Many phytochemicals show promise in cancer prevention and treatment, but their low aqueous solubi... more Many phytochemicals show promise in cancer prevention and treatment, but their low aqueous solubility, poor stability, unfavorable bioavailability, and low target specificity make administering them at therapeutic doses unrealistic. This is particularly true for (-)-epigallocatechin gallate, curcumin, quercetin, resveratrol, and genistein. There is an increasing interest in developing novel delivery strategies for these natural products. Liposomes, micelles, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and poly (lactide-co-glycolide) nanoparticles are biocompatible and biodegradable nanoparticles. Those nanoparticles can increase the stability and solubility of phytochemicals, exhibit a sustained release property, enhance their absorption and bioavailability, protect them from premature enzymatic degradation or metabolism, prolong their circulation time, improve their target specificity to cancer cells or tumors via passive or targeted delivery, lower toxi...
A high potency of Lycopodium clavatum Linn. (200th centesimal potency) is tested for its hepatopr... more A high potency of Lycopodium clavatum Linn. (200th centesimal potency) is tested for its hepatoprotective action against carbon tetrachloride-induced hepatic damage in rat. It has been established from biochemical and histopathological studies that at least 4 doses of Lycopodium 200 can control the CC14-induced alteration of plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acetylcholinesterase, lactate deyhydrogenase, bilirubin and urea. Protective action of the drug has also been confirmed by microanatomical studies on hepatic tissues. Lycopodium clavatum L, commonly known as wolf's foot, is a clubmoss belonging to the family Lycopodiaceae. This moss has been described to have marked action on the liver by many authors. I-4 The present experiment has been designed to prove biochemically and histopathologically the beneficial effect of a higher potency (200th centesimal) of Lycopodium clavatum in experimentally induced liver disease by carbon tetrachloride (CC14) in albino rats.
Many phytochemicals show promise in cancer prevention and treatment, but their low aqueous solubi... more Many phytochemicals show promise in cancer prevention and treatment, but their low aqueous solubility, poor stability, unfavorable bioavailability, and low target specificity make administering them at therapeutic doses unrealistic. This is particularly true for (-)-epigallocatechin gallate, curcumin, quercetin, resveratrol, and genistein. There is an increasing interest in developing novel delivery strategies for these natural products. Liposomes, micelles, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and poly (lactide-co-glycolide) nanoparticles are biocompatible and biodegradable nanoparticles. Those nanoparticles can increase the stability and solubility of phytochemicals, exhibit a sustained release property, enhance their absorption and bioavailability, protect them from premature enzymatic degradation or metabolism, prolong their circulation time, improve their target specificity to cancer cells or tumors via passive or targeted delivery, lower toxi...
A high potency of Lycopodium clavatum Linn. (200th centesimal potency) is tested for its hepatopr... more A high potency of Lycopodium clavatum Linn. (200th centesimal potency) is tested for its hepatoprotective action against carbon tetrachloride-induced hepatic damage in rat. It has been established from biochemical and histopathological studies that at least 4 doses of Lycopodium 200 can control the CC14-induced alteration of plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acetylcholinesterase, lactate deyhydrogenase, bilirubin and urea. Protective action of the drug has also been confirmed by microanatomical studies on hepatic tissues. Lycopodium clavatum L, commonly known as wolf's foot, is a clubmoss belonging to the family Lycopodiaceae. This moss has been described to have marked action on the liver by many authors. I-4 The present experiment has been designed to prove biochemically and histopathologically the beneficial effect of a higher potency (200th centesimal) of Lycopodium clavatum in experimentally induced liver disease by carbon tetrachloride (CC14) in albino rats.
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