OBJECTIVE This study aimed to review the risk factors for silicosis together with survival analys... more OBJECTIVE This study aimed to review the risk factors for silicosis together with survival analysis and a perspective for lung transplantation with data from a single center. MATERIAL AND METHODS We reviewed the medical records of denim sandblasters who were referred to our center between January 2006 and December 2011 and evaluated 219 patients with a history of denim sandblasting with a minimum follow-up period of 5 years until 2016. We analyzed several personal and occupational features, together with functional and radiologic data. RESULTS Of the 219 denim sandblasters, 107 (49%) had been diagnosed with silicosis. In the logistic regression analysis, the duration of exposure was the only independent risk factor for the development of silicosis, indicating a 9% increased risk of silicosis for every month of exposure (p<0.001; odds ratio 1.09; 95% confidence interval 1.050-1.132). Of the patients, 7 (3%) died. A forced expiratory volume in the first second of <44% and a forced vital capacity of <47% were associated with an increased risk of mortality. Mortality was significantly higher in the international labor office category 3 patients, and 5-year survival rates of patients with A, B, and C lung opacities were 88%, 67%, and 25%, respectively. CONCLUSION Silicosis still kills young workers. Severe radiologic involvement and decreased lung volumes are related to mortality, and lung transplantation is the only therapeutic option.
AimTo assess C-reactive protein to albumin ratio (CAR) before and after treatment with biological... more AimTo assess C-reactive protein to albumin ratio (CAR) before and after treatment with biological agents in patients with psoriasis to determine whether CAR can be used as an inflammation biomarker.MethodsMedical records of patients with psoriasis treated with biological agents at the Department of Dermatology, Gazi University Hospital were retrospectively evaluated between June 2018 and August 2019. The patients were divided into four groups based on the type of treatment (adalimumab, ustekinumab, infliximab, secukinumab). CAR was evaluated before and three months after treatment.ResultsThe study enrolled 157 patients with psoriasis vulgaris (91 male) aged between 18 and 85. CAR significantly decreased in all treatment groups (adalimumab group P < 0.001; ustekinumab P = 0.006; infliximab P = 0.007; secukinumab P < 0.001). The most prominent decrease in CAR was observed in patients treated with secukinumab (median CAR before treatment 1.52 [1.01-3.04] and after treatment 0.84 [0.62-0.99]).ConclusionCAR may be a good indicator of systemic inflammation in psoriasis patients treated with biological agents.
GIRIŞ: Kirim Kongo Kanamali Atesi (KKKA), Afrika, Asya, Dogu Avrupa ve Orta Doguda gorulen kene k... more GIRIŞ: Kirim Kongo Kanamali Atesi (KKKA), Afrika, Asya, Dogu Avrupa ve Orta Doguda gorulen kene kaynakli, akut, olumcul, viral bir hastaliktir. Mortalitesi %3-30 arasinda olup, bu yuzde oldukca yuksektir. Ozellikle kene populasyonunun yuksek oldugu endemik yerlerde kisilerin KKKA hastaligi konusunda bilgiyi nereden alacagini bilmesi, yerinde sorular sormasi, verilen tibbi tavsiyeleri ve tedavi yonergelerini anlamasi, uygulamasi ve bu baglamda son 30 yilda okuryazarlik ve saglik iliskisinde saglik ve saglikla ilgili karar vermede arabulucu faktor olarak kisinin okuryazarlik kapasitesini tanimlayan davranis olarak tanimlanmis olan “saglik okuryazarligi” hastalikla mucadele konusunda buyuk onem tasimaktadir. Bu calismada Ankara ilinde Golbasi, Sincan ve Etimesgut ilcelerinde Aile Sagligi Merkezi’ne basvuran bireylerin Kirim Kongo Kanamali Atesi ile ilgili saglik okur yazarlik duzeylerini degerlendirme araci gelistirmek, saglik okuryazarlik duzeylerini ve etkileyen faktorleri saptamak a...
