Biomedical ethics is not taught as a subject in undergraduate or postgraduate studies in our coun... more Biomedical ethics is not taught as a subject in undergraduate or postgraduate studies in our country. Recently governing bodies have introduced the subject in medical school in a limited manner. A majority of doctors are unable to appreciate the importance of the subject in the curriculum. This article emphasises the importance of this subject by sharing the author's personal experiences after attaining a diploma in the subject.
DOAJ (DOAJ: Directory of Open Access Journals), Apr 1, 2011
Objective: To study the frequency o f various hypertensive disorders o f pregnancy and to determi... more Objective: To study the frequency o f various hypertensive disorders o f pregnancy and to determine their maternal and perinatal outcome. Study Design: Retrospective descriptive study.
Journal of the Dow University of Health Sciences, Apr 25, 2016
Reproductive health status of women in Pakistan requires immediate attention from all the stakeho... more Reproductive health status of women in Pakistan requires immediate attention from all the stakeholders, including the State as well.
Disseminated intravascular coagulopathy (DIC) is an uncommon but serious complication of pregnanc... more Disseminated intravascular coagulopathy (DIC) is an uncommon but serious complication of pregnancy. Placental abruption is the most common associated condition among the causes of acute obstetrical DIC. We present a case of life-threatening DIC complicating placental abruption in the second trimester of pregnancy with protein S deficiency as a triggering factor, which necessitated urgent termination of pregnancy.
JCPSP. Journal of the College of Physicians & Surgeons Pakistan, 2005
A case of partial hydatidiform mole is presented, occurring in a young primiparous woman after na... more A case of partial hydatidiform mole is presented, occurring in a young primiparous woman after natural conception. She presented with incomplete miscarriage. Histological diagnosis of partial mole was made. Failure of beta HCG to fall resulted in the start of chemotherapy. WHO scoring placed her in low risk group. In spite of the low risk, she required third line chemotherapy for complete eradication of disease.
Objective: To determine clinical characteristics, obstetrics and perinatal outcome of coronavirus... more Objective: To determine clinical characteristics, obstetrics and perinatal outcome of coronavirus disease 2019 infection in pregnant women. Method: The cross-sectional study was conducted at the Department of Obstetrics and Gynaecology of the Ruth Pfau Civil Hospital, Karachi, and Dow University of Health Sciences, Karachi, from August 2020 to July 2021, and comprised pregnant women with suspicion of coronavirus disease 2019 infection, who underwent recommended testing, and were found to be positive. Oral swabs for the presence of infection were also taken from the neonate within 24 hours of delivery. Data was analysed using Stata 11. Results: There were 41 women with a mean age of 27±5 years, a mean gestational age of 35±3 weeks, and mean parity 1.2±1.01. Of them, 3(7.3%) women died. Medical complications found along with coronavirus disease 2019 infection were pregnancy-induced hypertension 2(4.8%), eclampsia 4(11%) and diabetes mellitus 2(4.8%). Fever was the most common symptom ...
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016
OBJECTIVE To study the perceptions of medical students about factors responsible for physicians&#... more OBJECTIVE To study the perceptions of medical students about factors responsible for physicians'migration. STUDY DESIGN Cross-sectional survey. PLACE AND DURATION OF STUDY Dow Medical College and Civil Hospital, Karachi, from April to May 2015. METHODOLOGY Aself-administered structured questionnaire was used including demographic details, attitudes about push and pull factors of migration, and reasons for migrating or not migrating abroad. Final year students and interns were included. Likert scale from 1 to 4 (1=strongly disagree to 4=strongly agree) was used to assess attitudes. Data was analyzed by SPSS version 16. RESULTS Atotal of 240 medical students, mostly females (n=181, 75%) (60% final year and 40% interns), participated in the study. Majority wished to go abroad (n=127; 54%) with United States being the favourite destination (n=80; 66.1%) and internal medicine fields being the preferred choice for specialization (n=126; 54%). The major pull factors were better quality...
