Critical civilian facilities and military infrastructure in India have been a target of several t... more Critical civilian facilities and military infrastructure in India have been a target of several terrorist attacks in the last few decades. In order to address the risk of explosion threats, it has become critical to design and construct blast-resistant structures to save lives and protect infrastructure. The focus of this paper is to develop performance-based guidelines for the blast-resistant design of reinforced concrete (RC) columns. Columns are the most vulnerable component of a structure and are at a high risk under a detonation scenario. The paper presents a comprehensive review of the blast-resistant design procedures followed by different design documents. The gaps and challenges in the blast resistance of RC columns were identified and addressed. Specific issues in the axial, flexure, and shear design of columns are highlighted. A performance-based analysis and design approach for blast-resistant design of RC column were developed and is presented in the paper. The design approach was verified using high-fidelity numerical simulations. The performances of the design columns was assessed using nonlinear FE models developed in LS-DYNA. The ultimate capacities of the columns subject to blast loads were obtained. The numerical simulations assist in verifying the proposed design procedures and provide critical information on the failure modes, safety margin, and other parameters for blast-resistant design of RC columns. Recommendations on safe and efficient design of RC members are also provided.
Proceedings of the Ninth International Conference on Enterprise Information Systems
A decision support system for Computer Aided Process Planning (CAPP) system has been designed, de... more A decision support system for Computer Aided Process Planning (CAPP) system has been designed, developed and implemented. The need to introduce decision support system for CAPP system arises specifically to solve the poorly structured stages in process planning such as determination of blank size, setup planning, operations planning in each setup, selection of machine tools, calculation of machining time etc. Decision Support System (DSS) is capable to support operations like turning, facing, tapering, arcing, grooving, filleting, chamfering, knurling, threading etc. The proposed system is capable to generating process plans for different types of rotational parts.
Heat shock proteins are chaperonic proteins, which are present in every domain of life. They play... more Heat shock proteins are chaperonic proteins, which are present in every domain of life. They play a crucial role in folding/unfolding of proteins, their sorting and assembly into multi-protein complex, cell cycle control and also protect the cell during stress. Considering the fact that no web-based predictor is available for simultaneous prediction and classification of HSPs, it is imperative to develop a method, which can predict and classify them efficiently. In this study, we have developed coupled amino acid composition and support vector machine based two-tier method, PredHSP that identifies heat shock proteins (1st tier) and classifies it to different families (at 2nd tier). At 1st tier, we achieved maximum accuracy 76.66% with MCC 0.43, while at 2nd tier we achieved maximum accuracy 96.36% with MCC 0.87 for HSP20, 91.91% with MCC 0.83 for HSP40, 95.96% with MCC 0.72 for HSP60, 91.87% with MCC 0.71 for HSP70, 98.43% with MCC 0.70 for HSP90 and 97.48% with MCC 0.71 for HSP100....
A large number of 600 mm diameter spherical mirrors with 8000 mm radius of curvature, are require... more A large number of 600 mm diameter spherical mirrors with 8000 mm radius of curvature, are required for TACTIC gamma-ray telescope. A prototype was successfully formed from a 500-micron mirror finished aluminum reflective sheet, using vacuum as a primary driving force. The template was designed and fabricated from SS 304 plate, using CNC machining, with proper arrangements to create vacuum between the flat sheet and the template. This includes proper vacuum sealing between the sheet and template using neoprene gasket, multiple vacuum vents between the sheet and template and a clamping arrangements. A vacuum of the order of 1milli-bar created using a rotary pump stretched the sheet to the required shape, without any wrinkles and any apparent deterioration to the reflectivity. This method is tried for the first time for the formation of mirror and is having its importance, as the mirror-finished surface is free from wrinkles and abrasion. The conventional method of applying contact pre...
