Introduction: A number of questionnaires are currently used to assess HRQOL in NCFB, however litt... more Introduction: A number of questionnaires are currently used to assess HRQOL in NCFB, however little is known about their validity in this condition. Aims: To assess the validity of HRQOL questionnaires in NCFB. Methods: A search was conducted on Embase, Pubmend, Medline, PsychINFO and Cochrane Library. Studies (including abstracts) were selected if assessed internal consistency, repeatability and responsiveness of a HRQOL tools. Analysis used descriptive and qualitatively methods. Results: Nine (3 abstracts) out of 392 studies were included. Four questionnaires were identified, but only QOL-B was disease specific for NCFB. Internal consistency ranged from moderate to very good and repeatability was very good. Studies that reported responsiveness, supported SGRQ, LCQ and QOL-B. Conclusions: A few studies support adequate validity of HRQOL questionnaires in NCFB. SGRQ and QOL-B were the most frequently studied questionnaires, but these have 37 items or more. There is a need for brief, disease specific, well validated HRQOL questionnaires in NCFB.
SIGLEAvailable from British Library Document Supply Centre- DSC:3831. 03767(5) / BLDSC - British ... more SIGLEAvailable from British Library Document Supply Centre- DSC:3831. 03767(5) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Diversos questionários desenvolvidos em língua inglesa visam avaliar especificamente a limitação ... more Diversos questionários desenvolvidos em língua inglesa visam avaliar especificamente a limitação pela dispnéia durante actividades da vida diá ria (AVD) em doentes com doença pulmonar obstrutiva crónica (DPOC), como a escala London
Journal of Cardiopulmonary Rehabilitation, Mar 1, 2001
The addition of noninvasive positive pressure ventilation (NPPV) to an exercise training (ET) pro... more The addition of noninvasive positive pressure ventilation (NPPV) to an exercise training (ET) program in severe chronic obstructive pulmonary disease (COPD) may produce greater benefits in exercise tolerance and quality of life than after training alone. Forty-five patients with severe stable COPD-mean (SD) FEV 1 0.96 (0.31) L, Pa O 2 65.4 (9.07) mm Hg, Pa CO 2 45.6 (7.89) mm Hg-were randomized to domiciliary NPPV ϩ ET (n ϭ 23) or ET alone (n ϭ 22). Exercise capacity and health status were assessed at baseline and after an 8-wk training program. There was a significant improvement in mean shuttle walk test (SWT) in the NPPV ϩ ET group: from 169 (112) to 269 (124) m (p ϭ 0.001), compared with the ET group: 205 (100) to 233 (123) m (p ϭ 0.19); mean difference (95% confidence interval [CI]): 72 (12.9 to 131) m. Repeated measures analysis of variance (ANOVA) showed that the differences between the two groups became evident only in the final 4 wk of the training program with a mean end study difference (95% 1CI) of 65.8 (17.1 to 114) m. There was a significant improvement in the Chronic Respiratory Disease Questionnaire (CRDQ) of mean (SD) 24.0 (17.4) (p ϭ Ͻ 0.001) in the NPPV ϩ ET group and 11.8 (15.8) (p ϭ 0.003) points in the ET group; mean difference: 12.3 (1.19 to 23.4). Only the NPPV ϩ ET group demonstrated a significant improvement in arterial oxygenation; mean difference: 3.70 mm Hg (0.37 to 7.27). This study suggests that domiciliary NPPV can be used successfully to augment the effects of rehabilitation in severe COPD.
Health-related quality of life or health status is significantly impaired in bronchiectasis. Ther... more Health-related quality of life or health status is significantly impaired in bronchiectasis. There is a paucity of brief, simple-to-use, disease-specific health status measures. The aim of this study was to develop and validate the Bronchiectasis Health Questionnaire (BHQ), a new health status measure that is brief and generates a single overall score. Patients with bronchiectasis were recruited from two outpatient clinics, during a clinically stable stage. The development of the questionnaire followed three phases: item generation and item reduction using Rasch analysis, validation, and repeatability testing. The BHQ was translated into 11 languages using standardised methodology. 206 patients with bronchiectasis completed a preliminary 65-item questionnaire. 55 items were removed due to redundancy or poor fit to the Rasch model. The final version of the BHQ consisted of 10 items. Internal consistency was good (Cronbach's α=0.85). Convergent validity of the BHQ with the St George's Respiratory Questionnaire was high (r= −0.82; p<0.001) and moderate with lung function (forced expiratory volume in 1 s % predicted r= −0.27; p=0.001). There was a significant association between BHQ scores and number of exacerbations of bronchiectasis in the last 12 months (p<0.001), hospital admissions (p=0.001) and computed tomography scan bronchiectasis pulmonary lobe counts (p<0.001). BHQ scores were significantly worse in patients with sputum bacterial colonisation versus no colonisation (p=0.048). The BHQ was highly repeatable after 2 weeks (intraclass correlation coefficient 0.89). The BHQ is a brief, valid and repeatable, self-completed health status questionnaire for bronchiectasis that generates a single total score. It can be used in the clinic to assess bronchiectasis from the patient's perspective.
