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muhammad alim

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Wellesley College

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Papers by muhammad alim

Penggunaan Sistem Informasi Geografis (Sig) Dalam Analisis Daya Dukung Dan Daya Tampung Lingkungan Hidup DI Kabupaten Tanah Laut

INFO-TEKNIK, 2020

The objective of the study was to provide an overview of the using of Analytical Geographical Inf... more The objective of the study was to provide an overview of the using of Analytical Geographical Information System (GIS) to determine Environmental Carrying Capacity and Capability in Tanah Laut Regency Province of South Kalimantan. The combination methode of Pairwise Comparation and The spatial capacity offered by GIS is directly applicable to understanding the spatial variation by environmental factors. The result of this study shows that carrying capacity and capability can reflect a potential and availability of natural resources in the area of Tanah Laut Regency so that it can be known in which areas have the greatest potential and availability of indicators where the percentage distribution of the extent of the environmental carrying capacity of each ecosistem service potential and the most dominant availability are in the District of Jorong, which is 60% for the High category including 6 Ecosistem Services and 40% for the very high category for 4 Ecosistem Services. 30% Kintap ...

Study of Spleen and Liver Injuries in Patients of Blunt Trauma Abdomen

Pakistan Journal of Medical and Health Sciences

Objective: To study the spleen and liver injuries in patients of blunt trauma abdomen. Material a... more Objective: To study the spleen and liver injuries in patients of blunt trauma abdomen. Material and methods: This was a cross sectional study which conducted at Department of Surgery Loralai Medical College Loralai from May 2021 to November 2021 over the period of 6 months. Total 130 patients aged 18-50 years either gender with blunt trauma abdomen were recruited for this study. Spleen and liver injuries and their grading was studied. Results: Total 130 patients of blunt abdominal trauma were recruited. Age range was 18-50 years with mean age 30.85 ± 8.84 years. Out of 130 patients, liver injury was found in 67 (52%) patients. Total 84 (65%) patients had spleen injury. Total 20 (15%) patients had both liver and spleen injury. Conclusion: Results of this study concluded that spleen was the most common injured organ. Grade-I liver and spleen injury was commonly seen. Age group 18-33 years was common age group and males were prominent than females. Keywords: trauma, abdomen, liver, spleen

An Assessment of Different Clinical Presentations in Cases of Colorectal Cancer

Pakistan Journal of Medical and Health Sciences

Objective: To assess the different clinical presentations in cases of colorectal cancer. Material... more Objective: To assess the different clinical presentations in cases of colorectal cancer. Material and methods: Between April 2021 to October 2021 total 90 diagnosed patients of colorectal cancer confirmed on histopathology, either male or female having age 25-75 years were selected from Department of Surgery, Loralai Medical College Loralai. Different clinical presentations of colorectal cancer were assessed. Results: In present study age range was 25-75 years with mean age 48.58 ± 15.16 years. Grade-I cancer was found in 24 (27%) patients followed by grade-II cancer in 29 (32%) patients and grade-III cancer in 37 (41%) patients. Regarding clinical presentation of patients, bleeding per rectum was found in 73 (81.1%) patients followed by altered bowel habits in 67 (74.4%) patients, anemia in 27 (30%) patients and weight loss was seen in 19 (21.1%) patients. Conclusion: Results of present study showed that most of the patients had grade-III colorectal cancer. Males were prominent as ...

O Descarte do Lixo Eletrônico e o Uso da Logística Reversa: O Caso dos Municípios Integrantes da Região Central Serrana do Espirito Santo / The Disposal of Electronic Waste and the Use of Reverse Logistics: The Case of the Municipalities of the Central Mountainous Region of Espirito Santo