... Aruna and Sivaramakrishnan [3] studied the anticarcinogenic effect of C. cyminum in wistar ra... more ... Aruna and Sivaramakrishnan [3] studied the anticarcinogenic effect of C. cyminum in wistar rat. ... Chithra and Leelamna [8] reported the effect of C. sativum on lipid metabolism in 1, 2dimethyhydrazine induced colon cancer in rats. Cortes-Eslava et al. ...
In this paper, we present a generic theoretical chemotactic model that accounts for certain emerg... more In this paper, we present a generic theoretical chemotactic model that accounts for certain emergent behaviors observed in ant foraging. The model does not have many of the constraints and limitations of existing models for ants colony dynamics and takes into account the distinctly different behaviors exhibited in nature by ant foragers in search of food and food ferrying ants. Numerical simulations based on the model show trail formation in foraging ant colonies to be an emergent phenomenon and, in particular, replicate behavior observed in experiments involving the species P. megacephala. The results have broader implications for the study of randomness in chemotactic models. Potential applications include the developments of novel algorithms for stochastic search in engineered complex systems such as robotic swarms.
2010 IEEE Asian Solid-State Circuits Conference, 2010
Lincroft, the next generation Intel® ATOM™ processor based SoC specifically designed for smartpho... more Lincroft, the next generation Intel® ATOM™ processor based SoC specifically designed for smartphones, is fabricated in 45nm Hi-K metal gate CMOS. The design contains 140 million transistors in a die size of 65 mm2. Thermal design power (TDP) consumption is measured at 1.25W at 90°C at a frequency of 1.20GHz. Low power IO interfaces such as LPDDR1/DDR2, cDMI to IOH
Abstract. This work is about the relevance of Gibson's concept of affordances [1] for visual... more Abstract. This work is about the relevance of Gibson's concept of affordances [1] for visual perception in interactive and autonomous robotic systems. In extension to existing functional views on visual feature representations, we identify the importance of learning in perceptual cueing for ...
Abstract In this paper, we propose a real-time ground plane extraction and obstacle detection tec... more Abstract In this paper, we propose a real-time ground plane extraction and obstacle detection technique for mobile robot navigation based on a combination of segmentation and optical flow techniques using monocular image sequences. The ground plane, which ...
ABSTRACT Objective The use of natural phytoconstituents for food and as nutritional supplements i... more ABSTRACT Objective The use of natural phytoconstituents for food and as nutritional supplements is an easiest way to be healthier. Anthraquinone pigments have been traditionally used for various purposes viz. food colorants, textile staining, color paints and medicines. Rubia cordifolia L. is a perennial, herbaceous climbing plant belonging to family Rubiaceae. This plant contain substantial amounts of anthraquinones, especially in the roots. The present study deals with the bioactivity evaluation of phytoconstituents viz. alizarin and purpurin from Rubia cordifolia.Methods The DNA protective and antioxidant potential of alizarin and purpurin was evaluated using different in vitro assays viz. DNA protection assay, ABTS assay, DPPH assay, Ferric ion reduction potential and Phosphomolybdenum assay.ResultsAlizarin and purpurin exhibited good free radical scavenging activity in various assays. In DNA protection assay, alizarin showed more DNA protection against hydroxyl radicals generated by Fenton's reagent in comparison to purpurin.Conclusions Being potent antioxidants, these natural coloring compounds can be boon to the food industry as nutraceuticals. Further, these phytochemicals can be explored for their anticancer activity and may serve as potent cancer chemopreventive molecules.
International Journal of Data Mining, Modelling and Management, 2010
... Biographical notes: Manish Kumar is an MTech (Computer Science) and pursuing his PhD in ... 2... more ... Biographical notes: Manish Kumar is an MTech (Computer Science) and pursuing his PhD in ... 217 Shekhar Verma received his PhD in Computer Networks from the Institute of Technology ... He is an Associate Professor at Indian Institute of Information Technology, Allahabad, India ...