Background A range of questionnaires have been used to assess health-related quality of life (HRQ... more Background A range of questionnaires have been used to assess health-related quality of life (HRQOL) in bronchiectasis. A systematic review was conducted to evaluate their psychometric properties and assess associations between HRQOL and clinical measures. Methods Five electronic databases were searched. Studies eligible for inclusion were those that investigated the validity of HRQOL questionnaires and/or their association with other outcomes in adults with bronchiectasis. Patients with cystic fibrosis were excluded. The identified questionnaires were assessed for convergent, discriminant and cross-cultural translation validity; missing data, floor and ceiling effects, internal consistency, responsiveness and test-retest reliability. A meta-analysis was conducted to estimate the strength of associations between HRQOL and clinical measures. Results From 1918 studies identified, 43 studies were included in the systematic review, of which 38 were suitable for the meta-analysis. Nine HRQOL questionnaires were identified, with the most widely used being: St George's Respiratory Questionnaire, Leicester Cough Questionnaire, Quality of Life-Bronchiectasis and Short Form-36. HRQOL questionnaires had moderate to good internal consistency and good test-retest reliability. Only 8 of 18 studies that used translated HRQOL questionnaires reported or referred to the validity of the translated questionnaire. There was a stronger correlation (mean r (95% CI)) between HRQOL and subjective outcome measures, such as dyspnoea (0.55 (0.41 to 0.68)) and fatigue (0.42 (0.23 to 0.58)) compared with objective measures; exercise capacity (−0.41 (−0.54 to −0.24)), FEV 1 % predicted (−0.31 (−0.40 to −0.23)) and extent of bronchiectasis on CT scan (0.35 (0.03 to 0.61)); all p<0.001. Conclusions This review supports most HRQOL questionnaires used in bronchiectasis have good psychometric properties. There was a weak to moderate association between HRQOL and objective outcome measures. This suggests that HRQOL questionnaires assess a unique aspect of health not captured by objective measures.
Funding The meeting room, travel expenses, literature search and associated administration costs ... more Funding The meeting room, travel expenses, literature search and associated administration costs were funded by the BTS.
Introduction: A number of questionnaires are currently used to assess HRQOL in NCFB, however litt... more Introduction: A number of questionnaires are currently used to assess HRQOL in NCFB, however little is known about their validity in this condition. Aims: To assess the validity of HRQOL questionnaires in NCFB. Methods: A search was conducted on Embase, Pubmend, Medline, PsychINFO and Cochrane Library. Studies (including abstracts) were selected if assessed internal consistency, repeatability and responsiveness of a HRQOL tools. Analysis used descriptive and qualitatively methods. Results: Nine (3 abstracts) out of 392 studies were included. Four questionnaires were identified, but only QOL-B was disease specific for NCFB. Internal consistency ranged from moderate to very good and repeatability was very good. Studies that reported responsiveness, supported SGRQ, LCQ and QOL-B. Conclusions: A few studies support adequate validity of HRQOL questionnaires in NCFB. SGRQ and QOL-B were the most frequently studied questionnaires, but these have 37 items or more. There is a need for brief, disease specific, well validated HRQOL questionnaires in NCFB.
SIGLEAvailable from British Library Document Supply Centre- DSC:3831. 03767(5) / BLDSC - British ... more SIGLEAvailable from British Library Document Supply Centre- DSC:3831. 03767(5) / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Diversos questionários desenvolvidos em língua inglesa visam avaliar especificamente a limitação ... more Diversos questionários desenvolvidos em língua inglesa visam avaliar especificamente a limitação pela dispnéia durante actividades da vida diá ria (AVD) em doentes com doença pulmonar obstrutiva crónica (DPOC), como a escala London
Journal of Cardiopulmonary Rehabilitation, Mar 1, 2001
The addition of noninvasive positive pressure ventilation (NPPV) to an exercise training (ET) pro... more The addition of noninvasive positive pressure ventilation (NPPV) to an exercise training (ET) program in severe chronic obstructive pulmonary disease (COPD) may produce greater benefits in exercise tolerance and quality of life than after training alone. Forty-five patients with severe stable COPD-mean (SD) FEV 1 0.96 (0.31) L, Pa O 2 65.4 (9.07) mm Hg, Pa CO 2 45.6 (7.89) mm Hg-were randomized to domiciliary NPPV ϩ ET (n ϭ 23) or ET alone (n ϭ 22). Exercise capacity and health status were assessed at baseline and after an 8-wk training program. There was a significant improvement in mean shuttle walk test (SWT) in the NPPV ϩ ET group: from 169 (112) to 269 (124) m (p ϭ 0.001), compared with the ET group: 205 (100) to 233 (123) m (p ϭ 0.19); mean difference (95% confidence interval [CI]): 72 (12.9 to 131) m. Repeated measures analysis of variance (ANOVA) showed that the differences between the two groups became evident only in the final 4 wk of the training program with a mean end study difference (95% 1CI) of 65.8 (17.1 to 114) m. There was a significant improvement in the Chronic Respiratory Disease Questionnaire (CRDQ) of mean (SD) 24.0 (17.4) (p ϭ Ͻ 0.001) in the NPPV ϩ ET group and 11.8 (15.8) (p ϭ 0.003) points in the ET group; mean difference: 12.3 (1.19 to 23.4). Only the NPPV ϩ ET group demonstrated a significant improvement in arterial oxygenation; mean difference: 3.70 mm Hg (0.37 to 7.27). This study suggests that domiciliary NPPV can be used successfully to augment the effects of rehabilitation in severe COPD.
