Naosuke Kamei

Followers

Following

Co-authors

Public Views

Ashraf M. Salama

Northumbria University

Anna M. Czarnecka

Medical University of Warsaw

David Seamon

Kansas State University

David Kent

University of Cambridge

Neil Theise

NYU School of Medicine

Arifa Savanur

University of Karachi

Máté Varga

Eötvös Loránd University

Gonzalo Bello

Fundação Oswaldo Cruz

Ricardo Pujol-Borrell

Universitat Autònoma de Barcelona

István Jóna

University of Debrecen

Interests

Uploads

Papers by Naosuke Kamei

Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury

Neural Regeneration Research, 2018

Download

miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models

Frontiers in Cell and Developmental Biology, Jan 4, 2023

Download

Novel Hybrid Hydroxyapatite Spacers Ensure Sufficient Bone Bonding in Cervical Laminoplasty

Asian Spine Journal, Dec 31, 2018

Download

Magnetic Resonance Imaging Evaluation of Cartilage Repair and Iron Particle Kinetics After Magnetic Delivery of Stem Cells

Tissue Engineering Part C-methods, Dec 1, 2018

Download

Microcervical Foraminotomy for Cervical Juxtafacet Cysts: Case Series and Literature Review

The International Journal of Spine Surgery, Feb 24, 2023

Download

Physical Signs and Clinical Features of Cervical Myelopathy in Elderly Patients, Especially 80 Years or Older: Comparison of 100 Consecutive Operative Cases across Three Age Groups

Asian Spine Journal, Jul 6, 2023

Download

An Investigation of Spinal Surgery Using a Navigation System

Intradiscal Condoliase Injection Therapy for Recurrent Lumbar Disc Herniation: Case Series and Literature Review

Medicina

Background and objectives: Although chemonucleolysis with condoliase for lumbar disc herniation (... more Background and objectives: Although chemonucleolysis with condoliase for lumbar disc herniation (LDH) has become common, few reports have described its application in the treatment of recurrent LDH. Therefore, this study aimed to evaluate the safety and efficacy of condoliase treatment in six patients with recurrent LDH and review the available literature on condoliase treatment for LDH. Materials and Methods: Six patients (four men and two women; mean age, 64.7 years) with recurrent LDH who were treated with condoliase at our hospital between 2019 and 2022 were included. The clinical records and images of the patients were retrospectively evaluated. In addition, the available English literature on condoliase treatment for LDH was retrieved and reviewed. Results: Among the six patients included in the study, three showed >50% improvement in leg pain after treatment, which is a lower efficacy rate than that in previous reports. In addition, two patients required surgery after trea...

Download

Immediate Closed Reduction Technique for Cervical Spine Dislocations

Asian Spine Journal

Study Design: Retrospective study.Purpose: This research aimed to assess the clinical outcomes of... more Study Design: Retrospective study.Purpose: This research aimed to assess the clinical outcomes of patients with traumatic cervical spine dislocation who underwent closed reduction employing our approach.Overview of Literature: Bedside closed reduction is the quickest procedure for repairing traumatic cervical spine dislocations; nevertheless, it also possesses the risk of neurological deterioration.Methods: For closed reduction, the patient’s head was elevated on a motorized bed, the cervical spine was placed at the midline, traction of 10 kg was applied, the motorized bed was gradually returned to a flat position, the head was lifted off the bed, and the cervical spine was slowly adjusted to a flexed position. The weight of traction was elevated by 5-kg increments until the positional shift was attained. Subsequently, the bed was gradually tilted while traction was applied again to return the cervical spine to the midline position.Results: Of the 43 cases of cervical spine dislocat...

Download

$Research paper thumbnail of Prognostic factors of balloon kyphoplasty for osteoporotic vertebral fractures with diffuse idiopathic skeletal hyperostosis$

Prognostic factors of balloon kyphoplasty for osteoporotic vertebral fractures with diffuse idiopathic skeletal hyperostosis

Journal of Neurosurgery: Spine

OBJECTIVE The authors aimed to determine the poor prognostic factors of balloon kyphoplasty for t... more OBJECTIVE The authors aimed to determine the poor prognostic factors of balloon kyphoplasty for the treatment of fractures of the most distal or distal-adjacent vertebrae in ankylosing spines with diffuse idiopathic skeletal hyperostosis (DISH). METHODS Eighty-nine patients with fractures of the most distal or distal-adjacent vertebrae of ankylosing spines with DISH were included and divided into two groups: those with (n = 51) and without (n = 38) bone healing 6 months postoperatively. Clinical evaluation included age, sex, time from onset to surgery, the visual analog scale score for low-back pain, and the Oswestry Disability Index (ODI). The VAS scores and ODI were measured both preoperatively and at 6 months postoperatively. Radiological evaluations included bone density; wedge angles of the fractured vertebrae in the supine and sitting positions on lateral radiographs; differences in the wedge angles (change in wedge angle); and the amount of polymethylmethacrylate used. RESULT...

