Papers by Napakorn Sangchay
Siriraj Medical Journal, May 1, 2022
Objective: In situations where skeletal human remains are recovered, pelvic bone morphology has b... more Objective: In situations where skeletal human remains are recovered, pelvic bone morphology has been demonstrated to have an essential role in forensic sex identification. Determination of sex is one of the four pillars used to construct a biological profile of unidentified skeletal remains. Such analysis has mainly been confined to direct visual inspection or morphometric analysis of pelvic elements available. This study evaluates the identification accuracy and classification error established based on a morphometric sex determination of this bone either by direct observation or digital image analysis. Materials and Methods: We used morphometric analysis of human pelvic bone from modern Thai samples to clarify the effect of variation in pelvic morphometric parameters on prediction accuracy. A total number of 408 pelvic bones (Male, n=249 and Female, n=159) were examined. Pelvic morphometric variables were measured in multiple regions for each bone. Results: We found statistically significant differences in the pelvic morphometric parameters measured between the two sexes with considerably accurate classification and unavoidable errors by all means of analytical assessment. Conclusion: Our findings suggest that it is not only variation of pelvic morphometric parameters between the two sexes in this population, but also the selection of analytical approach that can impact prediction accuracy and thus may contribute to the effect on the determination of sex. Ethical approval was not required for this study.
Siriraj Medical Journal
Objective: Botulinum toxin (BoTX) injection to the longus colli (LCo) muscle has been demonstrate... more Objective: Botulinum toxin (BoTX) injection to the longus colli (LCo) muscle has been demonstrated to have a role in treating cervical dystonic (CD) patients. It can, however, cause critical complications and awareness of such complications is required. Currently, there is no substantial information regarding this novel procedure. This study aims to define the potentially safe method of injection based on assessment of anatomical measurements.Materials and Methods: We examined distances between the puncture sites and adjacent structures in Thiel-embalmed human cadavers (n=20) to propose an alternative technique for BoTX injection. Parameters were examined for the medial and lateral approaches at the fifth and sixth cervical vertebral levels. We compared each variable between the two different vertebral levels and the two different approaches to evaluate statistical differences.Results: Comparing distances between the puncture sites and neck anatomical structures in each of the two a...
The best way to learn human gross anatomy is achieved by dissecting human cadaver. Conventional e... more The best way to learn human gross anatomy is achieved by dissecting human cadaver. Conventional embalming human cadaver was used in teaching Gross anatomy in Department of Anatomy, Siriraj Hospital for more than 80 years. With significant disadvantages which were joint stiffness and tissue rigidity, the newest type of human cadaveric preservation “Soft cadaver; Thiel’s method” was developed in our department. The main purpose was to provide hand-on surgical skills improvement to both post-graduate and under-graduate medical students in our faculty before facing the real situation in patients.
Background: Liver is the organ which is responsible for the production of complements, cytokines ... more Background: Liver is the organ which is responsible for the production of complements, cytokines and acute phase proteins. Activation of complement system leads to inflammatory activation, lysis of an affected cell and finally cell death by three different pathways, including classical, the lectin and alternative pathways. There are many previous studies identified complement activation in plasma of many liver diseases but less studies could identified terminal complement complex within the liver tissue by immunohistopathology. Methods: 40 liver specimens from autopsy cases, liver core biopsy and surgical specimens were analyzed for histomorphology. Reticulin and C5b-9 staining were also performed. Results: Hepatocyte damage was varying from mild (15/40, 37.5%) to severe (10/40, 25%). Hepatocyte necrosis was absent in 1 case (2.5%) and presence in 39 of 40 (97.5%) cases (17 were mild, 12 were moderate and 10 of 39 cases were severe hepatic necrosis). Reticulin framework alteration w...
Oncology Letters, 2013
Diffuse parenchymal metastasis is an unusual pattern of liver metastasis that is capable of causi... more Diffuse parenchymal metastasis is an unusual pattern of liver metastasis that is capable of causing liver failure. In the present study, the authors describe malignant infiltration of the liver by primary breast carcinoma in an autopsy of a 49-year-old female who had a rapid onset of liver failure and died after three weeks. Ultrasonography and computed tomography (CT) scans of the abdomen, as well as macroscopic examination, failed to detect liver metastasis; while microscopic examination revealed diffuse tumor cells with a loss of E-cadherin expression infiltrating into the liver parenchyma. The prognosis of liver failure associated with malignant infiltration is extremely poor; the survival time of patients is extremely low. Liver biopsy may be the most efficient technique for confirming the diagnosis during the patient's life.