Health-related quality of life or health status is significantly impaired in bronchiectasis. Ther... more Health-related quality of life or health status is significantly impaired in bronchiectasis. There is a paucity of brief, simple-to-use, disease-specific health status measures. The aim of this study was to develop and validate the Bronchiectasis Health Questionnaire (BHQ), a new health status measure that is brief and generates a single overall score. Patients with bronchiectasis were recruited from two outpatient clinics, during a clinically stable stage. The development of the questionnaire followed three phases: item generation and item reduction using Rasch analysis, validation, and repeatability testing. The BHQ was translated into 11 languages using standardised methodology. 206 patients with bronchiectasis completed a preliminary 65-item questionnaire. 55 items were removed due to redundancy or poor fit to the Rasch model. The final version of the BHQ consisted of 10 items. Internal consistency was good (Cronbach's α=0.85). Convergent validity of the BHQ with the St George's Respiratory Questionnaire was high (r= −0.82; p<0.001) and moderate with lung function (forced expiratory volume in 1 s % predicted r= −0.27; p=0.001). There was a significant association between BHQ scores and number of exacerbations of bronchiectasis in the last 12 months (p<0.001), hospital admissions (p=0.001) and computed tomography scan bronchiectasis pulmonary lobe counts (p<0.001). BHQ scores were significantly worse in patients with sputum bacterial colonisation versus no colonisation (p=0.048). The BHQ was highly repeatable after 2 weeks (intraclass correlation coefficient 0.89). The BHQ is a brief, valid and repeatable, self-completed health status questionnaire for bronchiectasis that generates a single total score. It can be used in the clinic to assess bronchiectasis from the patient's perspective.
Background A range of questionnaires have been used to assess health-related quality of life (HRQ... more Background A range of questionnaires have been used to assess health-related quality of life (HRQOL) in bronchiectasis. A systematic review was conducted to evaluate their psychometric properties and assess associations between HRQOL and clinical measures. Methods Five electronic databases were searched. Studies eligible for inclusion were those that investigated the validity of HRQOL questionnaires and/or their association with other outcomes in adults with bronchiectasis. Patients with cystic fibrosis were excluded. The identified questionnaires were assessed for convergent, discriminant and cross-cultural translation validity; missing data, floor and ceiling effects, internal consistency, responsiveness and test-retest reliability. A meta-analysis was conducted to estimate the strength of associations between HRQOL and clinical measures. Results From 1918 studies identified, 43 studies were included in the systematic review, of which 38 were suitable for the meta-analysis. Nine HRQOL questionnaires were identified, with the most widely used being: St George's Respiratory Questionnaire, Leicester Cough Questionnaire, Quality of Life-Bronchiectasis and Short Form-36. HRQOL questionnaires had moderate to good internal consistency and good test-retest reliability. Only 8 of 18 studies that used translated HRQOL questionnaires reported or referred to the validity of the translated questionnaire. There was a stronger correlation (mean r (95% CI)) between HRQOL and subjective outcome measures, such as dyspnoea (0.55 (0.41 to 0.68)) and fatigue (0.42 (0.23 to 0.58)) compared with objective measures; exercise capacity (−0.41 (−0.54 to −0.24)), FEV 1 % predicted (−0.31 (−0.40 to −0.23)) and extent of bronchiectasis on CT scan (0.35 (0.03 to 0.61)); all p<0.001. Conclusions This review supports most HRQOL questionnaires used in bronchiectasis have good psychometric properties. There was a weak to moderate association between HRQOL and objective outcome measures. This suggests that HRQOL questionnaires assess a unique aspect of health not captured by objective measures.
Funding The meeting room, travel expenses, literature search and associated administration costs ... more Funding The meeting room, travel expenses, literature search and associated administration costs were funded by the BTS.
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