Brazilian Journal of Development, 2021

O presente trabalho descreve o emprego da logística reversa para a realização do correto descarte... more O presente trabalho descreve o emprego da logística reversa para a realização do correto descarte do lixo eletrônico em repartições públicas da região Central Serrana do Espírito Santo, tendo como parâmetro a Política Nacional de Resíduos Sólidos (PNRS). A pesquisa se caracteriza como exploratória, com caráter de avaliação de resultados, instrumentalizada por meio de um questionário, na qual se obteve 220 respostas. Como principais resultados, foi verificado que parte significativa dos entrevistados entende que a determinação pela responsabilidade na gestão dos resíduos proveniente de lixo eletrônico não está bem estabelecida, pois não estão tendo visibilidade por parte dos servidores, necessitando de serem mais transparentes. Foi, ainda, observado, que para a maioria dos entrevistados, os resíduos sólidos do lixo eletrônico estão recebendo o tratamento adequado em seu local de trabalho. Além disso, percebeu-se que, sem uma gestão onde todos estejam engajados e envolvidos, onde os procedimentos não sejam conhecidos ou simplesmente não exista, não se consegue ser eficiente e realmente fazer a PNRS funcionar.

Asas-asas Hukum Modern Dalam Hukum Islam

Jurnal Media Hukum, 2010

Tulisan ringkas ini fokus pada analisis pengertian asas-asas hukum, perbedaan asas hukum dengan n... more Tulisan ringkas ini fokus pada analisis pengertian asas-asas hukum, perbedaan asas hukum dengan norma/kaidah hukum, kedudukan asas hukum, fungsi dan jenis asas-asas hukum dalam sistem hukum. Bahannya merupakan rangkuman dari beberapa literatur yang penulis simak pada perpustakaan pribadi. Metode yang digunakan dalam artikel ini adalah penelitian hukum normatif. Pendekatan masalah yang digunakan dalam penelitian ini adalah dengan menggunakan pendekatan perundang-undangan. Dipahami asas-asas hukum itu sebagai pikiran-pikiran dasar yang terdapat di dalam dan di belakang sistem hukum, masing-masing dirumuskan dalam aturan-aturan perundang-undangan dan putusan-putusan hakim, yang berkenaan dengannya ketentuan-ketentuan dan keputuankeputusan individual dapat dipandang sebagai penjabarannya. Apabila dalam bidang hukum kita telah sepakat, bahwa Pancasila sumber dari segala sumber hukum negara, maka sudah wajarlah, kalau kita membicarakan asas, berpendapat bahwa sumber dari segala asas hukum adalah Pancasila, Pancasila dipegang teguh sebagai kaidah dasar, sebagai suatu beginsel rechtsideologie atau asas ideologi hukum Indonesia.

Tinjauan Kosep Pemasaran Islam Terhadap Implementasi Strategi Bauran Pemasaran Produk Takafullink Salam Cendikia (Asuransi Pendidikan) Di PT Asuransi Takaful Keluarga Cabang Bandung

Prosiding Hukum Ekonomi Syariah; Vol 1, No 1, Prosiding Hukum Ekonomi Syariah (Februari, 2015), Feb 9, 2015

Konsep pemasaran Islam pada produk Asuransi di Lembaga Asuransi Syariah adalah konsep dakwah, yai... more Konsep pemasaran Islam pada produk Asuransi di Lembaga Asuransi Syariah adalah konsep dakwah, yaitu ajakan, pengarahan, dan tindak lanjut dari Inisiator (dai) kepada stakeholdernya (jamaah). Hal ini, harus dilaksanakan dengan cara Hikmah, sebagaimana yang tertuang dalam Al-Qur’an surat An-Nahl: 125. Implementasi strategi bauran pemasaran produk Takaful link Salam Cendikia yang diterapkan di Asuransi Takaful adalah menggunakan Advertising, marketing communications, da n personal selling . Konsep bauran pemasaran produk Takaful Link Salam Cendikia yang diimplementasikan di PT Asuransi Takaful sudah sesuai dengan konsep pemasaran Islam.