GIRIŞ: Dunya Saglik Orgutu, saglik okuryazarligini(SOY); bireylerin iyi saglik halinin surdurulme... more GIRIŞ: Dunya Saglik Orgutu, saglik okuryazarligini(SOY); bireylerin iyi saglik halinin surdurulmesi ve gelistirilmesi amaciyla saglikla ilgili bilgiye ulasmasi, anlamasi ve kullanmasi icin gerekli olan bilissel ve sosyal beceri kapasitesi olarak tanimlamaktadir. Bu calismada; annelerin anne sutu ile ilgili saglik okuryazarlik duzeylerini degerlendirme aracinin gelistirilmesi, saglik okuryazarlik degerlendirme aracini kullanarak annelerin anne sutu ile ilgili saglik okuryazarlik duzeylerinin degerlendirilmesi, annelerin anne sutu ile ilgili saglik okuryazarlik duzeylerini etkileyen faktorlerin saptanmasi amaclanmistir. GEREC YONTEM: Arastirma 01.12.2012 ve 28.02.2013 tarihleri arasinda Gazi Universitesi Saglik Arastirma ve Uygulama Hastanesi Saglam Cocuk poliklinigine basvuran 0-24 aylik bebegi olup, ilk kez basvuruda bulunan, arastirmaya katilmayi kabul eden ≥18 yas annelere uygulanmis tanimlayici tipte bir arastirmadir. 0-2 yas grubu ilk kez basvuru sayisi 459’dur. Ulasim yuzdesi ...
Objective To understand the impact of the measurement method to predict actual birthweight in pre... more Objective To understand the impact of the measurement method to predict actual birthweight in pregnancies complicated with isolated polyhydramnios in the third trimester. Methods A prospective study was conducted with 60 pregnant women between the 37th and 40th weeks of gestation. Routine biometric measurements were obtained by two-dimensional (2D) ultrasonography. When a satisfactory image was obtained, the image was frozen to get two measurements. First, calipers were placed to get the manual measurement. Then automated measurement was captured by the ultrasonography machine in the same image. The fetal weight was estimated by using the Hadlock II formula. Results The mean difference was found to be 0.03, −0.77, −0.02 and 0.17 for biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL), respectively. Pearson’s correlation coefficient between automated and manual estimated fetal weights (EFWs) and the actual birthweight was 0.919 and 0...
The prognosis of small cell lung cancer (SCLC) has been improving with the advances in diagnostic... more The prognosis of small cell lung cancer (SCLC) has been improving with the advances in diagnostic and therapeutic modalities. Positron emission tomography/computed tomography (FDG-PET/CT) which has been studied in non-small cell lung cancer (NSCLC) for a long time, and it has only recently been applied to SCLC. Therefore we sought to observe firstly the prognostic importance of the FDG uptake in limited disease small cell lung cancer (LD-SCLC) patients and secondly the clinical outcomes and toxicity profiles of LD-SCLC patients treated with conformal radiation therapy (RT) using FDG-PET/CT simulation. Between 2009 and 2011, 33 LD-SCLC patients with LD-SCLC underwent disease staging using FDG-PET/CT conformal RT. Thoracic radiation was administered at a daily fraction of 2 Gy. Total dose was prescribed according to the treatment protocol such as, concurrent or sequential chemotherapy and in some patients according to the response of CT. All patients underwent chemotherapy. Survival w...
This study aimed to determine the effectiveness of seasonal influenza vaccine in pre- and full-te... more This study aimed to determine the effectiveness of seasonal influenza vaccine in pre- and full-term children aged 6-23 months. We examined a cohort of 683,354 young children (7.7% preterm) over five influenza seasons (2004-2005 to 2008-2009) in Ontario, Canada. Vaccine effectiveness was estimated using influenza-coded ambulatory visits during virologically-confirmed influenza season periods as the outcome and multivariable Cox proportional hazards modeling. Full vaccination was associated with a 19% reduction in influenza-coded ambulatory visits (HR=0.81; 95% CI, 0.68-0.97) in all children, and an 18% reduction in full-term children (HR=0.82; 95% CI, 0.68-0.99). We did not find significant vaccine effectiveness for preterm children. No benefit was found for partial vaccination. In children younger than two years, only full influenza vaccination is associated with reduced influenza-coded ambulatory visits. Since the effectiveness of influenza vaccination in preterm children remains uncertain, further study of this highly vulnerable population is warranted.