Differentiation Between Compressive Cervical and Thoracic Myelopathy Using the Central Motor Conduction Time Ratio

Journal of Clinical Neurophysiology

Differences between spinal cord injury and cervical compressive myelopathy in intramedullary high-intensity lesions on T2-weighted magnetic resonance imaging: A retrospective study

Medicine

Increases in aging populations have raised the number of patients with cervical spinal cord injur... more Increases in aging populations have raised the number of patients with cervical spinal cord injury (SCI) without fractures due to compression of the cervical spinal cord. In such patients, it is necessary to clarify whether SCI or cervical compressive myelopathy (CCM) is the cause of disability after trauma. This study aimed to clarify the differences in magnetic resonance imaging (MRI) features between SCI and CCM. Overall, 60 SCI patients and 60 CCM patients with intramedullary high-intensity lesions on T2-weighted MRI were included in this study. The longitudinal lengths of the intramedullary T2 high-intensity lesions were measured using sagittal MRI sections. Snake-eye appearance on axial sections was assessed as a characteristic finding of CCM. The T2 values of the high-intensity lesions and normal spinal cords at the first thoracic vertebra level were measured, and the contrast ratio was calculated using these values. The longitudinal length of T2 high-intensity lesions was si...

Foramen Magnum Decompression with Outer Dura Matter Layer Resection for Chiari Type I Malformation: Factors Correlated with Syrinx Reduction

Asian Spine Journal

Study Design: A retrospective cohort study.Purpose: We aimed to investigate the surgical results ... more Study Design: A retrospective cohort study.Purpose: We aimed to investigate the surgical results of foramen magnum decompression (FMD) to identify the potential factors associated with syrinx reduction in Chiari malformation type I (CMI).Overview of Literature: The predictive value of preoperative factors for syrinx reduction in patients with CMI remains debatable.Methods: We enrolled patients who underwent microscopic FMD with outer dural layer resection for CMI. The distance from the tip of the cerebellar tonsil to the C2 vertebral endplate on sagittal magnetic resonance imaging (MRI) was defined as the tonsillar distance (TD). Patients who showed a >20% syrinx diameter reduction on the 1-year follow-up MRI were defined as the syrinx reduction group while the others were categorized in the syrinx nonreduction group. Patients with syringomyelia were categorized into the clinically improved and unimproved groups using the Chicago Chiari Outcome Scale. The imaging and clinical par...

Download

Intra - articular injection of autologous bone marrow mesenchymal stem cells for articular cartilage repair

Nihon rinsho. Japanese journal of clinical medicine, 2015

Randomized trial of granulocyte colony-stimulating factor for spinal cord injury

Brain, 2021

Attenuation of the secondary injury of spinal cord injury (SCI) can suppress the spread of spinal... more Attenuation of the secondary injury of spinal cord injury (SCI) can suppress the spread of spinal cord tissue damage, possibly resulting in spinal cord sparing that can improve functional prognoses. Granulocyte colony-stimulating factor (G-CSF) is a haematological cytokine commonly used to treat neutropenia. Previous reports have shown that G-CSF promotes functional recovery in rodent models of SCI. Based on preclinical results, we conducted early phase clinical trials, showing safety/feasibility and suggestive efficacy. These lines of evidence demonstrate that G-CSF might have therapeutic benefits for acute SCI in humans. To confirm this efficacy and to obtain strong evidence for pharmaceutical approval of G-CSF therapy for SCI, we conducted a phase 3 clinical trial designed as a prospective, randomized, double-blinded and placebo-controlled comparative trial. The current trial included cervical SCI [severity of American Spinal Injury Association (ASIA) Impairment Scale (AIS) B or ...

Download

Quantitative evaluation of abnormal finger movements in myelopathy hand during the grip and release test using gyro sensors

PLOS ONE, 2021

Previous studies have reported qualitative characteristics of myelopathy hand, but few studies ha... more Previous studies have reported qualitative characteristics of myelopathy hand, but few studies have reported quantitative kinematic parameters of this condition. Our purpose of this study was to quantitatively evaluate the abnormal finger movements in patients with cervical compressive myelopathy (CCM) (termed myelopathy hand) and to understand the characteristics of myelopathy hand during the grip and release test (GRT) using gyro sensors. Sixty patients with CCM (severe: n = 30; mild-to-moderate: n = 30) and sixty healthy adults (age-matched control: n = 30; young control: n = 30) were included in this study. All participants performed the GRT. The index and little fingers’ and the wrist’s movements during the GRT were recorded using three gyro sensors. The number of cycles, switching time-delay, time per cycle, and peak angular velocity were calculated and compared between groups. Patients with severe CCM had the lowest number of cycles and longest switching time-delays, followed...