Bioethics is not taught as a subject discipline in the undergraduate and postgraduate curriculum ... more Bioethics is not taught as a subject discipline in the undergraduate and postgraduate curriculum in Pakistan. Recently, medical colleges have introduced the behavioural sciences in the undergraduate curriculum, but this has its own limitations, as students are not examined at the end of course work, as in other subjects, which they have to clear in order to get promoted.
JPMA. The Journal of the Pakistan Medical Association, 2016
Diabetes mellitus has assumed the role of an epidemic. Previously considered a disease of affluen... more Diabetes mellitus has assumed the role of an epidemic. Previously considered a disease of affluent developed countries, it has become more common in developing countries. Pakistan is included among the countries with a high prevalence of diabetes. In this scenario, postpartum management of a woman with diabetes mellitus becomes more important as in this period counseling and educating a woman is essential. Counselling includes life style modifications to prevent future risks involving all the systems of the body. This review article discusses management of diabetes mellitus in postpartum period, guidelines for postpartum screening of women with gestational diabetes mellitus, risks involved in future life and stresses upon the need of local population based studies. Primary care providers and gynaecologists must realize the importance of postpartum screening for diabetes mellitus and provide relevant information to women as well.
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2014
Objective: To compare the efficacy of spot urinary protein/creatinine ratio with 24 h urinary pro... more Objective: To compare the efficacy of spot urinary protein/creatinine ratio with 24 h urinary protein excretion in women with pre-eclampsia. Methods: A total of 85 women with hypertensive disorders during pregnancy were prospectively studied. Urine protein/creatinine ratio in spot urine sample was compared with 24 h urinary protein. Sensitivity and specificity for urinary spot P/C (protein/creatinine) ratio was assessed, and receiver operating curve was used to determine the value against the gold standard of >300 mg proteinuria in 24 h urinary sample. Results: Of 85 women, complete data were available for 81 women. There was a strong correlation between spot urinary P/C ratio and 24 h urine protein excretion (r = 0.81, P value <0.000). The optimal spot P/C ratio cutoff point was 0.14 for 300 mg/24 h of protein excretion (preeclampsia) with a sensitivity of 82% and specificity of 79%. Conclusion: We found a strong correlation between spot urinary P/C and 24 h urinary protein. Spot urinary protein/creatinine ratio is a good predictor of proteinuria for preeclampsia.
International Journal of Gynecology & Obstetrics, 2011
Objective: To determine the prevalence of vitamin D deficiency in Pakistani parturients and their... more Objective: To determine the prevalence of vitamin D deficiency in Pakistani parturients and their newborns and to assess the correlation between maternal and newborn serum levels of the vitamin D metabolite 25-hydroxy vitamin D3. Methods: A prospective study of parturients presenting to the labor suite with a singleton pregnancy. Maternal and cord blood were collected for estimation of serum 25-hydroxy vitamin D3. Results: In total, 89% of the gravidae were deficient in vitamin D (serum 25-hydroxy vitamin D3 b 30 ng/mL). There was a positive correlation between maternal and cord blood 25-hydroxy vitamin D3 levels(r =0.68; P b 0.001). Inverse correlations were noted between cord blood 25-hydroxy vitamin D3 and a longer duration of gestation (r = − 0.33; P = 0.003) and with the newborn's birth weight (r = − 0.23; P = 0.048). Maternal 25-hydroxy vitamin D3 levels were inversely correlated with maternal mean arterial pressure (r = 0.029; P b 0.020). Conclusion: There was a high prevalence of vitamin D deficiency in the Pakistani parturients and their newborns. There was a correlation between higher maternal vitamin D levels and lower blood pressure in the mothers.
Paidas/Hemostasis and Thrombosis in Obstetrics & Gynecology, 2011
... By Michael J. Paidas, Nazli Hossain, Tahir S. Shamsi, Marc A. Rodger, Jens Langhoff-Roos, and... more ... By Michael J. Paidas, Nazli Hossain, Tahir S. Shamsi, Marc A. Rodger, Jens Langhoff-Roos, and Charles J. Lockwood ... nia), prolonged partial thromboplastin time, decrease factor VIII levels, decreased vWF antigen (ELISA assay), functional assays including Risto-cetin co factor ...