GIRIŞ-AMAC Bitkilerin hastaliklarin tedavisi veya hastaliklardan korunmak amaciyla kullanilmasi i... more GIRIŞ-AMAC Bitkilerin hastaliklarin tedavisi veya hastaliklardan korunmak amaciyla kullanilmasi insanlik tarihi ile baslar. Bugun yeryuzunde bulunan bitki turu sayisinin 250.000-500.000 arasinda oldugu kabul edilmektedir. Tedavi veya korunmak amaciyla yararlanilan bitki turunun 70.000 kadar oldugu tahmin edilmektedir. Dunya Saglik Orgutu tarafindan 21.000 bitki turu ilac hazirlamak icin uygun bulunmustur ve dunya nufusunun %70-80’i tedavi veya korunmak amaciyla bitkilerden yararlanmaktadir. Bu calismada Gazi Universitesi Tip Fakultesi ogrencilerinin bitkisel urun ve ilac kullanimi konusunda tutum ve davranislarinin saptanmasi amaclanmistir. GEREC-YONTEM Arastirmanin evrenini 07-14.09.2012 tarihleri arasinda Gazi Universitesi Tip Fakultesi’nde 4.,5. ve 6. donemde egitim goren tip fakultesi ogrencileri olusturmustur. Arastirma kapsaminda 779 kisiye ulasilmistir. Ulasim yuzdesi 93,4’dur. Arastirma verisi SPSS 15.0 istatistik paket programi araciligi ile degerlendirilmistir ve ortalama...
OBJECTIVE This study aimed to review the risk factors for silicosis together with survival analys... more OBJECTIVE This study aimed to review the risk factors for silicosis together with survival analysis and a perspective for lung transplantation with data from a single center. MATERIAL AND METHODS We reviewed the medical records of denim sandblasters who were referred to our center between January 2006 and December 2011 and evaluated 219 patients with a history of denim sandblasting with a minimum follow-up period of 5 years until 2016. We analyzed several personal and occupational features, together with functional and radiologic data. RESULTS Of the 219 denim sandblasters, 107 (49%) had been diagnosed with silicosis. In the logistic regression analysis, the duration of exposure was the only independent risk factor for the development of silicosis, indicating a 9% increased risk of silicosis for every month of exposure (p<0.001; odds ratio 1.09; 95% confidence interval 1.050-1.132). Of the patients, 7 (3%) died. A forced expiratory volume in the first second of <44% and a forced vital capacity of <47% were associated with an increased risk of mortality. Mortality was significantly higher in the international labor office category 3 patients, and 5-year survival rates of patients with A, B, and C lung opacities were 88%, 67%, and 25%, respectively. CONCLUSION Silicosis still kills young workers. Severe radiologic involvement and decreased lung volumes are related to mortality, and lung transplantation is the only therapeutic option.
AimTo assess C-reactive protein to albumin ratio (CAR) before and after treatment with biological... more AimTo assess C-reactive protein to albumin ratio (CAR) before and after treatment with biological agents in patients with psoriasis to determine whether CAR can be used as an inflammation biomarker.MethodsMedical records of patients with psoriasis treated with biological agents at the Department of Dermatology, Gazi University Hospital were retrospectively evaluated between June 2018 and August 2019. The patients were divided into four groups based on the type of treatment (adalimumab, ustekinumab, infliximab, secukinumab). CAR was evaluated before and three months after treatment.ResultsThe study enrolled 157 patients with psoriasis vulgaris (91 male) aged between 18 and 85. CAR significantly decreased in all treatment groups (adalimumab group P < 0.001; ustekinumab P = 0.006; infliximab P = 0.007; secukinumab P < 0.001). The most prominent decrease in CAR was observed in patients treated with secukinumab (median CAR before treatment 1.52 [1.01-3.04] and after treatment 0.84 [0.62-0.99]).ConclusionCAR may be a good indicator of systemic inflammation in psoriasis patients treated with biological agents.