Biosurfactant Produced by Indigenous Bacteria during Composting Process of Crude Oil Polluted Soil: Properties and Role

Journal of Ecological Engineering, 2022

Bacterial co-metabolism in composting process has been widely used to remove hydrocarbons, aided ... more Bacterial co-metabolism in composting process has been widely used to remove hydrocarbons, aided by in-situ production of bio-based surfactants, in terms of compost humic acid-like substances and biosurfactants. The properties of compost humic acid-like substances have been shown in previous studies as potential surface tension reducers and emulsifiers for hydrocarbons. The current study aimed to analyze the properties of biosurfactant of surface tension decrease, emulsification activity, and hydrocarbon solubilization ability. Four indigenous bacteria consortia were isolated from composted materials of yard waste, rumen residue, crude oil-polluted soil, and the mixture of polluted soil with organic waste (1:1, w/w) at day 0 th , 20 th , 40 th , and 60 th. Organic waste consists of yard waste and rumen residue in the ratio of 1:1. The isolated indigenous bacteria consortia were incubated for 7 days in different media, i.e., organic waste extract, 6.00% of crude oil, and a mixture of organic waste extract with 6.00% crude oil. The results indicated that the surface tension decrease and emulsification activity of biosurfactants were 8.35-52.90 mN m-1 and 0.00-12.00%, respectively, which showed the potential as surface tension reducers with low emulsification activity. The higher hydrocarbon solubility was shown by the biosurfactant from the rumen residue (13 620 µg g-1) and the mixture (10 998 µg g-1) at day 40 th , which was comparable to 1.50% of Tween 80. The biosurfactants in the current research were produced with the same materials, process, and time as compost humic acid-like substances which acts as in-situ bio-based surfactants. The respective ability to solubilize hydrocarbon might be combined and estimated to be higher than Tween 80 of 24 329 µg g-1 and 21 619 µg g-1 for rumen residue and the mixture, respectively. Therefore, it was concluded that the best composition for in-situ bio-based surfactant production to assist the degradation of hydrocarbon through composting process is polluted soil with organic waste (1:1, w/w). The solubility of hydrocarbons can be increased without synthetic surfactants addition, but through providing nutrients to maintain in-situ bio-based surfactant production with intermittent addition of organic waste every 40 days. This method is expected to be an appropriate approach in composting development as a cost-effective sustainable bioremediation technique for polluted soil.

Analisis Perbandingan Tingkat Resiko Kebangkrutan Pada Bank Syariah Dan Bank Konvensional Yang Terdaftar DI Website Resmi Bank

The Effect of Job Embeddedness on Turnover Intention of Yoga Instructors: Focused on the Mediating Effect of Job Satisfaction

The Korean Journal of Physical Education, 2018

Job embeddedness is defined as '… the combined forces that keep a person from leaving his or her ... more Job embeddedness is defined as '… the combined forces that keep a person from leaving his or her job' [13]. Job embeddedness links the employee with the firm and their job in a closer manner, and stronger influence of job embeddedness leads to tendencies to stay within the organization instead of escaping the organization. Interestingly, research demonstrates that job embeddedness is a stronger predictor of

Syncope in a Young Woman With Chronic Back Pain

Hospital Practice, 1993

Pendidikan Agama Islam Upaya Pembentukan Pemikiran dan Kepribadian Muslim

xi, 265 hal.; 23 cm

Tinutuan Manado : antalogi esay bengkel sastra 2019

Esai-esai yang termuat dalam buku Tinutuan Manado, Antologi Esai Bengkel Sastra 2019 ini adalah k... more Esai-esai yang termuat dalam buku Tinutuan Manado, Antologi Esai Bengkel Sastra 2019 ini adalah karya peserta Bengkel Sastra Penulisan Esai Tahun 2019. Peserta bengkel sastra ini adalah para sastrawan muda daerah yang sangat potensial, guru bahasa Indonesia, duta bahasa, para peneliti Balai Bahasa Sulawesi Utara, dan mahasiswa jurusan bahasa dan sastra dari beberapa perguruan tinggi di Sulawesi Utara. Mereka dilatih oleh Kang Maman, sapaan akrab Maman S. Mahayana, seorang sastrawan kondang, kritikus sastra yang mumpuni yang telah menghasilkan banyak karya, dan telah memperoleh beberapa penghargaan dari berbagai pihak. Kang Maman juga seorang dosen yang andal di Fakultas Ilmu Pengetahuan Budaya Universitas Indonesia dan dosen di beberapa perguruan tinggi, baik di dalam negeri maupun di luar negeri. Topik yang diangkat pun beragam sesuai dengan minat tiap-tiap peserta. Namun, secara garis besar, topik-topik tersebut dapat kami golongkan ke dalam empat kelompok, yakni kelompok sejarah,...

