European Journal of Orthopaedic Surgery & Traumatology, 2021
Purpose The aim of this prospective study was to evaluate the clinical-radiological outcomes of t... more Purpose The aim of this prospective study was to evaluate the clinical-radiological outcomes of the Alteon Neck Preserving Stem (ANPS) (Exactech, Gainesville, FL, USA) implanted in four different centres by five senior hip surgeons with a minimum of 5 years of follow-up. Material and method We conducted a multicentre prospective study that analysed 155 consecutive total hip replacements during 2014. We performed clinical-radiological analysis measuring Harris Hip Score (HHS), subjective satisfaction evaluation, radiolucencies, position of components, limb length discrepancy, heterotopic ossification, medical and surgical complications and a survival analysis at 5 years follow-up. Results Thigh pain was reported in 5 cases (3.2%), 2 of which reported mild pain, 2 moderate, and 1 severe. In 2 cases, subsidences of 3 mm were detected in the first scheduled X-ray, both related to intraoperative fractures with no progression after 3 months. The overall complication rate was 5.8% and 6 of the 9 complications were in the first 30 cases. Mean HHS improved from 42.9 points (range 37.2–55.7 points) preoperatively to 94.9 on average (range 87–98) at the end of the follow-up ( p <0.01). Subjective evaluation was excellent in 130 (83.87%) cases and good in 25 patients (16.13%). Conclusions The clinical-radiographic results of ANPS THR are satisfactory. The mid-term results are promising. However, long-term follow-up studies are necessary to confirm the validity of the concept.
We have developed a simple and convenient synthetic strategy for the preparation of tetrahydropyr... more We have developed a simple and convenient synthetic strategy for the preparation of tetrahydropyranyl, 4‐methoxytetrahydropyranyl, and tetrahydrofuranyl ethers of 2′‐deoxynucleosides, which are useful building blocks for nucleic acid chemistry. Enzymatic benzoylation provides an efficient alternative for protecting the 5′‐hydroxy group of the parent nucleosides in a regioselective manner. Subsequently, tetrahydropyranylation and tetrahydrofuranylation of the 2′‐deoxynucleosides at the 3′‐hydroxy group were accomplished with p‐toluensulfonic acid, MgBr2, or camphorsulfonic acid as catalysts. Deprotection of the 5′‐O‐benzoyl group furnished 3′‐O‐acetal‐protected 2′‐deoxynucleosides. The three‐step process is expected to enable the large‐scale synthesis of protected nucleosides.
European Journal of Orthopaedic Surgery & Traumatology, 2021
Purpose The aim of this prospective study was to evaluate the clinical-radiological outcomes of t... more Purpose The aim of this prospective study was to evaluate the clinical-radiological outcomes of the Alteon Neck Preserving Stem (ANPS) (Exactech, Gainesville, FL, USA) implanted in four different centres by five senior hip surgeons with a minimum of 5 years of follow-up. Material and method We conducted a multicentre prospective study that analysed 155 consecutive total hip replacements during 2014. We performed clinical-radiological analysis measuring Harris Hip Score (HHS), subjective satisfaction evaluation, radiolucencies, position of components, limb length discrepancy, heterotopic ossification, medical and surgical complications and a survival analysis at 5 years follow-up. Results Thigh pain was reported in 5 cases (3.2%), 2 of which reported mild pain, 2 moderate, and 1 severe. In 2 cases, subsidences of 3 mm were detected in the first scheduled X-ray, both related to intraoperative fractures with no progression after 3 months. The overall complication rate was 5.8% and 6 of the 9 complications were in the first 30 cases. Mean HHS improved from 42.9 points (range 37.2–55.7 points) preoperatively to 94.9 on average (range 87–98) at the end of the follow-up ( p <0.01). Subjective evaluation was excellent in 130 (83.87%) cases and good in 25 patients (16.13%). Conclusions The clinical-radiographic results of ANPS THR are satisfactory. The mid-term results are promising. However, long-term follow-up studies are necessary to confirm the validity of the concept.
We have developed a simple and convenient synthetic strategy for the preparation of tetrahydropyr... more We have developed a simple and convenient synthetic strategy for the preparation of tetrahydropyranyl, 4‐methoxytetrahydropyranyl, and tetrahydrofuranyl ethers of 2′‐deoxynucleosides, which are useful building blocks for nucleic acid chemistry. Enzymatic benzoylation provides an efficient alternative for protecting the 5′‐hydroxy group of the parent nucleosides in a regioselective manner. Subsequently, tetrahydropyranylation and tetrahydrofuranylation of the 2′‐deoxynucleosides at the 3′‐hydroxy group were accomplished with p‐toluensulfonic acid, MgBr2, or camphorsulfonic acid as catalysts. Deprotection of the 5′‐O‐benzoyl group furnished 3′‐O‐acetal‐protected 2′‐deoxynucleosides. The three‐step process is expected to enable the large‐scale synthesis of protected nucleosides.
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Papers by saul martinez