifying chemicals from a lower to a higher class of persistence, in line with the precautionary principle. Finally, the reliability of the proposed QSPR models was verified further with new data from the literature. The structure-based classification models, applicable for the prediction of potential persistence of heterogeneous organic compounds, could be useful as preliminary support tools for the identification and prioritization of new potential POPs among already existing chemicals as well as ''screening prior to synthesis'' procedures to avoid the production, and consequent release into the environment, of new POPs. ß
Chemical biology & drug design, Jan 16, 2015
Contribution of Cdc42, a member of Rho family, has been characterized for the beginning of variet... more Contribution of Cdc42, a member of Rho family, has been characterized for the beginning of variety of cellular responses including cellular transformation, cell division, cell invasion, migration, invadopodia formation, enzyme activity, filopodia formation and cell polarity in cells. Deregulation of Cdc42 can alter the normal functioning of the cells, responsible for the initiation of signaling pathways and is correlated with several pathogenic processes such as cancer. Therefore, maintaining the level of Cdc42 and its effectors in cells, tumor progression can be controlled. Therefore, it can be suggested that deeper understanding about the Cdc42 contribution in cancer cell progression at molecular level can approach to development of Cdc42 inhibitors in cancer management. This article is protected by copyright. All rights reserved.
Uploads
Papers by Muhammad Furqon Ali