Context. Arsenicosis is caused by long term (6 months plus) ingestion of arsenic above a safe dos... more Context. Arsenicosis is caused by long term (6 months plus) ingestion of arsenic above a safe dose, characterized by skin lesions and possible involvement of internal organs. Arsenicosis is common in India and Bangladesh where naturally occurring high concentrations of arsenic in the earth's crust contaminate ground water, causing adverse health effects. Case Presentation. We report a case of a 55-year-old Indian male, resident of a known arsenic endemic region of Uttar Pradesh who suffered from characteristic pulmonary and cutaneous features of chronic arsenic toxicity which included radiological findings of interstitial lung disease, hyperkeratotic lesions over the palms and soles, rain drop like pigmentation over the trunk, and carcinomatous changes at the wrist joint. The patient was started on chelating agents (d-penicillamine) and oral retinoids (isotretinoin) followed by the surgical excision of the carcinoma. Discussion. Environmental contamination with arsenic is a well...
Journal of Pakistan Association of Dermatology, 2017
Xanthomas are focal infiltrates of lipid-containing histiocytic foam cells that are usually found... more Xanthomas are focal infiltrates of lipid-containing histiocytic foam cells that are usually found within the dermis or tendons. It is a clinical manifestation of lipoprotein metabolic disorders. We report a case of tuberous xanthoma in a 45-year-old woman who presented with multiple firm papules and nodules involving multiple sites of the body including the amputated right forearm with elevated serum cholesterol, triglycerides, LDL and VLDL.
Cutis Marmorata Telangiectatica Congenita (CMTC) is an uncommon, sporadic, usually congenital, cu... more Cutis Marmorata Telangiectatica Congenita (CMTC) is an uncommon, sporadic, usually congenital, cutaneous vascular disorder of unknown aetiology. Clinically characterised by persistent cutis marmorata , telangiectasia, cutaneous atrophy and ulceration. CMTC have been found to be associated with many anomalies like limb asymmetry, cutis aplasia congenital, hemangiomas , pigmented nevi , macrocephaly , glaucoma etc. Diagnosis is made on clinical grounds. The prognosis of CMTC is mostly benign with half of patients demonstrating resolution of fixed reticulated erythema over two years but because of associated anomalies patients should be properly examined and investigated. Here, we are reporting a 3 month old girl child with fixed reticulated erythematous lesion distributed in a generalized pattern with limb hypertrophy present since
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by a unique susceptib... more Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by a unique susceptibility to cutaneous infection by a group of phylogenetically related human papilloma viruses (HPVs). These patients show a defect in cell-mediated immunity specific toward the causative HPVs that leads to lifelong disease. The defect is usually inherited as autosomal recessive trait and presents clinically with plane warts, pityriasis versicolor-like lesions and reddish verrucous plaques. Dysplastic and malignant changes in the form of actinic keratoses, Bowen's disease and squamous cell carcinoma (SCC) are common but metastasis occurs rarely. A totally effective treatment against EV is as yet highly desirable. We report a case of EDV in a 13-year-old female patient with confluent wart like lesions, pityriasis versicolor like lesions and reddish plaques. The case is being reported in view of rarity of disease.
Context. Arsenicosis is caused by long term (6 months plus) ingestion of arsenic above a safe dos... more Context. Arsenicosis is caused by long term (6 months plus) ingestion of arsenic above a safe dose, characterized by skin lesions and possible involvement of internal organs. Arsenicosis is common in India and Bangladesh where naturally occurring high concentrations of arsenic in the earth's crust contaminate ground water, causing adverse health effects. Case Presentation. We report a case of a 55-year-old Indian male, resident of a known arsenic endemic region of Uttar Pradesh who suffered from characteristic pulmonary and cutaneous features of chronic arsenic toxicity which included radiological findings of interstitial lung disease, hyperkeratotic lesions over the palms and soles, rain drop like pigmentation over the trunk, and carcinomatous changes at the wrist joint. The patient was started on chelating agents (d-penicillamine) and oral retinoids (isotretinoin) followed by the surgical excision of the carcinoma. Discussion. Environmental contamination with arsenic is a well...
Journal of Pakistan Association of Dermatology, 2017
Xanthomas are focal infiltrates of lipid-containing histiocytic foam cells that are usually found... more Xanthomas are focal infiltrates of lipid-containing histiocytic foam cells that are usually found within the dermis or tendons. It is a clinical manifestation of lipoprotein metabolic disorders. We report a case of tuberous xanthoma in a 45-year-old woman who presented with multiple firm papules and nodules involving multiple sites of the body including the amputated right forearm with elevated serum cholesterol, triglycerides, LDL and VLDL.
Cutis Marmorata Telangiectatica Congenita (CMTC) is an uncommon, sporadic, usually congenital, cu... more Cutis Marmorata Telangiectatica Congenita (CMTC) is an uncommon, sporadic, usually congenital, cutaneous vascular disorder of unknown aetiology. Clinically characterised by persistent cutis marmorata , telangiectasia, cutaneous atrophy and ulceration. CMTC have been found to be associated with many anomalies like limb asymmetry, cutis aplasia congenital, hemangiomas , pigmented nevi , macrocephaly , glaucoma etc. Diagnosis is made on clinical grounds. The prognosis of CMTC is mostly benign with half of patients demonstrating resolution of fixed reticulated erythema over two years but because of associated anomalies patients should be properly examined and investigated. Here, we are reporting a 3 month old girl child with fixed reticulated erythematous lesion distributed in a generalized pattern with limb hypertrophy present since
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by a unique susceptib... more Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by a unique susceptibility to cutaneous infection by a group of phylogenetically related human papilloma viruses (HPVs). These patients show a defect in cell-mediated immunity specific toward the causative HPVs that leads to lifelong disease. The defect is usually inherited as autosomal recessive trait and presents clinically with plane warts, pityriasis versicolor-like lesions and reddish verrucous plaques. Dysplastic and malignant changes in the form of actinic keratoses, Bowen's disease and squamous cell carcinoma (SCC) are common but metastasis occurs rarely. A totally effective treatment against EV is as yet highly desirable. We report a case of EDV in a 13-year-old female patient with confluent wart like lesions, pityriasis versicolor like lesions and reddish plaques. The case is being reported in view of rarity of disease.
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Papers by Sonal Sachan