Download

The safety and efficacy of magnetic targeting using autologous mesenchymal stem cells for cartilage repair

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, Jan 16, 2018

A new cell delivery system using magnetic force, termed magnetic targeting, was developed for the... more A new cell delivery system using magnetic force, termed magnetic targeting, was developed for the accumulation of locally injected cells in a lesion. The aim of this study was to assess the safety and efficacy of mesenchymal stem cell (MSC) magnetic targeting in patients with a focal articular cartilage defect in the knee. MSC magnetic targeting for five patients was approved by the Ministry of Health Labour and Welfare of Japan. Autologous bone marrow MSCs were cultured and subsequently magnetized with ferucarbotran. The 1.0-T compact magnet was attached to a suitable position around the knee joint to allow the magnetic force to be as perpendicular to the surface of the lesion as possible. Then 1 × 10 MSCs were injected into the knee joint. The magnet was maintained in the same position for 10 min after the MSC injection. The primary endpoint was the occurrence of any adverse events. The secondary endpoints were efficacy assessed by magnetic resonance imaging (MRI) T2 mapping and c...

Download

Local administration of WP9QY (W9) peptide promotes bone formation in a rat femur delayed-union model

Journal of Bone and Mineral Metabolism, 2017

Download

Discrimination of a nerve fiber that is the origin of a cauda equina tumor using acetylcholinesterase staining

Neuropathology, 2017

Download

Cell magnetic targeting system for repair of severe chronic osteochondral defect in a rabbit model

Cell transplantation, Jan 28, 2015

The aim of this study was to investigate a cell delivery system for repair of severe chronic oste... more The aim of this study was to investigate a cell delivery system for repair of severe chronic osteochondral defect using magnetically labeled mesenchymal stem cells (m-MSCs), with the aid of an external magnetic device, through the accumulation of a small number of m-MSCs into a desired area and to detect the suitable number of autologous m-MSCs needed for repair of the defect. Twenty-six male Japanese white rabbits aged 6 months were used. An osteochondral defect (OD) was created bilaterally at the weight bearing surface of the medial femoral condyle of the rabbits' knees (3mm diameter; 4mm depth). At 4 weeks after creation of the defect, autogenic transplantation of the m-MSc into the defect area was performed, followed by 10 min exposure to an external magnetic device, where animals were divided into 4 groups: high (1×10(6) m-MSCs), medium (2×10(5) m-MSCs), low (4×10(4) m-MSCs) and control (PBS injection). At 4 and 12 weeks post-transplantation of m-MSCs, repaired tissue was a...

Download

Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury

Neural Regeneration Research, 2018

Download

miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models

Frontiers in Cell and Developmental Biology, Jan 4, 2023

Download

Novel Hybrid Hydroxyapatite Spacers Ensure Sufficient Bone Bonding in Cervical Laminoplasty

Asian Spine Journal, Dec 31, 2018

Download

Magnetic Resonance Imaging Evaluation of Cartilage Repair and Iron Particle Kinetics After Magnetic Delivery of Stem Cells

Tissue Engineering Part C-methods, Dec 1, 2018

Download

Microcervical Foraminotomy for Cervical Juxtafacet Cysts: Case Series and Literature Review

The International Journal of Spine Surgery, Feb 24, 2023

Download

Physical Signs and Clinical Features of Cervical Myelopathy in Elderly Patients, Especially 80 Years or Older: Comparison of 100 Consecutive Operative Cases across Three Age Groups

Asian Spine Journal, Jul 6, 2023

Download

An Investigation of Spinal Surgery Using a Navigation System

Intradiscal Condoliase Injection Therapy for Recurrent Lumbar Disc Herniation: Case Series and Literature Review

Medicina

Download

Immediate Closed Reduction Technique for Cervical Spine Dislocations

Asian Spine Journal

Download

$Research paper thumbnail of Prognostic factors of balloon kyphoplasty for osteoporotic vertebral fractures with diffuse idiopathic skeletal hyperostosis$

Prognostic factors of balloon kyphoplasty for osteoporotic vertebral fractures with diffuse idiopathic skeletal hyperostosis

Journal of Neurosurgery: Spine