Perda Bernuansa Syariah Dan Hubungannya Dengan Konstitusi

Jurnal Hukum Ius Quia Iustum

Legal history found that the practice of judicial review has been long recognized in the Muslim c... more

Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein

Journal of Alzheimers …, 2004

α-Synuclein is a major constituent of pathological intracellular inclusion bodies, a common featu... more α-Synuclein is a major constituent of pathological intracellular inclusion bodies, a common feature of several neurodegenerative diseases. Two missense mutations in the α-synuclein gene have been identified in confirmed autosomal-dominant familial Parkinson's disease, which segregate with the illness. However, the physiological function of α-synuclein remains unknown. After biochemical investigations we have revealed tubulin to be an α-synuclein associated/binding protein. Here, we show that α-synuclein induces polymerization of purified tubulin into microtubules. Mutant forms of α-synuclein lose this potential. The binding site of α-synuclein to tubulin is identified, and co-localization of α-synuclein with microtubules is shown in cultured cells. To our knowledge, this is the first demonstration of microtubule-polymerizing activity of α-synuclein. Now we can see a striking resemblance between α-synuclein and tau: both have the same physiological function and pathological features, making abnormal structures in diseased brains known as synucleinopathies and tauopathies. The discovery of a physiological role for α-synuclein may provide a new dimension in researches into the mechanisms of α-synuclein-associated neurodegenerative diseases.

Tubulin seeds α-synuclein fibril formation

Journal of Biological …, 2002

Increasing evidence suggests that α-synuclein is a common pathogenic molecule in several neurodeg... more

Penggunaan Sistem Informasi Geografis (Sig) Dalam Analisis Daya Dukung Dan Daya Tampung Lingkungan Hidup DI Kabupaten Tanah Laut

INFO-TEKNIK, 2020

The objective of the study was to provide an overview of the using of Analytical Geographical Inf... more The objective of the study was to provide an overview of the using of Analytical Geographical Information System (GIS) to determine Environmental Carrying Capacity and Capability in Tanah Laut Regency Province of South Kalimantan. The combination methode of Pairwise Comparation and The spatial capacity offered by GIS is directly applicable to understanding the spatial variation by environmental factors. The result of this study shows that carrying capacity and capability can reflect a potential and availability of natural resources in the area of Tanah Laut Regency so that it can be known in which areas have the greatest potential and availability of indicators where the percentage distribution of the extent of the environmental carrying capacity of each ecosistem service potential and the most dominant availability are in the District of Jorong, which is 60% for the High category including 6 Ecosistem Services and 40% for the very high category for 4 Ecosistem Services. 30% Kintap ...

Study of Spleen and Liver Injuries in Patients of Blunt Trauma Abdomen

Pakistan Journal of Medical and Health Sciences

Objective: To study the spleen and liver injuries in patients of blunt trauma abdomen. Material a... more Objective: To study the spleen and liver injuries in patients of blunt trauma abdomen. Material and methods: This was a cross sectional study which conducted at Department of Surgery Loralai Medical College Loralai from May 2021 to November 2021 over the period of 6 months. Total 130 patients aged 18-50 years either gender with blunt trauma abdomen were recruited for this study. Spleen and liver injuries and their grading was studied. Results: Total 130 patients of blunt abdominal trauma were recruited. Age range was 18-50 years with mean age 30.85 ± 8.84 years. Out of 130 patients, liver injury was found in 67 (52%) patients. Total 84 (65%) patients had spleen injury. Total 20 (15%) patients had both liver and spleen injury. Conclusion: Results of this study concluded that spleen was the most common injured organ. Grade-I liver and spleen injury was commonly seen. Age group 18-33 years was common age group and males were prominent than females. Keywords: trauma, abdomen, liver, spleen