GIRIŞ: Kirim Kongo Kanamali Atesi (KKKA), Afrika, Asya, Dogu Avrupa ve Orta Doguda gorulen kene k... more GIRIŞ: Kirim Kongo Kanamali Atesi (KKKA), Afrika, Asya, Dogu Avrupa ve Orta Doguda gorulen kene kaynakli, akut, olumcul, viral bir hastaliktir. Mortalitesi %3-30 arasinda olup, bu yuzde oldukca yuksektir. Ozellikle kene populasyonunun yuksek oldugu endemik yerlerde kisilerin KKKA hastaligi konusunda bilgiyi nereden alacagini bilmesi, yerinde sorular sormasi, verilen tibbi tavsiyeleri ve tedavi yonergelerini anlamasi, uygulamasi ve bu baglamda son 30 yilda okuryazarlik ve saglik iliskisinde saglik ve saglikla ilgili karar vermede arabulucu faktor olarak kisinin okuryazarlik kapasitesini tanimlayan davranis olarak tanimlanmis olan “saglik okuryazarligi” hastalikla mucadele konusunda buyuk onem tasimaktadir. Bu calismada Ankara ilinde Golbasi, Sincan ve Etimesgut ilcelerinde Aile Sagligi Merkezi’ne basvuran bireylerin Kirim Kongo Kanamali Atesi ile ilgili saglik okur yazarlik duzeylerini degerlendirme araci gelistirmek, saglik okuryazarlik duzeylerini ve etkileyen faktorleri saptamak a...
GIRIŞ: Dunya Saglik Orgutu, saglik okuryazarligini(SOY); bireylerin iyi saglik halinin surdurulme... more GIRIŞ: Dunya Saglik Orgutu, saglik okuryazarligini(SOY); bireylerin iyi saglik halinin surdurulmesi ve gelistirilmesi amaciyla saglikla ilgili bilgiye ulasmasi, anlamasi ve kullanmasi icin gerekli olan bilissel ve sosyal beceri kapasitesi olarak tanimlamaktadir. Bu calismada; annelerin anne sutu ile ilgili saglik okuryazarlik duzeylerini degerlendirme aracinin gelistirilmesi, saglik okuryazarlik degerlendirme aracini kullanarak annelerin anne sutu ile ilgili saglik okuryazarlik duzeylerinin degerlendirilmesi, annelerin anne sutu ile ilgili saglik okuryazarlik duzeylerini etkileyen faktorlerin saptanmasi amaclanmistir. GEREC YONTEM: Arastirma 01.12.2012 ve 28.02.2013 tarihleri arasinda Gazi Universitesi Saglik Arastirma ve Uygulama Hastanesi Saglam Cocuk poliklinigine basvuran 0-24 aylik bebegi olup, ilk kez basvuruda bulunan, arastirmaya katilmayi kabul eden ≥18 yas annelere uygulanmis tanimlayici tipte bir arastirmadir. 0-2 yas grubu ilk kez basvuru sayisi 459’dur. Ulasim yuzdesi ...
Objective To understand the impact of the measurement method to predict actual birthweight in pre... more Objective To understand the impact of the measurement method to predict actual birthweight in pregnancies complicated with isolated polyhydramnios in the third trimester. Methods A prospective study was conducted with 60 pregnant women between the 37th and 40th weeks of gestation. Routine biometric measurements were obtained by two-dimensional (2D) ultrasonography. When a satisfactory image was obtained, the image was frozen to get two measurements. First, calipers were placed to get the manual measurement. Then automated measurement was captured by the ultrasonography machine in the same image. The fetal weight was estimated by using the Hadlock II formula. Results The mean difference was found to be 0.03, −0.77, −0.02 and 0.17 for biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL), respectively. Pearson’s correlation coefficient between automated and manual estimated fetal weights (EFWs) and the actual birthweight was 0.919 and 0...