Biomedical ethics is not taught as a subject in undergraduate or postgraduate studies in our coun... more Biomedical ethics is not taught as a subject in undergraduate or postgraduate studies in our country. Recently governing bodies have introduced the subject in medical school in a limited manner. A majority of doctors are unable to appreciate the importance of the subject in the curriculum. This article emphasises the importance of this subject by sharing the author&#39;s personal experiences after attaining a diploma in the subject.
DOAJ (DOAJ: Directory of Open Access Journals), Apr 1, 2011
Objective: To study the frequency o f various hypertensive disorders o f pregnancy and to determi... more Objective: To study the frequency o f various hypertensive disorders o f pregnancy and to determine their maternal and perinatal outcome. Study Design: Retrospective descriptive study.
Journal of the Dow University of Health Sciences, Apr 25, 2016
Reproductive health status of women in Pakistan requires immediate attention from all the stakeho... more Reproductive health status of women in Pakistan requires immediate attention from all the stakeholders, including the State as well.
Disseminated intravascular coagulopathy (DIC) is an uncommon but serious complication of pregnanc... more Disseminated intravascular coagulopathy (DIC) is an uncommon but serious complication of pregnancy. Placental abruption is the most common associated condition among the causes of acute obstetrical DIC. We present a case of life-threatening DIC complicating placental abruption in the second trimester of pregnancy with protein S deficiency as a triggering factor, which necessitated urgent termination of pregnancy.
JCPSP. Journal of the College of Physicians & Surgeons Pakistan, 2005
A case of partial hydatidiform mole is presented, occurring in a young primiparous woman after na... more A case of partial hydatidiform mole is presented, occurring in a young primiparous woman after natural conception. She presented with incomplete miscarriage. Histological diagnosis of partial mole was made. Failure of beta HCG to fall resulted in the start of chemotherapy. WHO scoring placed her in low risk group. In spite of the low risk, she required third line chemotherapy for complete eradication of disease.
Objective: To determine clinical characteristics, obstetrics and perinatal outcome of coronavirus... more Objective: To determine clinical characteristics, obstetrics and perinatal outcome of coronavirus disease 2019 infection in pregnant women. Method: The cross-sectional study was conducted at the Department of Obstetrics and Gynaecology of the Ruth Pfau Civil Hospital, Karachi, and Dow University of Health Sciences, Karachi, from August 2020 to July 2021, and comprised pregnant women with suspicion of coronavirus disease 2019 infection, who underwent recommended testing, and were found to be positive. Oral swabs for the presence of infection were also taken from the neonate within 24 hours of delivery. Data was analysed using Stata 11. Results: There were 41 women with a mean age of 27±5 years, a mean gestational age of 35±3 weeks, and mean parity 1.2±1.01. Of them, 3(7.3%) women died. Medical complications found along with coronavirus disease 2019 infection were pregnancy-induced hypertension 2(4.8%), eclampsia 4(11%) and diabetes mellitus 2(4.8%). Fever was the most common symptom ...
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016
OBJECTIVE To study the perceptions of medical students about factors responsible for physicians&#... more OBJECTIVE To study the perceptions of medical students about factors responsible for physicians'migration. STUDY DESIGN Cross-sectional survey. PLACE AND DURATION OF STUDY Dow Medical College and Civil Hospital, Karachi, from April to May 2015. METHODOLOGY Aself-administered structured questionnaire was used including demographic details, attitudes about push and pull factors of migration, and reasons for migrating or not migrating abroad. Final year students and interns were included. Likert scale from 1 to 4 (1=strongly disagree to 4=strongly agree) was used to assess attitudes. Data was analyzed by SPSS version 16. RESULTS Atotal of 240 medical students, mostly females (n=181, 75%) (60% final year and 40% interns), participated in the study. Majority wished to go abroad (n=127; 54%) with United States being the favourite destination (n=80; 66.1%) and internal medicine fields being the preferred choice for specialization (n=126; 54%). The major pull factors were better quality...