An Assessment of Different Clinical Presentations in Cases of Colorectal Cancer

Pakistan Journal of Medical and Health Sciences

Objective: To assess the different clinical presentations in cases of colorectal cancer. Material... more Objective: To assess the different clinical presentations in cases of colorectal cancer. Material and methods: Between April 2021 to October 2021 total 90 diagnosed patients of colorectal cancer confirmed on histopathology, either male or female having age 25-75 years were selected from Department of Surgery, Loralai Medical College Loralai. Different clinical presentations of colorectal cancer were assessed. Results: In present study age range was 25-75 years with mean age 48.58 ± 15.16 years. Grade-I cancer was found in 24 (27%) patients followed by grade-II cancer in 29 (32%) patients and grade-III cancer in 37 (41%) patients. Regarding clinical presentation of patients, bleeding per rectum was found in 73 (81.1%) patients followed by altered bowel habits in 67 (74.4%) patients, anemia in 27 (30%) patients and weight loss was seen in 19 (21.1%) patients. Conclusion: Results of present study showed that most of the patients had grade-III colorectal cancer. Males were prominent as ...

O Descarte do Lixo Eletrônico e o Uso da Logística Reversa: O Caso dos Municípios Integrantes da Região Central Serrana do Espirito Santo / The Disposal of Electronic Waste and the Use of Reverse Logistics: The Case of the Municipalities of the Central Mountainous Region of Espirito Santo

Brazilian Journal of Development, 2021

O presente trabalho descreve o emprego da logística reversa para a realização do correto descarte... more O presente trabalho descreve o emprego da logística reversa para a realização do correto descarte do lixo eletrônico em repartições públicas da região Central Serrana do Espírito Santo, tendo como parâmetro a Política Nacional de Resíduos Sólidos (PNRS). A pesquisa se caracteriza como exploratória, com caráter de avaliação de resultados, instrumentalizada por meio de um questionário, na qual se obteve 220 respostas. Como principais resultados, foi verificado que parte significativa dos entrevistados entende que a determinação pela responsabilidade na gestão dos resíduos proveniente de lixo eletrônico não está bem estabelecida, pois não estão tendo visibilidade por parte dos servidores, necessitando de serem mais transparentes. Foi, ainda, observado, que para a maioria dos entrevistados, os resíduos sólidos do lixo eletrônico estão recebendo o tratamento adequado em seu local de trabalho. Além disso, percebeu-se que, sem uma gestão onde todos estejam engajados e envolvidos, onde os procedimentos não sejam conhecidos ou simplesmente não exista, não se consegue ser eficiente e realmente fazer a PNRS funcionar.

Asas-asas Hukum Modern Dalam Hukum Islam

Jurnal Media Hukum, 2010

Tulisan ringkas ini fokus pada analisis pengertian asas-asas hukum, perbedaan asas hukum dengan n... more Tulisan ringkas ini fokus pada analisis pengertian asas-asas hukum, perbedaan asas hukum dengan norma/kaidah hukum, kedudukan asas hukum, fungsi dan jenis asas-asas hukum dalam sistem hukum. Bahannya merupakan rangkuman dari beberapa literatur yang penulis simak pada perpustakaan pribadi. Metode yang digunakan dalam artikel ini adalah penelitian hukum normatif. Pendekatan masalah yang digunakan dalam penelitian ini adalah dengan menggunakan pendekatan perundang-undangan. Dipahami asas-asas hukum itu sebagai pikiran-pikiran dasar yang terdapat di dalam dan di belakang sistem hukum, masing-masing dirumuskan dalam aturan-aturan perundang-undangan dan putusan-putusan hakim, yang berkenaan dengannya ketentuan-ketentuan dan keputuankeputusan individual dapat dipandang sebagai penjabarannya. Apabila dalam bidang hukum kita telah sepakat, bahwa Pancasila sumber dari segala sumber hukum negara, maka sudah wajarlah, kalau kita membicarakan asas, berpendapat bahwa sumber dari segala asas hukum adalah Pancasila, Pancasila dipegang teguh sebagai kaidah dasar, sebagai suatu beginsel rechtsideologie atau asas ideologi hukum Indonesia.