Background: Liver is the organ which is responsible for the production of complements, cytokines ... more Background: Liver is the organ which is responsible for the production of complements, cytokines and acute phase proteins. Activation of complement system leads to in ammatory activation, lysis of an affected cell and nally cell death by three different pathways, including classical, the lectin and alternative pathways. There are many previous studies identi ed complement activation in plasma of many liver diseases but less studies could identi ed terminal complement complex within the liver tissue by immunohistopathology.
Methods: 40 liver specimens from autopsy cases, liver core biopsy and surgical specimens were analyzed for histomorphology. Reticulin and C5b-9 staining were also performed.
Results: Hepatocyte damage was varying from mild (15/40, 37.5%) to severe (10/40, 25%). Hepatocyte necrosis was absent in 1 case (2.5%) and presence in 39 of 40 (97.5%) cases (17 were mild, 12 were moderate and 10 of 39 cases were severe hepatic necrosis). Reticulin framework alteration was absent in 11/40 (27.5%) but present in 29 of 40 (72.5%) cases (24/40 of mild and 5/40 of moderate alteration). Degree of in ammation was varying from mild (32/40, 80%) to severe (2/40, 5%) with lymphocytic predominant of 34/40 (85%) and neutrophilic predominant of 6/40 (15%). Immunohistochemistry staining for C5b-9 is found in 2 of 40 cases (5%). Conclusion: In hepatic injury that was caused from different etiology other than viral infection, complement- mediated cellular injury may play as a role in pathogenesis of the cellular change and leading to cell death.
The best way to learn human gross anatomy is achieved by dissecting human cadaver. Conventional e... more The best way to learn human gross anatomy is achieved by dissecting human cadaver. Conventional embalming human cadaver was used in teaching Gross anatomy in Department of Anatomy, Siriraj Hospital for more than 80 years. With signi cant disadvantages which were joint stiffness and tissue rigidity, the newest type of human cadaveric preservation “Soft cadaver; Thiel’s method” was developed in our department. The main purpose was to provide hand-on surgical skills improvement to both post-graduate and under-graduate medical students in our faculty before facing the real situation in patients.
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Papers by Napakorn Sangchay
Methods: 40 liver specimens from autopsy cases, liver core biopsy and surgical specimens were analyzed for histomorphology. Reticulin and C5b-9 staining were also performed.
Results: Hepatocyte damage was varying from mild (15/40, 37.5%) to severe (10/40, 25%). Hepatocyte necrosis was absent in 1 case (2.5%) and presence in 39 of 40 (97.5%) cases (17 were mild, 12 were moderate and 10 of 39 cases were severe hepatic necrosis). Reticulin framework alteration was absent in 11/40 (27.5%) but present in 29 of 40 (72.5%) cases (24/40 of mild and 5/40 of moderate alteration). Degree of in ammation was varying from mild (32/40, 80%) to severe (2/40, 5%) with lymphocytic predominant of 34/40 (85%) and neutrophilic predominant of 6/40 (15%). Immunohistochemistry staining for C5b-9 is found in 2 of 40 cases (5%). Conclusion: In hepatic injury that was caused from different etiology other than viral infection, complement- mediated cellular injury may play as a role in pathogenesis of the cellular change and leading to cell death.
Methods: 40 liver specimens from autopsy cases, liver core biopsy and surgical specimens were analyzed for histomorphology. Reticulin and C5b-9 staining were also performed.
Results: Hepatocyte damage was varying from mild (15/40, 37.5%) to severe (10/40, 25%). Hepatocyte necrosis was absent in 1 case (2.5%) and presence in 39 of 40 (97.5%) cases (17 were mild, 12 were moderate and 10 of 39 cases were severe hepatic necrosis). Reticulin framework alteration was absent in 11/40 (27.5%) but present in 29 of 40 (72.5%) cases (24/40 of mild and 5/40 of moderate alteration). Degree of in ammation was varying from mild (32/40, 80%) to severe (2/40, 5%) with lymphocytic predominant of 34/40 (85%) and neutrophilic predominant of 6/40 (15%). Immunohistochemistry staining for C5b-9 is found in 2 of 40 cases (5%). Conclusion: In hepatic injury that was caused from different etiology other than viral infection, complement- mediated cellular injury may play as a role in pathogenesis of the cellular change and leading to cell death.