2010 International Conference on Signal Acquisition and Processing, 2010
Face is a complex multidimensional visual model and developing a computational model for face rec... more Face is a complex multidimensional visual model and developing a computational model for face recognition is difficult. The paper presents a methodology for face recognition based on information theory approach of coding and decoding the face image. Proposed methodology is connection of two stages-Feature extraction using principle component analysis and recognition using the feed forward back propagation Neural Network. The algorithm has been tested on 400 images (40 classes). A recognition score for test lot is calculated by considering almost all the variants of feature extraction. The proposed methods were tested on Olivetti and Oracle Research Laboratory (ORL) face database. Test results gave a recognition rate of 97.018%
We report the phenomenological impact of unparticles in the production of di-jet at the LHC. We c... more We report the phenomenological impact of unparticles in the production of di-jet at the LHC. We compute the scalar, spin-1 and spin-2 unparticle contributions to the dijet cross sections and present our results in different kinematical distributions. We find that the scalar unparticle contribution is dominant over that of the spin-1 and spin-2 unparticles for the same coupling values.
β-Lactam class of antibiotics is used as major therapeutic agent against a number of pathogenic m... more β-Lactam class of antibiotics is used as major therapeutic agent against a number of pathogenic microbes. The widespread and indiscriminate use of antibiotics to treat bacterial infection has prompted evolution of several evading mechanisms from the lethal effect of antibiotics. β-Lactamases are endogenously produced enzyme that makes bacteria resistant against β-lactam antibiotics by cleaving the β-lactam ring. On the basis of primary structures, β-lactamase family of enzymes is divided into four classes namely A, B, C and D. Class B are metallo-enzymes while A, C and D does not need any metal in the enzyme catalysis. In the present study we developed a SVM based two level β-lactamases protein prediction method, which differentiate β-lactamases from non-β-lactamases at first level and then classify predicted β-lactamases into different classes at second level. We evaluated performance of different input vectors namely simple amino acid composition, Type-1 and Type-2 Chou's pseu...
The NS1 protein from avian influenza A viruses contains a PDZ binding motif (PBM) at its carboxyl... more The NS1 protein from avian influenza A viruses contains a PDZ binding motif (PBM) at its carboxyl terminus with the consensus sequence ESEV. The ESEV PBM confers binding to several cellular PDZ proteins, including Dlg1, MAGI-1 and Scribble. The interaction between NS1 and Scribble protects infected cells from apoptosis, while the interaction between NS1 and both Dlg1 and Scribble disrupts tight junctions. In this study, we examined the MAGI-1 protein. We made the unexpected observation that siRNA depletion of MAGI-1 activates IRF3 and induces the IFN-b promoter. We found that the ESEV NS1 protein sequesters MAGI-1 away from the plasma membrane in infected cells. Using plasmid vectors to express NS1 proteins, we observed that the ESEV PBM elicits an IFN-b induction signal as indicated by activation of IRF3 and a relative deficiency in NS1 inhibition of induction of the IFN-b promoter by dsRNA or RIG-I. Taken together, our data suggest that disruption of MAGI-1 by the ESEV PBM activates an IFN-b induction signal. During viral infection, however, induction of the IFN-b gene does not occur presumably because other anti-IFN functions dominate over the IFN-activation activity of the ESEV PBM. We postulate that the ESEV PBM's broad binding activity for PDZ proteins may allow NS1 to bind to some PDZ proteins such as MAGI-1 that confer no benefit or may even be detrimental to viral replication. However, the advantage of binding to key PDZ proteins such as Dlg1 and Scribble may dominate and therefore provide an overall benefit for the virus to encode the ESEV PBM.
with production errors in Eqs. (11) and (12). In Eqs. (11) and (12) the multiplication 's should ... more with production errors in Eqs. (11) and (12). In Eqs. (11) and (12) the multiplication 's should be replaced by multiplication dots. The equations have been corrected as of 3 April 2008. The equations are incorrect in the printed version of the journal.