Tinjauan Kosep Pemasaran Islam Terhadap Implementasi Strategi Bauran Pemasaran Produk Takafullink Salam Cendikia (Asuransi Pendidikan) Di PT Asuransi Takaful Keluarga Cabang Bandung

Prosiding Hukum Ekonomi Syariah; Vol 1, No 1, Prosiding Hukum Ekonomi Syariah (Februari, 2015), Feb 9, 2015

Konsep pemasaran Islam pada produk Asuransi di Lembaga Asuransi Syariah adalah konsep dakwah, yai... more Konsep pemasaran Islam pada produk Asuransi di Lembaga Asuransi Syariah adalah konsep dakwah, yaitu ajakan, pengarahan, dan tindak lanjut dari Inisiator (dai) kepada stakeholdernya (jamaah). Hal ini, harus dilaksanakan dengan cara Hikmah, sebagaimana yang tertuang dalam Al-Qur’an surat An-Nahl: 125. Implementasi strategi bauran pemasaran produk Takaful link Salam Cendikia yang diterapkan di Asuransi Takaful adalah menggunakan Advertising, marketing communications, da n personal selling . Konsep bauran pemasaran produk Takaful Link Salam Cendikia yang diimplementasikan di PT Asuransi Takaful sudah sesuai dengan konsep pemasaran Islam.

Biosurfactant Produced by Indigenous Bacteria during Composting Process of Crude Oil Polluted Soil: Properties and Role

Journal of Ecological Engineering, 2022

Bacterial co-metabolism in composting process has been widely used to remove hydrocarbons, aided ... more Bacterial co-metabolism in composting process has been widely used to remove hydrocarbons, aided by in-situ production of bio-based surfactants, in terms of compost humic acid-like substances and biosurfactants. The properties of compost humic acid-like substances have been shown in previous studies as potential surface tension reducers and emulsifiers for hydrocarbons. The current study aimed to analyze the properties of biosurfactant of surface tension decrease, emulsification activity, and hydrocarbon solubilization ability. Four indigenous bacteria consortia were isolated from composted materials of yard waste, rumen residue, crude oil-polluted soil, and the mixture of polluted soil with organic waste (1:1, w/w) at day 0 th , 20 th , 40 th , and 60 th. Organic waste consists of yard waste and rumen residue in the ratio of 1:1. The isolated indigenous bacteria consortia were incubated for 7 days in different media, i.e., organic waste extract, 6.00% of crude oil, and a mixture of organic waste extract with 6.00% crude oil. The results indicated that the surface tension decrease and emulsification activity of biosurfactants were 8.35-52.90 mN m-1 and 0.00-12.00%, respectively, which showed the potential as surface tension reducers with low emulsification activity. The higher hydrocarbon solubility was shown by the biosurfactant from the rumen residue (13 620 µg g-1) and the mixture (10 998 µg g-1) at day 40 th , which was comparable to 1.50% of Tween 80. The biosurfactants in the current research were produced with the same materials, process, and time as compost humic acid-like substances which acts as in-situ bio-based surfactants. The respective ability to solubilize hydrocarbon might be combined and estimated to be higher than Tween 80 of 24 329 µg g-1 and 21 619 µg g-1 for rumen residue and the mixture, respectively. Therefore, it was concluded that the best composition for in-situ bio-based surfactant production to assist the degradation of hydrocarbon through composting process is polluted soil with organic waste (1:1, w/w). The solubility of hydrocarbons can be increased without synthetic surfactants addition, but through providing nutrients to maintain in-situ bio-based surfactant production with intermittent addition of organic waste every 40 days. This method is expected to be an appropriate approach in composting development as a cost-effective sustainable bioremediation technique for polluted soil.

