Papers by RAFAEL S A N T O S PEREIRA
BackgroundSARS-CoV-2 serologic surveys estimate the proportion of the population with antibodies ... more BackgroundSARS-CoV-2 serologic surveys estimate the proportion of the population with antibodies against historical variants which nears 100% in many settings. New analytic approaches are required to exploit the full information in serosurvey data.MethodUsing a SARS-CoV-2 anti-Spike (S) protein chemiluminescent microparticle assay, we attained a semi-quantitative measurement of population IgG titres in serial cross-sectional monthly samples of routine blood donations across seven Brazilian state capitals (March 2021-November 2021). In an ecological analysis (unit of analysis: age-city-calendar month) we assessed the relative contributions of prior attack rate and vaccination to antibody titre in blood donors. We compared blood donor anti-S titre across the seven cities during the growth phase of the Delta variant of concern (VOC) and use this to predict the resulting age-standardized incidence of severe COVID-19 cases.ResultsOn average we tested 780 samples per month in each locatio...
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Archives of gerontology and geriatrics
The aims of this study were to compare the autonomic heart control parameters from sarcopenic and... more The aims of this study were to compare the autonomic heart control parameters from sarcopenic and non-sarcopenic community-dwelling elders. This is a cross-sectional study including 76 community-dwelling old adults, which was clinically stratified as sarcopenic or non-sarcopenic, according to the current recommendations. They were submitted to 5-min recordings of successive RR intervals. The analysis of the RR intervals variability was carried out in time (mean RR, RMSSD, pNN50, SDNN and triangular index) and frequency domains (LFnu, HFnu and LF/HF ratio), and with nonlinear methods (SD1, SD2, and D). The parameters of autonomic heart rate modulation (AHRM) were adjusted for potential confounders: sex, diabetes, beta-blockers use, cardiovascular disease, body mass index and physical activity level, smoking habit. Normality of the data was tested by Kolmogorov-Smirnov test and, since most variables did not exhibit a normal distribution the Mann-Whitney test was used to compare the pa...
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BMC Health Services Research, 2016
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Ciência & Saúde Coletiva, 2015
Objective: to ascertain the association between the social support and the quality of life of rel... more Objective: to ascertain the association between the social support and the quality of life of relative caregivers of elderly dependents at home.Method: a cross-sectional study conducted with 58 relative caregivers of elderly dependents, registered in the Family Health Strategy. Data were collected from the Katz instrument, sociodemographic, Zarit Burden Interview, WHOQOL-bref, and analyzed using descriptive statistics and multiple linear regression.Results: the majority of caregivers were women, who took care full-time and presented moderate to severe burden. Most caregivers are satisfied with their social relationships and the social support received. It is found that the burden and the time of care correlated with the social relationships domain, which is associated with social support, and consequently, reduced quality of life.Conclusion: social support for caregivers is important to prevent health implications, burden, biopsychosocial stress, and provide favorable conditions for...
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Advances in Intelligent Systems and Computing, 2013
Biological data integration is currently one of the major challenges in the field of Bioinformati... more Biological data integration is currently one of the major challenges in the field of Bioinformatics. Several studies show that biological knowledge is growing at a continuous rate and is usually distributed among many databases. This paper presents an overview of data integration and the existing approaches that aim to solve this problem. The paper will also review the different ontology approaches that were introduced by researchers for representing biological data.
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The International Journal of Cardiovascular Imaging, 2008
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There are large differences in the shape and size of regional SARS-CoV-2 epidemics in Brazil. Her... more There are large differences in the shape and size of regional SARS-CoV-2 epidemics in Brazil. Here we tested monthly blood donation samples for IgG antibodies from March 2020 to March 2021 in eight of Brazil’s most populous cities. There was large variation in the inferred attack rate adjusted for seroreversion across cities, and seroprevalence was consistently smaller in women and donors older than 55 years. The age-specific infection fatality rate differed between cities and consistently increased with age. The infection hospitalisation rate (IHR) increased significantly during the gamma-dominated second wave in Manaus, suggesting increased morbidity of the Gamma VOC compared to previous variants circulating in Manaus. The higher disease penetrance associated with the health system’s collapse increased the overall IFR by a minimum factor of 2.91 (95% CrI 2.43–3.53). These results demonstrate large heterogeneity in epidemic spread and highlight the utility of blood donor serosurvei...
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Research, Society and Development, Feb 1, 2022
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Psicopedagogia, 2022
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Revista Eletrônica Acervo Saúde, Mar 12, 2019
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Revista Mosaico, Jun 1, 2015
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Medicina, Dec 27, 2022
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Congresso Brasileiro de Mecânica dos Solos e Engenharia Geotécnica, 2020
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Papers by RAFAEL S A N T O S PEREIRA