The prognosis of small cell lung cancer (SCLC) has been improving with the advances in diagnostic... more The prognosis of small cell lung cancer (SCLC) has been improving with the advances in diagnostic and therapeutic modalities. Positron emission tomography/computed tomography (FDG-PET/CT) which has been studied in non-small cell lung cancer (NSCLC) for a long time, and it has only recently been applied to SCLC. Therefore we sought to observe firstly the prognostic importance of the FDG uptake in limited disease small cell lung cancer (LD-SCLC) patients and secondly the clinical outcomes and toxicity profiles of LD-SCLC patients treated with conformal radiation therapy (RT) using FDG-PET/CT simulation. Between 2009 and 2011, 33 LD-SCLC patients with LD-SCLC underwent disease staging using FDG-PET/CT conformal RT. Thoracic radiation was administered at a daily fraction of 2 Gy. Total dose was prescribed according to the treatment protocol such as, concurrent or sequential chemotherapy and in some patients according to the response of CT. All patients underwent chemotherapy. Survival w...
This study aimed to determine the effectiveness of seasonal influenza vaccine in pre- and full-te... more This study aimed to determine the effectiveness of seasonal influenza vaccine in pre- and full-term children aged 6-23 months. We examined a cohort of 683,354 young children (7.7% preterm) over five influenza seasons (2004-2005 to 2008-2009) in Ontario, Canada. Vaccine effectiveness was estimated using influenza-coded ambulatory visits during virologically-confirmed influenza season periods as the outcome and multivariable Cox proportional hazards modeling. Full vaccination was associated with a 19% reduction in influenza-coded ambulatory visits (HR=0.81; 95% CI, 0.68-0.97) in all children, and an 18% reduction in full-term children (HR=0.82; 95% CI, 0.68-0.99). We did not find significant vaccine effectiveness for preterm children. No benefit was found for partial vaccination. In children younger than two years, only full influenza vaccination is associated with reduced influenza-coded ambulatory visits. Since the effectiveness of influenza vaccination in preterm children remains uncertain, further study of this highly vulnerable population is warranted.
GIRIŞ-AMAC Bitkilerin hastaliklarin tedavisi veya hastaliklardan korunmak amaciyla kullanilmasi i... more GIRIŞ-AMAC Bitkilerin hastaliklarin tedavisi veya hastaliklardan korunmak amaciyla kullanilmasi insanlik tarihi ile baslar. Bugun yeryuzunde bulunan bitki turu sayisinin 250.000-500.000 arasinda oldugu kabul edilmektedir. Tedavi veya korunmak amaciyla yararlanilan bitki turunun 70.000 kadar oldugu tahmin edilmektedir. Dunya Saglik Orgutu tarafindan 21.000 bitki turu ilac hazirlamak icin uygun bulunmustur ve dunya nufusunun %70-80’i tedavi veya korunmak amaciyla bitkilerden yararlanmaktadir. Bu calismada Gazi Universitesi Tip Fakultesi ogrencilerinin bitkisel urun ve ilac kullanimi konusunda tutum ve davranislarinin saptanmasi amaclanmistir. GEREC-YONTEM Arastirmanin evrenini 07-14.09.2012 tarihleri arasinda Gazi Universitesi Tip Fakultesi’nde 4.,5. ve 6. donemde egitim goren tip fakultesi ogrencileri olusturmustur. Arastirma kapsaminda 779 kisiye ulasilmistir. Ulasim yuzdesi 93,4’dur. Arastirma verisi SPSS 15.0 istatistik paket programi araciligi ile degerlendirilmistir ve ortalama...
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