Critical civilian facilities and military infrastructure in India have been a target of several t... more Critical civilian facilities and military infrastructure in India have been a target of several terrorist attacks in the last few decades. In order to address the risk of explosion threats, it has become critical to design and construct blast-resistant structures to save lives and protect infrastructure. The focus of this paper is to develop performance-based guidelines for the blast-resistant design of reinforced concrete (RC) columns. Columns are the most vulnerable component of a structure and are at a high risk under a detonation scenario. The paper presents a comprehensive review of the blast-resistant design procedures followed by different design documents. The gaps and challenges in the blast resistance of RC columns were identified and addressed. Specific issues in the axial, flexure, and shear design of columns are highlighted. A performance-based analysis and design approach for blast-resistant design of RC column were developed and is presented in the paper. The design approach was verified using high-fidelity numerical simulations. The performances of the design columns was assessed using nonlinear FE models developed in LS-DYNA. The ultimate capacities of the columns subject to blast loads were obtained. The numerical simulations assist in verifying the proposed design procedures and provide critical information on the failure modes, safety margin, and other parameters for blast-resistant design of RC columns. Recommendations on safe and efficient design of RC members are also provided.
Proceedings of the Ninth International Conference on Enterprise Information Systems
A decision support system for Computer Aided Process Planning (CAPP) system has been designed, de... more A decision support system for Computer Aided Process Planning (CAPP) system has been designed, developed and implemented. The need to introduce decision support system for CAPP system arises specifically to solve the poorly structured stages in process planning such as determination of blank size, setup planning, operations planning in each setup, selection of machine tools, calculation of machining time etc. Decision Support System (DSS) is capable to support operations like turning, facing, tapering, arcing, grooving, filleting, chamfering, knurling, threading etc. The proposed system is capable to generating process plans for different types of rotational parts.
Heat shock proteins are chaperonic proteins, which are present in every domain of life. They play... more Heat shock proteins are chaperonic proteins, which are present in every domain of life. They play a crucial role in folding/unfolding of proteins, their sorting and assembly into multi-protein complex, cell cycle control and also protect the cell during stress. Considering the fact that no web-based predictor is available for simultaneous prediction and classification of HSPs, it is imperative to develop a method, which can predict and classify them efficiently. In this study, we have developed coupled amino acid composition and support vector machine based two-tier method, PredHSP that identifies heat shock proteins (1st tier) and classifies it to different families (at 2nd tier). At 1st tier, we achieved maximum accuracy 76.66% with MCC 0.43, while at 2nd tier we achieved maximum accuracy 96.36% with MCC 0.87 for HSP20, 91.91% with MCC 0.83 for HSP40, 95.96% with MCC 0.72 for HSP60, 91.87% with MCC 0.71 for HSP70, 98.43% with MCC 0.70 for HSP90 and 97.48% with MCC 0.71 for HSP100....
A large number of 600 mm diameter spherical mirrors with 8000 mm radius of curvature, are require... more A large number of 600 mm diameter spherical mirrors with 8000 mm radius of curvature, are required for TACTIC gamma-ray telescope. A prototype was successfully formed from a 500-micron mirror finished aluminum reflective sheet, using vacuum as a primary driving force. The template was designed and fabricated from SS 304 plate, using CNC machining, with proper arrangements to create vacuum between the flat sheet and the template. This includes proper vacuum sealing between the sheet and template using neoprene gasket, multiple vacuum vents between the sheet and template and a clamping arrangements. A vacuum of the order of 1milli-bar created using a rotary pump stretched the sheet to the required shape, without any wrinkles and any apparent deterioration to the reflectivity. This method is tried for the first time for the formation of mirror and is having its importance, as the mirror-finished surface is free from wrinkles and abrasion. The conventional method of applying contact pre...