Analisis Perbandingan Tingkat Resiko Kebangkrutan Pada Bank Syariah Dan Bank Konvensional Yang Terdaftar DI Website Resmi Bank

The Effect of Job Embeddedness on Turnover Intention of Yoga Instructors: Focused on the Mediating Effect of Job Satisfaction

The Korean Journal of Physical Education, 2018

Job embeddedness is defined as '… the combined forces that keep a person from leaving his or her ... more Job embeddedness is defined as '… the combined forces that keep a person from leaving his or her job' [13]. Job embeddedness links the employee with the firm and their job in a closer manner, and stronger influence of job embeddedness leads to tendencies to stay within the organization instead of escaping the organization. Interestingly, research demonstrates that job embeddedness is a stronger predictor of

Syncope in a Young Woman With Chronic Back Pain

Hospital Practice, 1993

Pendidikan Agama Islam Upaya Pembentukan Pemikiran dan Kepribadian Muslim

xi, 265 hal.; 23 cm

Tinutuan Manado : antalogi esay bengkel sastra 2019

Esai-esai yang termuat dalam buku Tinutuan Manado, Antologi Esai Bengkel Sastra 2019 ini adalah k... more Esai-esai yang termuat dalam buku Tinutuan Manado, Antologi Esai Bengkel Sastra 2019 ini adalah karya peserta Bengkel Sastra Penulisan Esai Tahun 2019. Peserta bengkel sastra ini adalah para sastrawan muda daerah yang sangat potensial, guru bahasa Indonesia, duta bahasa, para peneliti Balai Bahasa Sulawesi Utara, dan mahasiswa jurusan bahasa dan sastra dari beberapa perguruan tinggi di Sulawesi Utara. Mereka dilatih oleh Kang Maman, sapaan akrab Maman S. Mahayana, seorang sastrawan kondang, kritikus sastra yang mumpuni yang telah menghasilkan banyak karya, dan telah memperoleh beberapa penghargaan dari berbagai pihak. Kang Maman juga seorang dosen yang andal di Fakultas Ilmu Pengetahuan Budaya Universitas Indonesia dan dosen di beberapa perguruan tinggi, baik di dalam negeri maupun di luar negeri. Topik yang diangkat pun beragam sesuai dengan minat tiap-tiap peserta. Namun, secara garis besar, topik-topik tersebut dapat kami golongkan ke dalam empat kelompok, yakni kelompok sejarah,...

Perda Bernuansa Syariah Dan Hubungannya Dengan Konstitusi

Jurnal Hukum Ius Quia Iustum

Legal history found that the practice of judicial review has been long recognized in the Muslim c... more

Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein

Journal of Alzheimers …, 2004

α-Synuclein is a major constituent of pathological intracellular inclusion bodies, a common featu... more α-Synuclein is a major constituent of pathological intracellular inclusion bodies, a common feature of several neurodegenerative diseases. Two missense mutations in the α-synuclein gene have been identified in confirmed autosomal-dominant familial Parkinson's disease, which segregate with the illness. However, the physiological function of α-synuclein remains unknown. After biochemical investigations we have revealed tubulin to be an α-synuclein associated/binding protein. Here, we show that α-synuclein induces polymerization of purified tubulin into microtubules. Mutant forms of α-synuclein lose this potential. The binding site of α-synuclein to tubulin is identified, and co-localization of α-synuclein with microtubules is shown in cultured cells. To our knowledge, this is the first demonstration of microtubule-polymerizing activity of α-synuclein. Now we can see a striking resemblance between α-synuclein and tau: both have the same physiological function and pathological features, making abnormal structures in diseased brains known as synucleinopathies and tauopathies. The discovery of a physiological role for α-synuclein may provide a new dimension in researches into the mechanisms of α-synuclein-associated neurodegenerative diseases.

Tubulin seeds α-synuclein fibril formation

Journal of Biological …, 2002

Increasing evidence suggests that α-synuclein is a common pathogenic molecule in several neurodeg... more