This paper demonstrates an environmental friendly methodology for implementing an air conditionin... more This paper demonstrates an environmental friendly methodology for implementing an air conditioning or refrigeration system. In particular, the cooler does not deplete the earth's limited fossil fuel reserves nor does it harm the global environment either by depleting stratospheric ozone or by contributing to global warming through the emission of greenhouse gases. The electrical energy input needed to power the cooler is supplied from a solar panel. The air-conditioning based on thermoelectricity may play an important role despite a lower cooling performance compared with gas compression cycles. With the usual arrangement of a heat sink on each side of the Peltier device, air would be directed away on the hot side and forward on the cool side, thus cooling the surrounding area. The proposed model is verified using appropriated hardware, where the results are found to be satisfactory.
The present study has been designed to pharmacologically expound the significance of inducible ni... more The present study has been designed to pharmacologically expound the significance of inducible nitric oxide synthase in the pathophysiological progression of seizures using mouse models of chemically induced kindled epilepsy and status epilepticus induced spontaneous recurrent seizures. Pentylenetetrazole (40 mg kg À1 ) (PTZ) administration every second day for a period of 15 days was used to elicit kindled seizure activity in mice. Severity of kindled seizures was assessed in terms of a composite kindled seizure severity score (KSSS). Pilocarpine (100 mg kg À1 ) was injected every 20 min until the onset of status epilepticus. A spontaneous recurrent seizure severity score (SRSSS) was recorded as a measure of quantitative assessment of the progressive development of spontaneous recurrent seizures induced after pilocarpine status epilepticus. Sub-acute PTZ administration induced the development of severe form of kindled seizures in mice. Further, pharmacological status epilepticus elicited a progressive evolution of spontaneous recurrent seizures in the animals. However, treatment of aminoguanidine, a relatively selective inhibitor of inducible nitric oxide synthase, markedly and dose dependently suppressed the development of both PTZ induced kindled seizures as well as pilocarpine induced spontaneous recurrent seizures. Therefore inducible nitric oxide synthase may be implicated in the development of seizures.
This paper demonstrates an environmental friendly methodology for implementing an air conditionin... more This paper demonstrates an environmental friendly methodology for implementing an air conditioning or refrigeration system. In particular, the cooler does not deplete the earth's limited fossil fuel reserves nor does it harm the global environment either by depleting stratospheric ozone or by contributing to global warming through the emission of greenhouse gases. The electrical energy input needed to power the cooler is supplied from a solar panel. The air-conditioning based on thermoelectricity may play an important role despite a lower cooling performance compared with gas compression cycles. With the usual arrangement of a heat sink on each side of the Peltier device, air would be directed away on the hot side and forward on the cool side, thus cooling the surrounding area. The proposed model is verified using appropriated hardware, where the results are found to be satisfactory.
The present study has been designed to pharmacologically expound the significance of inducible ni... more The present study has been designed to pharmacologically expound the significance of inducible nitric oxide synthase in the pathophysiological progression of seizures using mouse models of chemically induced kindled epilepsy and status epilepticus induced spontaneous recurrent seizures. Pentylenetetrazole (40 mg kg À1 ) (PTZ) administration every second day for a period of 15 days was used to elicit kindled seizure activity in mice. Severity of kindled seizures was assessed in terms of a composite kindled seizure severity score (KSSS). Pilocarpine (100 mg kg À1 ) was injected every 20 min until the onset of status epilepticus. A spontaneous recurrent seizure severity score (SRSSS) was recorded as a measure of quantitative assessment of the progressive development of spontaneous recurrent seizures induced after pilocarpine status epilepticus. Sub-acute PTZ administration induced the development of severe form of kindled seizures in mice. Further, pharmacological status epilepticus elicited a progressive evolution of spontaneous recurrent seizures in the animals. However, treatment of aminoguanidine, a relatively selective inhibitor of inducible nitric oxide synthase, markedly and dose dependently suppressed the development of both PTZ induced kindled seizures as well as pilocarpine induced spontaneous recurrent seizures. Therefore inducible nitric oxide synthase may be implicated in the development of seizures.
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Papers by Rohit Thakur