... Aruna and Sivaramakrishnan [3] studied the anticarcinogenic effect of C. cyminum in wistar ra... more ... Aruna and Sivaramakrishnan [3] studied the anticarcinogenic effect of C. cyminum in wistar rat. ... Chithra and Leelamna [8] reported the effect of C. sativum on lipid metabolism in 1, 2dimethyhydrazine induced colon cancer in rats. Cortes-Eslava et al. ...
In this paper, we present a generic theoretical chemotactic model that accounts for certain emerg... more In this paper, we present a generic theoretical chemotactic model that accounts for certain emergent behaviors observed in ant foraging. The model does not have many of the constraints and limitations of existing models for ants colony dynamics and takes into account the distinctly different behaviors exhibited in nature by ant foragers in search of food and food ferrying ants. Numerical simulations based on the model show trail formation in foraging ant colonies to be an emergent phenomenon and, in particular, replicate behavior observed in experiments involving the species P. megacephala. The results have broader implications for the study of randomness in chemotactic models. Potential applications include the developments of novel algorithms for stochastic search in engineered complex systems such as robotic swarms.
2010 IEEE Asian Solid-State Circuits Conference, 2010
Lincroft, the next generation Intel® ATOM™ processor based SoC specifically designed for smartpho... more Lincroft, the next generation Intel® ATOM™ processor based SoC specifically designed for smartphones, is fabricated in 45nm Hi-K metal gate CMOS. The design contains 140 million transistors in a die size of 65 mm2. Thermal design power (TDP) consumption is measured at 1.25W at 90°C at a frequency of 1.20GHz. Low power IO interfaces such as LPDDR1/DDR2, cDMI to IOH
Abstract. This work is about the relevance of Gibson's concept of affordances [1] for visual... more Abstract. This work is about the relevance of Gibson's concept of affordances [1] for visual perception in interactive and autonomous robotic systems. In extension to existing functional views on visual feature representations, we identify the importance of learning in perceptual cueing for ...
Abstract In this paper, we propose a real-time ground plane extraction and obstacle detection tec... more Abstract In this paper, we propose a real-time ground plane extraction and obstacle detection technique for mobile robot navigation based on a combination of segmentation and optical flow techniques using monocular image sequences. The ground plane, which ...
ABSTRACT Objective The use of natural phytoconstituents for food and as nutritional supplements i... more ABSTRACT Objective The use of natural phytoconstituents for food and as nutritional supplements is an easiest way to be healthier. Anthraquinone pigments have been traditionally used for various purposes viz. food colorants, textile staining, color paints and medicines. Rubia cordifolia L. is a perennial, herbaceous climbing plant belonging to family Rubiaceae. This plant contain substantial amounts of anthraquinones, especially in the roots. The present study deals with the bioactivity evaluation of phytoconstituents viz. alizarin and purpurin from Rubia cordifolia.Methods The DNA protective and antioxidant potential of alizarin and purpurin was evaluated using different in vitro assays viz. DNA protection assay, ABTS assay, DPPH assay, Ferric ion reduction potential and Phosphomolybdenum assay.ResultsAlizarin and purpurin exhibited good free radical scavenging activity in various assays. In DNA protection assay, alizarin showed more DNA protection against hydroxyl radicals generated by Fenton's reagent in comparison to purpurin.Conclusions Being potent antioxidants, these natural coloring compounds can be boon to the food industry as nutraceuticals. Further, these phytochemicals can be explored for their anticancer activity and may serve as potent cancer chemopreventive molecules.
International Journal of Data Mining, Modelling and Management, 2010
... Biographical notes: Manish Kumar is an MTech (Computer Science) and pursuing his PhD in ... 2... more ... Biographical notes: Manish Kumar is an MTech (Computer Science) and pursuing his PhD in ... 217 Shekhar Verma received his PhD in Computer Networks from the Institute of Technology ... He is an Associate Professor at Indian Institute of Information Technology, Allahabad, India ...