Bioethics is not taught as a subject discipline in the undergraduate and postgraduate curriculum ... more Bioethics is not taught as a subject discipline in the undergraduate and postgraduate curriculum in Pakistan. Recently, medical colleges have introduced the behavioural sciences in the undergraduate curriculum, but this has its own limitations, as students are not examined at the end of course work, as in other subjects, which they have to clear in order to get promoted.
JPMA. The Journal of the Pakistan Medical Association, 2016
Diabetes mellitus has assumed the role of an epidemic. Previously considered a disease of affluen... more Diabetes mellitus has assumed the role of an epidemic. Previously considered a disease of affluent developed countries, it has become more common in developing countries. Pakistan is included among the countries with a high prevalence of diabetes. In this scenario, postpartum management of a woman with diabetes mellitus becomes more important as in this period counseling and educating a woman is essential. Counselling includes life style modifications to prevent future risks involving all the systems of the body. This review article discusses management of diabetes mellitus in postpartum period, guidelines for postpartum screening of women with gestational diabetes mellitus, risks involved in future life and stresses upon the need of local population based studies. Primary care providers and gynaecologists must realize the importance of postpartum screening for diabetes mellitus and provide relevant information to women as well.
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2014
Objective: To compare the efficacy of spot urinary protein/creatinine ratio with 24 h urinary pro... more Objective: To compare the efficacy of spot urinary protein/creatinine ratio with 24 h urinary protein excretion in women with pre-eclampsia. Methods: A total of 85 women with hypertensive disorders during pregnancy were prospectively studied. Urine protein/creatinine ratio in spot urine sample was compared with 24 h urinary protein. Sensitivity and specificity for urinary spot P/C (protein/creatinine) ratio was assessed, and receiver operating curve was used to determine the value against the gold standard of >300 mg proteinuria in 24 h urinary sample. Results: Of 85 women, complete data were available for 81 women. There was a strong correlation between spot urinary P/C ratio and 24 h urine protein excretion (r = 0.81, P value <0.000). The optimal spot P/C ratio cutoff point was 0.14 for 300 mg/24 h of protein excretion (preeclampsia) with a sensitivity of 82% and specificity of 79%. Conclusion: We found a strong correlation between spot urinary P/C and 24 h urinary protein. Spot urinary protein/creatinine ratio is a good predictor of proteinuria for preeclampsia.
International Journal of Gynecology & Obstetrics, 2011
Objective: To determine the prevalence of vitamin D deficiency in Pakistani parturients and their... more Objective: To determine the prevalence of vitamin D deficiency in Pakistani parturients and their newborns and to assess the correlation between maternal and newborn serum levels of the vitamin D metabolite 25-hydroxy vitamin D3. Methods: A prospective study of parturients presenting to the labor suite with a singleton pregnancy. Maternal and cord blood were collected for estimation of serum 25-hydroxy vitamin D3. Results: In total, 89% of the gravidae were deficient in vitamin D (serum 25-hydroxy vitamin D3 b 30 ng/mL). There was a positive correlation between maternal and cord blood 25-hydroxy vitamin D3 levels(r =0.68; P b 0.001). Inverse correlations were noted between cord blood 25-hydroxy vitamin D3 and a longer duration of gestation (r = − 0.33; P = 0.003) and with the newborn's birth weight (r = − 0.23; P = 0.048). Maternal 25-hydroxy vitamin D3 levels were inversely correlated with maternal mean arterial pressure (r = 0.029; P b 0.020). Conclusion: There was a high prevalence of vitamin D deficiency in the Pakistani parturients and their newborns. There was a correlation between higher maternal vitamin D levels and lower blood pressure in the mothers.
Paidas/Hemostasis and Thrombosis in Obstetrics & Gynecology, 2011
... By Michael J. Paidas, Nazli Hossain, Tahir S. Shamsi, Marc A. Rodger, Jens Langhoff-Roos, and... more ... By Michael J. Paidas, Nazli Hossain, Tahir S. Shamsi, Marc A. Rodger, Jens Langhoff-Roos, and Charles J. Lockwood ... nia), prolonged partial thromboplastin time, decrease factor VIII levels, decreased vWF antigen (ELISA assay), functional assays including Risto-cetin co factor ...
Uploads
Papers by Nazli Hossain