2010 International Conference on Signal Acquisition and Processing, 2010
Face is a complex multidimensional visual model and developing a computational model for face rec... more Face is a complex multidimensional visual model and developing a computational model for face recognition is difficult. The paper presents a methodology for face recognition based on information theory approach of coding and decoding the face image. Proposed methodology is connection of two stages-Feature extraction using principle component analysis and recognition using the feed forward back propagation Neural Network. The algorithm has been tested on 400 images (40 classes). A recognition score for test lot is calculated by considering almost all the variants of feature extraction. The proposed methods were tested on Olivetti and Oracle Research Laboratory (ORL) face database. Test results gave a recognition rate of 97.018%
We report the phenomenological impact of unparticles in the production of di-jet at the LHC. We c... more We report the phenomenological impact of unparticles in the production of di-jet at the LHC. We compute the scalar, spin-1 and spin-2 unparticle contributions to the dijet cross sections and present our results in different kinematical distributions. We find that the scalar unparticle contribution is dominant over that of the spin-1 and spin-2 unparticles for the same coupling values.
β-Lactam class of antibiotics is used as major therapeutic agent against a number of pathogenic m... more β-Lactam class of antibiotics is used as major therapeutic agent against a number of pathogenic microbes. The widespread and indiscriminate use of antibiotics to treat bacterial infection has prompted evolution of several evading mechanisms from the lethal effect of antibiotics. β-Lactamases are endogenously produced enzyme that makes bacteria resistant against β-lactam antibiotics by cleaving the β-lactam ring. On the basis of primary structures, β-lactamase family of enzymes is divided into four classes namely A, B, C and D. Class B are metallo-enzymes while A, C and D does not need any metal in the enzyme catalysis. In the present study we developed a SVM based two level β-lactamases protein prediction method, which differentiate β-lactamases from non-β-lactamases at first level and then classify predicted β-lactamases into different classes at second level. We evaluated performance of different input vectors namely simple amino acid composition, Type-1 and Type-2 Chou's pseu...
The NS1 protein from avian influenza A viruses contains a PDZ binding motif (PBM) at its carboxyl... more The NS1 protein from avian influenza A viruses contains a PDZ binding motif (PBM) at its carboxyl terminus with the consensus sequence ESEV. The ESEV PBM confers binding to several cellular PDZ proteins, including Dlg1, MAGI-1 and Scribble. The interaction between NS1 and Scribble protects infected cells from apoptosis, while the interaction between NS1 and both Dlg1 and Scribble disrupts tight junctions. In this study, we examined the MAGI-1 protein. We made the unexpected observation that siRNA depletion of MAGI-1 activates IRF3 and induces the IFN-b promoter. We found that the ESEV NS1 protein sequesters MAGI-1 away from the plasma membrane in infected cells. Using plasmid vectors to express NS1 proteins, we observed that the ESEV PBM elicits an IFN-b induction signal as indicated by activation of IRF3 and a relative deficiency in NS1 inhibition of induction of the IFN-b promoter by dsRNA or RIG-I. Taken together, our data suggest that disruption of MAGI-1 by the ESEV PBM activates an IFN-b induction signal. During viral infection, however, induction of the IFN-b gene does not occur presumably because other anti-IFN functions dominate over the IFN-activation activity of the ESEV PBM. We postulate that the ESEV PBM's broad binding activity for PDZ proteins may allow NS1 to bind to some PDZ proteins such as MAGI-1 that confer no benefit or may even be detrimental to viral replication. However, the advantage of binding to key PDZ proteins such as Dlg1 and Scribble may dominate and therefore provide an overall benefit for the virus to encode the ESEV PBM.
with production errors in Eqs. (11) and (12). In Eqs. (11) and (12) the multiplication 's should ... more with production errors in Eqs. (11) and (12). In Eqs. (11) and (12) the multiplication 's should be replaced by multiplication dots. The equations have been corrected as of 3 April 2008. The equations are incorrect in the printed version of the journal.
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